检索结果-南通市图书馆

Biomedical and Environmental Sciences 2018年第3期31卷 171-185页

作者： liU Meng Xin liAO Juan xie Ming GAO Zhi Kui WANG Xiang Hu ZHANG Ying SHANG Mu He YIN li Hong PU Yue Pu liU Ran Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Nanjing 210009 Jiangsu China Hangzhou First People's Hospital Hangzhou 310000 Zhejiang China North China Petroleum Bureau General Hospital Renqiu 062552 Hebei China

Objective To investigate the relationship between plasma miR-93-5p and the risk of esophageal cancer, as well as the influence of miR-93-5p on the biological function of esophageal cancer cells,exerted through *** The expression of plasma miR-93-5p in esophageal cancer patients and healthy controls was analysed by real-time quantitative PCR. The influence of miR-93-5p on the risk and prognosis of esophageal carcinoma was analyzed by conditional logistic regression and survival analysis. The effect of miR-93-5p on the biological function of recipient cells was investigated by establishing an in vitro donor cell co-culture model. The target gene of miR-93-5p was validated by luciferase reporter assay and Western *** Upregulation of plasma miR-93-5p expression significantly increases the risk of esophageal cancer and is associated with poor prognosis. miR-93-5p transferred by exosomes promotes the proliferation of recipient esophageal cancer cells and affects the expression of PTEN and its downstream proteins p21 and cyclin *** Our study provides a reference for the identification of biomarkers for the diagnosis and prognosis of esophageal cancer.

关键词： Exosomes miR-93-5p Esophageal cancer Plasma biomarker

Synergistic rheumatoid arthritis therapy by interrupting the detrimental feedback loop to orchestrate hypoxia M1 macrophage polarization using an enzyme-catalyzed nanoplatform

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2024年第11期41卷 221-238页

作者： Dong Guo Hui liu Sheng Zhao Xinya Lu Haoyu Wan Yitao Zhao Xinzhi liang Anbiao Zhang Mengyuan Wu Zhisheng Xiao Ning Hu Zhong li Denghui xie Department of Orthopedic Surgery Center for Orthopedic SurgeryThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou510630PR China Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases Guangzhou510630PR China Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationSchool of Materials and EnergySouthwest UniversityChongqing400715PR China Department of Orthopaedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016PR China Department of Biomedical Engineering The Chinese University of Hong KongNTHong KongPR China

Rapid and efficient tendon fixation to a bone following trauma or in response to degenerative processes can be facilitated using a tendon anchoring *** biomaterials,and in particular,bio-resorbable polymer composites designed to match the mineral phase content of native bone,have been shown to exhibit osteoinductive and osteoconductive properties in vivo and have been used in bone fixation for the past 2 *** this study,a resorbable,bioactive,and mechanically robust citrate-based composite formulated from poly(octamethylene citrate)(POC)and hydroxyapatite(HA)(POC-HA)was investigated as a potential tendon-fixation *** vitro analysis with human Mesenchymal Stem Cells(hMSCs)indicated that POC-HA composite materials supported cell adhesion,growth,and proliferation and increased calcium deposition,alkaline phosphatase production,the expression of osteogenic specific genes,and activation of canonical pathways leading to osteoinduction and ***,in vivo evaluation of a POC-HA tendon fixation device in a sheep metaphyseal model indicates the regenerative and remodeling potential of this citrate-based composite ***,this study presents a comprehensive in vitro and in vivo analysis of the functional response to a citrate-derived composite tendon anchor and indicates that citrate-based HA composites offer improved mechanical and osteogenic properties relative to commonly used resorbable tendon anchor devices formulated from poly(L-co-D,l-lactic acid)and tricalcium phosphate PLDLA-TCP.

关键词： Citrate Osteoinductive Tendon anchor Composite

Insertion sequence transposition activates antimycobacteriophage immunity through an Isr2-silenced lipid metabolism gene island

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

mlife 2024年第1期3卷 87-100页

作者： Yakun li Yuyun Wei Xiao Guo Xiaohui li lining Lu lihua Hu Zheng-Guo He State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangxi Research Center for Microbial and Enzyme Engineering TechnologyCollege of Life Scienceand TechnologyGuangxi UniversityNanningChina

Insertion sequences(ISs)exist widely in bacterial genomes,but their roles in the evolution of bacterial antiphage defense remain to be ***,we report that,under the pressure of phage infection,the IS1o96 transposition of Mycobacterium smegmatis into the Isr2 gene can occur at high frequencies,which endows the mutant mycobacterium with a broad-spectrum antiphage ***2 functions as a negative regulator and directly silences expression of a gene island composed of 11 lipid metabolism-related *** complete or partial loss of the gene island leads to a significant decrease of bacteriophage adsorption to the mycobacterium,thus defending against phage ***,a phage that has evolved mutations in two tail-filament genes can re-escape from the Isr2 inactivation-triggered host *** study uncovered a new signaling pathway for activating antimycobacteriophage immunity by Is transposition and provided insight into the natural evolution of bacterial antiphage defense.

关键词： antiphage defense bacteriophage gene island insertion sequence mycobacteria

基于应力分析Ni-Fe合金支撑固体氧化物燃料电池的结构稳定性研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

无机材料学报 2019年第6期34卷 611-617页

作者：李凯李霄李箭谢佳苗西安石油大学材料科学与工程学院西安710065 华中科技大学材料科学与工程学院材料成型及模具技术国家重点实验室武汉430074 西北工业大学工程力学系西安710065

本文以NiO和Fe2O3为原料,应用流延、丝网印刷、高温共烧结和原位还原的工艺制备多孔金属支撑固体氧化物燃料电池(MS-SOFC)。系统研究了支撑体中Fe含量对MS-SOFC的残余应力、抗弯断裂强度和电化学稳定性的影响。结果表明,在NiO中加入10at... 详细信息

本文以NiO和Fe2O3为原料,应用流延、丝网印刷、高温共烧结和原位还原的工艺制备多孔金属支撑固体氧化物燃料电池(MS-SOFC)。系统研究了支撑体中Fe含量对MS-SOFC的残余应力、抗弯断裂强度和电化学稳定性的影响。结果表明,在NiO中加入10at%Fe2O3,使得支撑体致密化开始温度提高到937℃,残余应力和变形翘曲度分别低至70MPa和0.15mm;电池还原之后,Ni0.9Fe0.1支撑SOFC骨架表面孔隙率为40.22%,抗弯断裂强度达到最大值62.34MPa;电化学测试过程中,Ni0.9Fe0.1支撑SOFC在650℃下,以H2为燃料,在400mA·cm^–2电流密度下可以稳定运行60h,主要因为电池具有较高的抗弯断裂强度,能够抵抗运行过程中的热应力。该研究工作为MS-SOFC结构设计和性能稳定性优化提供重要的理论依据。

关键词：金属支撑固体氧化物燃料电池 Ni-Fe合金支撑体热应力

Dual-Functional lithiophilic/Sulfiphilic Binary-Metal Selenide Quantum Dots Toward High-Performance li-S Full Batteries

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2023年第5期15卷 169-186页

作者： Youzhang Huang liang lin Yinggan Zhang lie liu Baisheng Sa Jie lin Laisen Wang Dong-liang Peng Qingshui xie State Key Lab for Physical Chemistry of Solid Surfaces Fujian Key Laboratory of Surface and Interface Engineering for High Performance MaterialsCollege of MaterialsXiamen UniversityXiamen 361005People’s Republic of China Shenzhen Research Institute of Xiamen University Shenzhen 518000People’s Republic of China College of Materials Science and Engineering Multiscale Computational Materials FacilityFuzhou UniversityFuzhou 350100People’s Republic of China

The commercial viability of lithium-sulfur batteries is still challenged by the notorious lithium polysulfides(li PSs)shuttle effect on the sulfur cathode and uncontrollable li dendrites growth on the li ***,a bi-service host with Co-Fe binary-metal selenide quantum dots embedded in three-dimensional inverse opal structured nitrogen-doped carbon skeleton(3DIO FCSe-QDs@NC)is elaborately designed for both sulfur cathode and li metal *** highly dispersed FCSe-QDs with superb adsorptive-catalytic properties can effectively immobilize the soluble li PSs and improve diffusion-conversion kinetics to mitigate the polysulfide-shutting ***,the 3D-ordered porous networks integrated with abundant lithophilic sites can accomplish uniform li deposition and homogeneous li-ion flux for suppressing the growth of *** advantage of these merits,the assembled li-S full batteries with 3DIO FCSe-QDs@NC host exhibit excellent rate performance and stable cycling ability(a low decay rate of 0.014%over 2,000 cycles at 2C).Remarkably,a promising areal capacity of 8.41 mAh cm^(-2)can be achieved at the sulfur loading up to 8.50 mg cm^(-2)with an ultra-low electrolyte/sulfur ratio of 4.1μL mg^(-1).This work paves the bi-serve host design from systematic experimental and theoretical analysis,which provides a viable avenue to solve the challenges of both sulfur and li electrodes for practical li-S full batteries.

关键词： Dual-functional host Fe_(2)CoSe_(4)quantum dots Shuttle effect Dendrite-free li anode li-S full batteries

Design and performance of the LLRF control system for CSNS linac

在线全文

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2020年第2期4卷 196-202页

作者： linyan Rong Zhencheng Mu Jian li Zhexin xie Wenzhong Zhou Bo Wang Maliang Wan Meifei liu Xinan Xu Institute of High Energy Physics Chinese Academy of SciencesBeijingChina Spallation Neutron Source Science Center DongguanChina

Objective The China Spallation Neutron Source(CSNS)linac is designed with beam energy of 80 MeV and a peak current of 15 mA in the first *** consists of RFQ,two bunchers of medium-energy beam transmission line,four DTL tanks and one debuncher of linac-to-ring beam transmission ***,eight online RF power sources are used to power these *** order to stabilize the amplitude,phase and resonant frequency of the RF accelerating field,and minimize beam loss,we have established digital low-level RF(LLRF)control *** The LLRF system includes RF reference line,analog module(AM),clock distribution module,digital control module(DCM),high-power protection module,timing and RF interlock module and so *** DCM is mainly responsible for the stability of the RF field amplitude and phase,and RF interlock module can quickly cut off the RF drive in case of arc in the RF transmission system,VSWR over threshold or cavity vacuum fault and so *** During beam commissioning,all of eight online units of LLRF control system were operating stably and *** amplitude and phase variations of the linac fields have been achieved about±0.4%and±0.15°with 10-mA beam loading,much better than the design requirements of±1%in amplitude and±1°in *** With the help of this system,we achieved stable operation under different beam ***,many important progresses have been achieved in the LLRF control system for amore convenient operation and a higher stability *** article describes the design and implementation of the LLRF for CSNS linac.

关键词： RF power source LLRF Reference system High-power protection Tracking resonant frequency of cavity

Collision performance of bitubular tubes with diaphragms

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University 2015年第9期22卷 3657-3665页

作者：董海鹏高广军谢素超李健 Key Laboratory of Traffic Safety on Track of Ministry of Education (School of Traffic and Transportation Engineering Central South University)

A numerical study of bitubular tubes with diaphragms compared with single and bitubular tubes subjected to dynamic axial impact force was presented. At first, the energy absorption response of the composite structure under axial loading was analyzed by finite element simulation. The results show that the efficiency of energy absorption can be improved by introducing diaphragms to the double-walled columns. Then, the effect of the amount and location of diaphragms, the shape and the size of the inner tubes, and the thickness of the composite structures were also studied numerically. The collision performance of the composite structure is affected by the deformation of diaphragms, as well as the interaction of outer and inner tube. The non-uniform distribution of diaphragms can improve the energy absorption efficiency of structures for a constant number of diaphragms. The specific energy absorption of the hexagonal inner tube is the highest, followed by the circular, octagonal and square ones.

关键词： bitubular tube diaphragm energy absorption crashworthiness

Tunable attenuator based on polymer microstructured optical fibers

在线全文

学校读者我要写书评

暂无评论

Optoelectronics Letters 2007年第1期3卷 47-49页

作者： ZHANG Ye-jin HE li-na JI Heng YANG Si-gang CHEN Ming xie Shi-zhong Department of Electronics and Engineering Tsinghua University Beijing 100084 China

Based on polymer microstructured optical fibers (PMOF) and selective liquid crystal injection technology, a novel tem- perature control tunable attenuator is designed theoretically in this paper. In our experiments, PMMA microstructured optical fibers with high performance are drawn successfully and the selective injection of liquid crystal 5CB into micro- holes is realized. The tunable attenuator is fabricated with an extinction ratio of over 60dB, which agrees well with the design.

关键词：聚合物微结构光纤调谐衰减器选择性晶体注入

Measuring the Internal Velocity of Debris Flows Using Impact Pressure Detecting in the Flume Experiment

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2011年第2期8卷 109-116页

作者： YANG Hongjuan WEI Fangqiang HU Kaiheng Sergey CHERNOMORETS HONG Yong li Xiaoyu xie Tao Key Laboratory of Mountain Hazards and Surface Process ChineseAcademy of Sciences Chengdu 610041 China Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 China Faculty of Geography Moscow State University Moscow Russia

Measuring the internal velocity of debris flows is very important for debris flow dynamics research and designing debris flow control works. However, there is no appropriate method for measuring the internal velocity because of the destructive power of debris flow process. In this paper, we address this problem by using the relationship between velocity and kinetic pressure, as described by surface velocity and surface kinetic pressure data. Kinetic pressure is the difference of impact pressure and static pressure. The former is detected by force sensors installed in the flow direction at the sampling section. Observations show that static pressure can be computed using the formula for static water pressure by simply substituting water density for debris flow density. We describe the relationship between surface velocity and surface kinetic pressure using data from seven laboratory flume experiments. It is consistent with the relationship for single phase flow, which is the measurement principle of the Pitot tube.

关键词： Internal velocity Measurement Debris flow Impact pressure

Synthesis of PdH0.43 nanocrystals with different surface structures and their catalytic activities towards formic acid electro-oxidation

在线全文

学校读者我要写书评

暂无评论

Science China Materials 2020年第3期63卷 375-382页

作者： Chenyang Zhan Huiqi li Xuemin li Yaqi Jiang Zhaoxiong xie State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China

The synthesis of nanocrystals(NCs)with defined morphology and surface structure provides an effective way to investigate the structure-activity relationship of nanocatalytsts,and it will facilitate the design of nanocatalysts with excellent catalytic *** this paper,we developed a facile method to synthesize PdH0.43 NCs with the shape of cube,octahedron and rhombic dodecahedron(RD),whose surface facets are{100},{111}and{110},*** asprepared PdH0.43 NCs are highly stable and exhibit enhanced catalytic activity and extremely low overpotential towards electro-oxidation of formic acid compared with the commercial Pd black and three types of Pd *** specific activity of the cubic PdH0.43 NCs is more than five times that of the commercial Pd black and two times that of the cubic Pd *** the three types of PdH0.43 NCs with different surface structure,the activity order is followed by PdH0.43{100}>PdH0.43{111}>PdH0.43{110}.

关键词： alloy nanoparticles palladium hydrides surface structure electrocatalytic activity