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Evaluation of non-covalent interaction between Seryl-Histidine dipeptide and cyclophilin A using NMr and molecular modeling

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Science china chemistry 2010年第9期53卷 1987-1993页

作者： liU yan1,SHI yanHong2,liU XiaoXia1,liN MingKun1,liN DongHai1,2 & ZHAO YuFen1,3.1key laboratory for chemical biology of Fujian province,department of chemical biology,{13.,College of chemistry and chemical Engineering,Xiamen university,Xiamen 3.1005,china 2Shanghai Institute of Materia Medica,Shanghai Institutes of Biological Sciences,Chinese Academy of Sciences,Shanghai 201203.china 3.6} laboratory for bioorganic phosphorus chemistry and chemical biology,Ministry of Education,{13.,School of life Sciences and Engineering,tsinghua university,beijing 100084,china 1. key laboratory for chemical {3. of Fujian province Department of Chemical Biology Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China2. Shanghai Institute of Materia Medica Shanghai Institutes of Biological Sciences Chinese Academy of Sciences Shanghai 201203 China3. Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education Department of Chemistry School of Life Sciences and Engineering Tsinghua University Beijing 100084 China

Seryl-Histidine dipeptide(Ser-His) has been previously reported to be capable of cleaving DNAs and carboxyl esters,as well as *** protein cleavage mechanism has not been addressed *** an initial step of protein cleavage activity,the non-covalent binding affinity of Ser-His for proteins is a crucial *** this work,we took cyclophilin A(CypA) as a substrate protein,and evaluated the non-covalent interaction between CypA and Ser-His using a combination of NMr spectroscopy and molecular modeling *** independent Ser-His binding sites on CypA were detected using 15N-1H heteronuclear single-quantum coherence(HSQC) *** binding site binds one Ser-His *** constants,Kd1 and Kd2,were estimated to be 2.07 and 6.66 mmol/L,respectively,indicative of the weak non-covalent interaction between Ser-His and *** on molecular modeling results,we suggest that both the α-amino and the side chain hydroxyl group of Ser-His are crucial for the non-covalent interaction between Ser-His and *** work sheds light on the molecular mechanism of Ser-His and its analogues cleaving proteins.

关键词： Ser-His cyclophilin A HSQC non-covalent interaction binding sites

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A New Efficient Synthesis of Bisphenol A Diether Bis-imidazoles and Bis-benzimidazoles

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Chinese chemical Letters 1998年第10期9卷 917-918页

作者： Cheng He ZHOU Jun WEI Zhong Jun li ru Gang XIE Meng Shen CAI( department of bioorganic {3., State key laboratory of Natural and Biomimetic Drugs,School of pharmaceutical Sciences, beijing Medical university, Beding 100083.Depotment of {3. beijing Med Univ Sch Pharmaceut Sci Dept Bioorgan Chem State Key Lab Nat & Biomimet Drugs Beijing 100083 Peoples R China Sichuan Union Univ Sch Sci Dept Chem Chengdu 610064 Peoples R China

A new efficient synthesis of bisphenol A diether bis-imidazoles and bis-benzimidazoles by bromoalkylation and imidazolylation or benzimidazolylation two-step reactions from commercial bisphenol A, imidazole, 2-methyli... 详细信息

关键词： bisphenol A imidazole benzimidazole ether synthesis

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Thiazolidine Derivatives as Chiral Catalysts in the Enantioselective Addition of Diethylzinc to Benzaldehyde

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Chinese chemical Letters 2000年第9期11卷 761-764页

作者： Qing lin MENG Yue Lan li yan HE Ye Di GUAN {3., peking university, beijing 100871 State key laboratory of Elemento-Organic chemistry, Nankai university, Tianjin 3.0071 peking Univ Dept Chem Beijing 100871 Peoples R China Nankai Univ State Key Lab Elementoorgan Tianjin 300071 Peoples R China

Four types of chiral thiazolidine derivatives were synthesized conveniently from natural L-cysteine and showed good enantioselectivity in up to 90% ee in the addition of diethylzine to benzaldehyde. Their enantioselec... 详细信息

关键词： chiral catalysts enantioselective addition % ee (enantiomeric excess) thiazolidine derivatives

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protein misfolding and inhibitor design

Protein misfolding and inhibitor design

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第六届全国化学生物学学术会议

作者： li yan-mei~* {3. laboratory of bioorganic phosphorus chemistry and chemical biology(Ministry of Education),department of chemistry,tsinghua university,beijing 100084,p.r.china

＜正＞Great deals of aetiologically distinct diseases have been linked by the likehood that they result from the progressive misfolding of specific proteins into aggregates that can cause cell *** are some secreted proteins that can,under abnormal circumstances,be converted in part to highly stable extracellular *** include amylin in the diabetic pancreas and proteins such as the amyloid -peptide（A） and Tau in Alzheimer’s disease.

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peptidase Mimics to Selectively Degrade β-Amyloid of Alzheimer's Disease

Peptidase Mimics to Selectively Degrade β-Amyloid of Alzhei...

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第五届全国化学生物学学术会议

作者： yan-mei li {3. laboratory of bioorganic phosphorus chemistry & chemical biology(Ministry of Education),department of chemistry,tsinghua university,beijing 100084,p.r.china,

The misfolded proteins are involved in the pathogenesis of human *** major representative of these proteins is β-amyloid peptide(Aβ)in Alzheimer’s disease(AD).The central theory for the cause of AD is the amyloid cascade hypothesis, which states that cerebral Aft accumulation is the initiating event in AD,and that the rest of the disease process results from an imbalance between Aft production and *** hypothesis implicates Aβ peptide as

关键词： Alzheimer’s disease β-amyloid peptide peptidase mimic

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EXCESS SpECTrOSCOpY:A NEW METHOD TO prOBE MOLECULAr INTErACTIONS

EXCESS SPECTROSCOPY:A NEW METHOD TO PROBE MOLECULAR INTERACT...

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40th IUpAC Congress

作者： Qingzhong li liming He and Zhiwu Yu* MOE key {3. of bioorganic phosphorous chemistry and chemical biology department of chemistry tsinghua university beijing 100084 p.r.china

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EFFECTS OF pHOSpHOrYLATION ON THE CONFOrMATION OF pEpTIDE AND prOTEIN

EFFECTS OF PHOSPHORYLATION ON THE CONFORMATION OF PEPTIDE AN...

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第17届国际磷化学大会

作者： yan-mei li Yu-Fen Zhao {3. laboratory of bioorganic phosphorus chemistry and chemical biology (Ministry of Education) department of chemistry tsinghua university beijing 100084

＜正＞The regulation of biochemical activity by protein post-translational modifications is a pervasive cellular control mechanism. protein phosphorylation is a key posttranslational modification

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X-ray Crystal Structure of a Mononuclear Copper (Ⅱ) Complex with Unusual Monodentate O-coordination of Carboxylate Group of Isonicotinate

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Chinese chemical Letters 1998年第5期9卷 497-499页

作者： Feng mei NIE yan mei {3. Yu Fen ZHAO (Bio-organic phosphor-us chemistry laboratory department of chemistrytsinghua university, beijing 100084)Zhe Ming WANG Chun Hua yan (State key laboratory of rare Earth Materials chemistry and App{3.cations,Depart Bio-Organ. phosphorus Chem. Lab. Department of Chemistry Tsinghua University Beijing 100084 China State key Lab. rare Earth Mat. C.A. Department of Chemistry Peking University Beijing 100871 China

reaction of Cu(ClO4)2'6H2O with tripodal ligand tri s (2-benzi nd dazol yl methyl ) aInine(ntb) and sodium isonicotinate (Iso) yielded a mononuclear complex lCu(ntb)(lso)]ClO4.3.5H2O. Thestructure has been established by X-ray crystallography The Cu (Ⅱ) atom is in a distorted trigonalbipyranddal environment with three benzimindazole N atoms of ntb defining the equatorial plane, oneandne N atom of ntb, and one O atom of the carboxylate group of isonicotinate occupying the axialpositions.

关键词： copper complex,tripodal ligand benzimidazole isonicotinate crystal structure

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COMprESSING BEHAVIOr OF BINArY MIXTUrES CONTAINING DIpALMITOYLpHOSpHATIDYLCHOliNE AND STErOLS AT AIr-WATEr INTErFACE

COMPRESSING BEHAVIOR OF BINARY MIXTURES CONTAINING DIPALMITO...

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40th IUpAC Congress

作者： Yunlan Su Qingzhong li lin Chen and Zhiwu Yu* MOE key {3. of bioorganic phosphorous chemistry and chemical biology department of chemistry tsinghua university beijing 100084 p.r.china

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Selective Lysis of Amyloid Beta-peptide with Capturing Copper by a Multifunctional Compound

Selective Lysis of Amyloid Beta-Peptide with Capturing Coppe...

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第六届全国化学生物学学术会议

作者： Wei-hui Wu,peng Lei,yan-mei li~* {3. laboratory of bioorganic phosphorus chemistry and chemical biology(Ministry of Education),department of chemistry,tsinghua university tsinghua university,beijing 100084,p.r.{13.

＜正＞Multiple lines of evidence indicate that cerebral amyloid beta-peptide（Aβ） plays a key role in pathogenesis of Alzheimer’s disease（AD）.Aβcan form pathological assemblies and evokes the generation of free radicals by binding and reducing redox-active *** activity and expression of some enzymes including neprilysin,insulin-degrading enzyme and cathepsin B appear to decline in the early stages of AD progression with aging.Aβaggregation blockers,copper chelators or Aβ

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