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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei liu Dai li Xiaoqi Pang Fanglian Chen Hailong Cao ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

Orientation factor analysis of deformation mechanisms under special processing techniques in AZ31 magnesium alloys

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Acta Metallurgica Sinica(English Letters) 2010年第1期23卷 63-71页

作者： ping YANG lina WANG Xiao li li MENU School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Material Department School of Tianjin University of Science and Technology Beijing Tianjin 301830 China

Experiments show that special processing techniques such as asymmetrical rolling （ASR）, equal channel angular pressing （ECAP） and equal channel angular rolling （ECAR） can weaken the basal texture of the magnesium alloys and therefore improve their plasticity. However, the deformation mechanisms related are different. In this paper, we determine the deformation mechanisms activated during ASR, ECAP and ECAR by calculation of orientation factors. Analysis shows that during ASR the shear stress σ13 on the rolling plane of the samples obviously weakens the basal slip and tension twinning that all produce basal texture and improve plasticity due to the promotion of tilt basal texture. During ECAP the shear stress σs on the intersecting plane of two channels promotes tension twinning in the basal oriented grains, whereas under ECAR the shear stress σ13 induced by roller friction on the rolling plane produces the shear stress as on the intersection plane of the two channels that also promotes tension twinning. Although the shear strain is lower in ECAR than in ECAP, the channel clearance in ECAR facilitates tension twinning.

关键词： Magnesium Asymmetrical rolling Equal channel angular pressing Equal channel angular rolling Deformation

Cs阳离子掺杂对CH_(3)NH_(3)PbI_(3)钙钛矿电子性质的影响研究

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原子与分子物理学报 2025年第6期42卷 174-182页

作者：张平丽吉林师范大学物理学院四平136000

有机-无机杂化钙钛矿太阳能电池被报道具有极高的功率转换效率,是下一代太阳能电池材料有希望的候选者,但其化学性质极不稳定,在高温高湿条件下易分解.本研究采用无机Cs阳离子取代CH_(3)NH_(3)PbI_(3)结构中的CH_(3)NH_(3)有机阳离子,... 详细信息

有机-无机杂化钙钛矿太阳能电池被报道具有极高的功率转换效率,是下一代太阳能电池材料有希望的候选者,但其化学性质极不稳定,在高温高湿条件下易分解.本研究采用无机Cs阳离子取代CH_(3)NH_(3)PbI_(3)结构中的CH_(3)NH_(3)有机阳离子,利用第一性原理密度泛函理论,计算了未掺杂CH_(3)NH_(3)PbI_(3)钙钛矿和Cs阳离子掺杂钙钛矿的电子性质.结果表明,适当比例的Cs阳离子掺杂能够增强Pb-I的相互作用力,且Cs阳离子掺杂并未改变钙钛矿直接半导体的属性.Cs阳离子与Pb-I框架之间强的共价相互作用,导致Cs阳离子掺杂钙钛矿具有更加稳定的晶体结构.这项工作阐明了Cs阳离子掺杂钙钛矿材料高稳定性的潜在机理,可以为将来设计高效稳定的钙钛矿光伏材料提供一定的理论依据.

关键词：钙钛矿 Cs阳离子掺杂能带结构态密度

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Distinct MLT asymmetry of auroral kilometric radiation observed by the FAST satellite

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Earth and Planetary Physics 2025年第1期9卷 188-193页

作者： JiaWen Tang Sai Zhang Fuliang Xiao HongMing Yang Si liu YiHua He Chang Yang YuYue Jin ZhouKun Deng ping li Archie James Johnston School of Physics and Electronic Sciences Changsha University of Science and TechnologyChangsha 410114China Hunan Province Higher Education Key Laboratory of Modeling and Monitoring on the Near-Earth Electromagnetic Environments Changsha University of Science and TechnologyChangsha 410114China School of Electrical and Information Engineering Changsha University of Science and TechnologyChangsha 410114China

Auroral Kilometric Radiation(AKR)is a common radio emission,which can contribute to the magnetosphere−ionosphere−atmosphere *** emissions have been observed in all magnetic planet magnetospheres of the solar *** this study,using observations from the FAST satellite from 30 August 1996 to 9 September 2001,the distribution of AKR in altitude=500−4500 km and invariant latitude(|ILAT|)=60°−80°has been analyzed.63045 AKR samples have been identified with~48%(52%)samples on the dayside(nightside).Of considerable interest,there is a distinct MLT asymmetry with the high occurrence rate in MLT=05−08 and 18−22(02−05 and 12−17)in the northern(southern)*** distinct MLT asymmetry is associated with the direction of Bxof the interplanetary magnetic *** addition,the occurrence rate on the nightside clearly increases as the index *** study further enriches *** and understanding of AKR in the magnetosphere as well as other similar radio emissions.

关键词： asymmetry auroral kilometric radiation interplanetary magnetic field

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan liao Zhenyu Yin Xintong Ge Dai li Rongrong Zhong Qiang liu Fanglian Chen ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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青少年的成人起病型糖尿病1型一家系报告

精准医学杂志 2018年第3期33卷 242-243,247页

作者：罗欢徐丽丽李萍宋利娜杨乃龙青岛大学附属医院内分泌科山东青岛2660031 青岛大学附属医院输血科山东青岛2660031

目的探讨青少年的成人起病型糖尿病(MODY)一家系的致病基因。方法分析1例MODY家系的临床特点、实验室资料等,对先证者及其家系成员进行基因测序。结果该家系中有3名成员(先证者及其姐姐、母亲)均检测到HNF4α(NM175914)突变基因,外显子... 详细信息

目的探讨青少年的成人起病型糖尿病(MODY)一家系的致病基因。方法分析1例MODY家系的临床特点、实验室资料等,对先证者及其家系成员进行基因测序。结果该家系中有3名成员(先证者及其姐姐、母亲)均检测到HNF4α(NM175914)突变基因,外显子8框移突变、杂合突变,框移结果使氨基酸编码提前终止。先证者规律应用胰岛素增敏剂,血糖控制良好。结论该家系为HNF4α基因突变所致MODY1家系,且同一家系内同时存在2型糖尿病病人。

关键词：糖尿病肝细胞核因子4 突变基因检测青少年病例报告

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China life Sciences 2025年第1期 300-302页

作者： Ze-Min lin Mai Xiang Wen-Hui Wei Shu-Hui Fan li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Properties of multi‑GNSS uncalibrated phase delays with considering satellite systems,receiver types,and network scales

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Satellite Navigation 2023年第3期4卷 92-106页

作者： ping Zeng Zhetao Zhang Yuanlan Wen Xiufeng He lina He Muzi li Wu Chen School of Earth Sciences and Engineering Hohai UniversityNanjing 211100China Shanghai Aerospace Control Technology Institute Shanghai 201109China Department of Land Surveying and Geo‑Informatics The Hong Kong Polytechnic UniversityHong KongChina

The Wide-Lane(WL)and Narrow-Lane(NL)Uncalibrated Phase Delays(UPDs)are the prerequisites in the traditional Precise Point Positioning(PPP)Ambiguity Resolution(AR).As the generation mechanism of various biases becomes more complex,we systematically studied the impact factors of four satellite systems WL and NL UPDs from the perspective of parameter *** 100 stations in a global network are used to generate the *** results of different satellite systems show that the estimation method,update frequency,and solution mode need to be treated *** regional networks with different receiver types,JAVAD,and Trimble,are also *** results indicate that the receiver-dependent bias has an influence on UPD ***,the hardware delays can inhibit the satellite-side UPDs if these receiver-specific errors are not fully deployed or even ***,the temporal stability and residual distribution of NL UPDs are significantly enhanced by utilizing a regional network,with the improvements by over 68%and 40%,*** demonstrates that different network scales exhibit the different implication of unmodeled errors,and the unmodeled errors cannot be ignored and must be handled in UPD estimation.

关键词： WL UPD NL UPD Satellite system Receiver type Network scale

Construction of highly stable selenium nanoparticles embedded in hollow nanofibers of polysaccharide and their antitumor activities

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Nano Research 2017年第11期10卷 3775-3789页

作者： Zhaohua ping Ting liu Hui Xu Yan Meng Wenhua li Xiaojuan Xu lina Zhang College of Chemistry amp Molecular Sciences Wuhan University Wuhan 430072 China Hubei Key Laboratory of Cell Homeostasis College of Life Sciences Wuhan University Wuhan 430072 China

Nanotechnologies have been exploited to develop safe and effective medicines and *** the present study,a novel functional nanomedicine constructed from a bioactive polysaccharide and selenium nanoparficles （SeNPs） was developed.A highly-branched [3-（1→3）-D-glucan （AF1） with high anti-tumor activity was used to self-assemble hollow nanofibers with an apparent average diameter of 92 nm;Se nanopartides were synthesized via the reduction of sodium *** results of light scattering,transmission electron microscopy,and X-ray diffraction demonstrated that the spherical SeNPs with a mean diameter of 46 nm were entrapped in the cavities of the AF1 hollow nanofibers through the formation of Se-O bonds between SeNPs and AF1,leading to the good dispersion and high stability in water for over 16 *** vitro and in vivo assays indicated that the AF1-Se nanocomposite had higher anti-tumor activities against breast ***,AF1-Se displayed a broad-spectrum inhibition against human cancers with low half maximal inhibitory concentration （IC50） values and low toxicity to normal ***,the inhibition ratio of AF1-Se against MCF-7 cancer cells reached 75% at a concentration of 200 μ***-1 with 29 μM Se content,much higher than that by treatment with AF1 alone,suggesting a strong synergic effect and nano ***,we developed a method for increasing the stability,anti-tumor activity,and safety of SeNPs by wrapping with bioactive polysaccharides.

关键词： selenium nanoparticles stability and dispersion bioactive polysaccharide anti-cancer activity synergistic effect