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Endocrine therapy of short duration prevents local and contralateral recurrence of ductal carcinoma in situ of the breast: A multicenter retrospective cohort study in China

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中华医学杂志(英文版) 2024年第14期137卷 1756-1758页

作者： Wang Zhen Jin Zining Zhang Huanrui Xu Guiying Zhang Dianlong Fang Fengqi Xing Hua Wang Jia Guo Baoliang Zhu Guolian liu Yongzhi li jieqing Cai Zhengang Sun liang Zhang Yuting Zhou Tianyang liu Chang Zhou Baosen Jin Feng Zhang Yan Song Dong Chen Bo Department of Breast Surgery The First Hospital of China Medical University Shenyang Liaoning China Department of Breast and Thyroid Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong China Department of Geriatric Medicine The First Hospital of China Medical University Shenyang Liaoning China Department of Breast Surgery Jilin Cancer Hospital Changchun Jilin China Department of Breast and Thyroid Surgery Affiliated Zhongshan Hospital of Dalian University Dalian Liaoning China Department of Oncology The First Affiliated Hospital of Dalian Medical University Dalian Liaoning China Department of Breast Surgery China-Japan Union Hospital Affiliated to Jilin University Changchun Jilin China Department of Breast Surgery The Second Hospital of Dalian Medical University Dalian Liaoning China Department of Breast Surgery The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China Department of Breast Surgery The Fifth People’s Hospital of Shenyang Shenyang Liaoning China Department of Breast Surgery General Hospital of Benxi Iron &amp Steel Industry Group of liaoning Health Industry Group Benxi Liaoning China Department of Breast Surgery The Fourth People’s Hospital of Shenyang Shenyang Liaoning China Department of Breast Surgery The First Affiliated Hospital of Dalian Medical University Dalian Liaoning China Department of Clinical Epidemiology and Center of Evidence Based Medicine The First Hospital of China Medical University Shenyang Liaoning China Department of Breast Surgery The Second Hospital of Jilin University Changchun Jilin China Department of Breast Surgery General Surgery Center The First Hospital of Jilin University Changchun Jilin China

To the Editor: De-escalating the treatment of ductal carcinoma in situ (DCIS) of the breast has been investigated in recent years. A 5-year adjuvant endocrine therapy (AET) regimen is the recommended treatment for hormone receptor-positive DCIS. Selective estrogen receptor modulators (such as the commonly used tamoxifen and toremifene) and aromatase inhibitors (AIs) are the currently used AET drugs. However, long-term AET is accompanied by severe side effects such as menopausal symptoms, endometrial carcinoma, cardiovascular events, venous thromboembolic events, osteoporosis, and joint pain that can significantly reduce patients’ quality of life. It was reported that only 50% of the patients completed the recommended 5-year AET mainly because of side effects, while higher adherence rates were observed with shorter-duration regimens. Therefore, de-escalation of AET should be considered to reduce the side effects of AET and improve adherence.

关键词： ADHERENCE

ZBED2 expression enhances interferon signaling and predicts better survival of estrogen receptor-negative breast cancer patients

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Cancer Communications 2022年第7期42卷 663-667页

作者： Dingxie liu Qiongyu Hao jieqing li Qun li Kun Wang Qing Geng Yutong Wu Jaydutt VVadgama Yong Wu Bluewater Biotech LLC New ProvidenceNJ 07974USA Division of Cancer Research and Training Department of Internal MedicineCharles Drew University of Medicine and ScienceDavid Geffen UCLA School of Medicine and UCLA Jonsson Comprehensive Cancer CenterLos AngelesCA 90095USA Department of Breast Cancer Cancer CenterGuangdong Provincial People’s Hospital&Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080P.R.China Department of Oncology Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200123P.R.China Department of Thoracic Surgery Renmin Hospital of Wuhan UniversityWuhanHubei 430060P.R.China

Dear Editor,The molecular pathogenesis of estrogen receptor(ER)-negative,especially triple-negative breast cancer(TNBC),is unclear,thus,the treatment of these types of cancers is still a great challenge[1].Chemotherapy remains the primary adjuvant treatment choice for TNBC patients[2],but a large number of these tumors are resistant to chemotherapy and relapse ormetastasize quickly after adjuvant therapy[3].

关键词： patients estrogen breast

Pipeline Embolization Device for intracranial aneurysms presenting with mass effect:a large Chinese cohort

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Stroke & Vascular Neurology 2024年第1期9卷 50-58页

作者： Yang Zhao Junlin Lu Hongqi Zhang Tianxiao li Donglei Song Sheng Guan Aisha Maimaitili Yunyan Wang Wenfeng Feng Yang Wang jieqing Wan Guohua Mao Huaizhang Shi Xinjian Yang Jianmin liu Yuanli Zhao Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Peking University International HospitalBeijingChina Department of Neurosurgery West China HospitalSichuan UniversityChengduSichuanChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Interventional Neuroradiology Zhengzhou University People's HospitalZhengzhouHenanChina Department of Neurosurgery Shanghai Donglei Brain HospitalShanghaiChina Department of Interventional Neuroradiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Neurosurgery The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina Department of Neurosurgery Qilu Hospital of Shandong University QingdaoJinanShandongChina Department of Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Neurosurgery The First Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghaiChina

Background Unruptured intracranial aneurysm treatment aims to reduce the risk of aneurysm rupture and bleeding,relieves symptoms and improve the quality of life for *** study aimed to assess the safety and efficacy of Pipeline Embolization Device(PED,Covidien/Medtronic,Irvine,CA)treatment for intracranial aneurysms presenting with mass effect in real-world *** We selected patients from the PED in China Post-Market Multi-Center Registry Study with mass effect *** study endpoints included postoperative mass effect deterioration and mass effect relief at follow-up(3–36 months).We conducted multivariate analysis to identify factors associated with mass effect *** analyses by aneurysm location,size and form were also *** This study included 218 patients with a mean age of 54.3±11.8 years and a female predominance of 74.0%(162/218).The postoperative mass effect deterioration rate was 9.6%(21/218).During a median follow-up period of 8.4 months,the mass effect relief rate was 71.6%(156/218).Notably,immediate aneurysm occlusion following treatment was significantly associated with mass effect relief(OR 0.392,95%CI,0.170 to 0.907,p=0.029).Subgroup analysis demonstrated that adjunctive coiling contributed to mass effect relief in cavernous aneurysms,while dense embolism impeded symptom relief in aneurysmslieving mass *** findings of this study provide support for endovascular treatment to alleviate mass effect in unruptured intracranial *** registration number NCT03831672.

关键词： aneurysm intracranial Irvine

森田疗法治疗一例医疗照射后强迫症的案例报告

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中国辐射卫生 2020年第3期29卷 221-223,228页

作者：李卫国方连英李洁清山东省医学科学院放射医学研究所山东第一医科大学(山东省医学科学院)山东济南250062

为寻找一种实用有效的心理干预方法应对核与辐射事故中人员心理异常情况,特报道一辐射诱发的强迫症案例,记录森田疗法对其进行治疗的过程及疗效,讨论森田疗法在辐射相关强迫症中的实践效果。该患者领悟能力提高和行为基本恢复正常的结... 详细信息

为寻找一种实用有效的心理干预方法应对核与辐射事故中人员心理异常情况,特报道一辐射诱发的强迫症案例,记录森田疗法对其进行治疗的过程及疗效,讨论森田疗法在辐射相关强迫症中的实践效果。该患者领悟能力提高和行为基本恢复正常的结果提示森田疗法可用于干预辐射相关的强迫症。

关键词：森田疗法辐射强迫症

“一带一路”背景下中意农产品贸易竞争性与互补性分析

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新疆农垦经济 2020年第9期 79-86页

作者：李洁清安徽大学经济学院安徽合肥230601

基于“一带一路”的合作背景,依据比较优势理论,结合显性比较优势指数(RCA)与贸易互补指数(TCI),分析中国和意大利在农产品贸易方面的竞争性及互补性。研究表明:在竞争性方面,中意之间具有比较优势的农产品在类别上并不一致;在互补性方... 详细信息

基于“一带一路”的合作背景,依据比较优势理论,结合显性比较优势指数(RCA)与贸易互补指数(TCI),分析中国和意大利在农产品贸易方面的竞争性及互补性。研究表明:在竞争性方面,中意之间具有比较优势的农产品在类别上并不一致;在互补性方面,中国在第3章、第5章、第7章、第13章、第16章等章的农产品出口上,对意大利市场的依赖性较强,而意大利的第19章、第22章农产品对中国市场的依赖性较强。两国在农产品贸易上的竞争性较弱而互补性较强,合作潜力较大。

关键词：一带一路农产品贸易 RCA TCI

18F-FDG-PET/CT长期照射对兔免疫指标的影响

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中华放射医学与防护杂志 2016年第4期36卷 264-267页

作者：张巍罗毅李洁清柳怡山东省疾病预防控制中心辐射防护安全所济南250014 山东省千佛山医院放射科济南250014 山东省医学科学院放射医学研究所济南250062

目的探讨18F-氟代葡萄糖正电子发射断层扫描术计算机层析成像（18F-FDG-PET/CT）长期反复扫描对动物免疫系统的影响。方法取成年大耳白兔,分为健康对照组和实验组。实验组以18F-FDG-PET/CT每天连续照射3个月,期间分别于第1、2和3个月... 详细信息

目的探讨18F-氟代葡萄糖正电子发射断层扫描术计算机层析成像（18F-FDG-PET/CT）长期反复扫描对动物免疫系统的影响。方法取成年大耳白兔,分为健康对照组和实验组。实验组以18F-FDG-PET/CT每天连续照射3个月,期间分别于第1、2和3个月,对兔免疫系统包括白细胞总数、胸腺系数与脾脏指数、巨噬细胞吞噬功能、血清 IgG、IgM、IgA 含量、血浆TNF-α和IL-1β水平分别进行测定。结果 18F-FDG-PET/CT长期照射条件下,实验组与健康对照组比较,白细胞总数增加,而脾脏和胸腺指数下降（t=3.144~72.903,P〈0.05）;照射1个月后巨噬细胞吞噬百分率、照射2~3个月后的吞噬指数与吞噬百分率与健康对照组比较出现下降（t=2.719~11.859,P〈0.05）;免疫T细胞CD4＋和CD8＋分别在照射2个和1个月后出现升高和降低（t=6.433~29.877,P〈0.05）;血清免疫球蛋白含量在长期照射后出现不同程度的下降（t=2.720~28.775,P〈0.05）,血清TNF-α、IL-1β蛋白表达亦与健康对照组存在明显差异。结论 18F-FDG-PET/CT对健康成年雄性日本大耳白兔长期照射对动物的免疫系统有一定的影响,在临床应用上应该注意其对人体的辐射效应。

关键词： 18F-FDG-PET/CT 长期照射免疫系统

傅里叶变换红外光谱和紫外光谱数据融合对牛肝菌种类的鉴别

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食品科学 2018年第20期39卷 302-307页

作者：姚森刘鸿高李涛李杰庆王元忠云南农业大学农学与生物技术学院云南昆明650201 云南省农业科学院农产品加工研究所云南昆明650221 玉溪师范学院资源环境学院云南玉溪653100 云南省省级中药原料质量监测技术服务中心云南昆明650200

采集5种共272份牛肝菌样品的傅里叶变换红外光谱和紫外光谱,结合多光谱信息融合策略,建立牛肝菌种类快速鉴别的方法。多元散射校正(multiplicative signal correction,MSC)及二阶导数(second derivative,2D)等预处理方法对原始光谱进行... 详细信息

采集5种共272份牛肝菌样品的傅里叶变换红外光谱和紫外光谱,结合多光谱信息融合策略,建立牛肝菌种类快速鉴别的方法。多元散射校正(multiplicative signal correction,MSC)及二阶导数(second derivative,2D)等预处理方法对原始光谱进行优化,比较优化处理对区分不同种类牛肝菌影响;利用优化处理后的光谱数据及融合数据建立偏最小二乘判别分析(partial least squares discriminant analysis,PLS-DA)模型和支持向量机(support vector machine,SVM)判别模型。结果显示:1)经过2D和MSC预处理后,不同种类牛肝菌的PLS-DA鉴别效果优于未优化模型,表明2D+MSC预处理优化了光谱信息并提高了分类准确度;2)基于傅里叶变换红外光谱、紫外光谱、低级融合和中级融合数据分别建立PLS-DA模型,预测正确率为86.87%、66.67%、78.89%和95.56%;建立SVM判别模型,预测正确率分别为88.89%、74.44%、91.11%和100.00%,表明中级融合技术对不同种类牛肝菌鉴别效果显著,优于其他技术;3)中级融合技术在PLS-DA模型和SVM判别模型中对样品的预测正确率分别为95.56%和100.00%,表明SVM判别模型对牛肝菌种类区分效果优于PLS-DA模型。采用中级融合技术建立SVM判别模型,快速鉴别牛肝菌种类,为牛肝菌种类鉴别和质量控制提供可靠、稳定的方法。

关键词：数据融合牛肝菌种类鉴别紫外光谱傅里叶变换红外光谱

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多光谱数据融合技术对绒柄牛肝菌产地的鉴别

食品科学 2018年第8期39卷 212-217页

作者：姚森李涛刘鸿高李杰庆王元忠云南农业大学农学与生物技术学院云南昆明650201 云南省农业科学院药用植物研究所云南昆明650200 玉溪师范学院资源环境学院云南玉溪653100 云南省省级中药原料质量检测技术服务中心云南昆明650200

采集5个产地96份绒柄牛肝菌样品的红外光谱和紫外光谱,结合多光谱信息融合策略,建立快速、有效鉴别绒柄牛肝菌产地的方法。运用多元散射校正、标准正态变量、二阶导数等预处理方法对原始光谱数据进行优化处理,减少噪音干扰。选取具有指... 详细信息

采集5个产地96份绒柄牛肝菌样品的红外光谱和紫外光谱,结合多光谱信息融合策略,建立快速、有效鉴别绒柄牛肝菌产地的方法。运用多元散射校正、标准正态变量、二阶导数等预处理方法对原始光谱数据进行优化处理,减少噪音干扰。选取具有指纹特性的光谱信息进行初级数据融合;通过偏最小二乘判别分析(partial least squares-discriminant analysis,PLS-DA)筛选光谱数据中变量在投影方向重要程度大于1的波段,进行中级数据融合。利用优化处理后的单一光谱数据及多光谱融合数据建立PLS-DA模型和支持向量机(support vector machine,SVM)判别模型,比较两种判别模型对绒柄牛肝菌产地的鉴别效果。结果显示,通过红外光谱、紫外光谱、初级融合和中级融合数据分别建立PLS-DA模型,对绒柄牛肝菌产地的预测正确率为56.25%、56.25%、62.50%和81.25%;建立SVM判别模型,产地预测正确率分别为90.63%、65.63%、87.50%和96.88%,表明中级融合技术对绒柄牛肝菌产地鉴别效果显著,优于其他技术;并且SVM判别模型对牛肝菌产地区分效果优于PLS-DA模型。采用中级融合技术建立SVM判别模型,能够快速、有效鉴别不同产地绒柄牛肝菌,同时为食品质量监控提供有效方法和理论基础。

关键词：数据融合绒柄牛肝菌产地鉴别紫外光谱红外光谱

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牺牲混凝土在高温作用下的损伤及机理分析

东南大学学报（自然科学版） 2013年第3期43卷 599-603页

作者：李杰青孙伟蒋金洋金祖权张巧芬李政于英俊东南大学材料科学与工程学院南京211189 青岛理工大学土木工程学院青岛266033 中国建筑第二工程局有限公司北京100054

为了研究牺牲混凝土的关键性能以及高温下性能演变与演变机理,采用105℃失重指标和X射线荧光分析仪测试牺牲混凝土的自由水含量和化学组成,并采用抗压强度指标、计算机断层扫描仪和扫描电镜研究了聚丙烯纤维对高温作用下牺牲混凝土强度... 详细信息

为了研究牺牲混凝土的关键性能以及高温下性能演变与演变机理,采用105℃失重指标和X射线荧光分析仪测试牺牲混凝土的自由水含量和化学组成,并采用抗压强度指标、计算机断层扫描仪和扫描电镜研究了聚丙烯纤维对高温作用下牺牲混凝土强度、孔结构和微观形貌的影响.试验结果表明,制备的牺牲混凝土具有良好的流动性和力学性能,自由水的质量分数仅为4.4%,而SiO2和Fe2O3的质量分数则分别达到48.8%和30.0%,满足第三代核电站的基本要求.随温度升高,牺牲混凝土中的Fe2O3逐步还原为Fe3O4,混凝土表面逐渐疏松,同时微细裂缝和宽大裂缝增多,孔隙率最多增加了31.3%～42.8%,而900℃时牺牲混凝土抗压强度则降低为初始强度的27.1%～33.0%.聚丙烯纤维的掺加降低了牺牲混凝土的流动性和强度,但其高温残余抗压强度提高了5%～8%,且试件在高温下不爆裂.

关键词：牺牲混凝土聚丙烯纤维自由水孔隙率强度抗爆裂性能