MULTILAYERS AND POLY(ALLYLAMINE HYDROCHLORIDE)-GRAFTPOLY(ETHYLENE GLYCOL) MODIFIED BOVINE SERUM ALBUMIN NANOPARTICLES:IMPROVED STABILITY AND pH-RESPONSIVE DRUG DELIVERY

作     者：Li-li Xie 仝维鋆 Jian-quan Xu Chang-you Gao 

作者机构：MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang University 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2012年第30卷第5期

页      面：719-726页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：financially supported by the Zhejiang Provincial Natural Science Foundation of China(Nos.Z4090177 and Y4110064) the Ministry of Science and Technology of China for the Indo-China Cooperation(No.2010DFA51510) the National Natural Science Foundation of China(Nos.51120135001 and 21174130) 

主　　题：BSA nanoparticle PEG LBL Drug delivery pH-responsive. 

摘      要：To improve the colloidal stability of bovine serum albumin （BSA） nanoparticles （hiPs） in diverse mediums, poly（allylamine hydrochloride） （PAH）/sodium poly（4-styrene sulfonate） （PSS） multilayers and poly（allylamine hydrochloride）-graft-poly（ethylene glycol） （PAH-g-PEG） coating were coated on the surface of BSA NPs. Stabilities of the BSA NPs in diverse mediums with different surfaces were detected by dynamic light scattering （DLS）. Multilayers and PAH-g-PEG coated BSA NPs can be well dispersed in various mediums with a narrow polydispersity index （PDI）. The BSA NPs with the highest surface density of PEG show the best stability. The multilayers and PAH-g-PEG coating do not deter the pH-dependent loading and release property of BSA NPs. At pH 9, the encapsulation efficiency of doxorubicin reaches almost 99%, and the release rate at pH 5.5 is significantly higher than that at pH 7.4.