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Treatment of SMA type 1 infants using a single-dose AAV9-mediated gene therapy via intrathecal injection of GC101: An open-label, single-arm study

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中华医学杂志(英文版) 2024年第16期137卷 2024 Jul 9页

作者： Ma Xiuwei Zhuang Lu Ma Wenhao li Jun Wang Xiaodong li zhongqiu Jiang Xinyang Wang Yongxia Du Ying Zhang Yingqian He Fang Zhu Zhiming Du Shaopeng Xu Juan Gu Ruijie Zhang Yanping Zhang Shan li Ting Yang Xiao Zhang Sheng Zhu lina li Qiuping Dong Xiaoyan Wu Xiaobing Feng Zhichun Department of Neurodevelopment Faculty of Pediatrics The Seventh Medical Center of Chinese PLA General Hospital Beijing China National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology Beijing China Research and Development Division Genecradle Therapeutics Inc. Beijing China Medical Division Genecradle Therapeutics Inc. Beijing China Department of Pharmacy Medical Supplies Center of Chinese PLA General Hospital Beijing China Beijing Key Laboratory of Pediatric Organ Failure Beijing China

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南京大学仙林校区流浪猫种群数量和繁殖调查

兽类学报 2024年第3期44卷 333-343页

作者：孙桃柱吴琼张振伟李忠秋南京大学生命科学学院动物行为与保护实验室南京210023

流浪猫已对全球生物多样性带来严重威胁,然而,中国对流浪猫的基础生物学研究却很少。2018—2022年,以南京大学仙林校区(约195 hm2)为研究区域,开展了基于个体识别的校园流浪猫种群及繁殖等基础生物学研究。通过连续20 d的样点调查,构建... 详细信息

流浪猫已对全球生物多样性带来严重威胁,然而,中国对流浪猫的基础生物学研究却很少。2018—2022年,以南京大学仙林校区(约195 hm2)为研究区域,开展了基于个体识别的校园流浪猫种群及繁殖等基础生物学研究。通过连续20 d的样点调查,构建了流浪猫的种群数量累积曲线,发现即便在熟知流浪猫种群分布的基础上,一天调查中流浪猫的发现率仅为51.22%(44.51%~53.66%),而累积6 d的重复调查,发现率可达到84.15%(81.10%~86.59%)。2018—2022年南京大学仙林校区流浪猫数量快速增长,从2018年的51只增加至2022年的220只。2021年3月至2022年3月每月6次调查,期间共记录到273只流浪猫,其中成年猫149只,幼猫124只,雌雄性比约为1∶1。在此期间流浪猫的一年留存率约为58.71%,且绝育流浪猫的留存率显著高于未绝育的流浪猫。流浪猫全年均可繁殖,但产仔高峰集中在3—6月。65窝幼猫中,有84只存活超过6个月,若家猫的平均产仔数为3~4只,则南京大学仙林校区的流浪猫幼仔6月龄成活率约为36.92%(32.31%~43.08%)。上述结果说明,低强度的样点调查可能低估了流浪猫的种群数量。同时,在人类提供庇佑的环境中,流浪猫的生存不受食物、住所以及疾病的限制,其生存率和繁殖成功率较高,高存活率和高繁殖力将为流浪猫种群数量的控制带来困难。

关键词：流浪猫种群数量种群动态繁殖参数

企业社交媒体交流可见性对工作场所学习的影响机制

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中国人力资源开发 2024年第7期41卷 55-68页

作者：梁亮潘保臻李仲秋张雪东北林业大学经济管理学院哈尔滨150040 广州大学教育学院广州510006 东北农业大学经济管理学院哈尔滨150030 上海师范大学哲学与法政学院上海200233

数字化背景下企业社交媒体的广泛应用使得企业社交媒体交流可见性成为学术界关注的热点。学者围绕企业社交媒体交流可见性在工作场所的具体效用展开了实证研究,探讨了企业社交媒体交流可见性对员工建言行为、知识共享等主动行为结果的... 详细信息

数字化背景下企业社交媒体的广泛应用使得企业社交媒体交流可见性成为学术界关注的热点。学者围绕企业社交媒体交流可见性在工作场所的具体效用展开了实证研究,探讨了企业社交媒体交流可见性对员工建言行为、知识共享等主动行为结果的影响。然而,员工工作场所学习作为一种主动行为是否受企业社交媒体交流可见性影响尚不明确。本研究基于自我决定理论,引入和谐式工作激情和主动性人格变量,探讨企业社交媒体交流可见性与员工工作场所学习之间的关系,并利用来自中国北方一家服务业企业的287份有效问卷进行实证检验。研究结果发现:企业社交媒体交流可见性对员工工作场所学习具有显著正向影响;和谐式工作激情在企业社交媒体交流可见性与员工工作场所学习之间起中介作用;主动性人格正向调节企业社交媒体交流可见性与和谐式工作激情之间的关系,并且正向调节了和谐式工作激情在企业社交媒体交流可见性与员工工作场所学习之间的中介作用。本研究丰富和拓展了企业社交媒体交流可见性在工作场所发挥的作用,也为管理者深入理解企业社交媒体给组织带来的影响提供了理论指导。

关键词：企业社交媒体交流可见性和谐式工作激情主动性人格工作场所学习

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低温对民猪骨骼肌线粒体能量代谢基因的影响

西北农业学报 2024年第7期33卷 1195-1201页

作者：张冬杰马守正汪亮李忠秋刘娣黑龙江省农业科学院畜牧研究所哈尔滨150086

为了探究低温环境下民猪肌肉组织内与线粒体能量代谢相关基因的变化情况,以解析民猪抗寒特性的遗传机制。将9头体质量相近的母猪随机分成3组,每组3头,在冬季将其中2组置于室外半敞篷舍内饲养,分别处理3 d(急性低温处理组)和58 d(慢性低... 详细信息

为了探究低温环境下民猪肌肉组织内与线粒体能量代谢相关基因的变化情况,以解析民猪抗寒特性的遗传机制。将9头体质量相近的母猪随机分成3组,每组3头,在冬季将其中2组置于室外半敞篷舍内饲养,分别处理3 d(急性低温处理组)和58 d(慢性低温处理组),1组置于常规舍内饲养,作为对照组。以背肌为试验材料,采用PCR array方法,对90个与线粒体能量代谢相关基因的表达水平进行检测。结果表明,与对照组相比,急性低温处理组基因的表达水平差异不显著,但慢性低温处理显著改变 ATP5H、 ATP5L、 ATP6V1G3、 COX5A、 COX7A2、 COX7A2L、 NDUFS4、 SDHB、 UQCRQ和 GADD45B基因的表达水平,尤其是 GADD45B,达到了极显著水平(P<0.01),这些基因均为编码OXPHOS系统亚基基因,推测慢性低温诱导了背肌ATP的生成。对 GADD45B基因进一步分析发现,该基因在哺乳动物中高度保守,基本符合分子进化规律,表达具有明显的组织特异性。急性低温处理对民猪背肌内ATP的生成影响不显著,但慢性低温处理诱导ATP的生成,以维持体温恒定。

关键词：民猪骨骼肌低温线粒体能量代谢

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The benefits of being smaller:Consistent pattern for climate-induced range shift and morphological difference of three falconiforme species

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Avian Research 2023年第1期14卷 13-24页

作者： Aichun Xu Ji Zhang Qian li zhongqiu li Qin Zhu School of life Sciences China Jiliang UniversityHangzhou310018China Lab of Animal Behavior and Conservation School of Life SciencesNanjing UniversityNanjing210023China

Climate exerts a dominant control over the distribution of ***,species migrate to higher elevations to track thermal niches,but variations in morphological traits can result in trait-specific responses to climate *** we attempted to explore how three sympatrically distributed raptor species(the Upland Buzzard Buteo hemilasius,UB;the Common Kestrel,also called Eurasian Kestrel Falco tinnunculus,EK;and the Saker Falcon Falco cherrug,SF)would respond to climate change over time,and whether their responses would bias by different *** tested the alternative hypotheses for Allen’s rule for UB,EK,and SF in Qinghai Province,China,by modeling their current and future habitat suitability and confirming whether a consistent pattern exists between climate-induced range shifts and morphological differences among *** extent of the projected distribution range within protected areas was also calculated for each *** identified the future downward elevation shift for all the species,but with the notable northeastward shifting of the suitable climate space for UB and *** change would induce range contraction in the future,and the most acute influence is always the result of the pessimistic SSP585 *** obvious pattern in climate-induced range shift was found for EK,for whom the morphological traits were significantly smaller all the *** seriously,the ratios of highly suitable habitats being protected for our three raptor species were almost at a deficient level(below 1%).This study firstly tested the alternative hypothesis of Allen’s rule among raptors in Qinghai Province unprecedently,confirmed the morphological basis for different responses to changing climate across species,and demonstrated the protection deficiency under the current protected area *** advocate more related studies in the future to verify our findings across more taxa.

关键词： Allen's rule Climate change Morphalogy Qinghai Province Raptors Range contraction

Vocal repertoire of Azure-winged Magpies(Cyanopica cyanus):A context-associated communication system

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Avian Research 2023年第1期14卷 45-53页

作者： Xu Wang Fan Yu Haozhong Si zhongqiu li Laboratory of Animal Behaviour and Conservation School of Life SciencesNanjing UniversityNarying 20023Chine

Signals within animals’vocal communication are considered functional referential and *** in the absence of the context,receivers are expected to acquire the information of calls and respond specificallyWhereas the framework was supported by plenty of evidence,its exhaustivity in describing all animal vocalisations has been ***,we investigated the vocal repertoire of a cooperatively breeding species,Azure-winged Magpie(Cyanopica cyanus),to present evidence for referential *** results showed that Azure-winged Magpies had a relatively large vocal repertoire,consisting of twelve distinct *** calls were associated with the context including movement,begging for food,contact,vigilance against predators,***,even the predator-specific alarm calls would induce various responses of *** implies that multiple pieces of information are involved in the vocalisation,which could be utilised by the receiver to select an appropriate response based on the *** study gives a detailed description of the context and function of the vocal repertoire in Azure-winged Magpies,laying the foundation for further investigation on the developmental mechanisms of bird *** study also suggests that the referential signals of animal vocalisations may not be limited to the context-specific responses of receivers and need to be discussed from a broader perspective.

关键词： Amure wingeod Magpies Behavioural ontext Reerential sigmals Vocal ammumication Vocal repertoire

Sequential vigilance is unpredictable in reproductive Black-necked Cranes

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Avian Research 2019年第1期10卷 82-88页

作者： Yuhang li Le Yang Yunchao Luo Yiqian Wu zhongqiu li School of life Sciences Nanjing University Tibet Plateau Institute of Biology

Background:Vigilance refers to the behavior of animals scanning their surroundings with a main purpose of *** vigilance can serve the function of anti-predation depends on its unpredictability,meaning instantaneous randomness,sequential randomness,and independence,the three assumptions from Pulliam model(J Theor Biol 38:419,1973).Here we tested two of these three assumptions in reproductive Black-necked Cranes(Grus nigricollis) in Tibetan Plateau:instantaneous randomness and sequential ***:Observations were carried out in July and September of 2014,July and August in 2017 in Selincuo National Nature Reserve,Tibet,with the help of focal sampling *** instantaneous randomness,we used Kolmogorov–Smirnov test for its negative exponential distribution;for sequential randomness,we used Run test,correlation analysis,and generalized linear model to see if an inter-scan and its previous scan were ***:Not similar to some recent studies,we did not find a significant predictable vigilance in this *** inter-scan intervals(86/100,86.0%) passed negative exponential distribution test,meaning vigilance sequences with instantaneous randomness;most inter-scan intervals(91/100,91.0%) passed sequential random test,showing vigilance sequences were random ***:Our results suggest that keeping a vigilance pattern with unpredictability is beneficial to the survival of the Black-necked Cranes,which are facing with both cruel natural environments and high predation risks.

关键词： Black-necked Cranes Instantaneous randomness Sequential randomness

The group size effect and synchronization of vigilance in the Tibetan wild ass

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Current Zoology 2021年第1期67卷 11-16页

作者： Xinxin WANG Le YANG Yumeng ZHAO Cong Yu zhongqiu li Lab of Animal Behavior and Conservation School of Life SciencesNanjing University163 Xianlin AvenueNanjing210023China Tibet Plateau Institute of Biology 19 Beiing West RoadLhasa850000China

Vigilance behavior is considered as an effective strategy for prey species to detect *** individual benefits from living in a group by reducing the time spent being vigilant without affecting the probability of detecting a ***,the mechanism producing a decrease in vigilance with increasing group size is *** models of vigilance assume that group members scan independently of one *** in recent studies,the other 2 patterns of vigilance,coordination and synchronization,were reported in some *** 2 summers(2018 and 2019),we studied the group-size effect on vigilance and foraging of Tibetan wild ass in Chang Tang Nature Reserve of *** also tested whether individuals scan the environment independently,tend to coordinate their scans,or tend to synchronize their *** results showed that individuals decreased the time spent on vigilance with increasing group size,while increased the time spent *** members scanned the environment at the same time more frequently and there was a positive correlation between group members'behaviors,indicating that Tibetan wild asses tend to synchronize their vigilance.

关键词： group size effect synchronization of vigilance Tibetan wild ass

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数字赋能我国高校创业教育探索与实践

对外经贸 2024年第9期 127-130页

作者：李仲秋于威段彩泉东北农业大学经济管理学院黑龙江哈尔滨150030 东北农业大学工程学院黑龙江哈尔滨150030

数字化时代为高等院校的创业教育开启了新的篇章。数字经济能够打破传统创业场景的限制,提供更广阔的创业机会、丰富的创业导师资源、新的教学方法和工具以及创新的创业孵化平台。数字经济也给高校创业教育带来了新的挑战。借鉴其他国... 详细信息

数字化时代为高等院校的创业教育开启了新的篇章。数字经济能够打破传统创业场景的限制,提供更广阔的创业机会、丰富的创业导师资源、新的教学方法和工具以及创新的创业孵化平台。数字经济也给高校创业教育带来了新的挑战。借鉴其他国家数字时代高校创业教育经验,提出我国高校应加强对数字经济下创业本质的理解、构建政企校多元主体协同的创业教育机制、加强创业教育内容与方法的有效性、建设政产学研用一体化的创业生态系统,进而促进高校创业教育的发展和实践应用。

关键词：数字经济数字技术创业教育实践应用