Zwitterionic polymers:Addressing the barriers for drug delivery
作者机构：School of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing 100083China
出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)
年 卷 期：2023年第34卷第11期
页 面：31-40页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学]
基 金：financially supported by the Fundamental Research Funds for the Central Universities(No.06500230) the National Natural Science Foundation of China(No.32071391) the Beijing Nova Program(No.Z201100006820140)
主 题：Zwitterionic polymers Nonfouling Physiological barriers Nanocarriers Drug delivery
摘 要：Nanocarriers play an important role in drug delivery for disease ***,nanocarriers face a series of physiological barriers after administration such as blood clearance,nonspecific tissue/cell localization,poor cellular uptake,and endosome *** physiological barriers seriously reduce the accumulation of drugs in target action site,which results in poor therapeutic *** polyethylene glycol(PEG)can increase the blood circulation time of nanocarriers,its application is limited due to the“PEG dilemma.Zwitterionic polymers have been emerging as an appealing alternative to PEG owing to their excellent performance in resisting nonspecific protein ***,the diverse structures bring functional versatility to zwitterionic polymers beyond *** review focuses on the structures and characters of zwitterionic polymers,and will discuss and summarize the application of zwitterionic polymers for drug *** will highlight the strategies of zwitterionic polymers to address the physiological barriers during drug ***,we will give some suggestions that can be utilized for the development of zwitterionic polymers for drug *** review will also provide an outlook for this *** aim is to provide a comprehensive and systemic review on the application of zwitterionic polymers for drug delivery and promote the development of zwitterionic polymers.
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