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Transcription factor Foxp1 is essential for the induction of choroidal neovascularization

Eye and Vision 2024年第3期10卷 1-12页

作者： Meifang Yan Junjian li li Yan Xue li Jie-Guang Chen School of Ophthalmology and Optometry and Eye Hospital Wenzhou Medical UniversityState Key Laboratory of OptometryOphthalmology and Vision Scienceand Zhejiang Provincial Key Laboratory of Optometry and Ophthalmology270 Xueyuan RoadWenzhouZhejiang325027People’s Republic of China Joint Shantou International Eye Center(JSIEC)of Shantou University and the Chinese University of Hong Kong ShantouGuangdong515000People’s Republic of China

Background The exudative form of age-related macular degeneration(AMD)is characterized by abnormal blood vessel growth,which is stimulated by vascular endothelial growth factor(VEGF)released from retinal pigment epithelium(RPE).The angiogenic behaviors of vascular endothelial cells in vitro depend on forkhead box protein P1(Foxp1),a transcription repressor widely expressed in human and murine tissues during *** this study,we aimed to determine whether loss of Foxp1 affects laser-induced choroidal neovascularization(CNV)in *** Eye-selective deletion of Foxp1 was obtained by crossing Foxp1flox/flox with Six3-Cre *** photocoagulation was delivered to six-to eight-week-old mice to induce *** expression of Foxp1 and Cre was determined by immunofluorescence in cryostat sections of the *** fluorescein angiography(FFA),optical coherence tomography(OCT),and B4 isolectin staining were applied to analyze the leakage,bulge height,and area of CNV lesions,***-choroid tissues were isolated for the determination of VEGF and pigment epithelium derived factor(PEDF)by Western *** Foxp1 was expressed in retinal ganglion cells,RPE,and the choroidal endothelial *** photocoagulation increased the number of Foxp1+-endothelial cells and induced ***3-Cre reduced Foxp1 expression in RPE but not the endothelium,leading to a lower level of VEGF in the ***1 knockout inhibited pathological angiogenesis and vascular leakage of the laser-induced CNV *** Foxp1 regulates the expression of VEGF in the RPE,and inhibition of Foxp1 could potentially be a novel strategy for the prevention and therapy of neovascularization related to AMD.

关键词： Foxp1 Choroidal neovascularization Angiogenesis Laser photocoagulation Age-related macular degeneration

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Nested Saturated Control of Uncertain Complex Cascade Systems Using Mixed Saturation Levels

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1163-1174页

作者： Meng li Zhigang Zeng Wuhan National Laboratory for Optoelectronics Wuhan 430074 School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074China School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074 Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan 430074China

This study addresses the problem of global asymptotic stability for uncertain complex cascade systems composed of multiple integrator systems and non-strict feedforward nonlinear systems. To tackle the complexity inherent in such structures, a novel nested saturated control design is proposed that incorporates both constant saturation levels and state-dependent saturation levels. Specifically, a modified differentiable saturation function is proposed to facilitate the saturation reduction analysis of the uncertain complex cascade systems under the presence of mixed saturation levels. In addition, the design of modified differentiable saturation function will help to construct a hierarchical global convergence strategy to improve the robustness of control design scheme. Through calculation of relevant inequalities, time derivative of boundary surface and simple Lyapunov function,saturation reduction analysis and convergence analysis are carried out, and then a set of explicit parameter conditions are provided to ensure global asymptotic stability in the closed-loop systems. Finally, a simplified system of the mechanical model is presented to validate the effectiveness of the proposed method.

关键词： method saturation differentiable

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Hierarchical model updating for high-speed maglev vehicle/guideway coupled system based on multiobjective optimization

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Frontiers of Structural and Civil Engineering 2024年第5期18卷 788-804页

作者： Dexiang li Jingyu Huang College of Civil Engineering Tongji UniversityShanghai 200092China National Maglev Transportation Engineering R&D Center Tongji UniversityShanghai 201804China

The high-speed maglev vehicle/guideway coupled model is an essential simulation tool for investigating vehicle dynamics and mitigating coupled *** improve its accuracy efficiently,this study investigated a hierarchical model updating method integrated with field ***,a high-speed maglev vehicle/guideway coupled model,taking into account the real effect of guideway material properties and elastic restraint of bearings,was developed by integrating the finite element method,multi-body dynamics,and electromagnetic levitation ***,simultaneous in-site measurements of the vehicle/guideway were conducted on a high-speed maglev test line to analyze the system response and structural modal *** the hierarchical updating,an Elman neural network with the optimal Latin hypercube sampling method was used to substitute the FE guideway model,thus improving the computational *** multi-objective particle swarm optimization algorithm with the gray relational projection method was applied to hierarchically update the parameters of the guideway layer and magnetic force layer based on the measured modal parameters and the electromagnet vibration,***,the updated coupled model was compared with the field measurements,and the results demonstrated the model’s accuracy in simulating the actual dynamic response,validating the effectiveness of the updating method.

关键词： high-speed maglev vehicle/guideway coupled model field measurement model updating neural network multi-objective optimization

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An unprecedented synthesis of axially chiral biaryls by rearrangement and aromatization of carbocations with central-to-axial conversion of chirality

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Science China Chemistry 2024年第9期67卷 2998-3003页

作者： Qi liu Xue-Dong li liang Cheng li liu Beijing National Laboratory for Molecular Sciences(BNLMS) CAS Key Laboratory of Molecular Recognition and FunctionCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The central-to-axial chirality conversion represents a fascinating class of chemical processes consisting of the destruction of stereogenic centers and the simultaneous installation of axial chiral elements,which provides efficient methods for the preparation of axially chiral ***,developing catalytic asymmetric approaches for constructing these central chirality precursors and the efficient central-to-axial chirality conversion remains a challenge due to the requirement of aromatization or elimination *** this work,we have developed an unprecedented enantioselective intramolecular FriedelCrafts alkylation with unactivated-ketone carbonyls from which a chiral tertiary alcohol was generated with high efficiency and excellent *** addition,the central-to-axial chirality conversion strategy has been successfully applied to the synthesis of enantioenriched biaryls via a less-explored carbocation-initiated rearrangement and aromatization under the promotion of Lewis *** methodology provided a straightforward and sustainable access to a broad range of biaryl-2-carboxylic acid and in excellent yields(up to 92%)and excellent central-to-axial chirality conversion(up to 99%conversion percentage).This work could be a great model for developing new methods for synthesizing axially chiral biaryls and a general protocol for the rearrangement and aromatization of carbocations for further functionalization.

关键词： br?nsted acid catalysis desymmetrization phosphoric acid axially chiral biaryls central-to-axial conversion

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Effect of electron beam irradiation on surface molecule and flashover voltage of epoxy composites

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High Voltage 2024年第3期9卷 528-536页

作者： Mingru li Huan Niu Kai Shang Jianyu Lang Yafang Gao Bingnan li Jiuhui Zhao Zhen li Yang Feng Shengtao li State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong UniversityXi'anShaanxiChina Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbinHeilongjiangChina

The unsatisfactory insulating properties of solid–gas interfaces seriously restrict the development of high-voltage electrical equipment and threaten their power supply ***-beam irradiation(EBI)can effectively improve the surface flashover voltage of ***,the underlying mechanism of EBI in tailoring the surface trap and improving the flashover voltage remains *** this study,the surface morphologies and chemical compositions of epoxy composites treated with EBI were *** addition,the surface wetting properties,surface charge migration pa-rameters,and surface flashover voltages were experimentally *** was found that EBI aggravated the surface morphology,changed the surface chemical components,and repressed surface charge *** a result,the contact angle was reduced from 103.7°to 78.43°,and the flashover voltage in SF6 was increased from 35.26 to 38.90 *** calculations showed that the newly generated C–O–H and C=O bonds on the surface molecules after EBI formed charge centres at the molecular electrostatic potential,which enhanced the trapping effect of the surface deep *** a result,surface charge migration was repressed,and the surface flashover voltage was *** study could promote the further development of EBI on materials modification.

关键词： composites surface beam

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April-September minimum temperature reconstruction based on Sabina tibetica ring-width chronology in the central eastern Tibetan Plateau,China

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Journal of Forestry Research 2024年第2期35卷 134-145页

作者： Teng li Jianfeng Peng Tsun Fung Au Jinbao li School of Geography and Remote Sensing Guangzhou UniversityGuangzhou 510006People’s Republic of China College of Geography and Environmental Science Henan UniversityKaifeng 475004People’s Republic of China Institute for Global Change Biology School for Environment and SustainabilityUniversity of MichiganAnn ArborMIUSA Department of Ecology and Evolutionary Biology University of MichiganAnn ArborMIUSA Department of Geography University of Hong KongHong Kong SARPeople’s Republic of China HKU Shenzhen Institute of Research and Innovation Shenzhen 518057People’s Republic of China

Minimum temperatures have remarkable impacts on tree growth at high-elevation sites on the Tibetan Plateau,but the shortage of long-term and high-resolution paleoclimate records inhibits understanding of recent minimum temperature *** this study,a warm season(April–September)reconstruction is presented for the past 467 years(1550–2016)based on Sabina tibetica ring-width chronology on the lianbaoyeze Mountain of the central eastern Tibetan *** warm periods and eight cold periods were ***-term minimum temperature variations revealed a high degree of coherence with nearby *** correlations between our reconstruction and global sea surface temperatures suggest that warm season minimum temperature anomalies in the central eastern Tibetan Plateau were strongly influenced by large-scale ocean atmospheric circulations,such as the El Ni?o-Southern Oscillation and the Atlantic Multidecadal Oscillation.

关键词： Tree-ring analysis Sabina tibetica Minimum temperatures Central eastern Tibetan Plateau Climate change

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鬼针草总黄酮对HepG2细胞胰岛素抵抗的影响

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中国药房 2022年第8期33卷 968-974页

作者：庞晓军卢琳琳黎东旺赵一宇刘国勇钦州市第二人民医院药学部广西钦州535000 广西医科大学药学院南宁530021 钦州市第二人民医院康复科广西钦州535000 钦州市第二人民医院放射科广西钦州535000

目的探究鬼针草总黄酮(TFB)对人肝癌HepG2细胞胰岛素抵抗(IR)的影响。方法取鬼针草,用80%乙醇回流提取,制得TFB。利用棕榈酸体外诱导HepG2细胞复制IR模型,考察低、中、高质量浓度(20、40、80 mg/L)TFB对细胞葡萄糖消耗量的影响;以二... 详细信息

目的探究鬼针草总黄酮(TFB)对人肝癌HepG2细胞胰岛素抵抗(IR)的影响。方法取鬼针草,用80%乙醇回流提取,制得TFB。利用棕榈酸体外诱导HepG2细胞复制IR模型,考察低、中、高质量浓度(20、40、80 mg/L)TFB对细胞葡萄糖消耗量的影响;以二甲双胍为阳性对照,考察低、中、高质量浓度(20、40、80 mg/L)TFB对细胞中胰岛素受体底物1(IRS-1)、c-Jun氨基端激酶(JNK)和蛋白激酶C(PKC)表达的影响。采用分子对接技术探讨槲皮素、槲皮苷等8个TFB主要活性成分与IRS-1、JNK、PKC蛋白的相互作用。结果 TFB低、中、高质量浓度组细胞的葡萄糖消耗量均较模型组显著升高(P<0.05或P<0.01)。与正常组比较,模型组细胞中的IRS-1、JNK蛋白的表达量均显著降低,PKC蛋白的表达量显著升高(P<0.01);与模型组比较,TFB低、中、高质量浓度组和二甲双胍阳性对照组能上调IRS-1、JNK蛋白的表达并下调PKC蛋白的表达(P<0.05或P<0.01)。TFB中的海生菊苷与IRS-1蛋白的分子对接能量打分值为-7.9 kcal/mol(1 kcal=4.816 kJ),海生菊苷、芦丁与JNK蛋白的分子对接能量打分值均为-9.3kcal/mol,槲皮苷与PKC蛋白的分子对接能量打分值为-4.9 kcal/mol,成分与蛋白间的相互作用包括形成氢键、疏水键等。结论TFB对HepG2细胞IR有显著的改善作用,其机制可能与调节IRS、JNK、PKC蛋白的表达有关;海生菊苷、芦丁和槲皮苷可能是改善IR的潜在活性成分。

关键词：鬼针草总黄酮人肝癌HepG2细胞胰岛素抵抗胰岛素受体底物1、c-Jun氨基端激酶蛋白激酶C 分子对接

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Design of distributed dynamic absorbers for vibration suppression of panel structures

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Acta Mechanica Sinica 2024年第7期40卷 164-180页

作者： liyuan li Bin li Zehua Xu School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China China Aero-Polytechnology Establishment Beijing 100028China

Distributed dynamic absorbers have many advantages such as wide frequency bandwidth for vibration suppression,strong detuning adaptability,and high system stability,making them very suitable for the vibration and noise control of continuous ***,they have broad application prospects in various fields such as transportation,aviation,and ***,there are still many challenges in the engineering applications of distributed dynamic absorbers for vibration suppression,including the engineering realization of the optimal damping of traditional optimal coherence dynamic absorbers,and the engineering applicability of the finite periodic array dynamic *** on the damping material properties obtained by the dynamic mechanical analyzer tests,this paper establishes the finite element model of the cantilever-beam-type dynamic absorber with constrained damping layers,aiming to realize the accurate determination of the optimal *** are conducted by attaching the traditional dynamic absorbers with the optimal damping to a thin-walled panel with four clamped *** show that the vibration of the panel is well suppressed,with the reduction of the frequency response peak larger than 14 dB and the reduction ratio of RMS larger than 58%within 500 ***,the periodically arrayed dynamic absorbers are designed according to the bandgap regulation *** tuning behavior of the arrayed dynamic absorbers by changing designing parameters is *** vibration reduction effect of arrayed dynamic absorbers is compared with that of the traditional dynamic absorbers under the same mass ratio through *** indicate that the arrayed dynamic absorbers are easier to design,and have a similar reduction effect on the modal vibration of the thin panel as the traditional dynamic absorbers within a narrow frequency range near the natural frequency,while they perform unsatisfactory in a broad ***,if t

关键词： Distributed dynamic absorbers Engineering realization of the optimal damping Vibration suppression Low-frequency and broadband

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Nadel-type multiplier ideal sheaves on complex spaces with singularities

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Science China Mathematics 2024年第5期67卷 951-974页

作者： Zhenqian li School of Mathematics and Computational Science Xiangtan UniversityXiangtan 411105China Siwuge Technology Co.Ltd. Chengdu 610093China

In this article,we introduce multiplier ideal sheaves on complex spaces with singularities(not necessarily normal)via Ohsawa’s extension measure,as a special case of which,it turns out to be the socalled Mather-Jacobian multiplier ideals in the algebro-geometric *** by Nadel’s coherence and Guan-Zhou’s strong openness properties of the multiplier ideal sheaves,we discuss similar properties for the generalized multiplier ideal *** applications,we obtain a reasonable generalization of(algebraic)adjoint ideal sheaves to the analytic setting and establish some extension theorems on K?hler manifolds from singular *** on our multiplier and adjoint ideals,we also give characterizations for several important classes of singularities of pairs associated with plurisubharmonic functions.

关键词： multiplier ideal sheaves plurisubharmonic functions Ohsawa-Takegoshi Luextension theorem rational singularities

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Characteristics of Bi-2223 HTS Tapes Under Short-Circuit Current Impacts in Hybrid Energy Transmission Pipelines

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 736-745页

作者： Yuguang Sun Chao Yin Weizhen li Xinyang li Xiaohua Jiang Department of Electric Engineering Tsinghua UniversityBeijing 100084China

A hybrid energy transmission pipeline is proposed with the aim of long-distance cooperative transmission of electricity and chemical fuels, which is composed of an inner high-temperature superconducting (HTS) power cable and outer liquefied natural gas (LNG) pipeline. The flowing LNG could maintain the operating temperature of the inner HTS power cable within the range of 85 K-90 K, thus the Bi-2223 superconductors in the HTS power cable produce little Joule loss with the transmission current below the critical current. Owing to the advantages of high power density, low transmission losses and economical manufacturing costs, the hybrid energy transmission pipeline is expected to be widely utilized in the near future. In order to ensure the safety of the HTS power cable and explosive LNG in case of short-circuit faults, this paper tests and analyzes the characteristics of Bi-2223 HTS tapes of the Type HT-CA, Type HT-SS and Type H models under short-circuit current impacts at the LNG cooling temperature (85 K-90 K). An experimental platform is designed and established for the ampacity tests of HTS tapes above LN2 cooling temperature (77 K). The AC over-current impact tests at 85 K-90 K are carried out on each sample of Bi-2223 tapes respectively, and the experimental results are analyzed and compared to evaluate their performances under different operating conditions. The results indicate that the Type HT-CA tape can withstand 50 Hz short-circuit current impact with the amplitude of 1108 A (10 times of critical current Ic ) for 100 ms at 90 K, and its resistance is the smallest of the three tested samples under similar current impacts. Therefore, the Type HT-CA Bi-2223 tape is the optimal superconductor of the HTS power cable in the hybrid energy transmission pipeline.

关键词： Bi-2223 high-temperature superconducting(HTS)tape critical current hybrid energy transmission pipeline liquefied natural gas(LNG)cooling temperature short-circuit current impact characteristics

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