Selective Lysis of Amyloid Beta-Peptide with Capturing Copper by a Multifunctional Compound

作     者：Wei-hui Wu,Peng Lei,Yan-mei Li~* Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education),Department of Chemistry,Tsinghua University Tsinghua University,Beijing 100084,P.R.China 

会议名称：《第六届全国化学生物学学术会议》

会议日期：2009年

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：Supported by grants from the National Natural Science Foundation of China(Nos.20532020 20672067) 

摘      要：正Multiple lines of evidence indicate that cerebral amyloid beta-peptide（Aβ） plays a key role in pathogenesis of Alzheimer’s disease（AD）.Aβcan form pathological assemblies and evokes the generation of free radicals by binding and reducing redox-active *** activity and expression of some enzymes including neprilysin,insulin-degrading enzyme and cathepsin B appear to decline in the early stages of AD progression with aging.Aβaggregation blockers,copper chelators or Aβ