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探讨补充维生素D对妊娠期糖尿病合并亚临床甲状腺功能减退患者的临床治疗效果

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中国医药科学 2024年第14期14卷 163-166页

作者：赵慧庞丽王令令高爱滨山东省滨州市中心医院内分泌科山东滨州251700 山东省滨州市人民医院全科医学科山东滨州256600

目的探讨对妊娠期糖尿病合并亚临床甲状腺功能减退患者实施维生素D治疗的临床效果。方法按照随机数表法将滨州市中心医院自2021年3月至2023年2月收治的妊娠期糖尿病合并亚临床甲状腺功能减退患者90例进行分组,每组各45例,对照组实施基... 详细信息

目的探讨对妊娠期糖尿病合并亚临床甲状腺功能减退患者实施维生素D治疗的临床效果。方法按照随机数表法将滨州市中心医院自2021年3月至2023年2月收治的妊娠期糖尿病合并亚临床甲状腺功能减退患者90例进行分组,每组各45例,对照组实施基础治疗,观察组加用维生素D治疗,两组均连续治疗1个月,比较两组血糖及甲状腺功能指标、统计两组不良妊娠结局发病率。结果观察组治疗后与对照组治疗后比较,空腹血糖、餐后2 h血糖、糖基化血红蛋白及不良妊娠结局发生率均较低;观察组治疗后与对照组治疗后比较,促甲状腺激素较低、甲状腺素、25-羟基维生素D2及血清钙离子均较高,差异有统计学意义(P<0.05)。结论对妊娠期糖尿病合并亚临床甲状腺功能减退患者实施补充维生素D治疗可促进调整血糖以及甲状腺功能指标,不良妊娠结局风险相对降低,预后表现好。

关键词：维生素D 妊娠期糖尿病甲状腺功能减退妊娠结局

Studies on the cyclization reaction of D-aspartic acid

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Chinese Chemical Letters 2007年第5期18卷 516-518页

作者： Yu Chuan li Si Ping pang Yong Zhong Yu School of life Science and Technology Beijing Institute of Technology Beijing 100083 China

The cyclization reaction of D-aspartic acid was studied, the carboxyl groups of D-aspartic acid were protected by benzyl alcohol to give compound D-dibenzyl aspartate. Then （4R）-benzyl azetidine-2-one-4-carboxylate and meso-3,6-disubstituted piperazine-2,5-diones were synthesized via intramolecular cyclization and intermolecular cycfization of D-dibenzyl aspartate, respectively, and their structures were confirmed by ^1 H NMR and MS. Both cyclization reaction conditions were also investigated in detail.

关键词： D-Aspartic acid Cyclization reaction Azetidine-2-ones 3,6-Disubstituted piperazine-2,5-diones

UV -theory of a Class of Semidefinite Programming and Its Applications

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Acta Mathematicae Applicatae Sinica 2021年第4期37卷 717-737页

作者： Ming HUANG Jin-long YUAN li-ping pang Zun-quan XIA School of Science Dalian Maritime UniversityDalian116026China School of Mathematical Science Dalian University of TechnologyDalian116023China

In this paper we study optimization problems involving convex nonlinear semidefinite programming(CSDP).Here we convert CSDP into eigenvalue problem by exact penalty function,and apply the U-Lagrangian theory to the function of the largest eigenvalues,with matrix-convex valued *** give the first-and second-order derivatives of U-Lagrangian in the space of decision variables Rm when transversality condition ***,an algorithm frame with superlinear convergence is ***,we give one application:bilinear matrix inequality(BMI)optimization;meanwhile,list their UV decomposition results.

关键词： semidefinite programming nonsmooth optimization eigenvalue optimization UV-decomposition,u-Lagrangian smooth manifold second-order derivative

Clinical correlates of hypotension in patients with acute organophosphorus poisoning

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World Journal of Emergency Medicine 2021年第1期12卷 24-28页

作者： Ning Dong Zhe-xi Lu Xing-liang li Wei li li pang Ji-hong Xing Department of Emergency the First Hospital of Jilin UniversityChangchun 130021China School of Medicine Pennsylvania State College of MedicineHershey 17033USA

BACKGROUND:The aim of the present study is to describe the clinical correlates of hypotension and its associated outcomes in patients with acute organophosphorus poisoning(AOPP).METHODS:In this retrospective cohort study,we analyzed data pertaining to 871 patients with AOPP who were treated at two *** from hypotensive and non-hypotensive patients were compared to identify clinical correlates of *** also evaluated the association between clinical parameters(including hypotension)and in-hospital ***:The incidence of hypotension in AOPP patients was 16.4%.Hypotensive patients showed signifi cantly higher in-hospital mortality(1.1%vs.39.9%,Plinesterase(OR 0.91,95%CI 0.84–0.94),plasma albumin(OR 0.88,95%CI 0.85–0.92),serum amylase(OR 1.01,95%CI 1.01–1.02),and blood pH(OR 0.64,95%CI 0.54–0.75)were signifi cantly associated with *** adjusting for potential confounders,hypotension was associated with increased in-hospital mortality(hazard ratio 8.77–37.06,depending on the controlled variables).CONCLUSIONS:Hypotension is a common complication of AOPP and is associated with increased in-hospital *** age,history of diabetes,and changes in laboratory parameters were associated with hypotension in AOPP patients.

关键词： Acute organophosphate poisoning Hypotension Cholinesterase inhibitor Cardiovascular complication Shock

芪黄健脾滋肾颗粒治疗类风湿关节炎的疗效观察

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时珍国医国药 2024年第6期35卷 1411-1414页

作者：程园园黄传兵钱爱朱雅文庞利君安徽中医药大学研究生院安徽合肥230038 安徽中医药大学第一附属医院安徽合肥230031

目的观察芪黄健脾滋肾颗粒对类风湿性关节炎(RA)患者临床症状及相关实验室指标的影响。方法将60例RA患者分为两组,治疗组30例,对照组30例。对照组予以口服甲氨蝶呤片及来氟米特片,治疗组在对照组的基础上加芪黄健脾滋肾颗粒口服,治疗周... 详细信息

目的观察芪黄健脾滋肾颗粒对类风湿性关节炎(RA)患者临床症状及相关实验室指标的影响。方法将60例RA患者分为两组,治疗组30例,对照组30例。对照组予以口服甲氨蝶呤片及来氟米特片,治疗组在对照组的基础上加芪黄健脾滋肾颗粒口服,治疗周期均为12周。观察治疗前后DAS28疾病活动度指数、ACR20、50、70达标率情况和中医症状评分的变化,检测治疗前后C反应蛋白(CRP)、血沉(ESR)、抑炎因子[白介素10(IL-10)、TGF-β]、促炎因子[白介素17(IL-17)、血清肿瘤坏死因子-α(TNF-α)]、基质金属蛋白酶指标[MMP-2、MMP-3、MMP-9]及血清趋化因子[CXCL9、CXCL10]水平。结果两组均无脱落病例,治疗后观察组ACR20达标率为86.7%,显著高于对照组的70.0%(χ^(2)=3.325,P<0.05);ACR50达标率为63.3%,显著高于对照组的36.7%(χ^(2)=5.487,P<0.05);与治疗前比较,两组治疗后临床疗效指标较前均有所改善。观察组治疗后DAS28、ACR、中医症状评分、CRP、RF、ESR、TNF-α、IL-17、MMP-2、MMP-3、MMP-9、CXCL9、CXCL10水平均显著低于对照组治疗后(P<0.05或P<0.01),IL-10、TGF-β显著高于对照组(P<0.05或P<0.01)。观察期间两组均未见明显不良反应。结论芪黄健脾滋肾颗粒可有效改善RA患者临床症状及实验室指标,安全性高,值得临床推广。

关键词：类风湿性关节炎芪黄健脾滋肾颗粒趋化因子9 趋化因子10

Diagnosis of gastric duplication cysts in a child by endoscopic ultrasonography

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Chinese Medical Journal 2019年第4期132卷 488-490页

作者： Xin-Tong Lyu Xiao-li pang Lan Wu li-Bo Wang Department of Pediatric Gastroenterology The First Hospital of Jilin UniversityChangchunJilin 130021China.

To the Editor:A 7-year-old girl was admitted to The First Hospital of Jilin University at 15:00 on August 28,2016 due to vomiting lasting 3 *** revealed a cystic echogenic mass (approximately 61.4mm×38.4mm×46.6mm)located between the gastric antrum and the *** boundary of the mass was clear, and its wall structure was similar to that of the digestive *** computed tomography (CT)showed a cystic low-density mass in the hilar region;the boundary between the antrum and duodenum was ***- copy (Olympus Ltd.,Tokyo,Japan)was performed under general anesthesia administered intravenously on August 31,*** child was placed in the left lateral position,and the gastroscope was passed through the mouth and esophagus into the stomach.

关键词： Diagnosis Editor gastric duplication

Preparation and characterization of thermosensitive poly(NIPAM-co-MAH-β-CD)/(TiO_2-MWCNTs) composites by UV light photoinitiating method

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Chinese Chemical Letters 2012年第9期23卷 1071-1074页

作者： Hui Long Wang li pang Wen Feng Jiang Chao Yang Department of Chemistry Dalian University of TechnologyChina Dalian 116023 PetroChina Dalian Lubricating Oil R&D Institute China Dalian 116032

In this report, a novel thermosensitive poly（N-isopropylacrylamide-co-maleic anhydride-β-cyclodextrin）/（TiO2-multi-wal,led carbon nanotubes）（poly（NIPAM-co-MAH-β-CD）/（TiO2-MWCNTs）） composite was synthesized by UV light photoinitiating method. The results indicated that MAH modifiedβ-CD （MAH-β-CD） could polymerize to NIPAM by UV light irradiation in the presence of TiO2-MWCNTs composite nanoparticles. The characteristic results confirmed that the TiO2-MWCNTs composite nanoparticles were embedded evenly within the thermally responsive copolymer of NIPAM and MAH-β-CD. The effects of irradiation time and TiO2-MWCNTs concentration on the yield of the composites were investigated by keeping NIPAM to MAH-β- CD mass ratio constant. The optimal polymerization reaction conditions were a TiO2-MWCNTs concentration of 10 wt.% under UV light for the illumination of 3 h.

关键词： Polymeric composite Thermosensitive Titania nanoparticles UV light

A Multi-Conditional Proxy Broadcast Re-Encryption Scheme for Sensor Networks

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Computers, Materials & Continua 2020年第12期65卷 2079-2090页

作者： pang li lifeng Zhu Brij B.Gupta Sunil Kumar Jha Nanjing Vocational College of Information Technology Nanjing210044China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory of Remote Measurement and ControlSchool of Instrument Science and EngineeringSoutheast UniversityNanjing210096China Department of Computer Engineering National Institute of TechnologyKurukshetra136119India Department of Computer Science and Information Engineering Asia UniversityTaichung41449Taiwan IT Fundamentals and Education Technologies Applications University of Information Technology and Management in RzeszowRzeszow Voivodeship100031Poland

In sensor networks,it is a challenge to ensure the security of data exchange between packet switching nodes holding different private *** order to solve this problem,the present study proposes a scheme called multi-conditional proxy broadcast re-encryption(MC-PBRE).The scheme consists of the following roles:the source node,proxy server,and the target *** the condition is met,the proxy can convert the encrypted data of the source node into data that the target node can directly *** allows the proxy server to convert the ciphertext of the source node to a new ciphertext of the target node in a different group,while the proxy server does not need to store the key or reveal the *** the same time,the proxy server cannot obtain any valuable information in the *** paper formalizes the concept of MC-PBRE and its security model,and proposes a MC-PBRE scheme of ciphertext ***,the scheme security has been proved in the random oracle.

关键词： Proxy re-encryption sensor network security broadcast re-encryption

A multi-sensor-based distributed real-time measurement system for glacier deformation

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Journal of Mountain Science 2023年第10期20卷 2913-2927页

作者： DONG Han-chuan liU Shuang pang li-li TAO Zhi-gang FANG li-de ZHANG Zhong-hua li Xiao-ting College of Quality and Technical Supervision Hebei UniversityBaoding 071002China Technology Innovation Center for Geological Environment Monitoring Ministry of Natural ResourcesBaoding 071051China Center for Hydrogeology and Environmental Geology Survey China Geological SurveyChina Geological SurveyBaoding 071051China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610299China School of Mechanics and Civil Engineering China University of Mining and TechnologyBeijing 100083China

Glacier disasters occur frequently in alpine regions around the world,but the current conventional geological disaster measurement technology cannot be directly used for glacier disaster ***,in this study,a distributed multi-sensor measurement system for glacier deformation was established by integrating piezoelectric sensing,coded sensing,attitude sensing technology and wireless communication *** traditional Modbus protocol was optimized to solve the problem of data identification confusion of different acquisition *** indoor wireless transmission,adaptive performance analysis,error measurement experiment and landslide simulation experiment,the performance of the measurement system was analyzed and *** unmanned aerial vehicle technology,the reliability and effectiveness of the measurement system were verified on the site of Galongla glacier in southeastern Tibet,*** results show that the mean absolute percentage errors were only 1.13%and 2.09%for the displacement and temperature,*** distributed glacier deformation real-time measurement system provides a new means for the assessment of the development process of glacier disasters and disaster prevention and mitigation.

关键词： Glacier disasters Distributed deformation measurement Multi-sensor Real-time LoRa Data adaptive.