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Emerging progress: photochemical transformation of nitroso compounds

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Science China Chemistry 2025年第1期 118-133页

作者： Ze-Le Chen qiang-qiang li Armido Studer Jun Xuan Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials School of Chemistry & Chemical Engineering Anhui University Organisch-Chemisches Institut Universitat Münster

Nitroso compounds have emerged as highly valuable reaction partners or reagents in organic synthesis due to their rich *** versatile profile of these compounds allows them to function as electrophiles, nucleophiles, diradicals, and radical acceptors in diverse transformations. In recent years, notable progress has been made in harnessing photochemical reactions with nitroso compounds to prepare N,O-containing structures using mild and eco-friendly conditions. Various nitroso compounds like nitrosoarenes, acyloxy nitroso compounds, N-nitrosoamines and nitrites have received significant attention for their ability to introduce NO moieties into complex molecules that are otherwise difficult to access. In this review, we provide an overview of the recent advancements in the visible light-induced conversion of nitroso compounds, with particular emphasis on their role as bifunctional reagents and acceptors of radicals, carbenes and nitrenes.

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Riser Simulation and Radial Porosity Distribution Characterization for Gas-Fluidized Bed of Cork Particles

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Journal of Thermal Science 2014年第4期23卷 368-374页

作者： wu Guorong OUYANG Jie li qiang Department of Mathematics Gansu Normal University for Nationalities School of Science Northwestern Polytechnical University

Numerical simulations are carried out for gas-solid fluidized bed of cork particles, using discrete element method. Results exhibit the existence of a so-called anti core-annular porosity profile with lower porosity in the core and higher porosity near the wall for non-slugging fluidization. The tendency to form this unfamiliar anti core-annular porosity profile is stronger when the solid flux is higher. There exist multiple inflection points in the simulated axial solid volume fraction profile for non-slugging fluidization. Results also show that the familiar core-annular porosity profile still appears for slugging fluidization. In addition, the classical choking phenomenon can be captured at the superficial gas velocity slightly lower than the correlated transport velocity.

关键词： Fluidization Multiphase flow Simulation Discrete element method Anti core-annular regime

Dynamic Optimization Method on Electromechanical Coupling System by Exponential Inertia Weight Particle Swarm Algorithm

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Chinese Journal of Mechanical Engineering 2009年第4期22卷 602-607页

作者： li qiang wu Jianxin SUN Yan College of Mechanical and Electrical Engineering North China University of Technology Beijing 100144 China College of Mechanical Engineering lnner Mongolia University of Technology Hohhot 010051 China

Dynamic optimization of electromechanical coupling system is a significant engineering problem in the field of mechatronics. The performance improvement of electromechanical equipment depends on the system design parameters. Aiming at the spindle unit of refitted machine tool for solid rocket, the vibration acceleration of tool is taken as objective function, and the electromechanical system design parameters are appointed as design variables. Dynamic optimization model is set up by adopting Lagrange-Maxwell equations, Park transform and electromechanical system energy equations. In the procedure of seeking high efficient optimization method, exponential function is adopted to be the weight function of particle swarm optimization algorithm. Exponential inertia weight particle swarm algorithm（EPSA）, is formed and applied to solve the dynamic optimization problem of electromechanical system. The probability density function of EPSA is presented and used to perform convergence analysis. After calculation, the optimized design parameters of the spindle unit are obtained in limited time period. The vibration acceleration of the tool has been decreased greatly by the optimized design parameters. The research job in the paper reveals that the problem of dynamic optimization of electromechanical system can be solved by the method of combining system dynamic analysis with reformed swarm particle optimizati on. Such kind of method can be applied in the design of robots, NC machine, and other electromechanical equipments.

关键词： particle swarm algorithm electromechanical coupling system dynamic optimization

FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation

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Science China life Sciences 2025年

作者： Dake Xiao Haowen Ran lishu Chen Yuanyuan li Yan Cai Songyang Zhang Qinghui Qi Huiran wu Cheng Zhang Shuailiang Cao Lanjuan Mi Haohao Huang Ji Qi Qiuying Han Haiqing Tu Huiyan li Tao Zhou Fangye li Ailing li Jianghong Man Nanhu Laboratory National Center of Biomedical Analysis School of Traditional Chinese Medicine Capital Medical University Department of Neurosurgery General Hospital of Central Theater Command of Chinese PLA School of life and Health Sciences Huzhou College Department of Neurosurgery Beijing Fengtai Hospital Department of Neurosurgery First Medical Center of PLA General Hospital

The infiltration of glioblastoma multiforme(GBM) is predominantly characterized by diffuse spread, contributing significantly to therapy resistance and recurrence of GBM. In this study, we reveal that microtubule deacetylation, mediated through the downregulation of fibronectin type III and SPRY domain-containing 1(FSD1), plays a pivotal role in promoting GBM diffuse infiltration. FSD1 directly interacts with histone deacetylase 6(HDAC6) at its second catalytic domain, thereby impeding its deacetylase activity on α-tubulin and preventing microtubule deacetylation and depolymerization. This inhibitory interaction is disrupted upon phosphorylation of FSD1 at its Ser317 and Ser324 residues by activated CDK5, leading to FSD1 dissociation from microtubules and facilitating HDAC6-mediated α-tubulin deacetylation. Furthermore, increased expression of FSD1 or interference with FSD1 phosphorylation reduces microtubule deacetylation, suppresses invasion of GBM stem cells, and ultimately mitigates tumor infiltration in orthotopic GBM xenografts. Importantly, GBM tissues exhibit diminished levels of FSD1 expression, correlating with microtubule deacetylation and unfavorable clinical outcomes in GBM patients. These findings elucidate the mechanistic involvement of microtubule deacetylation in driving GBM cell invasion and offer potential avenues for managing GBM infiltration.

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基于Weibull分布函数的胡萝卜切片远红外干燥过程模拟及应用

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甘肃农业大学学报 2020年第1期55卷 204-212页

作者：李武强万芳新刘英韦博黄晓鹏甘肃农业大学机电工程学院甘肃兰州730070 酒泉奥凯种子机械股份有限公司甘肃酒泉735000

【目的】探讨胡萝卜切片远红外干燥的最优工艺参数,研究不同干燥条件对胡萝卜干制品平均干燥速率、单位能耗和品质指标的影响.【方法】以干燥温度、切片厚度和辐照距离为试验因素进行胡萝卜的远红外干燥特性试验,利用Weibull分布函数对... 详细信息

【目的】探讨胡萝卜切片远红外干燥的最优工艺参数,研究不同干燥条件对胡萝卜干制品平均干燥速率、单位能耗和品质指标的影响.【方法】以干燥温度、切片厚度和辐照距离为试验因素进行胡萝卜的远红外干燥特性试验,利用Weibull分布函数对胡萝卜切片的远红外干燥过程进行模拟,比较不同干燥条件下胡萝卜干制品的指标变化.【结果】干燥温度、切片厚度和辐照距离对胡萝卜的干燥特性曲线均有显著的影响;Weibull分布函数拟合的决定系数R2值均在0.98以上,离差平方和χ2值均很小;尺度参数α随着干燥温度、切片厚度和辐照高度的增加而呈现减小的趋势,形状参数β大于1;估算有效水分扩散系数Dcal在0.435×10^-7 ~3.080×10^-7 m^2/s之间,有效水分扩散系数Deff在1.542×10^-9 ~5.011×10^-9 m^2/s之间,均随着干燥温度、切片厚度和辐照高度的增加而增大;对比不同干燥条件下干制品的总色差值、单位能耗和平均干燥速率,发现远红外干燥技术对总色差值的影响不显著,对单位能耗和平均干燥速率的影响显著.对比热风干燥和远红外干燥方式下干制品的微观结构,发现远红外干燥可以增加物料内部微孔道的数量,提高干燥速率.【结论】Weibull可以较好地描述胡萝卜的远红外干燥过程,远红外干燥技术可以改善胡萝卜干制品的品质,减少单位能耗,缩短干燥时间.

关键词：胡萝卜远红外干燥干燥特性 Weibull分布函数拟合

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响应面法优化百香果的酶解工艺

食品工业科技 2017年第21期38卷 157-161页

作者：康超杨玉霞刘俐俐谢有强伍淑婕段振华贺州学院食品科学与工程技术研究院广西贺州542899 贺州学院食品与生物工程学院广西贺州542899

以百香果为原料,响应面法优化果胶酶、纤维素酶酶解百香果全果的最佳酶解工艺。单因素实验研究料液比、p H、酶解时间、酶解温度、酶添加量对百香果出汁率的影响,利用Box-Behnken设计实验响应面法优化三个因素对酶解全果百香果果汁工艺... 详细信息

以百香果为原料,响应面法优化果胶酶、纤维素酶酶解百香果全果的最佳酶解工艺。单因素实验研究料液比、p H、酶解时间、酶解温度、酶添加量对百香果出汁率的影响,利用Box-Behnken设计实验响应面法优化三个因素对酶解全果百香果果汁工艺。响应面法优化结果表明,百香果酶解最佳工艺参数为温度38.8℃,果胶酶添加量0.06‰,纤维素酶添加量0.09‰,在此条件下酶解百香果全果果汁60 min,出汁率为94.21%,和理论值94.237%模拟较好。本研究建立百香果酶解工艺二次线性回归模型准确有效,优化百香果酶解工艺参数是可行的,有一定的实用价值,可为百香果果汁、果酒及果醋等进一步研究提供理论依据。

关键词：百香果酶解工艺出汁率响应面法

电针“足三里”引起的肌梭传入对大鼠脊髓背角广动力型神经元伤害性反应的影响

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针刺研究 1999年第4期24卷 278-281页

作者：吴志新宋新爱张红梅李强吴苏娣樊小力西安医科大学生理教研室西安710061

以大鼠脊髓背角广动力型（ｗｉｄｅ－ｄｙｎａｍｉｃ－ｒａｎｇｅ，ＷＤＲ）神经元伤害性诱发反应为痛指标，观察了电针“足三里”穴引起肌梭传入对其的影响。结果如下：在２２只大鼠上记录到６２例ＷＤＲ神经元，“足三里”穴电针刺激... 详细信息

以大鼠脊髓背角广动力型（ｗｉｄｅ－ｄｙｎａｍｉｃ－ｒａｎｇｅ，ＷＤＲ）神经元伤害性诱发反应为痛指标，观察了电针“足三里”穴引起肌梭传入对其的影响。结果如下：在２２只大鼠上记录到６２例ＷＤＲ神经元，“足三里”穴电针刺激组２１例，其中有明显抑制作用的１５例，占７１．４３％；同样实验条件下，穴区分开０．５ｃｍ处给电针刺激组１４例，结果有明显抑制作用的仅为５例，占３５．７１％；穴区注射布比卡因破坏肌梭［８］后，施以同样参数的电针刺激组１６例，有明显抑制作用的也仅为５例，占３１．２５％。结果表明，电针“足三里”穴区引起的抑制效应是由于电针刺激引起穴位处的肌梭兴奋，后者的传入信息引起了ＷＤＲ神经元伤害性反应的抑制效应，从而进一步证实了肌梭的传入具有镇痛作用。

关键词： WDR神经元肌梭足三里镇痛电针

Recent advances in visible-light-driven organic reactions

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National Science Review 2017年第3期4卷 359-380页

作者： qiang liu li-Zhu wu State Key Laboratory of Applied Organic Chemistry Lanzhou University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences

In recent years, visible-light-driven organic reactions have been experiencing a significant renaissance in response to topical interest in environmentally friendly green chemical synthesis. The transformations using inexpensive, readily available visible-light sources have come to the forefront in organic chemistry as a powerful strategy for the activation of small molecules. In this review, we focus on recent advances in the development of visible-light-driven organic reactions, including aerobic oxidation, hydrogen-evolution reactions, energy-transfer reactions and asymmetric reactions. These key research topics represent a promising strategy towards the development of practical, scalable industrial processes with great environmental benefits.

关键词： visible light catalysis synthesis photocatalyst aerobic oxidation hydrogen evolution energy transfer asymmetric photoreaction

Design of a terahertz slotted waveguide array antenna based on photonic crystal

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Optoelectronics Letters 2025年

作者： PAN wu YE Kuan ZHANG Zhen li Renpu QIU Sen HUANG Lei College of Photoelectronic Engineering， Chongqing University of Posts and Telecommunications Chongqing Municipal Key Laboratory of Photoelectric Information Sensing and Transmission Technology， Chongqing University of Posts and Telecommunications Laboratory of Quantum Information Technology， Chongqing University of Posts and Telecommunications

In this paper， a terahertz slotted waveguide array antenna is designed based on photonic crystal， which can realize efficient radiation of terahertz waves. The electromagnetic wave is fed from the rectangular waveguide at the bottom of the antenna， coupled to photonic crystal waveguide through photonic crystal cavity， and radiated outward through slots at the top layer of antenna. The simulation results show that the antenna achieves a peak gain of 13.45dBi at 360 GHz， a half-power beamwidth of 10.9o， and a side lobe level of -13.9dB. The antenna based on photonic crystal has the advantages of low profile， low loss， and high radiation efficiency， which can be applied to terahertz wireless communication systems.

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