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Compound extreme inundation risk of coastal wetlands caused by climate change and anthropogenic activities in the Yellow River Delta,China

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Advances in Climate Change Research 2024年第1期15卷 134-147页

作者： Xiao-li WANG Ai-Qing FENG Xi-Yong HOU Qing-Chen CHAO Bai-Yuan SONG Yu-Bin liU Qi-Guang WANG He XU Yu-Xin ZHANG dong li li-jie dong Yu GUO CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Tongji Urban Planning Design Research Institute Shanghai 200092China School of Geography and Tourism Qilu Normal UniversityJinan 250200China China Meteorological Administration Training Centre China Meteorological AdministrationBeijing 10008China University of Chinese Academy of Sciences Beijing 100049China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316022China

The coastal wetlands of the Yellow River Delta(YRD)in China are crucial for their valuable resources,environmental significance,and economic ***,these wetlands are also vulnerable to the dual threats of climate change and human *** substantial attention to the historical shifts in YRD's coastal wetlands,uncertainties remain regarding their future trajectory in the face of compound risks from climate change and anthropogenic *** on a range of remote sensing data sources,this study undertakes a comprehensive investigation into the evolution of YRD's coastal wetlands between 2000 and ***,the potential fate of coastal wetlands is thoroughly analyzed through the Land Use/Cover Change(LUCC)simulation using System Dynamic-Future Land Use Simulation(SD-FLUS)model and the extreme water levels projection integrated future sea-level rise,storm surge,and astronomical high tide in 2030,2050,and 2100 under scenarios of SSP1-2.6,SSP2-4.5,and *** revealed that YRD's coastal wetlands underwent a marked reduction,shrinking by 1688.72 km²from 2000 to *** decline was mostly attributed to the substantial expansion in the areas of artificial wetlands(increasing by 823.78 km2),construction land(increasing by 767.71 km²),and shallow water(increasing by 274.58 km²).Looking ahead to 2030-2100,the fate of coastal wetlands appears to diverge based on different *** the SSP1-2.6 scenario,the area of coastal wetland is projected to experience considerable *** contrast,the SSP5-8.5 scenario anticipates a notable decrease in coastal *** to the inundated area suffered from the current extreme water levels,the study projects a decrease of 6.8%-10.6%in submerged coastal wetlands by 2030 and 9.4%-18.2%by 2050 across all *** 2100,these percentages are projected to decrease by 0.4%(SSP2-4.5)and 27.1%(SSP5-8.5),but increase by 35.7%(SSP1-2.6).Results suggest that coastal wetlands in th

关键词： Climate change Anthropogenic activities Compound extreme risk Coastal wetlands Yellow River Delta

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牛RASGRF1基因的组织印记表达与分析

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农业生物技术学报 2024年第10期32卷 2265-2274页

作者：张银蛟陈玮娜王思伟李冬杰杨利丹郑云畅张萃王昆李世杰河北农业大学生命科学学院河北大学中医学院河北省农林科学院粮油作物研究所河北省作物栽培生理与绿色生产重点实验室河北科技大学生物科学与工程学院

基因组印记是哺乳动物中的一种表观遗传学现象，其基因呈现亲本特异性的单等位基因表达。印记基因在胚胎发育以及胎盘的营养运输中发挥着重要作用。Ras蛋白特异性鸟苷酸释放因子1 (Ras protein specific guanine nucleotide releasing f... 详细信息

基因组印记是哺乳动物中的一种表观遗传学现象，其基因呈现亲本特异性的单等位基因表达。印记基因在胚胎发育以及胎盘的营养运输中发挥着重要作用。Ras蛋白特异性鸟苷酸释放因子1 (Ras protein specific guanine nucleotide releasing factor 1, RASGRF1)基因编码140 k D的Ras特异性鸟嘌呤核苷酸释放因子，并且该基因与动物幼年时期的生长发育性状相关。Rasgrf1基因在小鼠(Mus musculus)中是父源印记基因，而在牛(Bos taurus)中的印记状态尚未研究。为研究RASGRF1基因在牛中的印记状态和调控机理，本研究首先利用qRT-PCR对RASGRF1基因在牛的6个组织(心脏,肝脏,脾脏,肺脏,肾脏,大脑)及胎盘中的表达进行分析，然后应用基于SNP的逆转录PCR (reverse transcription PCR, RT-PCR)产物直接测序法分析RASGRF1基因在牛的组织及胎盘的等位基因表达状态，最后采用亚硫酸盐直接测序法对RASGRF1基因启动子区域的甲基化状态进行研究。结果显示，RASGRF1基因在牛中呈现组织特异性表达，在心脏和肝脏中没有检测到表达；在脾脏、肺脏、肾脏和大脑中为单等位基因表达；在胎盘中为父源等位基因表达。在牛RASGRF1基因启动子及第1个外显子区域没有发现差异甲基化区(differential methylation region, DMRs)，在被检测的组织(心脏,肝脏,脾脏,肺脏,肾脏,大脑)、胎盘和精子中均为轻甲基化，说明该区域的甲基化修饰不参与调控RASGRF1基因的印记表达，其印记表达可能由其他的表观遗传修饰调控。本研究可为深入研究RASGRF1基因的功能以及印记调控机制提供参考依据。

关键词： DNA甲基化基因组印记牛 Ras蛋白特异性鸟苷酸释放因子1 (RASGRF1)基因基因表达

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负压创面治疗技术的机制及在烧伤整形外科中的应用

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海南医学 2024年第1期35卷 143-148页

作者：李飞何延奇(综述) 李东杰(审校) 中国人民解放军总医院海南医院烧伤整形科海南三亚572013

负压创面治疗技术(NPWT)作为一种新兴的创面治疗方法,已经引起了广泛的关注和研究并被施用于多种临床实践。本文归纳了NPWT促进伤口愈合的作用机制,主要包括隔离外界环境、促进创面血液循环、缓解组织水肿、强化肉芽增生以及影响细胞因... 详细信息

负压创面治疗技术(NPWT)作为一种新兴的创面治疗方法,已经引起了广泛的关注和研究并被施用于多种临床实践。本文归纳了NPWT促进伤口愈合的作用机制,主要包括隔离外界环境、促进创面血液循环、缓解组织水肿、强化肉芽增生以及影响细胞因子分泌等。同时对其在烧伤整形外科的治疗范畴诸如烧伤、急慢性创伤及整形等领域中进行应用概述,阐明负压创面治疗技术在提高烧伤整形外科治疗效果、减少并发症和改善患者生活质量方面的潜在意义。

关键词：负压创面治疗技术烧伤整形外科机制应用

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Role of glycolysis in retinal vascular endothelium, glia, pigment epithelium, and photoreceptor cells and as therapeutic targets for related retinal diseases

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1302-1309页

作者： Ting-Ting Yang Hui li li-jie dong Editorial Department of Chinese Journal of Ocular Fundus Diseases West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Tianjin Key Laboratory of Retinal Functions and Diseases Tianjin Branch of National Clinical Research Center for Ocular DiseasesEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China

Glycolysis produces large amounts of adenosine triphosphate(ATP)in a short *** retinal vascular endothelium feeds itself primarily through aerobic glycolysis with less *** when it generates new vessels,aerobic glycolysis provides rapid and abundant ATP support for angiogenesis,and thus inhibition of glycolysis in endothelial cells can be a target for the treatment of *** glycolysis has a protective effect on Müller cells,and it can provide with a target for visual protection and maintenance of the blood-retinal *** physiological conditions,the mitochondria of RPE can use lactic acid produced by photoreceptor cells as an energy source to provide ATP for *** pathological conditions,because RPE cells avoid their oxidative damage by increasing glycolysis,a large number of glycolysis products accumulate,which in turn has a toxic effect on photoreceptor *** shows that stabilizing the function of RPE mitochondria may become a target for the treatment of diseases such as retinal *** decrease of aerobic glycolysis leads to the decline of photoreceptor cell function and impaired vision;therefore,aerobic glycolysis of stable photoreceptor cells provides a reliable target for delaying vision *** is of great significance to study the role of glycolysis in various retinal cells for the targeted treatment of ocular fundus diseases.

关键词： glycolysis microglia retinal pigment epithelium photoreceptor cells

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Research progress on the role of connective tissue growth factor in fibrosis of diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1550-1554页

作者： Teng Ma li-jie dong Xue-li Du Rui Niu Bo-jie Hu Tianjin Medical University Eye Hospital Tianjin Medical University Eye InstituteOphthalmology College of Tianjin Medical University

Diabetic retinopathy（DR） is one of the most important types of diabetic microangiopathy, which is a specific change of fundus lesions and is one of the most serious complications of diabetes. When DR develops to proliferative DR, the main factors of decreasing vision, and even blindness, include retinal detachment and vitreous hemorrhage caused by contraction of blood vessels by fiber membrane. Recent studies reported that the formation of fiber vascular membrane is closely related to retinal fibrosis. The connective tissue growth factor（CTGF） is a cytokine that is closely related to DR fibrosis. However, its mechanism is poorly understood. This paper summarizes the recent studies about CTGF on DR fibrosis for a comprehensive understanding of the role and mechanism of CTGF in PDR.

关键词： proliferative diabetic retinopathy fibrosis connective tissue growth factor vascular endothelial growth factor

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Surgical induced astigmatism correlated with corneal pachymetry and intraocular pressure: transconjunctival sutureless 23-gauge versus 20-gauge sutured vitrectomy in diabetes mellitus

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 528-533页

作者： Yan Shao li-jie dong Yan Zhang Hui liu Bo-jie Hu Ju-Ping liu Xiao-Rong li Tianjin Medical University Eye Hospital Tianjin Medical University Eye Institute The College of Optometry & Ophthalmology

AIM: To determine the difference of surgical induced astigmatism between conventional 20-gauge sutured vitrectomy and 23-gauge transconjunctival sutureless vitrectomy, and the influence of corneal pachymetry and intraocular pressure(IOP) on surgical induced astigmatism in diabetic ***: This retrospective, consecutive case series consisted of 40 eyes of 38 diabetic subjects who underwent either 20-gauge or 23-gauge vitrectomy. The corneal curvature and thickness were measured with Scheimpflug imaging before surgery and 1wk; 1, 3mo after surgery. We compared the surgical induced astigmatism(SIA) on the true net power in 23-gauge group with that in 20-gauge group. We determined the correlation between corneal thickness change ratio, IOP and SIA measured by Pentacam. RESULTS: The mean SIAs were 1.082 ±0.085 D( mean ± SEM), 0.689 ±0.070 D and 0.459 ±0.063 D at postoperative 1wk; 1, 3mo respectively in diabetic subjects. The vitrectomy induced astigmatisms were declined significantly with time(F2,36=33.629, P =0.000)postoperatively. The 23-gauge surgery group induced significantly less astigmatism than 20-gauge surgery group(F1,37=11.046, P =0.020). Corneal thickness in diabetes elevated after surgery(F3,78=10.532, P =0.000).The linear regression analysis at postoperatively 1wk went as: SIA =-4.519 +4.931 change ratio(Port3) +0.026IOP(R2=0.46, P =0.000), whereas the rate of cornealthickness change and IOP showed no correlation with the change of astigmatism at postoperatively 1 and ***: There are significant serial changes in both 20-gauge and 23-gauge group in diabetic subjects.23-gauge induce less astigmatism than 20-gauge and become stable more rapidly than 20-gauge. The elevation of corneal thickness and IOP was associated with increased astigmatim at the early postoperative stage both in 23-gauge and 20-gauge surgery group.

关键词： astigmatism cornealpachymetry vitrectomy intraocular pressure diabetes mellitus

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Numerical study on the effective thermal conductivity and thermal tortuosity of porous media with different morphologies

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Science China(Technological Sciences) 2024年第6期67卷 1685-1694页

作者： DU Shen li dong li Meng-jie HE Ya-ling Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an710049China

Effective thermal conductivity and thermal tortuosity are crucial parameters for evaluating the effectiveness of heat conduction within porous *** direct pore-scale numerical simulation method is applied to investigate the heat conduction processes inside porous structures with different *** thermal conduction performances of idealized porous structures are directly compared with real foams across a wide range of *** foam structures are reconstructed using X-ray computed tomography and image processing techniques,while Kelvin and Weaire-Phelan structures are generated through periodic unit cell *** detailed temperature fields inside the porous structures are determined by solving the heat conduction equation at the pore *** results present that the equivalent thermal conductivity of Kelvin and Weaire-Phelan structures is similar to and greater than that of the real foam structure with the same strut *** thermal tortuosity of real foam structure is relatively larger and the heat conduction path becomes straighter by adopting the anisotropic *** thermal tortuosity of the fluid channels for Kelvin,Weaire-Phelan,and real foam structures is close to *** thermal conductivity of porous structures with heat transfer fluid increases as the thermal conductivity ratio of fluid to solid becomes larger.A small porosity of porous media leads to a larger equivalent thermal conductivity due to the dominant contribution of porous skeleton in the heat conduction *** derived from parallel and series models,as well as the Maxwell-Eucken models,provide decent predictions of effective thermal conductivity,with an average error of less than 8%in the entire range of thermal conductivity ratio.

关键词： volumetric solar receiver porous morphology direct pore-scale simulation equivalent thermal conductivity thermal tortuosity empirical correlation

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A Review on Particle Reinforced Mg Matrix Composites Fabricated by Powder Metallurgy

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 391-400页

作者： Zhiyuan liu li Jin Jian Zeng Fulin Wang Fenghua Wang Shuai dong jie dong National Engineering Research Center of light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

This paper provides a comprehensive review of research progress in particle-reinforced Mg matrix composites prepared via powder *** article discusses different strategies,such as micro-sized,nano-sized particles,and multi-particle hybridization,which has been employed to enhance the performance of the *** addition,a range of preparation techniques that optimize the dispersion of the reinforcing particles are *** paper also highlights how the different configurations between the reinforcements and matrix alloy impact the composites’***,the article outlines the prospects of particles reinforced Mg matrix composites fabricated via powder metallurgy and recommends modification methods that could be explored to further develop these materials for various applications.

关键词： Magnesium matrix composites Reinforcing particle Powder metallurgy Mechanical properties Configuration

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Achromatopsia caused by novel missense mutations in the CNGA3 gene

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 910-915页

作者： Xi-Teng Chen Hui Huang Yan-Hua Chen li-jie dong Xiao-Rong li Xiao-Min Zhang Tianjin Medical University Eye Hospital Eye Institute &School of Optometry and Ophthalmology BGI Health Service Co. Ltd.Airport Industrial Zone

AIMTo identify the genetic defects in a Chinese family with *** 2.5-year-old boy, who displayed nystagmus, photophobia, and hyperopia since early infancy, was clinically evaluated. To further confirm and localize the causative mutations in this family, targeted region capture and next-generation sequencing of candidate genes, such as CNGA3, CNGB3, GNAT2, PDE6C, and PDE6H were performed using a custom-made capture ***-lamp examination showed no specific findings in the anterior segments. The optic discs and maculae were normal on fundoscopy. The unaffected family members reported no ocular complaints. Clinical signs and symptoms were consistent with a clinical impression of autosomal recessive achromatopsia. The results of sequence analysis revealed two novel missense mutations in CNGA3, c.633T>A (p.D211E) and c.1006G>T (p.V336F), with an autosomal recessive mode of *** analysis of a Chinese family confirmed the clinical diagnosis of achromatopsia. Two novel mutations were identified in CNGA3, which extended the mutation spectrum of this disorder.

关键词： achromatopsia genetic analysis missense mutation

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Rational design of hydroxytricyanopyrrole-based probes with high affinity and rapid visualization for amyloid-β aggregates in vitro and in vivo

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Chinese Chemical Letters 2024年第5期35卷 290-295页

作者： Jiajia Lv jie Gao Hongyu li Zeli Yuan Nan dong School of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China School of Pharmacy Zunyi Medical UniversityZunyi 563003China Guizhou International Scientific and Technological Cooperation Base for Medical Photo-Theranostics Technology and Innovative Drug Development Zunyi 563003China

As key biomarkers,amyloid-β(Aβ)plaques are frequently used to diagnose Alzheimer’s disease(AD).Although fluorescence imaging has proven to be effective in detecting these plaques,the gold standard probe thioflavin T(ThT),used for Aβaggregates,cannot be applied in vivo owing to its invasive ***,the development of novel fluorescent probes capable of identifying Aβplaques in situ is *** on the ThT structure,twoπ-conjugated heterocyclic D-π-A probes were designed bearing the hydroxytricyanopyrrole acceptor and N,N-dimethylaminophenyl *** probes exhibited red to near-infrared fluorescence emission(λ_(max)=732 nm),large Stokes shifts(>100 nm),exceptional signal-to-noise ratio,rapid response(<30 s),and high binding affinity(NT-HTCP=33.32 nmol/L;NF-HTCP=53.35 nmol/L)for Aβ*** the best candidate,NT-HTCP was used for in situ imaging of Aβplaques in AD mouse ***,in vivo research demonstrated that NT-HTCP could cross the blood-brain barrier and continue imaging the Aβplaques with a good signal-to-noise ***,the outcomes of the docking computations helped guide the development of the Aβ*** study expands the family of N,N-dimethylaminophenyl-based Aβ-sensitive fluorophores,with NTHTCP emerging as a highly promising imaging agent.

关键词： Amyloid-β Fluorescent probe Hydroxytricyanopyrrole Fluorescence imaging Alzheimer’s disease

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