检索结果-南通市图书馆

Assessment of structural brain changes in patients with type 2 diabetes mellitus using the MRI-based brain atrophy and lesion index

引用

Neural Regeneration Research 2022年第3期17卷 618-624页

作者： Heng Zhao Fang Wang Guang-Hua Luo Hao Lei Fei Peng Qiu-Ping Ren Wei Chen Yan-Fang Wu li-chun yin Jin-Cai liu Shi-Nong Pan Department of Radiology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Radiology The First Affiliated Hospital of University of South ChinaHengyangHunan ProvinceChina

Patients with type 2 diabetes mellitus(T2 DM) often have cognitive impairment and structural brain *** magnetic resonance imaging(MRI)-based brain atrophy and lesion index can be used to evaluate common brain changes and their correlation with cognitive function,and can therefore also be used to reflect whole-brain structural changes related to T2 DM.A total of 136 participants(64 men and 72 women,aged 55–86 years) were recruited for our study between January 2014 and December *** participants underwent MRI and Mini-Mental State Examination assessment(including 42 healthy control,38 T2 DM without cognitive impairment,26 with cognitive impairment but without T2 DM,and 30 T2 DM with cognitive impairment participants).The total and sub-category brain atrophy and lesion index scores in patients with T2 DM with cognitive impairment were higher than those in healthy *** in the brain atrophy and lesion index of gray matter lesions and subcortical dilated perivascular spaces were found between non-T2 DM patients with cognitive impairment and patients with T2 DM and cognitive *** adjusting for age,the brain atrophy and lesion index retained its capacity to identify patients with T2 DM with cognitive *** findings suggest that the brain atrophy and lesion index,based on T1-weighted and T2-weighted imaging,is of clinical value for identifying patients with T2 DM and cognitive *** matter lesions and subcortical dilated perivascular spaces may be potential diagnostic markers of T2 DM that is complicated by cognitive *** study was approved by the Medical Ethics Committee of University of South China(approval ***20131109003) on November 9,2013,and was retrospectively registered with the Chinese Clinical Trial Registry(registration *** CTR1900024150) on June 27,2019.

关键词： brain atrophy and lesion index cognitive impairments gray matter lesions magnetic resonance imaging Mini-Mental State Examination structural brain subcortical dilated perivascular spaces T1-weighted image T2-weighted image type 2 diabetes mellitus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The effect of platyspondyly and pubertal growth spurt on the stature of patients with β-thalassaemia major

引用

Chinese Medical Journal 1998年第8期 59-63页

作者： chungkai Low, yinwah Kwan, Pikto Cheung, Mingchun li, Sauyin Ha Yulung Lau and Johan Karlberg 

Objective To study the effect of the body proportion and pubertal growth spurt on the stature of children with β-thalassaemia *** An abnormal U:L ratio was commonly observed in patients with β-thalassaemia major and may be one factor contributing to the short stature of these patients. Abnormal puberty was present in a significant proportion of children and the lack of a pubertal growth spurt was found to be detrimental to adult height.

关键词： The

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

汽车空调旋叶式压缩机排气阀片的振动特性

引用

振动与冲击 2014年第8期33卷 186-191页

作者：李春银王树林上海理工大学能源与动力工程学院上海200093 上海理工大学材料科学与工程学院上海200093

排气阀片是汽车空调旋叶式压缩机中的关键零件,是压缩机主要振动噪声源之一。通过对排气阀片结构运动分析,建立了阀片振动的数学模型,并求解了压缩机排气阀片的固有频率及强迫振动。利用UG NX Nastran模态计算,确定了排气阀片的固有频... 详细信息

排气阀片是汽车空调旋叶式压缩机中的关键零件,是压缩机主要振动噪声源之一。通过对排气阀片结构运动分析,建立了阀片振动的数学模型,并求解了压缩机排气阀片的固有频率及强迫振动。利用UG NX Nastran模态计算,确定了排气阀片的固有频率和振型。测试结果证明,压缩机的外壳振动总加速度、噪声和排气脉动都低于美国通用汽车公司"GMW标准"的规定上限,证明排气阀片工作的工作状态是可靠的。但研究结果表明,阀片振动的极限位移同限位板高度比较接近,因此,提高限位板的高度或者限制阀片的振幅以进一步控制系统的排气脉动和噪声仍然具有一定的空间。分析结果对排气阀片乃至压缩机整体的振动分析与控制以及故障诊断具有参考价值。

关键词：旋叶式压缩机空调压缩机排气阀片振动与噪声控制模态分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

浅谈企业管理中的法律顾问制度

引用

韶关学院学报 2008年第4期29卷 60-62页

作者：李春银广东外语外贸大学法学院广东广州510420

法律顾问在企业管理中有重要作用,具体实施法律顾问制度要有切实可行的规划,以便更好地促进企业管理的规范化、制度化。

关键词：法律顾问重要作用制度设计

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

引用

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li yin Wang Peifeng li Hai Zhu Dong Wang Jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

浅析冲击地压成因及影响因素

引用

陕西煤炭 2009年第2期28卷 23-24页

作者：李春印双鸭山矿务局技工学校黑龙江双鸭山155100

对冲击地压发生的开采技术因素减少冲击地压发生的方法,以及如何防止冲击地压的发生,作了简要介绍。

关键词：冲击地压能量释放力学状态.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

围岩松动圈理论在巷道支护中的应用

引用

陕西煤炭 2009年第3期28卷 98-99页

作者：李春印双鸭山矿务局技工学校黑龙江双鸭山155100

介绍了围岩松动圈的测试方法。研究结果表明通过围岩松动圈测试来确定巷道顶板支护是合理的,应用超声波测试围岩松动圈十分简便,能获得良好的经济效益。

关键词：围岩的松动圈超声波探测议锚杆支护

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

象山港不同温度区围隔浮游生态系统营养盐迁移—转化的模拟对比

引用

水产学报 2011年第7期35卷 1030-1036页

作者：杨红李春新印春生储鸣上海海洋大学海洋科学学院

为评估象山港海域电厂温排水对水体富营养化影响,以生态系统中氮、磷营养盐循环为主线,建立了适用于海洋围隔浮游生态系统的多变量的营养盐迁移—转化动力学模型。该模型包括浮游植物、浮游动物、溶解无机态营养盐、溶解有机态营养盐和... 详细信息

为评估象山港海域电厂温排水对水体富营养化影响,以生态系统中氮、磷营养盐循环为主线,建立了适用于海洋围隔浮游生态系统的多变量的营养盐迁移—转化动力学模型。该模型包括浮游植物、浮游动物、溶解无机态营养盐、溶解有机态营养盐和生物碎屑5个模块,涉及溶解无机氮、磷酸盐、溶解有机氮、溶解有机磷、浮游植物、浮游动物和生物碎屑7个状态变量。利用2010年10月象山港其中一个温度区的围隔生态实验数据成功地进行了模型的验证,确定了相关参数的量值,并用该参数同时模拟3个不同温度区围隔氮、磷营养盐生物化学迁移—转化过程,进而得出温度对围隔浮游生态系统氮、磷营养盐迁移—转化影响的结论。结果表明,象山港电厂温排水加剧了受纳水体的富营养化程度。

关键词：氮磷营养盐迁移—转化模型围隔温度象山港

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Ultra‑High Sensitivity Anisotropic Piezoelectric Sensors for Structural Health Monitoring and Robotic Perception

引用

Nano-Micro Letters 2025年第2期17卷 432-446页

作者： Hao yin Yanting li Zhiying Tian Qichao li Chenhui Jiang Enfu liang Yiping Guo State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Beijing Vacuum Electronics Research Institute Beijing 100015People’s Republic of China Fundamental Science On Vibration Shock and Noise LaboratoryState Key Laboratory of Mechanical System and VibrationSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Monitoring minuscule mechanical signals,both in magnitude and direction,is imperative in many application scenarios,e.g.,structural health monitoring and robotic sensing ***,the piezoelectric sensor struggles to satisfy the requirements for directional recognition due to the limited piezoelectric coefficient matrix,and achieving sensitivity for detecting micrometer-scale deformations is also ***,we develop a vector sensor composed of lead zirconate titanate-electronic grade glass fiber composite filaments with oriented arrangement,capable of detecting minute anisotropic *** as-prepared vector sensor can identify the deformation directions even when subjected to an unprecedented nominal strain of 0.06%,thereby enabling its utility in accurately discerning the 5μm-height wrinkles in thin films and in monitoring human pulse *** ultra-high sensitivity is attributed to the formation of porous ferroelectret and the efficient load transfer efficiency of continuous lead zirconate titanate ***,when integrated with machine learning techniques,the sensor’s capability to recognize multi-signals enables it to differentiate between 10 types of fine textures with 100%*** structural design in piezoelectric devices enables a more comprehensive perception of mechanical stimuli,offering a novel perspective for enhancing recognition accuracy.

关键词： Flexible piezoelectric filaments Anisotropic Ultra-high sensitivity Structural health detection Texture recognition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang liu Xiang li Shen Du Ming Gao Yanbin yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：