检索结果-南通市图书馆

Vertex-transitive Diameter Two Graphs

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2022年第1期38卷 209-222页

作者： Wei JIN li tan School of Statistics Jiangxi University of Finance and EconomicsNanchang 330013China School of Mathematics and Statistics HNP-LAMACentral South UniversityChangsha 410075China Research Center of Applied Statistics Jiangxi University of Finance and EconomicsNanchang 330013China

We investigate the family of vertex-transitive graphs with diameter ***Γbe such a *** that its automorphism group is transitive on the set of ordered non-adjacent vertex *** eitherΓis distance-transitive orΓhas girth at most ***,ifΓhas valency 2,thenΓ≌C4 or C5;and for any integer n≥3,there exist such graphsΓof valency n such that its automorphism group is not transitive on the set of ***,we determine this family of graphs of valency less than ***,the family of diameter 2 circulants is characterized.

关键词： vertex-transitive graph diameter automorphism group

Crack propagation with different radius local random damage based on peridynamic theory

在线全文

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2021年第5期15卷 1238-1248页

作者： Jinhai ZHAO li tan Xiaojing DOU Department of Civil Engineering Zhejiang University City CollegeHangzhou 3100015China College of Civil Engineering and Architecture Zhejiang UniversityHangzhou 310058China College of Civil Engineering Tongji UniversityShanghai 200092China Shanghai Baoye Group Corp. Ltd.Shanghai 200941China

Drawing from the advantages of Classical Mechanics,the peridynamic theory can clarify the crack propagation mechanism by an integral solution without initially setting the factitious crack and crack *** study implements the peridynamic theory by subjecting bilateral notch cracked specimens to the conditions of no local damage,small radius local damage,and large radius local ***,to study the effects of local stochastic damage with different radii on the crack propagation path and Y-direction displacement,a comparison and contact methodology was adopted,in which the crack propagation paths under uniaxial tension and displacement in the Y-direction were compared and *** method can be applied to steel structures under similar local random damage conditions.

关键词： peridynamics stochastic damage bilateral notch crack

Upconversion nanorods anchored metal-organic frameworks via hierarchical and dynamic assembly for synergistic therapy

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第8期15卷 7533-7541页

作者： Wenfeng Guo li-li tan Qiang li Juanmin li li Shang State Key Laboratory of Solidification Processing School of Materials Science and EngineeringChongqing Science and Technology Innovation CenterNorthwestern Polytechnical UniversityXi’an 710072China

Heterogeneous materials made of metal-organic frameworks(MOFs)and optically active nanomaterials have attracted intensive interests in recent years due to their distinct physicochemical properties,but controllable fabrication of these materials remains challenging *** this work,we report a new strategy to in situ fabricate heterogeneous nanomaterials based on UiO-66-NH2 and upconversion nanorods(UCNRs)via a hierarchical and dynamic assembly ***–satellite structured UiO-66-NH2@UCNRs have been successfully fabricated,and the formation mechanism was thoroughly investigated by the combined use of scanning electron microscopy(SEM)and Fourier transform infrared(FTIR)*** results revealed the involvement of three main stages:supramolecular assembly of UiO-66-NH2 precursors with UCNRs,nucleation and growth of UiO-66-NH2 crystal,and dynamic assembly with UCNRs accompanied by Ostwald ***,based on the hereditary optical and porous features of the heterogeneous nanomaterials,an enhanced multimodal synergistic anticancer platform has been established by integrating near-infrared(NIR)-triggered photodynamic therapy(PDT)and pH-triggered anticancer drug delivery,as confirmed by cellular *** present study provides a new avenue for developing advanced functional heterogeneous nanomaterials via the hierarchical and dynamic assembly strategy.

关键词： heterogeneous nanomaterials metal-organic frameworks upconversion nanorods assembly therapy

L^p-estimates on a ratio involving a Bessel process

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第1期8卷 158-163页

作者： LU li-gang YAN li-tan XIANG li-chi Basic College Zhejiang Wanli University Ningbo 315101 China Department of Mathematics College of Science Donghua University Shanghai 200051 China

Let Z=（ Zt）t≥0 be a Bessel process of dimension δ（ δ〉0） starting at zero and let K（t） be a differentiable function on [0,∞） with K（t）〉0 （A↓t≥0）. Then we establish the relationship between L^p-norm of log^1/2（1 ＋δJτ） and L^p-norm of sup Zt[t＋k（t）]^-1/2 （0≤t≤τ） for all stopping times τ and all 0〈p〈＋∞.As an interesting example, we show that ｜｜log^1/2（1＋δLm＋1（τ）｜｜p and ｜｜supZtП[1＋Lj（t]^1/2｜｜p （0≤j≤m,j∈Z;0≤t≤τ） are equivalent with 0〈p〈＋∞ for all stopping times rand all integer numbers m, where the function Lm（t）（t≥0） is inductively defined by Lm＋1（t）=log[ 1 ＋Lm（t）] with L0（t）= 1.

关键词： Bessel processes Diffusion process Ito's formula Domination relation

Differential Graded Structures on Path Categories

在线全文

学校读者我要写书评

暂无评论

Algebra Colloquium 2015年第4期22卷 677-686页

作者： Fang li Dezhan tan Department of Mathematics Zhejiang University Hangzhou Zhejiang 310027 China

In this paper, we consider the graded path category associated to a quiver. We investigate all n-differentials on such a category, and also study the associated graded lie algebra. Moreover, a necessary and sufficient... 详细信息

关键词： quiver path category graded differential operator graded lie algebra dif-ferential graded category

Sol-Gel Based Soft lithography and Piezoresponse Force Microscopy of Patterned Pb(Zr_(0.52)Ti _(0.48))O_3 Microstructures

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2010年第5期26卷 439-444页

作者： lining Lani Shuhong Xie li tan Jiangyu li Key Laboratory of Low Dimensional Materials and Application Technology of Ministry of Education and Faculty of Materials Optoelectronics and Physics Xiangtan University Xiangtan 411105 China Department of Engineering Mechanics University of Nebraska Lincoln 68588-0526 USA Department of Mechanical Engineering University of Washington Seattle Washington 98195-2600 USA

Sol-gel based soft lithography technique has been developed to pattern a variety of ferroelectric Pb（Zr0.52Ti0.48）O3（PZT） microstructures,with feature size approaching 180 nm and good pattern transfer between the master mold and patterned films.X-ray diffraction and high-resolution transmission electron microscopy confirm the perovskite structure of the patterned *** force microscopy（PFM） and switching spectroscopy piezoresponse force microscopy（SSPFM） confirm their piezoelectricity and *** as high as 2.75 nm has been observed,comparable to typical PZT *** patterned PZT microstructures are promising for a wide range of device applications.

关键词： Soft lithography Piezoresponse force microscopy Pb(Zr0.52Ti0.48)O3

A Study on the Transport Process in Gas Diffusion Layer of Proton Exchange Membrane Fuel Cells

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2011年第5期20卷 449-453页

作者： Zetao tan li Jia Zhuqian Zhang Department of Power Engineering Beijing Jiaotong University

Gas diffusion layer(GDL) plays a great important role in proton exchange membrane fuel cell(PEMFC).Water transport mechanism in GDL is still not *** the present study,an ex-situ transparent setup is built to visualize the transport phenomena and to measure the threshold pressure of water in GDL at different *** is found that the relationship between the breakthrough pressure and the temperature is nearly linear(*** pressure decreases linearly with the increase of temperature).To avoid the problems faced by the continuum models,the pore network model is developed to simulate the liquid water transport through the carbon paper.A uniform pressure boundary condition is used in simulation and the results are similar to the ones obtained in the *** reason is that the contact angle and surface tension coefficient of water in GDLs change accordingly with the change of temperature.

关键词： PEMFC gas diffusion layer pore network model water breakthrough temperature

Microstructure, mechanical and biodegradable properties of a Mg–2Zn–1Gd–0.5Zr alloy with different solution treatments

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2019年第6期38卷 532-542页

作者： Jun-Xiu Chen Ming Gao li-li tan Ke Yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Solution treatment is a useful way to improve the degradation resistance of Mg *** this work,effects of solution treatment temperature on mechanical and biodegradable properties of an extruded Mg–2Zn–1Gd–0.5Zr alloy were *** analysis,tensile test, three-point bending test, immersion test and electrochemical test were *** results showed that increasing solution temperature decreases the mechanical properties of the ***, three-point bending test revealed that the solution-treated alloy at 510 ℃ could maintain 95% of its maximum bending force(Fmax) during the 28-day immersion *** treatment at 510 ℃ for 5 h, all the second phases were dissolved into the alloy, the galvanic corrosion was inhibited, and the alloy exhibited good corrosion resistance with a corrosion rate of 0.35 mm·year-1 in Hank’s solution.

关键词： Mg alloy Solution treatment Microstructure Mechanical property Biodegradable property

When Kinases Meet PROTACs

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2018年第10期36卷 971-977页

作者： li tan Nathanael S. Gray Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 26 Qiuyue Rd Pudong Shanghai 201210 China Department of Cancer Biology Dana-Father Cancer Institute Boston MA 02215 USA Department of Biochemistry and Molecular Pharmacology Harvard Med- ical School Boston MA 02115 USA

Small molecule drugs targeting kinases have revolutionized treatment options for millions of patients worldwide, especially in oncology. These targeted treatments have less side effects because they inhibit a specific dysfunctional kinase usually with relatively narrow selectivity. However, kinase inhibitors do have well-established liabilities, most prominently the emergence of drug resistance. Moreover, the majority of kinases are multi- domain and multifunctional proteins that in addition to their enzymatic activity have scaffolding and other roles, and inhibitors seldom address these alternative functions. Recently, small molecule mediated targeted protein degradation emerged as a new pharmacological strategy. The majority of small molecule degraders are bispecific molecules called proteolysis targeting chimeras （PROTACs）, and their mechanism of action is based on simultaneous recruitment of the target of interest and an E3 ligase, resulting in target polyubiquitination and eventual destruction by the proteasome. Over the last couple of years, PROTAC strategy has been developed and validated for a range of targets, including kinases. Here, we introduce the targeted protein degradation strategy, provide an overview of representative kinase PROTACs, and describe design rationales, efficacy and specificity. We also discuss their potential advantages, as well as comment on some of the limitations of this emerging pharmacological modality.

关键词： kinase inhibitors PROTACs drug discovery ligases kinase degradation drug design