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Profibrotic role of the SOX9-MMP10-ECM biosynthesis axis in the tracheal fibrosis after injury and repair

Genes & Diseases 2024年第5期11卷 360-373页

作者： Lei Gu Anmao li Chunyan He Rui Xiao Jiaxin liao li Xu Junhao Mu Xiaohui Wang Mingjin Yang Jinyue Jiang Yang Bai Xingxing Jin Meiling Xiao Xia Zhang Tairong Tan Yang Xiao Jing lin yishi li Shuliang Guo Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Infection Disease The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China

Fibroblast activation and extracellular matrix(ECM)deposition play an important role in the tracheal abnormal repair process and *** a transcription factor,SOX9 is involved in fibroblast activation and ECM ***,the mechanism of how SOX9 regulates fibrosis after tracheal injury remains *** investigated the role of SOX9 in TGF-b1-induced fibroblast activation and ECM deposition in rat tracheal fibroblast(RTF)***9 overexpression adenovirus(Ad-SOX9)and siRNA were transfected into RTF *** found that SOX9 expression was up-regulated in RTF cells treated with ***9 overexpression activated fibroblasts and promoted ECM *** SOX9 inhibited cell proliferation,migration,and ECM deposition,induced G2 arrest,and increased apoptosis in RTF ***-seq and chromatin immunoprecipitation sequencing(ChIP-seq)assays identified MMP10,a matrix metalloproteinase involved in ECM deposition,as a direct target of SOX9,which promotes ECM degradation by increasing MMP10 expression through the Wnt/b-catenin signaling ***,in vivo,SOX9 knockdown ameliorated granulation proliferation and tracheal fibrosis,as manifested by reduced tracheal *** conclusion,our findings indicate that SOX9 can drive fibroblast activation,cell proliferation,and apoptosis resistance in tracheal fibrosis via the Wnt/b-catenin signaling *** SOX9eMMP10 eECM biosynthesis axis plays an important role in tracheal injury and *** SOX9 and its downstream target MMP10 may represent a promising therapeutic approach for tracheal fibrosis.

关键词： Extracellular matrix deposition Fibroblast activation MMP10 SOX9 Tracheal fibrosis

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Framework of service standard system for the seismological sector and object of the standardization

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China Standardization 2005年第5期50卷 12-18页

作者： Feng Yijun li yishi National Standardization Seismological Committee of China National Standardization Seismological Committee of China

China is one of the countries suffering from the most severe earthquakedisasters. The death toll from earthquakes in China is estimated to be 600,000, accounting for 1/3of the global number. Twenty-three provincial capitals in China and two thirds of its big cities,each with a population over one million, are located at high risk areas with seismic intensity overVII degrees. The two violent earthquakes in the world during the 20^(th) century, which both causeda death toll of over 200,000 and occurred in China. Therefore, as viewed from earthquake disastermitigation, the seismological sector holds an important position in safeguarding national security,boosting national economic growth and protecting the life and property of people. 'Seismologicalstandardization'-a completely new concept was first proposed by China in 1990. Through more than 10years of development, the Standardization Administration of China (SAC) has incorporated 'seismological standardization' into the standardization field of China. A total of 15 nationalstandards and 18 seismological sector standards have been formulated in three working systems:earthquake monitoring and prediction, earthquake disaster prevention, earthquake emergency responseand rescue, which have helped boost the orderly development in respect of protecting against andmitigating earthquake disasters in China. With special regard to providing the society with seismicsafety services, SAC puts forward a framework of service standard system for the seismologicalsector and object of the standardization on the basis of Seismological technical standards,following a systematic study.

关键词： code

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Spatial light modulation for femtosecond laser manufacturing:Current developments and challenges

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Science China(Technological Sciences) 2024年第1期67卷 60-72页

作者： ZANG Xue liU ZiTing XU yishi WANG Yi WANG Qing li ZhenZe WANG Lei State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China State Key Laboratory of Precision Measurement and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China

Since the invention of lasers,spatial-light-modulated laser processing has become a powerful tool for various *** enables multidimensional and dynamic modulation of the laser beam,which significantly improves the processing efficiency,accuracy,and flexibility,and presents wider prospects over traditional mechanical technologies for machining three-dimensional,hard,brittle,or transparent *** this review,we introduce:(1)The role of spatial light modulation technology in the development of femtosecond laser manufacturing;(2)the structured light generated by spatial light modulation and its generation methods;and(3)representative applications of spatial-light-modulated femtosecond laser manufacturing,including aberration correction,parallel processing,focal field engineering,and polarization ***,we summarize the present challenges in the field and possible future research.

关键词： femtosecond laser manufacturing spatial light modulation structured light aberration correction parallel processing focal field engineering polarization control

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Designing simple non-fused terthiophene-based electron acceptors for efficient organic solar cells

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Journal of Energy Chemistry 2024年第9期96卷 501-508页

作者： Jiayu li Kun li Zhe Mei Yu Chen Qian Xie Chenxu Yu Xuefeng liu Yanqi Wang yishi Wu Qing liao Cunbin An Hongbing Fu Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China Beijing Synchrotron Radiation Laboratory Institute of High Energy PhysicsChinese Academy of Sciences(CAS)Beijing 100049China

Low-cost photovoltaic materials are essential for realizing large-scale commercial applications of organic solar cells(OSCs).However,highly efficient OSCs based on low-cost photovoltaic materials are scarce due to a deficiency in understanding the structure-property ***,we investigated two low-cost terthiophene-based electron acceptors,namely,3TC8 and 3TEH,with 3,4-bis(octan-3-yloxy)thiophene,differing only in the alkylated *** acceptors exhibit low optical gaps(∼1.43 eV)and possess deep highest occupied molecular orbital(HOMO)levels(∼−5.8 eV).Notably,the single-crystal structure of 3TEH demonstrates highly planar conjugated backbone and strongπ-πstacking between intermolecular terminal groups,attributed to the presence of the bulky alkylated noncovalently conformational *** utilizing both acceptors to fabricate OSCs,the 3TC8-based device exhibited a power conversion efficiency(PCE)of 11.1%,while the 3TEH-based OSC demonstrated an excellent PCE of 14.4%.This PCE is the highest among OSCs based on terthiophene-containing electron *** results offer a new strategy for designing low-cost electron acceptors for highly efficient OSCs.

关键词： Organic solarcells Low cost Terthiophene Non-fused electron acceptor

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Comparison of loading with maintenance dose of clopidogrel on platelet reactivity in Chinese with different CYP2C19 genotypes prior to percutaneous coronary intervention

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Chinese Medical Journal 2014年第14期127卷 2571-2577页

作者： Zhang Xiaoxing Yan lirong Wang Dongxue li Yan Han Lulu Tian Lei liu Hong li yishi Chinese Acad Med Sci Key Lab Clin Trial Res Cardiovasc Drugs Minist Hlth State Key Lab Cardiovasc DisFuwai HospNatl Ctr Beijing 100037 Peoples R China Peking Union Med Coll Beijing 100037 Peoples R China

Background Whether two clopidogrel pretreatment strategies prior to elective percutaneous coronary intervention （PCI）： a 300 mg loading dose （LD） in clopidogrel naive patients and a 75 mg maintenance dose （MD） once daily in patients on chronic clopidogrel therapy play the same role in the platelet inhibition in Chinese with different CYP2C19 genotypes remains unknown. We aim to evaluate the impact on platelet inhibition by clopidogrel pretreatment strategy and its interaction effect with CYP2C19 genotype. Methods Chinese patients undergoing PCI （n=840） were assigned to 2x2 groups in the trial according to different clopidogrel pretreatment strategies （470 patients in LD, 370 patients in MD） and CYP2C19 genotypes （494 carriers of any CYP2C19 ＊2 or ＊3 loss-of-function allele, 346 non-carriers）. The primary outcome was platelet aggregation （PA） as measured by the 10 umol/L adenosine diphosphate induced light transmission aggregation. Results Compared with MD group, LD strategy showed a significantly higher PA-（（59.22＋11.67）% vs. （52.83±12.17）%, P 〈0.01）, similar PA difference was observed in CYP2C19 loss-of-function carriers compared with non-carriers （（59.41±10.91）% vs. （52.10±12.90）%, P 〈0.01）. LD patients in either the CYP2C19 loss-of-function allele carrier or non- carrier group showed a significantly higher PA compared with MD group （（61.50±10.61）% vs. （56.84±10.74）%, P 〈0.01; （56.06±12.34）% vs. （46.88±11.78）%, P 〈0.01, respectively）. A quantitative interaction effect was observed between clopidogrel pretreatment strategy and CYP2C19 genotype （P=0.001）. Conclusion The 300 mg LD strategy results in a decreased effect on platelet inhibition compared with the 75 mg MD in Chinese patients receiving clopidogrel prior to PCI, especially in the CYP2C19 ＊2 or ＊3 loss-of-function allele non-carriers. （*** number NCT01710436） Chin tided J 2014;127 （14）： 2571-2577

关键词： clopidogrel CYP2C19 percutaneous coronary intervention platelet aggregation

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Effectiveness and safety of red yeast rice predominated by monacolin Kβ-hydroxy acid form for hyperlipidemia treatment and management

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Journal of Traditional Chinese Medicine 2022年第2期42卷 264-271页

作者： CHEN Benjian HUANG Xiaodan PENG Huiting li yishi CAO Yongtao WU Huanlin XU Danping Department of Medical Guangdong Provincial Hospital of Chinese MedicineThe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China the Second Clinical College Guangzhou University of Chinese MedicineGuangzhou 510405China the First Clinical College Guangzhou University of Chinese MedicineGuangzhou 510405China Department of Mathematical&Computer Sciences Indiana University of PennsylvaniaIndiana 15705PAUSA Department of Cardiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 350122China Department of Traditional Chinese Medicine the Eighth Affiliated HospitalSunYat-Sen UniversityShenzhen 518033China

OBJECTIVE:To assess the lipid-lowering activity and safety of a dietary supplement containing monacolin Kβ-hydroxy acid form(MKA),Heye(Folium Nelumbinis),and Cangzhu(Rhizoma Atractylodis Lanceae),compared to lifestyle ***:Totally 117 subjects with moderate to severe dyslipidemia(according to Chinese guidelines)and low CV risk were randomly assigned into three treatment groups:lifestyle modification(LM),LM plus a low dosage of MKA,LM plus a high dosage of MKA,and treated for 60 *** primary endpoint was the reduction of low density lipoprotein cholesterol(LDL-C)and total cholesterol(TC).Safeties along with Traditional Chinese Medicine Syndromes were assessed through the ***:A low dosage of MKA along with lifestyle modifications caused a significant decrease in LDL-C by 15.6%on average(95%CI,9.6%to 21%)with,a decrease in TC by 15.3%on average(95%CI,9.26%to 21.4%),and a decrease in non-HDL-C by 35.4%(95%CI,25.76%to 41.34%).Weak evidence of a reduction of triglycerides but an increment of HDL-C was observed in patients with severe *** severe adverse events occurred during the ***:Our results confirm the LDL-C and TC lowering properties of MKA is clinically *** also produces a significant reduction of non-HDL-C,and slightly effects on TG and HDL-C as well.

关键词： hydroxy acids lovastatin hyperlipidemias cholesterol cardiovascular prevention lifestyle modifications red yeast rice

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General　Decomposition　of　Spin　Connection　and　Topological　Structurein　Gauss－Bonnet－Chern　Theorem

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IMP & HIRFL Annual Report 1994年 124-126页

作者： li Xiguo and Duan yishi(Institute of Theoretical Physics, Lanzhou University.)

ＧｅｎｅｒａｌＤｅｃｏｍｐｏｓｉｔｉｏｎｏｆＳｐｉｎＣｏｎｎｅｃｔｉｏｎａｎｄＴｏｐｏｌｏｇｉｃａｌＳｔｒｕｃｔｕｒｅｉｎＧａｕｓｓ－Ｂｏｎｎｅｔ－ＣｈｅｒｎＴｈｅｏｒｅｍ￥ＬｉＸｉｇｕｏａｎｄＤｕ... 详细信息

ＧｅｎｅｒａｌＤｅｃｏｍｐｏｓｉｔｉｏｎｏｆＳｐｉｎＣｏｎｎｅｃｔｉｏｎａｎｄＴｏｐｏｌｏｇｉｃａｌＳｔｒｕｃｔｕｒｅｉｎＧａｕｓｓ－Ｂｏｎｎｅｔ－ＣｈｅｒｎＴｈｅｏｒｅｍ￥ＬｉＸｉｇｕｏａｎｄＤｕａｎＹｉｓｈｉ（Ｉｎｓｔｉｔｕｔｅ...

关键词： f ?

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From Topological Structure in Gauss-Bonnet-Chern Theorem to Morse Theory

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IMP & HIRFL Annual Report 1994年 126-127页

作者： li Xiguo and Duan yishi(Intitute of Theoretical Physics,Lanzhou University.)

ＦｒｏｍＴｏｐｏｌｏｇｉｃａｌＳｔｒｕｃｔｕｒｅｉｎＧａｕｓｓ－Ｂｏｎｎｅｔ－ＣｈｅｒｎＴｈｅｏｒｅｍｔｏＭｏｒｓｅＴｈｅｏｒｙ￥ＬｉＸｉｇｕｏａｎｄＤｕａｎＹｉｓｈｉ（ＩｎｔｉｔｕｔｅｏｆＴｈｅｏｒ... 详细信息

ＦｒｏｍＴｏｐｏｌｏｇｉｃａｌＳｔｒｕｃｔｕｒｅｉｎＧａｕｓｓ－Ｂｏｎｎｅｔ－ＣｈｅｒｎＴｈｅｏｒｅｍｔｏＭｏｒｓｅＴｈｅｏｒｙ￥ＬｉＸｉｇｕｏａｎｄＤｕａｎＹｉｓｈｉ（ＩｎｔｉｔｕｔｅｏｆＴｈｅｏｒｅｔｉｃａｌＰｈｙｓｉｃｓ，Ｌａｎ...

关键词： Bonnet Morse

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关于云南省地方志工作的回顾与思考

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中国地方志 2007年第9期 11-14页

作者：李一是云南省昆明市春苑小区春明里28号省地方志办公室 650118

本文对云南省首轮修志实践进行回顾并对云南省第二轮修志进行思考。指出首轮云南地方志编修工作成果丰硕;年鉴、地情书籍丰富多彩;整理出版一批旧志文献;方志理论研究方兴未艾。同时也指出了修志工作存在的困难和问题。作者对第二轮云... 详细信息

本文对云南省首轮修志实践进行回顾并对云南省第二轮修志进行思考。指出首轮云南地方志编修工作成果丰硕;年鉴、地情书籍丰富多彩;整理出版一批旧志文献;方志理论研究方兴未艾。同时也指出了修志工作存在的困难和问题。作者对第二轮云南省地方志编修从时间断限、内容容量、体例体式、力戒失误、记述改革开放、反映经济多元化、记述小康7个方面进行了探讨。主张第二轮修志注重选择资料,创新体例,突出时代特色与地方特色,力戒失误。采用集中与分散相结合的方式记述改革开放,全面反映经济多元化和全面建设小康问题。

关键词：云南地方志工作回顾与思考

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防震减灾工作中的标准化

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防灾博览 2010年第3期 20-23页

作者：黎益仕

新修订的《中华人民共和国防震减灾法》在进一步强化政府职能、部门职责、社会参与、条件保障、科技支撑和法律责任的同时,也首次对防震减灾活动过程的标准化制度做出了明确规定。在总则第十条提到＂从事防震减灾活动,应当遵守国家有关... 详细信息

新修订的《中华人民共和国防震减灾法》在进一步强化政府职能、部门职责、社会参与、条件保障、科技支撑和法律责任的同时,也首次对防震减灾活动过程的标准化制度做出了明确规定。在总则第十条提到＂从事防震减灾活动,应当遵守国家有关防震减灾标准＂,这既体现了近年来防震减灾工作实践经验的总结,也充分体现了标准化对震减灾工作的强大支撑作用，同时也对地震标准化工作提出了更高和更迫切的要求。

关键词：防震减灾工作标准化《中华人民共和国防震减灾法》政府职能社会参与法律责任科技支撑活动过程

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