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Investigation of the Severity of Modular Construction Adoption Barriers with Large-Scale Group Decision Making in an Organization from Internal and External Stakeholder Perspectives

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Computer Modeling in Engineering & Sciences 2023年第12期137卷 2465-2493页

作者： muzi li Department of Civil Engineering University of Southern CaliforniaLos Angeles90007USA

Modular construction as an innovativemethod aids the construction industry in transforming to off-site construction production with high efficiency and environmental *** the obvious advantages,the uptake of modular construction is not booming as ***,previous studies have investigated and summarized the barriers to the adoption ofmodular *** this research,a Large-ScaleGroupDecisionMaking(LSGDM)-based analysis is first made of the severity of barriers to modular construction adoption from the perspective of construction *** addition,the Technology-Organization-Environment(TOE)framework is utilized to identify the barriers based on three contexts(technology,organization,and environment).The Technique for Order Preference by Similarity to Ideal Solution(TOPSIS)and LSGDM models are both implemented for the first time to analyze the severity of the barriers to modular adoption based on questionnaire results from internal and external stakeholders in an ***,in this research,in-depth insights into the severity of barriers are gained,providing a reference for construction organizations to manage modular adoption.

关键词： Modular construction barriers technology application construction organization

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达格列净治疗糖尿病肾病的临床疗效

中国医药指南 2025年第1期23卷 110-112页

作者：李木子辽宁省金秋医院肾内科辽宁沈阳110016

目的分析糖尿病肾病患者治疗中应用达格列净的临床效果。方法选取辽宁省金秋医院2020年1月至2023年12月的糖尿病肾病患者80例,进行回顾性分析,根据治疗方案的不同对患者进行分组,采用二甲双胍缓释片及替米沙坦治疗的40例患者为对照组,... 详细信息

目的分析糖尿病肾病患者治疗中应用达格列净的临床效果。方法选取辽宁省金秋医院2020年1月至2023年12月的糖尿病肾病患者80例,进行回顾性分析,根据治疗方案的不同对患者进行分组,采用二甲双胍缓释片及替米沙坦治疗的40例患者为对照组,采用二甲双胍、替米沙坦及达格列净治疗的40例患者为观察组,均进行3个月治疗。对比两组血糖水平、肾功能、炎症因子水平。结果治疗后观察组空腹血糖、餐后2 h血糖和糖化血红蛋白水平较对照组低(均P<0.05)。观察组患者的肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、白细胞介素6(IL-6)、24 h尿蛋白排泄率(UAER)、尿白蛋白肌酐比值(UACR)水平较对照组低,肾小球滤过率(eGFR)水平较对照组高(均P<0.05)。结论临床上将达格列净用于糖尿病肾病患者的治疗中,不仅对患者的血糖水平进行了有效的控制,还使患者的炎症反应和肾功能得到了一定程度的改善。

关键词：糖尿病肾病达格列净治疗效果

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Leukocyte immunoglobulin-like receptor B4 (liLRB4) in acute myeloid leukemia: From prognostic biomarker to immunotherapeutic target

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中华医学杂志(英文版) 2024年第22期137卷 2697-2711页

作者： li muzi Zhao Xiangyu Peking University People’s Hospital Peking University Institute of Hematology Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation National Clinical Research Center for Hematologic Disease Beijing China

Leukocyte immunoglobulin-like receptor (liLR) B4 (also known as ILT3/CD85k) is an immune checkpoint protein that is highly expressed in solid tumors and hematological malignancies and plays a significant role in the pathophysiology of cancer. liLRB4 is highly expressed in acute myeloid leukemia (AML), and this phenotype is associated with adverse patient outcomes. Its differential expression in tumors compared to normal tissues, its presence in tumor stem cells, and its multifaceted roles in tumorigenesis position it as a promising therapeutic target in AML. Currently, several immunotherapies targeting liLRB4 are undergoing clinical trials. This review summarizes advancements made in the study of liLRB4 in AML, focusing on its structure, ligands, expression, and significance in normal tissues and AML; its protumorigenic effects and mechanisms in AML; and the application of liLRB4-targeted therapies in AML. These insights highlight the potential advantages of liLRB4 as an immunotherapeutic target in the context of AML.

关键词： liLRB4 Leukemia, myeloid, acute Immune checkpoint Tumor microenvironment Immunotherapy

Rosaceae fruit transcriptome database(ROFT)-a useful genomic resource for comparing fruits of apple,peach,strawberry,and raspberry

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Horticulture Research 2023年第12期10卷 276-285页

作者： muzi li Stephen M.Mount Zhongchi liu Department of Cell Biology and Molecular Genetics University of MarylandCollege ParkMD 20742USA

Rosaceae is a large plant family consisting of many economically important fruit crops including peach,apple,pear,strawberry,raspberry,plum,and *** into their growth and development will promote both basic understanding and progress toward increasing fruit yield and *** the ever-increasing high-throughput sequencing data of Rosaceae,comparative studies are hindered by inconsistency of sample collection with regard to tissue,stage,growth conditions,and by vastly different handling of the ***,databases that enable easy access and effective utilization of directly comparable transcript data are highly ***,we describe a database for comparative analysis,ROsaceae Fruit Transcriptome database(ROFT),based on RNA-seq data generated from the same laboratory using similarly dissected and staged fruit tissues of four important Rosaceae fruit crops:apple,peach,strawberry,and red ***,the database is unique in allowing easy and robust comparisons among fruit gene expression across the four *** enables researchers to query orthologous genes and their expression patterns during different fruit developmental stages in the four species,identify tissue-specific and tissue-/stage-specific genes,visualize and compare ortholog expression in different fruit types,explore consensus co-expression networks,and download different data *** database provides users access to vast amounts of RNA-seq data across the four economically important fruits,enables investigations of fruit type specification and evolution,and facilitates the selection of genes with critical roles in fruit development for further studies.

关键词： straw crops database

Reannotation of the cultivated strawberry genome and establishment of a strawberry genome database

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Horticulture Research 2021年第1期8卷 590-598页

作者： Tianjia liu muzi li Zhongchi liu Xiaoyan Ai Yongping li Institute of Fruit and Tea Hubei Academy of Agricultural Sciences/Fruit and Tea Subcenter of Hubei Innovation Center of Agricultural Science and TechnologyWuhanChina Department of Cell Biology and Molecular Genetics University of Maryland College ParkCollege ParkMDUSA School of life Sciences and State Key Laboratory of Agrobiotechnology Chinese University of Hong KongShatinHong KongChina

Cultivated strawberry(Fragaria×ananassa)is an important fruit crop species whose fruits are enjoyed by many *** octoploid of hybrid origin,the complex genome of this species was recently sequenced,serving as a key reference genome for cultivated strawberry and related species of the Rosaceae *** current annotation of the *** genome mainly relies on ab initio predictions and,to a lesser extent,transcriptome ***,we present the structure and functional reannotation of the *** genome based on one PacBio full-length RNA library and ninety-two Illumina RNA-Seq *** improved annotation of the *** genome,v1.0.a2,comprises a total of 108,447 gene models,with 97.85%complete *** models of 19,174 genes were modified,360 new genes were identified,and 11,044 genes were found to have alternatively spliced ***,we constructed a strawberry genome database(SGD)for strawberry gene homolog searching and annotation ***,the transcriptome of the receptacles and achenes of *** at four developmental stages were reanalyzed and qualified,and the expression profiles of all the genes in this annotation are also ***,this study provides an updated annotation of the *** genome,which will facilitate genomic analyses across the Rosaceae family and gene functional studies in cultivated strawberry.

关键词： straw Fragaria database

Zwitterionic polymers:Addressing the barriers for drug delivery

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Chinese Chemical Letters 2023年第11期34卷 31-40页

作者： muzi li Wen Zhang Jiaxin li Yinghe Qi Chen Peng Nan Wang Huili Fan Yan li School of Chemistry and Biological Engineering University of Science and Technology BeijingBeijing 100083China

Nanocarriers play an important role in drug delivery for disease ***,nanocarriers face a series of physiological barriers after administration such as blood clearance,nonspecific tissue/cell localization,poor cellular uptake,and endosome *** physiological barriers seriously reduce the accumulation of drugs in target action site,which results in poor therapeutic *** polyethylene glycol(PEG)can increase the blood circulation time of nanocarriers,its application is limited due to the“PEG dilemma”.Zwitterionic polymers have been emerging as an appealing alternative to PEG owing to their excellent performance in resisting nonspecific protein ***,the diverse structures bring functional versatility to zwitterionic polymers beyond *** review focuses on the structures and characters of zwitterionic polymers,and will discuss and summarize the application of zwitterionic polymers for drug *** will highlight the strategies of zwitterionic polymers to address the physiological barriers during drug ***,we will give some suggestions that can be utilized for the development of zwitterionic polymers for drug *** review will also provide an outlook for this *** aim is to provide a comprehensive and systemic review on the application of zwitterionic polymers for drug delivery and promote the development of zwitterionic polymers.

关键词： Zwitterionic polymers Nonfouling Physiological barriers Nanocarriers Drug delivery

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Insights into effects of thermotolerant nitrifying and sulfur-oxidizing inoculants on nitrogen-sulfur co-metabolism in sewage sludge composting

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Journal of Environmental Sciences 2024年第10期144卷 76-86页

作者： Tingting Hou Yujie Zhou Rongchun Du Jiali liu Weiguang li Shumei Zhang muzi li Junhong Chu liqiang Meng Institute of Microbiology Heilongjiang Academy of SciencesHarbin 150010China Hebei University of Environmental Engineering Hebei Key Laboratory of Agroecological SafetyQinhuangdao 066102China School of Environment Harbin Institute of TechnologyHarbin 150090China

In this study,high temperature thermotolerant nitrifying bacteria(TNB)and high temperature thermotolerant sulfide oxidizing bacteria(TSOB)were obtained from compost samples and inoculated into sewage sludge(SS)*** effects of inoculation on physical and chemical parameters,ammonia and hydrogen sulfide release,nitrogen form and sulfur compound content change and physical-chemical properties during nitrogen and sulfur conversion were *** results showed that inoculation of TNB and TSOB increased the temperature,pH,OM degradation,C/N ratio and germination index(GI)of *** with the control treatment(CK),the addition of inoculants reduced the release of NH_(3) and H_(2)S,and transformed them into nitrogen and sulfur compounds,the hydrolysis of polymeric ferrous sulfate was promoted,resulting in relatively high content of sulfite and *** the same time,the physical and chemical properties of SS have a strong correlation with nitrogen and sulfur compounds.

关键词： Sewage sludge Composting Inoculation Thermotolerant nitrifying bacteria Thermotolerant sulfurized oxidizing bacteria

Properties of multi‑GNSS uncalibrated phase delays with considering satellite systems,receiver types,and network scales

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Satellite Navigation 2023年第3期4卷 92-106页

作者： Ping Zeng Zhetao Zhang Yuanlan Wen Xiufeng He lina He muzi li Wu Chen School of Earth Sciences and Engineering Hohai UniversityNanjing 211100China Shanghai Aerospace Control Technology Institute Shanghai 201109China Department of Land Surveying and Geo‑Informatics The Hong Kong Polytechnic UniversityHong KongChina

The Wide-Lane(WL)and Narrow-Lane(NL)Uncalibrated Phase Delays(UPDs)are the prerequisites in the traditional Precise Point Positioning(PPP)Ambiguity Resolution(AR).As the generation mechanism of various biases becomes more complex,we systematically studied the impact factors of four satellite systems WL and NL UPDs from the perspective of parameter *** 100 stations in a global network are used to generate the *** results of different satellite systems show that the estimation method,update frequency,and solution mode need to be treated *** regional networks with different receiver types,JAVAD,and Trimble,are also *** results indicate that the receiver-dependent bias has an influence on UPD ***,the hardware delays can inhibit the satellite-side UPDs if these receiver-specific errors are not fully deployed or even ***,the temporal stability and residual distribution of NL UPDs are significantly enhanced by utilizing a regional network,with the improvements by over 68%and 40%,*** demonstrates that different network scales exhibit the different implication of unmodeled errors,and the unmodeled errors cannot be ignored and must be handled in UPD estimation.

关键词： WL UPD NL UPD Satellite system Receiver type Network scale

Shear behavior and off-fault damage of saw-cut smooth and tension-induced rough joints in granite

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1216-1230页

作者： Fanzhen Meng Feili Wang Louis Ngai Yuen Wong Jie Song muzi li Chuanqing Zhang liming Zhang College of Science Qingdao University of TechnologyQingdao266033China Department of Earth Sciences The University of Hong KongPokfulamHong KongChina State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China Cooperative Innovation Center of Engineering Construction and Safety Shandong Peninsula Blue Economic Zone Qingdao266033China

The damage of rock joints or fractures upon shear includes the surface damage occurring at the contact asperities and the damage beneath the shear surface within the host *** latter is commonly known as off-fault damage and has been much less investigated than the surface *** main contribution of this study is to compare the results of direct shear tests conducted on saw-cut planar joints and tension-induced rough granite joints under normal stresses ranging from 1 MPa to 50 *** shear-induced off-fault damages are quantified and compared with the optical microscope *** results clearly show that the planar joints slip stably under all the normal stresses except under 50 MPa,where some local fractures and regular stick-slip occur towards the end of the *** post-peak stress drop and stick-slip occur for all the rough *** residual shear strength envelopes for the rough joints and the peak shear strength envelope for the planar joints almost *** root mean square(RMS)of asperity height for the rough joints decreases while it increases for the planar joint after shear,and a larger normal stress usually leads to a more significant decrease or increase in ***,the extent of off-fault damage(or damage zone)increases with normal stress for both planar and rough joints,and it is restricted to a very thin layer with limited micro-cracks beneath the planar joint *** comparison,the thickness of the damage zone for the rough joints is about an order of magnitude larger than that of the planar joints,and the coalesced micro-cracks are generally inclined to the shear direction with acute *** findings obtained in this study contribute to a better understanding on the frictional behavior and damage characteristics of rock joints or fractures with different roughness.

关键词： Planar joint Rough joint Shear behavior Off-fault damage Micro-cracks