A green light-enhanced cytosolic protein delivery platform based on BODIPY-protein interactions
作者机构：State Key Laboratory of Pharmaceutical BiotechnologyThe University of Hong KongHong KongChina Department of Pharmacology and PharmacyLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Dr.Li Dak-Sum Research CentreThe University of Hong KongHong KongChina Department of SurgerySchool of Clinical MedicineHKU-SZH&LKS Faculty of MedicineThe University of Hong KongHong KongChina
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第1期
页 面：1042-1051页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0802[工学-机械工程] 0703[理学-化学] 0702[理学-物理学]
基 金：This work was supported by the Research Grants Council of Hong Kong(Early Career Scheme,No.27115220) Ming Wai Lau Centre for Reparative Medicine Associate Member Program
主 题：photoresponsive nanoparticles intracellular delivery protein delivery polyamidoamine(PAMAM) boron-dipyrromethene(BODIPY)
摘 要：Development of cytosolic protein delivery platforms brings new possibilities for various incurable *** based on polymer/protein self-assembly have shown their potential in protein ***,versatile photocontrolled platforms based on self-assembly for protein delivery are seldom ***,we report a boron-dipyrromethene(BODIPY)-modified polyamidoamine(PAMAM)with excellent photo-controllability and efficiency for the cytosolic delivery of various *** serum stability was achieved by coating hyaluronic acid and human serum albumin on the surface of BODIPY-modified PAMAM/protein *** nanoparticles under green light irradiation allowed efficient intracellular delivery of multiple cargo proteins with different charges and molecular weights and promoted endosome *** study provides valuable guidance for the development of BODIPY derivative-based protein delivery systems and advances the research in intracellular protein delivery.
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