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Correlation Study of Operational Data and System Performance of District Cooling System with Ice Storage

Journal of Power and Energy Engineering 2024年第3期12卷 75-98页

作者： Hui Cao Nan li Jiajing lin School of Civil Engineering Chongqing University Chongqing China National Centre for International Research of Low-Carbon and Green Buildings Ministry of Science & Technology Chongqing University Chongqing China

The district cooling system (DCS) with ice storage can reduce the peak electricity demand of the business district buildings it serves, improve system efficiency, and lower operational costs. This study utilizes a monitoring and control platform for DCS with ice storage to analyze historical parameter values related to system operation and executed operations. We assess the distribution of cooling loads among various devices within the DCS, identify operational characteristics of the system through correlation analysis and principal component analysis (PCA), and subsequently determine key parameters affecting changes in cooling loads. Accurate forecasting of cooling loads is crucial for determining optimal control strategies. The research process can be summarized briefly as follows: data preprocessing, parameter analysis, parameter selection, and validation of load forecasting performance. The study reveals that while individual devices in the system perform well, there is considerable room for improving overall system efficiency. Six principal components have been identified as input parameters for the cold load forecasting model, with each of these components having eigenvalues greater than 1.and contributing to an accumulated variance of 87.26%, and during the dimensionality reduction process, we obtained a confidence ellipse with a 95% confidence interval. Regarding cooling load forecasting, the Relative Absolute Error (RAE) value of the light gradient boosting machine (lightGBM) algorithm is 3.62%, Relative Root Mean Square Error (RRMSE) is 42.75%, and R-squared value (R2) is 92.96%, indicating superior forecasting performance compared to other commonly used cooling load forecasting algorithms. This research provides valuable insights and auxiliary guidance for data analysis and optimizing operations in practical engineering applications. .

关键词： DCS Correlation Coefficient PCA Hourly Cooling Load System Performance

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Paleoenvironmental changes recorded by grain size of loess/paleosol sequence from the Chifeng City, Northeastern China since the Last Glacial

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Journal of Mountain Science 2024年第09期 3068-3082页

作者： li Juan BRYE Kristofor R. ZHANG Mengge JIANG Zhuodong WANG Qiubing College of Land and Environment Shenyang Agricultural University Department of Crop Soil and Environmental Sciences University of Arkansas

The accumulation processes of loess in northeastern（NE） China record the varying characteristics of the East Asian Monsoons（EAM） and the evolution of the local *** this study,grain size end-member analysis of the Dajiugang（DJG） section deposited since the Last Glacial in Chifeng City,NE China was used to reveal the dynamic depositional characteristics of loess and environmental evolution of NE *** showed that the Chifeng loess comprises three grain size endmembers（EM）,EM1.7.38 μm）,EM2（49.4 μm） and EM3（90.00 μm）,indicating the three transport dynamics of dust delivered to the *** EM1.epresents atmospheric dust as the *** EM2,mainly derived from relatively distant-sources deposition,and EM3,material transported over a short distance,correspond to the intensity of southwesterly winds and the East Asian Winter Monsoon（EAWM）,*** of climate reconstruction,combined with other records,showed that the climate was generally cold and dry with a strong EAWM and a weak East Asian summer monsoon（EASM） during the stadial-period [Marine Isotope Stage（MIS）4and MIS2stage].The climate was predominantly warm and humid,with weak EAWM and surface winds and strong EASM in interstadial-period（MIS3and MIS1.tage）.Comparisons between indicators,e.g.,EM3,the LR04 benthic δ1.O stack and summer insolation at65°N suggest that the strong EAWM is induced by increasing the Northern Hemisphere ice volume and reduced summer solar radiation.

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柚皮苷诱导卵巢癌细胞凋亡的机制研究

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赣南医学院学报 2024年第4期44卷 327-334页

作者：周潇妮蔡丽萍南昌大学第一附属医院妇产科江西南昌330000

目的:探究柚皮苷在卵巢癌中的抗肿瘤活性并评估其潜在信号传导机制。方法:⑴将雌性Balb/c裸鼠随机分为6组:阴性对照组(PBS溶液)、0.5 mg·kg^(-1.柚皮苷组(柚皮苷0.5 mg·kg^(-1.)、1.0 mg·kg^(-1.柚皮苷组(柚皮苷1.0 mg·kg^(-1.)、2.... 详细信息

目的:探究柚皮苷在卵巢癌中的抗肿瘤活性并评估其潜在信号传导机制。方法:⑴将雌性Balb/c裸鼠随机分为6组:阴性对照组(PBS溶液)、0.5 mg·kg^(-1.柚皮苷组(柚皮苷0.5 mg·kg^(-1.)、1.0 mg·kg^(-1.柚皮苷组(柚皮苷1.0 mg·kg^(-1.)、2.0 mg·kg^(-1.柚皮苷组(柚皮苷2.0 mg·kg^(-1.)、阳性对照组(顺铂25.0 mg·kg^(-1.)、联合用药组(顺铂25.0 mg·kg^(-1.、柚皮苷2.0 mg·kg^(-1.),取对数生长期的SKOV3细胞皮下注射Balb/c裸鼠,当肿瘤大小达到50 mm3时,按照分组情况在腹膜内注射相应试剂。给药1. d后处死并切除小鼠整个肿瘤,测量肿瘤大小及体积并通过RT-PCR检测各组肿瘤凋亡相关基因mRNA的表达。⑵将SKOV3细胞随机分为4组:阴性对照组(PBS溶液)、1.μmol·L^(-1.柚皮苷组、20μmol·L^(-1.柚皮苷组、40μmol·L^(-1.柚皮苷组。EliSA检测各组相关蛋白表达。⑶取对数生长期SKOV3细胞,以每孔2×1.^(5)个细胞接种于6孔板中。将SKOV3细胞随机分8组:空白对照组(不导入质粒及siRNA)、空质粒对照组、siRNA对照组、NF-κB过表达组、NF-κB siRNA组、P38MAPK过表达组、P38MAPK siRNA组、PKC抑制剂组。RT-PCR检测各组细胞P-gp和ERK mRNA表达。⑷对NF-κB过表达组和P38MAPK过表达组SKOV3细胞进行柚皮苷干预,测量各组细胞P-gp和ERK mRNA表达。结果:⑴给药1. d后,肿瘤体积及重量由大到小依次为阴性对照组、0.5 mg·kg^(-1.柚皮苷组、1.0 mg·kg^(-1.柚皮苷组、2.0 mg·kg^(-1.柚皮苷组、阳性对照组、联合用药组,且与阴性对照组相比,差异均有统计学意义(P1.柚皮苷组、阳性对照组、联合用药组Caspase-3和Caspase-7 mRNA表达增加,差异均有统计学意义(P1.柚皮苷组、1.0 mg·kg^(-1.柚皮苷组、2.0 mg·kg^(-1.柚皮苷组、阳性对照组、联合用药组Bcl-2、Bcl-xl mRNA表达降低,差异均有统计学意义(P1.柚皮苷组、阳性对照组、联合用药组Cyclin D1.C-Myc和Survivin mRNA表达降低,差异均有统计学意义(P1.柚皮苷组PKC、P38MAPK、ERK、NF-κB、P-gp、COX-2蛋白表达降低,Caspase-3和Caspase-7蛋白表达增加,差异均有统计学意义(P0.05),P38MAPK过表达组ERK mRNA表达增加,P38MAPK siRNA组及PKC抑制剂组ERK mRNA表达降低,NF-κB过表达组P-gp mRNA表达增加,NF-κB siRNA组及P-gp mRNA表达降低,差异均有统计学意义(P<0.05)。⑸与空质粒组比较,柚皮苷+P38MAPK过表达组PKC、ERK、COX-2 mRNA表达降低,差异均有统计学意义(P<0.05),P38MAPK mRNA无明显差异;柚皮苷+NF-κB过表达组PKC、NF-κB、P-gp表达降低,Caspase-3、Caspase-7表达增加,差异均有统计学意义(P<0.05)。结论:柚皮苷能够通过抑制PKC所介导的不同信号路径调控卵巢癌细胞凋亡与生长,并具有剂量依赖性。

关键词：柚皮苷蛋白激酶C 卵巢癌细胞凋亡

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Anxiety Mouse Model Constructed by Single Intraperitoneal Injection of m-Chlorophenpiperazine

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Journal of Biosciences and Medicines 2024年第2期12卷 22-38页

作者： Tianyuan Ye Maijia li Xiaorui Cheng Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese Medicine Jinan China School of Chinese Medicine Shandong University of Traditional Chinese Medicine Jinan China

Anxiety disorder is a common mental disorder. It is necessary to establish a rapid, stable and specific anxiety model to provide a theoretical basis for further research on the pathogenesis of anxiety and drug development. A single intraperitoneal injection of m-chlorophenylpipera-zine (mCPP) (1. 2, 4 mg/kg) was given to male ICR mice to establish an anxiety model, and the effects of mCPP on anxiety behavior, pain, athletic ability, passive avoidance response ability and depressive behavior of male ICR mice were evaluated. A single intraperitoneal injection of mCPP shortened the time in open arms and decreased the percentage of time in open arms of mice in the elevated plus-maze test. mCPP also shortened center zone distance and reduced the number of entries to the central zone in the open field test. Moreover, mCPP reduced head-dip counts and increased the head-dip latency of mice in the hole-board test. After being administrated with a single intraperitoneal injection of mCPP for 24h, the mice showed no significant difference in the entry into the light side and the percentage of time in the light side of the light-dark box test. A single intraperitoneal injection of mCPP had no effects on tail flick latency, rotating time, number of errors and the step-down latency, the immobility time of mice in the tail-flick test, rotarod test, step-down test and TST respectively. In conclusion, we established a rapid and stable anxiety mouse model by single intraperitoneal injection of mCPP.

关键词： Anxiety Model mCPP Behavior

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Comparison of Photochemical Reactions of m-Cresol in Aqueous Solution and in Ice

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Chemical Research in Chinese Universities 2012年第1期28卷 47-52页

作者： PENG Fei1. XUE Hong-hai1. TANG Xiao-jian1.2, KANG Chun-li1. li lin-lin1.and li Zhe1.1. Key Laboratory of Groundwater Resources and Environment, Ministry of Education, Jilin University, Changchun 1.0021. P. R. China 2. School of Municipal and Environmental Engineering, Jilin Institute of Architecture and Civil Engineering, Changchun 1.01.8, P. R. China Jilin University Key Laboratory of Groundwater Resources and Environment Ministry of Education Changchun 130021

We compared the photochemical reaction of m-cresol containing ·OH precursors such as H2O2, NO2 and NO3 in aqueous solution with those in ice. The results show that the conversion rate of m-cresol in aqueous solution was higher than that in ice. H2O2, NO2 and NO3 all accelerated the photoconversion of m-cresol in both aqueous solution and ice. The photochemical reactions of m-cresol obeys the first order kinetics equation. According to the photoproducts identified by GC-MS, we proposed that hydroxylation and nitration reactions occurred in both aqueous solution and ice. Coupling reaction was common in ice, however, in aqueous solution it was found only in UV system. Our results suggest that the photochemical reactions of m-cresol were different in aqueous solution and in ice.

关键词： m-Cresol Photochemistry Aqueous solution Ice Mechanism

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瓜蒌薤白半夏汤通过chemerin/CMKLR1.PPARα信号通路干预2型糖尿病合并急性心肌梗死的作用

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中国中药杂志 2024年第6期49卷 1579-1586页

作者：王蕾官帅吴梦雪周慧赵启韬荀丽英山东中医药大学药学院山东济南250355 山东中医药大学中医学院山东济南250355

基于chemerin/趋化样因子受体1.CMKLR1./过氧化酶体增殖物激活受体(PPAR)α信号通路研究瓜蒌薤白半夏汤(GXBD)对2型糖尿病合并急性心肌梗死(T2DM⁃AMI)模型大鼠的干预作用,探讨GXBD对改善T2DM⁃AMI早期糖脂代谢紊乱现象的潜在机制。实验... 详细信息

基于chemerin/趋化样因子受体1.CMKLR1./过氧化酶体增殖物激活受体(PPAR)α信号通路研究瓜蒌薤白半夏汤(GXBD)对2型糖尿病合并急性心肌梗死(T2DM⁃AMI)模型大鼠的干预作用,探讨GXBD对改善T2DM⁃AMI早期糖脂代谢紊乱现象的潜在机制。实验分为空白对照组(Ctrl)、模型组(T2DM⁃AMI)、阳性对照组(复方丹参片,DS)、瓜蒌薤白半夏汤高剂量组(GXBD⁃H)和瓜蒌薤白半夏汤低剂量组(GXBD⁃L)。采用灌胃高脂乳剂(HFE)和腹腔注射链脲佐菌素(STZ)的方法建立2型糖尿病(T2DM)模型,然后冠状动脉结扎以诱导形成急性心肌梗死(AMI)。空白对照组和模型组灌胃等量生理盐水,各给药组给予相应药物灌胃。通过EliSA和生化检测评估相关代谢指标的变化,Western blot分析肝脏、腹腔脂肪和心脏中chemerin、趋化样因子受体1.CMKLR1.、过氧化物酶体增殖物激活受体α(PPARα)的蛋白表达。实验结果表明GXBD改善了T2DM⁃AMI的心脏病理损伤,降低了血脂、心肌酶和炎性因子水平,但对血糖变化不明显。此外,与模型组相比,GXBD降低了外周血中chemerin的表达,升高了肝脏中环磷酸腺苷(cAMP)和蛋白激酶A(PKA)的水平,且经GXBD治疗后肝脏、腹腔脂肪和心脏中chemerin、CMKLR1.白表达水平降低,肝脏和腹腔脂肪中PPARα蛋白表达水平上升。以上研究结果说明GXBD可显著改善T2DM⁃AMI的糖脂代谢紊乱,进而对受损心肌具有保护作用。其机制可能与干预chemerin/CMKLR1.PPARα信号通路有关。这为临床进一步研究GXBD防治T2DM⁃AMI提供新的理论依据,也是中药治疗胸痹“痰浊壅塞”证候在蛋白水平的体现。

关键词：瓜蒌薤白半夏汤 2型糖尿病急性心肌梗死 chemerin CMKLR1 PPARα

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The Role of NF-κβ and HIF-1. in the Formation of Deep Vein Thrombosis

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Journal of Biosciences and Medicines 2024年第9期12卷 307-313页

作者： Erchang Zhu Yueqiu liu Lei li Department of Vascular Surgery The First Affiliated Hospital of Bengbu Medical University Bengbu China

Deep vein thrombosis (DVT) remains a significant clinical challenge, with complex underlying pathophysiological mechanisms. Among the myriad factors contributing to DVT, the transcription factors NF-κβ and HIF-1. have been increasingly recognized for their roles. This study aims to deepen the understanding of NF-κβ and HIF-1. in the pathogenesis of DVT and explore potential therapeutic implications. This research investigates the expression of NF-κβ and HIF-1. in patients with DVT compared to a healthy control group, utilizing EliSA techniques for quantification. The results of the study showed that the expression of NF-κβ and HIF-1. in the blood samples of patients with DVT was significantly higher than that of normal subjects, and the difference was statistically significant (P κβ and HIF-1. in the peripheral blood of DVT patients, suggesting their critical roles in inflammation and hypoxia regulation, with potential for future research into their mechanisms and therapeutic applications.

关键词： DVT NF-κβ HIF-1. Inflammation Biomarker

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伴PTPN1.基因突变的成人急性髓系白血病患者的临床特征分析

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中国实验血液学杂志 2024年第4期32卷 1063-1070页

作者：盛丽刘亚姣周竞奋晁红颖华海应周新赵晓红江南大学附属医院血液科江苏无锡214122 江南大学无锡医学院江苏无锡214122 常州市第二人民医院血液科江苏常州213003 无锡市人民医院血液科江苏无锡214023 无锡市第二人民医院血液科江苏无锡214001

目的:探讨成人急性髓系白血病(AML)患者PTPN1.基因突变及其伴随基因突变的发生情况及临床特征。方法:应用二代测序技术联合Sanger测序,回顾性分析从201.年1.至2022年7月由江南大学附属医院、常州市第二人民医院、无锡市人民医院以及无... 详细信息

目的:探讨成人急性髓系白血病(AML)患者PTPN1.基因突变及其伴随基因突变的发生情况及临床特征。方法:应用二代测序技术联合Sanger测序,回顾性分析从201.年1.至2022年7月由江南大学附属医院、常州市第二人民医院、无锡市人民医院以及无锡市第二人民医院收治的初诊成人AML患者51.基因突变,采用多重PCR检测41.常见白血病融合基因。结果:451.初诊成人AML中,共检测出34例患者携带PTPN1.基因突变,突变率为7.5%。34例患者中,检测出37个PTPN1.突变位点,其受N-SH2(31.)和PTP(6例)结构域内的错义突变影响,且大部分聚集在第3外显子(31.)。伴有PTPN1.突变患者的血小板计数为76.5(23.5,1.9.0)×1.^(9)/L,高于野生型患者的41.0(22.0,82.5)×1.^(9)/L(P0.05)。PTPN1.突变主要表现为M5亚型,其次为M2及M4亚型,较少发生于M3及M6亚型。PTPN1.突变型及野生型患者的FAB亚型分布差异无统计学意义(P>0.05)。共有1.8例AML患者检测到融合基因阳性,其中,伴有PTPN1.突变患者的MLL-AF6阳性发生率高于野生型患者(P1.。34例PTPN1.基因突变中有97.1.同时伴随其他基因突变,最常见的由高到低依次为NPM1.38.2%)、NRAS(32.4%)、FLT3-ITD(32.4%)、DNMT3A(32.4%)、KRAS(23.5%)等。结论:PTPN1.基因突变在AML患者中有一定的发生率,多见于第3号外显子,且均为错义突变。该基因突变多与NPM1.因突变同时存在,FAB分型多表现为M5亚型,具有更高的血小板水平。

关键词：急性髓系白血病 PTPN1. 基因突变临床特征

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社会网络视阈下鼓岭近代避暑地文化景观形成机制研究

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园林 2024年第9期41卷 39-47页

作者：林轶南周天懿李婧华东理工大学艺术设计与传媒学院上海200237

外侨避暑地是中国近代形成的一种特殊的文化景观,其整体布局和房屋选址不仅体现了外侨对自然环境的认知和审美,同时也是住民社会网络的投影,但以往研究对社会关系的关注较少。以福州鼓岭避暑地为研究对象,从历史文献中提取房屋分布和住... 详细信息

外侨避暑地是中国近代形成的一种特殊的文化景观,其整体布局和房屋选址不仅体现了外侨对自然环境的认知和审美,同时也是住民社会网络的投影,但以往研究对社会关系的关注较少。以福州鼓岭避暑地为研究对象,从历史文献中提取房屋分布和住民的社会关系,借助空间可达性分析(Accessibility Analysis)、社会网络分析(Social Network Analysis)和二次指派程度(Quadratic Assignment Procedure)相关分析工具,探讨房屋分布和住民社会关系的相关性。研究发现:(1.鼓岭避暑地的空间“中密外疏”,公共建筑集中的区域可达性较高;(2)鼓岭避暑别墅选址有明显的“人以群分”特征,宗派和行业的影响尤为突出;(3)鼓岭的住民社群有显著的小世界特征,且存在具有吸引力的关键人物;(4)地理位置相近的房屋,其主人之间通常存在更紧密的社会关系。研究结果表明:鼓岭的空间关系与社会关系在结构上存在耦合,鼓岭避暑地是外侨社会关系建构下形成的特殊文化景观。研究成果已应用于鼓岭的保护与利用,并为揭示空间与社会关系之间的联系、认识文化景观的形成机制提供了新的思路。

关键词：文化景观社会网络分析近代避暑地形成机制鼓岭

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Branching particle systems in spectrally one-sided Levy processes

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Frontiers of Mathematics in China 2015年第4期10卷 875-900页

作者： Hui HE Zenghu li Xiaowen {1. Laboratory of Mathematics and Complex Systems School of Mathematical SciencesBeijing Normal University Beijing 100875 China Department of Mathematics and Statistics Concordia UniversityMontreal Quebec H3G 1M8 Canada

We investigate the branching structure coded by the excursion above zero of a spectrally positive Levy process. The main idea is to identify the level of the Levy excursion as the time and count the number of jumps upcrossing the level. By regarding the size of a jump as the birth site of a particle, we construct a branching particle system in which the particles undergo nonlocal branchings and deterministic spatial motions to the left on the positive half line. A particle is removed from the system as soon as it reaches the origin. Then a measure-valued Borel right Markov process can be defined as the counting measures of the particle system. Its total mass evolves according to a Crump- Mode-Jagers （CMJ） branching process and its support represents the residual life times of those existing particles. A similar result for spectrally negative Levy process is established by a time reversal approach. Properties of the measure- valued processes can be studied via the excursions for the corresponding Levy processes.

关键词： Levy process spectrally one-sided subordinator branchingparticle system non-local branching Crump-Mode-Jagers (CMJ) branchingprocess

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