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DNA Methylation Variation Is Identified in Monozygotic Twins Discordant for Congenital Heart Diseases

Congenital Heart Disease 2024年第2期19卷 247-256页

作者： Shuliang Xia Huikang Tao Shixin Su Xinxin Chen li Ma jianru li Bei Gao Xumei liu Lei Pi Jinqing Feng Fengxiang li Jia li Zhiwei Zhang Guangdong Provincial People’s Hospital Southern Medical UniversityGuangzhou510100China Department of Cardiovascular Surgery Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhou510623China Department of Pediatric Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of South China Structural Heart DiseaseGuangzhou510100China Clinical Physiology Laboratory Institute of PediatricsGuangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Key Laboratory of Research in Structural Birth Defect DiseaseGuangzhou510623China Department of Echocardiogram Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhou510623China Department of Pediatrics Washington University School of MedicineSt.LouisMO63130USA Clinical Biological Resource Bank of Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou510623China

Aims:Multiple genes and environmental factors are known to be involved in congenital heart disease(CHD),but epigenetic variation has received little ***(MZ)twins with CHD provide a unique model for exploring this *** order to investigate the potential role of Deoxyribonucleic Acid(DNA)methyla-tion in CHD pathogenesis,the present study examined DNA methylation variation in MZ twins discordant for CHD,especially ventricular septal defect(VSD).Methods and Results:Using genome-wide DNA methylation profiles,we identified 4004 differentially methylated regions(DMRs)in 18 MZ twin pairs discordant for CHD,and 2826 genes were *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis revealed a list of CHD-associated *** further investigate the role of DNA methylation in VSD,data from 7 pairs of MZ twins with VSD were *** identified 1614 DMRs corresponding to 1443 genes associated with arrhythmogenic right ventricular cardiomyopathy,cyclic guanosine monopho-sphate-protein kinase G(cGMP-PKG)signaling pathway by KEGG analysis,and cell-cell adhesion,calcium ion transmembrane transport by GO analysis.A proportion of DMR-associated genes were involved in calcium signaling *** methylation changes of calcium signaling genes might be related to VSD ***:CHD is associated with differential DNA methylation in MZ *** may be etiologically linked to DNA methylation,and methylation of calcium signaling genes may be involved in the development of VSD.

关键词： Congenital heart disease monozygotic twins methylation modification epigenetics

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北京友谊医院发热门诊流行性感冒流行病学特征及临床特征分析

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河北医药 2024年第14期46卷 2211-2214页

作者：李建如李蒙王红蕊李玲马海艳首都医科大学附属北京友谊医院感染内科北京100050 河北省唐山市工人医院急诊

目的探讨北京友谊医院发热门诊流行性感冒(流感)流行特征及临床特征分析,并分析其临床特征,为科学防治疾病提供策略指导。方法收集2022年1~6月北京友谊医院流感监测系统上报的2 133例流感样病例(Ili)资料,整理、总结流感的流行趋势变... 详细信息

目的探讨北京友谊医院发热门诊流行性感冒(流感)流行特征及临床特征分析,并分析其临床特征,为科学防治疾病提供策略指导。方法收集2022年1~6月北京友谊医院流感监测系统上报的2 133例流感样病例(Ili)资料,整理、总结流感的流行趋势变化以及临床特征。结果 2022年1~6月北京友谊医院发热门诊(通州院区)就诊人数为7 919例,收集到Ili为2 133例,占比为26.94%。其中Ili阳性308例,阳性率为14.44%,其中甲流161例,占比为52.27%;乙流为147例,占比为47.73%。2 133例Ili病例中男1 073例,女1 060例,其中男性Ili阳性率高于女性,差异有统计学意义(P60岁Ili阳性率最高,依次递减分别为26~60岁、15~25岁;>60岁患者在甲流、乙流中占比最高,依次递减为26~60岁、15~25岁。不同时间中,1月Ili阳性率最高,依次递减为2月、3月、4月、6月、5月。甲流变化趋势为1月最高,2月、5月仅次于1月,剩余3月、4月、6月占比最少。乙流变化趋势为1月占比最高,依次递减为2月、3月、4月、6月、5月。甲流患者发热、肝功能损害占比,白细胞计数、中性粒细胞计数、血小板计数以及C反应蛋白水平高于乙流,差异均有统计学意义(P0.05)。结论北京友谊医院发热门诊调查中显示流感患者主要为甲流,>60岁是流感高发人群,男性更易感染流感,1、2月为流感高发月份,临床应加强流感高发人群和季节监控,采取相应措施,避免出现大范围流行。

关键词：发热门诊流行性感冒流行趋势临床特征

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黄渤海地区大气折射环境参数统计分析

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微波学报 2024年第4期40卷 41-45,51页

作者：张利军杜峰李建儒王红光赵振维中国电波传播研究所青岛266107 解放军31401部队济南250002

大气折射环境显著影响微波、超短波无线电装备的性能,能够减小或者扩展标准大气环境下的无线电视距。文中以黄渤海交界处的荣成为例,基于2018年探空数据统计分析了荣成站的大气折射环境参数,包括地面折射率、1 km折射率梯度、100 m折射... 详细信息

大气折射环境显著影响微波、超短波无线电装备的性能,能够减小或者扩展标准大气环境下的无线电视距。文中以黄渤海交界处的荣成为例,基于2018年探空数据统计分析了荣成站的大气折射环境参数,包括地面折射率、1 km折射率梯度、100 m折射率梯度等参数。其中,地面折射率年度变化范围可达100 N单位,地面折射率年平均值为332.3 N单位;1 km折射率梯度年平均值为-48.5 N/km;100 m折射率梯度年平均值为-44.2 N/km,100 m折射率梯度小于-100 N/km的时间概率为3%。进一步地,文中给出了计算雷达视距需要用到的等效地球半径因子以及用于表征相对标准大气无线电视距的扩展或减小的视距因子分布。结果表明:等效地球半径因子最大可达4.5;相对标准大气环境下,大气折射环境对视距影响的最大变化范围可达80%以上。研究结果可为黄渤海地区试验装备的系统设计、性能评估提供大气折射环境参考。

关键词：大气折射地面折射率 1 km折射率梯度 100 m折射率梯度无线电视距

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低共熔溶剂中电沉积铬的研究进展

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材料保护 2024年第8期57卷 155-167页

作者：付飞娥徐存英栗健茹王姝羡昆明理工大学冶金与能源工程学院云南昆明650093 云南开放大学/云南国防工业职业技术学院化学工程学院云南昆明650500 复杂有色金属资源清洁利用国家重点实验室云南昆明650093

金属铬镀层具有硬度高、耐磨耐蚀性优良、外观优美等优点,作为装饰性和功能性镀层被广泛用于冶金、化工等行业。传统的镀铬工艺采用六价铬电镀,然而六价铬具有很强的毒性,是强致癌物质,在危害人体健康的同时污染环境。三价铬被认为是最... 详细信息

金属铬镀层具有硬度高、耐磨耐蚀性优良、外观优美等优点,作为装饰性和功能性镀层被广泛用于冶金、化工等行业。传统的镀铬工艺采用六价铬电镀,然而六价铬具有很强的毒性,是强致癌物质,在危害人体健康的同时污染环境。三价铬被认为是最重要、最直接有效替代六价铬电镀的工艺之一,但是水溶液中三价铬电镀存在析氢、镀层难以增厚、电流效率低等缺点,制约了三价铬的发展。寻求可替代水溶液的新型电解液体系成为三价铬电镀的研究方向之一。低共熔溶剂(DESs)作为一种新型绿色溶剂,具有制备简单、导电性好、电化学窗口宽、溶解性好等特点,克服了有机溶剂挥发性强、离子液体制备过程复杂、价格高等缺点,使其在金属电沉积方面具备广阔的应用前景。介绍了用于电沉积铬DESs的物理化学性质,以及金属离子在其中的存在形式;综述了在DESs中电沉积铬及其合金的研究进展;阐述了添加剂对DESs中电沉积铬的影响;分析了DESs体系电沉积铬存在的问题,探讨了进一步的研究方向。

关键词：低共熔溶剂铬电沉积研究进展

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A 200-ka carbon isotope record from the South China Sea

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Chinese Science Bulletin 2006年第14期51卷 1780-1784页

作者： li jianru WANG Pinxian State Key Laboratory of Marine Geology Tongji University Shanghai200092 China

A stacked ocean carbon isotope (δ 13C) record of 200 ka is established on the basis of planktonic foraminifer (Globigerinoides ruber) δ 13C data from 8 sites in the South China Sea (SCS). The δ 13C record from the SCS displays a trend similar to that from the Pacific and Atlantic oceans mainly re-sponding to long eccentricity and precession cycles, with all the three δ 13C minima occurring at glacial terminations. Thus, the changes of the oceanic car-bon reservoir in glacial cycles should not be consid-ered as a response only to ice-sheet variations, but could have been driven also by low latitude proc-esses, such as the monsoon.

关键词：碳同位素华南地区碳循环第四纪

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Variations of opal accumulation rates and paleoproductivity over the past 12 Ma at ODP Site 1143, southern South China Sea

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Chinese Science Bulletin 2002年第7期47卷 596-598页

作者： li jianru Wang Rujian li Baohua Laboratory of Marine Geology MEOTongji University200092ShanghaiChina Nanjing Institute of Geology and Paleontology Chinese Academy of Sciences210008NanjingChina

The biogenic silica analysis was performed on 463 samples from ODP 184 Site 1143, the southern South China Sea. The results show that the opal content and MAR evidently increased between 12.3 and 5.7 Ma, which was contemporary with the high carbonate and total MARs, reflecting the high biogenic productivity in the late Miocene. This demonstrates the occurrence of the late Miocene 'Biogenic Bloom Event' in the southern South China Sea, corresponding to the late Miocene-early Pliocene 'Biogenic Bloom Event' in the Indian-Pacific Ocean. The increases of opal content and MAR after the middle Pleistocene (about 0.7 Ma) is inferred to result from the enhanced upwelling and nutrient supply, which was induced by the intensified monsoon circulation after the 'Mid-Pleistocene Revolution'.

关键词： opal MAR biogenic productivity Biogenic Bloom Event late Miocene South China Sea.

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Temporal and spatial evolution of a deep-reaching anticyclonic eddy in the South China Sea

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Science China Earth Sciences 2019年第6期62卷 1002-1023页

作者： Meng WANG Yanwei ZHANG Zhifei liU Yulong ZHAO jianru li State Key Laboratory of Marine Geology Tongji University

The temporal and spatial evolution of a deep-reaching anticyclonic eddy(AE) is studied using a combination of satellite measurements, moored observations and ocean model reanalysis data in the South China Sea(SCS). Three evolutionary stages in eddy's lifecycle are identified from changes in eddy dynamical characteristics estimated from satellite altimetry: birth(22 days), growth(64 days), and decay(47 days). Similar patterns are also distinguished from dynamic signals in ***, flows reversal and upwelling of cold water below 1500 m were captured by the in-situ records when this energetic,highly nonlinear and long-lived(over 19 weeks) AE passed by our mooring position. Its detailed vertical structure is examined through temperature anomalies, vertical shear of horizontal velocities, and horizontal streamlines estimated from ocean model reanalysis data. Results from the model reveal a mesoscale AE with first-mode baroclinic structure: a bowl-shaped anticyclonic flow in the upper ocean connected to a slant-cylinder cyclonic flow at depth, with a transition layer at depths between 400 and 700 m. It is in good agreement with moored observations but showing a shallower transition depth, suggesting a slight deficiency in the model due to limited deep-sea observations. Last, we estimate eddy heat transport at different depths and stages along the AE's path based on the model data. The result reveals that pronounced heat fluxes occur during growth stage(depths 700–1500 m).Dynamical characteristics suggest that the vertical structure and temporal evolution of the eddy play significant roles in basinscale movement and heat transferring. Considering that mesoscale eddies are ubiquitous in the SCS, our results support a recently-proposed mechanism, whereby upper ocean flows produce changes in the deep-sea circulation, potentially influencing boundary l

关键词： Deep-reaching mesoscale eddy Evolution HYCOM The South China Sea

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Changes in sea surface temperature in western South China Sea over the past 450 ka

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Chinese Science Bulletin 2009年第18期54卷 3335-3343页

作者： li li WANG Hui li jianru ZHAO MeiXun WANG PinXian State Key Laboratory of Marine Geology Tongji University Shanghai 200092 China

Sea surface temperature over the past 450 ka was obtained by the unsaturation of molecular fossil-long chain alkenone with a resolution of about 1 ka from the western South China Sea. This is the longest temperature profile in the South China Sea at such high resolution. The U3k7′-SST results revealed similar glacial-interglacial cycles as the δ18O profile of planktonic foraminifera, with SST variability of 23―25.5℃ for glacial and 25―28℃ for interglacial periods. The highest SST (28.4℃) was recorded at MIS5.5 and lowest SST (22.6℃) during MIS2. The SST record preceded the planktonic foraminiferal δ18O on five glacial-interglacial transitions. Comparison of temperature records from the Southern and Northern Hemispheres indicated a more Southern Hemisphere-like pattern for the temperature variation in the SCS. Strong precession and semiprecession signals in the spectra of our SST record manifest the tropical phenomena.

关键词：华南西部海表温度中国浮游有孔虫海温变化海上间冰期表面温度

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Dynamic control on grain-size distribution of terrigenous sediments in the western South China Sea:Implication for East Asian monsoon evolution

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Chinese Science Bulletin 2008年第10期53卷 1533-1543页

作者： CHEN GuoCheng ZHENG HongBo li jianru XIE Xin MEI Xi State Key Laboratory of Marine Geology Tongji University Shanghai 200092 China

High-resolution oxygen isotope stratigraphy of Core MD05-2901, which is located off eastern Vietnam in the western South China Sea (SCS), was established and indicated that the core spans a time period of the past 450 ka. Based on the bulk density, fractional porosity and lithogenic content of the sedi-ments, terrigenous mass accumulation rate (TMAR) was obtained, which is 4.9―6.0 g cm?2 ka?1 on average during interglacial stages, higher than that during glacial stages, i.e. 1.9―5.0 g cm-2 ka-1, which is different from northern and southern SCS which show higher TMAR in glacial stages. By principle component analysis of grain size distribution of all the samples, two main control factors (F1 and F2) were obtained, which are responsible for about 80% variance of granularity. The contents of grain size population 1.26―2.66 μm% and 10.8―14.3 μm% which are sensible to F1 show high-frequency fluctuation, and correlate well with the summer insolation at 15oN. They exhibit a dis-tinct cyclicity with frequencies near 23 ka and 13 ka, in contrast to a strong frequency peak near 100 ka obtained in proxies 4.24―7.42 μm% and 30.1―43.7 μm% controlled mainly by F2. The sedimentary character of this part of the SCS was controlled by variations of input flux from two main source areas, namely the southwest and north SCS, which were transported by different circulations of surface current forced by East Asian summer monsoon and winter monsoon respectively. We believe that the East Asian summer monsoon has fluctuated with high frequency and been forced by changes in solar in-solation in low latitude associated with precession and half precession, while ice-volume forcing is probably a primary factor in determining the strength and timing of the East Asian winter monsoon but with less important insolation forcing.

关键词：南中国海陆源沉积物颗粒尺寸东亚季风

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Genetic and lipidomic analyses reveal the key role of lipid metabolism for cold tolerance in maize

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Journal of Genetics and Genomics 2024年第3期51卷 326-337页

作者： Lei Gao Haifang Jiang Minze li Danfeng Wang Hongtao Xiang Rong Zeng limei Chen Xiaoyan Zhang jianru Zuo Shuhua Yang Yiting Shi State Key Laboratory of Plant Environmental Resilience College of Biological SciencesFrontiers Science Center for Molecular Design BreedingCenter for Crop Functional Genomics and Molecular BreedingChina Agricultural UniversityBeijing 100193China State Key Laboratory of Wheat&Maize Crop Science College of Life SciencesHenan Agricultural UniversityZhengzhouHenan 450002China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Suihua Branch of Heilongjiang Academy of Agricultural Machinery Sciences SuihuaHeilongjiang 152052China

lipid remodeling is crucial for cold tolerance in ***,the precise alternations of lipidomics during cold responses remain elusive,especially in maize(Zea mays L.).In addition,the key genes responsible for cold tolerance in maize lipid metabolism have not been ***,we integrate lipidomic,transcriptomic,and genetic analysis to determine the profile of lipid remodeling caused by cold *** find that the homeostasis of cellular lipid metabolism is essential for maintaining cold tolerance of ***,we detect 210 lipid species belonging to 13 major classes,covering phospholipids,glycerides,glycolipids,and free fatty *** lipid metabolites undergo specific and selective alterations in response to cold stress,especially mono-/di-unsaturated lysophosphatidic acid,lysophosphatidylcholine,phosphatidylcholine,and phosphatidylinositol,as well as polyunsaturated phosphatidic acid,monogalactosyldiacylglycerol,diacylglycerol,and *** addition,we identify a subset of key enzymes,including ketoacyl-acyl-carrier protein synthase II(KAS II),acyl-carrier protein 2(ACP2),male sterility33(Ms33),and stearoyl-acyl-carrier protein desaturase 2(SAD2)involved in glycerolipid biosynthetic pathways are positive regulators of maize cold *** results reveal a comprehensive lipidomic profile during the cold response of maize and provide genetic resources for enhancing cold tolerance in crops.

关键词： Maize Cold stress lipid metabolism Transcriptome lipidomic

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