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Electronic regulation to achieve efficient anaerobic digestion of organic fraction of municipal solid waste(OFMSW):strategies,challenges and potential solutions

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 159-165页

作者： Yongdong Chen Hong Wang Parisa Ghofrani-Isfahani li gu Xiaoguang liu Xiaohu Dai State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Tongji UniversityShanghai 200092China Department of Chemical and Biochemical Engineering Technical University of DenmarkKgs Lyngby DK-2800Denmark College of Environment and Ecology Chongqing UniversityChongqing 400045China

Anaerobic digestion(AD)of organic fraction of municipal solid waste(OFMSW)is prone to system breakdown under high organic loading rates(OLRs)condition,which subsequently reduces the efficiency of digestion process and results in substantial economic losses.In this perspective paper,the substances metabolisms,electrons flow,as well as microbial interaction mechanisms within AD process are comprehensively discussed,and the underlying bottleneck that causes inefficient methane production is identified,which is“electrons surplus”.Systems encountering severe electron surplus are at risk of process failure,making it crucial to proactively prevent this phenomenon through appropriate approaches.On this basis,the present perspective proposes three potential electronic regulation strategies to prevent electrons surplus,namely,electron shunt,accelerating electron transfer and regulating methanogenic metabolism pathway,and presents specific methodologies for each strategy.Furthermore,the potential solutions to challenges that may occur during the electronic regulation process are also presented in this paper.This perspective aims to provide innovative approaches to achieve the efficient and stable operation of OFMSW anaerobic digestion,especially under high OLRs condition.

关键词： Anaerobic digestion Electrons surplus Electronic regulation Electrons shunt Electron transfer Methanogenic metabolism pathway

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富氮气调--磷化氢的可供替换技术

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粮油食品科技 2024年第3期32卷 55-68页

作者： Manjree AGARWAL James NEWMAN Yan-yu li li gu Bei-bei li Yong-lin REN 李燕羽(译) 西澳大利亚政府化学中心澳大利亚珀斯WA 6102 CBH澳大利亚谷物有限公司澳大利亚珀斯WA 6000 默多克大学环境和生命科学学院澳大利亚珀斯WA 6150 国家粮食和物资储备局科学研究院粮食储运研究所北京100037 国家粮食和物资储备局科学研究院粮食储运研究所

在粮食储藏上利用氮气的方法已经有30多年的历史,但直到最近经济有效的变压吸附(PSA)和膜分离(MS)制氮设备的出现,才使得该技术在储粮上使用成为可能。本研究首先在25、30和35℃、99%、98%和97%氮气的环境下,对小麦、大麦、燕麦、羽扇... 详细信息

在粮食储藏上利用氮气的方法已经有30多年的历史,但直到最近经济有效的变压吸附(PSA)和膜分离(MS)制氮设备的出现,才使得该技术在储粮上使用成为可能。本研究首先在25、30和35℃、99%、98%和97%氮气的环境下,对小麦、大麦、燕麦、羽扇豆和油菜籽中的花斑皮蠹、赤拟谷盗、谷蠹和米象成虫和非成虫虫态进行了为期4、3和2周的实验室生物测定。然后在终端用户LakeGrace和CBH(Cooperative BulkHandling)谷物进出口公司Albany出口港码头开展实仓验证,测定小麦、大麦和油菜籽中不同储粮害虫虫种和油菜籽瓢虫和肖叶甲类两种田间害虫的防治效果。同时对处理后的粮食品质进行了测定。实验结果表明,害虫死亡率随着氧气浓度降低、暴露时间和温度的增加而增加,富氮低氧在低温条件下不能100%致死花斑皮蠹幼虫。氮气处理对磷化氢抗性和敏感品系储粮害虫防治效果没有差异。与其他粮种相比,在油菜籽中的防治效果更好。各种粮种的水分含量、蛋白质、含油量、淀粉和籽粒颜色品质指标均未受到影响。成功开发了富氮低氧商业规模应用模式,为磷化氢高抗性害虫治理提供了解决方案,满足市场日益增长对无害虫和无化学残留粮食的需求。

关键词：气调储藏害虫治理磷化氢抗药性粮食品质应用模式

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二硫化碳作为谷物熏蒸剂的新观点

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粮油食品科技 2024年第3期32卷 1-15页

作者： Jim DESMARCHEliER Yu XIAO li gu Yong-lin REN 李燕羽(译) 默多克大学环境和生命科学学院澳大利亚珀斯WA 6150 国家粮食和物资储备局科学研究院粮食储运研究所

虽然二硫化碳(CS_(2))是一种古老的熏蒸剂,但澳大利亚新数据以及中国和埃及已发表的研究数据使它可被人们重新关注。这些数据包括谷物质量、自然释放和加工食品中的残留,但目前并不广为人知。埃及研究数据显示,即使在400 mg/m^(3)高剂量... 详细信息

虽然二硫化碳(CS_(2))是一种古老的熏蒸剂,但澳大利亚新数据以及中国和埃及已发表的研究数据使它可被人们重新关注。这些数据包括谷物质量、自然释放和加工食品中的残留,但目前并不广为人知。埃及研究数据显示,即使在400 mg/m^(3)高剂量下,二硫化碳对水稻的发芽率和幼芽长度都没有影响。中国研究数据显示,200 mg/m^(3)高剂量对大麦、小麦、玉米、高粱、棉花、胡萝卜等大多数种子发芽率没有影响。本研究中150 mg/L剂量对澳大利亚小麦、大麦以及鹰嘴豆发芽率和幼芽长度的影响数据也证明了这一点。澳大利亚储藏谷物研究实验室(SGRL)的商业规模实验数据表明,二硫化碳在1000~1500 mg·h·L^(-1)的CT值(浓度×时间)范围内可杀死所有受试昆虫,并且对小麦最终产品质量没有影响。二硫化碳在谷物上的吸附力低于甲基溴,且主要是物理吸附。它会在谷物上有残留物,但这些残留物在储存和加工的过程中会被大量降解,而剩余的二硫化二苯醚残留物会在小麦制粉前的清理和润麦过程中减少。在制粉和烘烤的过程中,二硫化碳的残留量会逐渐减少。例如,将含有27 g/m^(3)二硫化碳的小麦在仓内密封放置6 d,然后通风24 h,清理会使制粉前的残留量从6.7 mg/kg降至4.6 mg/kg,润麦会使残留量从4.6 mg/kg降至2.2 mg/kg。在制粉的过程中,残留量会进一步减少,而在面条(甚至在烹饪前)、意大利面以及面包的制作过程中,残留量还会进一步减少。当前检测分析方法无法检测加工产品中的残留量(定量限值<0.005 mg/kg),且其残留水平与同一来源未经二硫化碳熏蒸的小麦制品相同。

关键词：熏蒸剂二硫化碳吸附性发芽率残留

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富氮低氧+磷化氢防治储粮害虫技术的实仓应用研究

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粮油食品科技 2024年第3期32卷 39-54页

作者： Manjree AGARWAL James NEWMAN Yan-yu li li gu Bei-bei li Sucharita BASAVARAJAPP Yong-lin REN 李燕羽(译) 西澳大利亚州政府化学中心澳大利亚珀斯WA 6102 CBH澳大利亚谷物有限公司澳大利亚珀斯WA 6000 默多克大学环境和生命科学学院澳大利亚珀斯WA 6150 国家粮食和物资储备局科学研究院粮食储运研究所北京100037 国家粮食和物资储备局科学研究院粮食储运研究所

为防治澳大利亚主要仓储害虫,开发富氮气调技术作为熏蒸剂的辅助手段。然而,由于成本问题,一直影响其在行业推广应用。本研究利用中国长顺安达公司的先进膜分离技术,与传统的制氮技术(变压吸附/PSA)进行性能比较,在西澳Kwinana的CBH粮食... 详细信息

为防治澳大利亚主要仓储害虫,开发富氮气调技术作为熏蒸剂的辅助手段。然而,由于成本问题,一直影响其在行业推广应用。本研究利用中国长顺安达公司的先进膜分离技术,与传统的制氮技术(变压吸附/PSA)进行性能比较,在西澳Kwinana的CBH粮食港,开展实仓应用实验,以解决阻碍其推广的运营和成本问题。为满足澳大利亚严格的标准操作条件,长顺安达专业团队对港口设备进行了升级改造,目标消杀成本设定为0.50澳元/吨粮(磷化氢的高端熏蒸成本)。研究表明,旧的PSA技术的运营成本为2.43澳元/吨粮,该技术在产生和维持控制害虫所需的99%氮气浓度水平方面也显示出操作局限性。相比之下,使用膜技术制氮的成本为0.99澳元/吨粮,其他性能增益还包括运行4.5天内即可产生所需的氮气浓度,且可维持14天以完全控制害虫。

关键词：粮食储藏储粮害虫管理氮气储藏变压吸附制氮机膜分离制氮机

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富氮气调——磷化氢的可供替换技术（中英文）

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粮油食品科技 2024年

作者： Manjree AGARWAL James NEWMAN Yan-yu li li gu Bei-bei li Yong-lin REN 西澳化学中心珀斯 CBH澳大利亚谷物有限公司珀斯国家粮食和物资储备局科学研究院粮食储运研究所默多克大学环境与生命科学学院珀斯

在粮食储藏上利用氮气的方法已经有30多年的历史，但直到最近经济有效的变压吸附（PSA）和膜分离（MS）制氮设备的出现，才使得该技术在储粮上使用成为可能。本研究成功开发了商业规模的清洁富氮技术，为磷化氢高抗性害虫治理提供了解... 详细信息

在粮食储藏上利用氮气的方法已经有30多年的历史，但直到最近经济有效的变压吸附（PSA）和膜分离（MS）制氮设备的出现，才使得该技术在储粮上使用成为可能。本研究成功开发了商业规模的清洁富氮技术，为磷化氢高抗性害虫治理提供了解决方案，满足市场日益增长对无害虫和无化学残留粮食的需求。默多克大学收获后植物生物安全实验室开展了富氮应用技术的研究，并与终端用户合作开展实仓验证，如Lake Grace (33°06′00″S 118°27′40″E)农场储存仓和CBH（Cooperative Bulk Handling）谷物进出口公司Albany 出口港码头（35°1′50.90″S 117°53′0.54″E）仓房。

关键词：粮食储藏储粮害虫治理储粮害虫抗药性气调储藏变压吸附制氮机膜分离制氮机

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Huangqin Decoction Delays Progress of Colitis-Associated Carcinogenesis by Regulating Nrf2/HO-1 Antioxidant Signal Pathwayin Mice

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Chinese Journal of Integrative Medicine 2024年第2期30卷 135-142页

作者： gu li-mei li He-zhong GAO Lei li Hui WEI Lan-fu PAN Cheng-yu WU Ke-xuan TIAN Yao-zhou Department of Gastrointestinal Endoscopy Affiliated Hospital of Nanjing University of Chinese MedicineNanjing(210029)China Department of Gastroenterology Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing(210028)China School of Integrated Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing(210023)China

Objective:To investigate the effect of Huangqin Decoction(HQD)on nuclear factor erythroid 2 related-factor 2(Nrf2)/heme oxygenase(HO-1)signaling pathway by inducing the colitis-associated carcinogenesis(CAC)model mice with azoxymethane(AOM)/dextran sodium sulfate(DSS).Methods:The chemical components of HQD were analyzed by liquid chromatography-quadrupole-time-of-flight mass spectrometry(LC-Q-TOF-MS/MS)to determine the molecular constituents of HQD.Totally 48 C57BL/6J mice were randomly divided into 6 groups by a random number table,including control,model(AOM/DSS),mesalazine(MS),low-,medium-,and high-dose HQD(HQD-L,HQD-M,and HQD-H)groups,8 mice in each group.Except for the control group,the mice in the other groups were intraperitoneally injected with AOM(10 mg/kg)and administrated with 2.5%DSS orally for 1 week every two weeks(totally 3 rounds of DSS)to construct a colitis-associated carcinogenesis mouse model.The mice in the HQD-L,HQD-M and HQD-H groups were given HQD by gavage at doses of 2.925,5.85,and 11.7 g/kg,respectively;the mice in the MS group was given a suspension of MS at a dose of 0.043 g/kg(totally 11 weeks).The serum levels of malondialdehyde(MDA)and superoxide dismutase(SOD)were measured by enzyme-linked immunosorbent assay.The mRNA and protein expression levels of Nrf2,HO-1,and inhibitory KELCH like ECH-related protein 1(Keap1)in colon tissue were detected by quantitative real-time PCR,immunohistochemistry,and Westem blot,respectively.Results:LC-Q-TOF-MS/MS analysis revealed that the chemical constituents of HQD include baicalin,paeoniflorin,and glycyrrhizic acid.Compared to the control group,significantly higher MDA levels and lower SOD levels were observed in the model group(P<0.05),whereas the expressions of Nrf2 and HO-1 were significantly decreased,and the expression of Keap1 increased(P<0.01).Compared with the model group,serum MDA level was decreased and SOD level was increased in the HQD-M,HQD-H and MS groups(P<0.05).Higher expressions of Nrf2 and HO-1 were observed in the HQD groups.Co

关键词： Huangqin Decoction colitis-associated carcinogenesis nuclear factor erythroid 2 related-factor 2/heme oxygenase signaling pathway oxidative stress Chinese medicine

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Cinobufotalin prevents bone loss induced by ovariectomy in mice through the BMPs/SMAD and Wnt/β-catenin signaling pathways

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Animal Models and Experimental Medicine 2024年第3期7卷 208-221页

作者： Da-zhuang Lu li-jun Zeng Yang li Ran-li gu Meng-long Hu Ping Zhang Peng Yu Xiao Zhang Zheng-wei Xie Hao liu Yong-sheng Zhou Department of Prosthodontics Peking University School and Hospital of StomatologyBeijingChina National Center of Stomatology BeijingChina National Clinical Research Center for Oral Diseases BeijingChina Beijing Key Laboratory of Digital Stomatology BeijingChina Department of Cariology and Endodontology Peking University School and Hospital of StomatologyBeijingChina Peking University International Cancer Institute Peking University Health Science CenterPeking UniversityBeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina National Engineering Research Center of Oral Biomaterials and Digital Medical Devices BeijingChina

Background:Osteoporosis is a chronic bone disease characterized by bone loss and decreased bone strength.However,current anti-resorptive drugs carry a risk of various complications.The deep learning-based efficacy prediction system(DLEPS)is a forecasting tool that can effectively compete in drug screening and prediction based on gene expression changes.This study aimed to explore the protective effect and potential mechanisms of cinobufotalin(CB),a traditional Chinese medicine(TCM),on bone loss.Methods:DLEPS was employed for screening anti-osteoporotic agents according to gene profile changes in primary osteoporosis.Micro-CT,histological and morphological analysis were applied for the bone protective detection of CB,and the osteogenic differentiation/function in human bone marrow mesenchymal stem cells(hBMMSCs)were also investigated.The underlying mechanism was verified using qRT-PCR,Western blot(WB),immunofluorescence(IF),etc.Results:A safe concentration(0.25mg/kg in vivo,0.05μM in vitro)of CB could effectively preserve bone mass in estrogen deficiency-induced bone loss and promote osteogenic differentiation/function of hBMMSCs.Both BMPs/SMAD and Wnt/β-catenin signaling pathways participated in CB-induced osteogenic differentiation,further regulating the expression of osteogenesis-associated factors,and ultimately promoting osteogenesis.Conclusion:Our study demonstrated that CB could significantly reverse estrogen deficiency-induced bone loss,further promoting osteogenic differentiation/function of hBMMSCs,with BMPs/SMAD and Wnt/β-catenin signaling pathways involved.

关键词： BMPs/SMAD bone loss cinobufotalin hBMMSCs osteogenesis osteoporosis Wnt/β-catenin signaling pathways

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Advanced nanomedicines and immunotherapeutics to treat respiratory diseases especially COVID-19 induced thrombosis

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World Journal of Clinical Cases 2024年第16期12卷 2704-2712页

作者： Jie Wu Ying Zheng li-Na Zhang Cai-li gu Wang-li Chen Min-Qiang Chang Department of Respiratory and Oncology 72nd Group Army Hospital of PLAHuzhou 313000Zhejiang ProvinceChina Department of Otorhinolaryngology 72^(nd)Group Army Hospital of PLAHuzhou 313000Zhejiang ProvinceChina

Immunotherapy and associated immune regulation strategies gained huge attraction in order to be utilized for treatment and prevention of respiratory diseases.Engineering specifically nanomedicines can be used to regulate host immunity in lungs in the case of respiratory diseases including coronavirus disease 2019(COVID-19)infection.COVID-19 causes pulmonary embolisms,thus new therapeutic options are required to target thrombosis,as conventional treatment options are either not effective due to the complexity of the immunethrombosis pathophysiology.In this review,we discuss regulation of immune response in respiratory diseases especially COVID-19.We further discuss thrombosis and provide an overview of some antithrombotic nanoparticles,which can be used to develop nanomedicine against thrombo-inflammation induced by COVID-19 and other respiratory infectious diseases.We also elaborate the importance of immunomodulatory nanomedicines that can block pro-inflammatory signalling pathways,and thus can be recommended to treat respiratory infectious diseases.

关键词： Nanomedicines Immunotherapeutics Respiratory diseases COVID-19 Thrombosis

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Peritoneal fluid indocyanine green test for diagnosis of gut leakage in anastomotic leakage rats and colorectal surgery patients

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1825-1834页

作者： Yu Huang Tian-Yang li Jie-Feng Weng Hui liu Yu-Jie Xu Shuai Zhang Wei-li gu Department of Surgery Guangzhou First People's HospitalGuangzhou 510180Guangdong ProvinceChina

BACKGROUND Application of indocyanine green(ICG)fluorescence has led to new developments in gastrointestinal surgery.However,little is known about the use of ICG for the diagnosis of postoperative gut leakage(GL).In addition,there is a lack of rapid and intuitive methods to definitively diagnose postoperative GL.AIM To investigate the effect of ICG in the diagnosis of anastomotic leakage in a surgical rat GL model and evaluate its diagnostic value in colorectal surgery patients.METHODS Sixteen rats were divided into two groups:GL group(n=8)and sham group(n=8).Approximately 0.5 mL of ICG(2.5 mg/mL)was intravenously injected postoperatively.The peritoneal fluid was collected for the fluorescence test at 24 and 48 h.Six patients with rectal cancer who had undergone laparoscopic rectal cancer resection plus enterostomies were injected with 10 mL of ICG(2.5 mg/mL)on postoperative day 1.Their ostomy fluids were collected 24 h after ICG injection to identify the possibility of the ICG excreting from the peripheral veins to the enterostomy stoma.Participants who had undergone colectomy or rectal cancer resection were enrolled in the diagnostic test.The peritoneal fluids from drainage were collected 24 h after ICG injection.The ICG fluorescence test was conducted using OptoMedic endoscopy along with a near-infrared fluorescent imaging system.RESULTS The peritoneal fluids from the GL group showed ICG-dependent green fluorescence in contrast to the sham group.Six samples of ostomy fluids showed green fluorescence,indicating the possibility of ICG excreting from the peripheral veins to the enterostomy stoma in patients.The peritoneal fluid ICG test exhibited a sensitivity of 100%and a specificity of 83.3%for the diagnosis of GL.The positive predictive value was 71.4%,while the negative predictive value was 100%.The likelihood ratios were 6.0 for a positive test result and 0 for a negative result.CONCLUSION The postoperative ICG test in a drainage tube is a valuable and simple technique for the diagnosis of GL.Hence,it should

关键词： gut leakage Indocyanine green Anastomotic leakage model Diagnostic test Diagnostic technique

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Forkhead box M1 transcription factor:a novel target for pulmonary arterial hypertension therapy

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World Journal of Pediatrics 2020年第2期16卷 113-119页

作者： li gu Han-Min liu Department of Pediatric Pneumology West China Second University HospitalSichuan UniversityChengduChina Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationWest China Second University HospitalSichuan UniversityNo.20Section 3Renmin South RoadWuhou DistrictChengduChina

Background Forkhead box M1(FoxM1),a member of forkhead family,plays a key role in carcinogenesis,progression,invasion,metastasis and drug resistance.Based on the similarities between cancer and pulmonary arterial hypertension,studies on the roles and mechanisms of FoxM1 in pulmonary arterial hypertension have been increasing.This article aims to review recent advances in the mechanisms of signal transduction associated with FoxM1 in pulmonary arterial hypertension.Data sources Articles were retrieved from PubMed and MEDliNE published after 1990,including-but not limited to FoxM1 and pulmonary arterial hypertension.Results FoxM 1 is overexpressed in pulmonary artery smooth muscle cells in both pulmonary arterial hypertension patients and animal models,and promotes pulmonary artery smooth muscle cell proliferation and inhibits cell apoptosis via regulating cell cycle progression.Multiple signaling molecules and pathways,including hypoxia-inducible factors,transforming growth factor-β/Smad,SET domain-containing 3/vascular endothelial growth factor,survivin,cell cycle regulatory genes and DNA damage response network,are reported to cross talk with FoxM1 in pulmonary arterial hypertension.Proteasome inhibitors are effective in the prevention and treatment of pulmonary arterial hypertension by inhibiting the expression and transcriptional activity of FoxM1.Conclusions FoxM1 has a crucial role in the pathogenesis of pulmonary arterial hypertension and may represent a novel therapeutic target.But more details of interaction between FoxM1 and other signaling pathways need to be clarified in the future.

关键词： Forkhead box M1 Proteasome inhibitor Pulmonary arterial hypertension Signaling pathway

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