Role of glycolysis in retinal vascular endothelium, glia, pigment epithelium, and photoreceptor cells and as therapeutic targets for related retinal diseases
作者机构：Editorial Department of Chinese Journal of Ocular Fundus DiseasesWest China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseasesEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China
出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)
年 卷 期：2021年第14卷第9期
页 面：1302-1309页
核心收录：
学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
主 题：glycolysis microglia retinal pigment epithelium photoreceptor cells
摘 要：Glycolysis produces large amounts of adenosine triphosphate(ATP)in a short *** retinal vascular endothelium feeds itself primarily through aerobic glycolysis with less *** when it generates new vessels,aerobic glycolysis provides rapid and abundant ATP support for angiogenesis,and thus inhibition of glycolysis in endothelial cells can be a target for the treatment of *** glycolysis has a protective effect on Müller cells,and it can provide with a target for visual protection and maintenance of the blood-retinal *** physiological conditions,the mitochondria of RPE can use lactic acid produced by photoreceptor cells as an energy source to provide ATP for *** pathological conditions,because RPE cells avoid their oxidative damage by increasing glycolysis,a large number of glycolysis products accumulate,which in turn has a toxic effect on photoreceptor *** shows that stabilizing the function of RPE mitochondria may become a target for the treatment of diseases such as retinal *** decrease of aerobic glycolysis leads to the decline of photoreceptor cell function and impaired vision;therefore,aerobic glycolysis of stable photoreceptor cells provides a reliable target for delaying vision *** is of great significance to study the role of glycolysis in various retinal cells for the targeted treatment of ocular fundus diseases.
维普期刊数据库