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Brain protective effect of dexmedetomidine vs propofol for sedation during prolonged mechanical ventilation in non-brain injured patients

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World Journal of Psychiatry 2024年第3期14卷 370-379页

作者： Hong-Xun Yuan li-na zhang Gang li li Qiao Intensive Care Unit Peking University International HospitalBeijing 102206China Central Operating Room The Affiliated Beijing Chaoyang Hospital of Capital Medical UniversityBeijing 100020China

BACKGROUND Dexmedetomidine and propofol are two sedatives used for long-term *** remains unclear whether dexmedetomidine provides superior cerebral protection for patients undergoing long-term mechanical *** To compare the neuroprotective effects of dexmedetomidine and propofol for sedation during prolonged mechanical ventilation in patients without brain *** Patients who underwent mechanical ventilation for>72 h were randomly assigned to receive sedation with dexmedetomidine or *** Richmond Agitation and Sedation Scale(RASS)was used to evaluate sedation effects,with a target range of-3 to *** primary outcomes were serum levels of S100-βand neuron-specific enolase(NSE)every 24 *** secondary outcomes were remifentanil dosage,the proportion of patients requiring rescue sedation,and the time and frequency of RASS scores within the target *** A total of 52 and 63 patients were allocated to the dexmedetomidine group and propofol group,*** data were comparable between *** significant differences were identified between groups within the median duration of study drug infusion[52.0(IQR:36.0-73.5)h vs 53.0(IQR:37.0-72.0)h,P=0.958],the median dose of remifentanil[4.5(IQR:4.0-5.0)μg/kg/h vs 4.6(IQR:4.0-5.0)μg/kg/h,P=0.395],the median percentage of time in the target RASS range without rescue sedation[85.6%(IQR:65.8%-96.6%)vs 86.7%(IQR:72.3%-95.3),P=0.592],and the median frequency within the target RASS range without rescue sedation[72.2%(60.8%-91.7%)vs 73.3%(60.0%-100.0%),P=0.880].The proportion of patients in the dexmedetomidine group who required rescue sedation was higher than in the propofol group with statistical significance(69.2%vs 50.8%,P=0.045).Serum S100-βand NSE levels in the propofol group were higher than in the dexmedetomidine group with statistical significance during the first six and five days of mechanical ventilation,respectively(all P<0.05).CONCLUSION Dexmedetomidine demonstrated

关键词： Dexmedetomidine Propofol Sedation Prolonged mechanical ventilation Brain protective

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Advanced nanomedicines and immunotherapeutics to treat respiratory diseases especially COVID-19 induced thrombosis

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World Journal of Clinical Cases 2024年第16期12卷 2704-2712页

作者： Jie Wu Ying Zheng li-na zhang Cai-li Gu Wang-li Chen Min-Qiang Chang Department of Respiratory and Oncology 72nd Group Army Hospital of PLAHuzhou 313000Zhejiang ProvinceChina Department of Otorhinolaryngology 72^(nd)Group Army Hospital of PLAHuzhou 313000Zhejiang ProvinceChina

Immunotherapy and associated immune regulation strategies gained huge attraction in order to be utilized for treatment and prevention of respiratory *** specifically nanomedicines can be used to regulate host immunity in lungs in the case of respiratory diseases including coronavirus disease 2019(COVID-19)***-19 causes pulmonary embolisms,thus new therapeutic options are required to target thrombosis,as conventional treatment options are either not effective due to the complexity of the immunethrombosis *** this review,we discuss regulation of immune response in respiratory diseases especially *** further discuss thrombosis and provide an overview of some antithrombotic nanoparticles,which can be used to develop nanomedicine against thrombo-inflammation induced by COVID-19 and other respiratory infectious *** also elaborate the importance of immunomodulatory nanomedicines that can block pro-inflammatory signalling pathways,and thus can be recommended to treat respiratory infectious diseases.

关键词： nanomedicines Immunotherapeutics Respiratory diseases COVID-19 Thrombosis

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Association between 5-HTR1A gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder:A meta-analysis

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World Journal of Psychiatry 2024年第10期14卷 1573-1582页

作者： Huai-Neng Wu Shuang-Yue Zhu li-na zhang Bian-Hong Shen lian-lian Xu Department of Psychiatry Affiliated Mental Health Center and Hangzhou Seventh People’s HospitalZhejiang University School of MedicineHangzhou 310013Zhejiang ProvinceChina

BACKGROUND Major depressive disorder(MDD)is a substantial global health concern,and its treatment is complicated by the variability in individual response to *** To consolidate research and clarify the impact of genetic variation on MDD treatment *** Adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines,a systematic search across PubMed,EMBASE,Web of Science,and the Cochrane library was conducted without date restrictions,utilizing key terms related to MDD,serotonin 1A receptor polymorphism(5-HTR1A),C-1019G polymorphism,and antidepressant *** meeting inclusion criteria were thoroughly screened,and quality assessed using the Newcastle-Ottawa *** analyses,includingχ2 and I²values,were used to evaluate heterogeneity and fixed-effect or random-effect models were applied *** The initial search yielded 1216 articles,with 11 studies meeting criteria for *** of various genetic models showed no significant association between the 5-HTR1A C-1019G polymorphism and antidepressant *** heterogeneity was low to moderate,and no publication bias was detected through funnel plot symmetry and Egger's and Begg's *** This meta-analysis does not support a significant association between the 5-HTR1A C-1019G polymorphism and the efficacy of antidepressant treatment in *** findings call for further research with larger cohorts to substantiate these results and enhance the understanding of antidepressant pharmacogenetics.

关键词： Major depressive disorder Antidepressant efficacy 5-HTR1A gene C-1019G polymorphism Meta-analysis

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Effect of Intermetallic Phases on Corrosion Initiation of AZ91 Alloy With Rare Earth Y Addition

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Journal of Materials Science & Technology 2015年第5期31卷 504-511页

作者： li-na zhang Ruiling Jia Dan li Wei zhang Feng Guo School of Materials Science and Engineering Inner Mongolia University of Technology State Key Laboratory for Corrosion and Protection Institute of Metal ResearchChinese Academy of Sciences

The effect of the rare earth（RE） element Y on the microstructure of AZ91 Mg alloy is investigated.A detailed description of the procedure of identifying the intermetallic phases containing Y in the AZ91 Mg alloy with 0.9 wt%Y addition is *** results shows that there are two different kinds of RE phases in scanning electron microscopy（SEM） *** dispersive spectrum（EDS） analysis shows that one is rich in Y element and the other is rich in Mn *** to the element mapping of electron probe microanalysis（EPMA）.the element Al can be found not only in the β-Mg17Al12phase but also in these two RE phases.X-ray diffraction（XRD） and transmission electron microscopy（TEM） results further confirm one of the two RE phases is AI2Y;the phase of Al10Mn2Y has just been determined by transmission electron microscopy（TEM） instead of XRD probably because it is *** shapes of these two RE intermetallic phases are pretty *** 3D digital microscopy is employed to observe in-situ the effect of the(5 phase and the above two RE intermetallic phases on the corrosion initiation of the *** results show that the corrosion attack of AZ91 Mg alloy without Y addition starts around the eutectic phase β-*** the addition of 0.9 wt%Y,the two kinds of Y-rich intermetallic phases act as cathodic effect and a phase in the adjacent of them was activated and cathodic effect of the β-Mg17Al12phase was inhibited.

关键词： Mg alloy Yttrium Intermetallic phase Corrosion ini

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Novel Poly(methyl methacrylate)-based Ionomers Used as Multifunctional Aids to Modify Poly(vinyl chloride)

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Chinese Journal of Polymer Science 2016年第4期34卷 483-490页

作者： li-na zhang 宋义虎郑强 Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Zhejiang University Hangzhou 310027 China

Poly（methyl methacrylate）（PMMA） based ionomers with different lanthanum （La（III）） contents （PMMA-XLa） synthesized by free radical solution polymerization were applied to poly（vinyl chloride）（PVC） resins as a kind of multifunctional aids, and their performances were evaluated by measuring the static stability time, initial discoloration, transparency, fusion behavior and tensile strength of the modified PVC. The ionomers with proper lanthanum （La（III）） contents show a better thermal stability efficiency in comparison with traditional stabilizer lanthanum stearate. Meantime, they can accelerate PVC plasticization more efficiently than PMMA. The rigid PVC products stabilized with the ionomers present good transparency and enhanced tensile strength.

关键词： Rigid PVC Ionomers Thermal stability Plasticization Multifunction.

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New Exact Solutions for Konopelchenko-Dubrovsky Equation Using an Extended Riccati Equation Rational Expansion Method

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Communications in Theoretical Physics 2006年第5期45卷 I0003-I0003,770-776页

作者： SONG li-na zhang Hong-Qing Department of Applied Mathematics Dalian University of Technology Dalian 116024 China

Taking the Konopelchenko-Dubrovsky system as a simple example, some familles of rational formal hyperbolic function solutions, rational formal triangular periodic solutions, and rational solutions are constructed by using the extended Riccati equation rational expansion method presented by us. The method can also be applied to solve more nonlinear partial differential equation or equations.

关键词： Konopelchenko-Dubrovsky equation extended Riccati equation rational expansion method nonlinear partial differential equation or equations

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Extended sine-Gordon Equation Method and Its Application to Maccari＇s System

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Communications in Theoretical Physics 2005年第5X期44卷 783-788页

作者： SONG li-na zhang Hong-Qing Department of Applied Mathematics Dalian University of Technology Dalian 116024 China

An extended sine-Gordon equation method is proposed to construct exact travelling wave solutions to Maccari's equation based upon a generalized sine-Gordon equation. It is shown that more new travelling wave solutions can be found by this new method, which include bell-shaped soliton solutions, kink-shaped soliton solutions, periodic wave solution, and new travelling waves.

关键词： Maccari's system exact travelling wave solution extended sine-Gordon equation method

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Extended Jacobi Elliptic Function Rational Expansion Method and Its Application to （2＋1）-Dimensional Stochastic Dispersive Long Wave System

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Communications in Theoretical Physics 2007年第6期47卷 969-974页

作者： SONG li-na zhang Hong-Qing Department of Applied Mathematics Dalian University of Technology Dalian 116024 China

In this work, by means of a generalized method and symbolic computation, we extend the Jacobi elliptic function rational expansion method to uniformly construct a series of stochastic wave solutions for stochastic evolution equations. To illustrate the effectiveness of our method, we take the （2＋ 1）-dimensional stochastic dispersive long wave system as an example. We not only have obtained some known solutions, but also have constructed some new rational formal stochastic Jacobi elliptic function solutions.

关键词： stochastic evolution equations (2+ 1)-dimensional stochastic dispersive long wave system rational formal stochastic Jacobi elliptic function solutions

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Fast segmentation approach for SAR image based on simple Markov random field

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Journal of Systems Engineering and Electronics 2010年第1期21卷 31-36页

作者： Xiaogang Lei Ying li na Zhao Yanning zhang Department of Computer Science Northwestern Polytechnical University Xi'an 710072 E R. China

Traditional image segmentation methods based on MRF converge slowly and require pre-defined weight. These disadvantages are addressed, and a fast segmentation approach based on simple Markov random field （MRF） for SAR image is proposed. The approach is firstly used to perform coarse segmentation in blocks. Then the image is modeled with simple MRF and adaptive variable weighting forms are applied in homogeneous and heterogeneous regions. As a result, the convergent speed is accelerated while the segmentation results in homogeneous regions and boarders are improved. Simulations with synthetic and real SAR images demonstrate the effectiveness of the proposed approach.

关键词： SAR image segmentation simple Markov random field coarse segmentation maximum a posterior iterated condition mode.

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Effect of kaolin on tensile strength and humidity resistance of a water-soluble potassium carbonate sand core

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China Foundry 2016年第1期13卷 15-21页

作者： Long zhang li-na zhang Yuan-cai li School of Metallurgical Engineering Anhui University of Technology School of Material Science and Engineering Huazhong University of Science and Technology

Water soluble cores(WSCs) have been widely applied in manufacture of complex metal components with hollow configurations or internal channels. However, the WSCs without any additons have low tensile strength and low humidity resistance. The purpose of this study is to prepare a water-soluble potassium carbonate sand core with addition of kaolin by the hot-temping method. The effects of kaolin on tensile strength, humidity resistance, fracture mechanism, as well as the gas evolution and collapsibility of WSCs were investigated. Results show that both the crystal morphology and the fracture mechanism of the inorganic salt are changed under the participation of kaolin, contributing to the increase of the tensile strength and the humidity resistance of the core. With the addition of 3wt.% kaolin, the tensile strength could be increased by a factor of 2, reached 1.50 MPa and the hygroscopic rate could be decreased by 14%, achieved 0.559%(after stored for 8 h), respectively. As the addition amount of kaolin increases from 0wt.% to 3wt.%, the main fracture mechanism changes from a adhesive to a cohesive fracture mechanism. The water-soluble potassium carbonate core obtained has the low gas evolution and excellent collapsibility, which makes it suitable for casting low melting metal with complex cavities and crooked channels.

关键词： water-soluble core kaolin tensile strength humidity resistance strengthening mechanism

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