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Leveraging electrochemical sensors to improve efficiency of cancer detection

World Journal of Clinical Oncology 2024年第3期15卷 360-366页

作者： li fu Hassan Karimi-Maleh College of Materials and Environmental Engineering Hangzhou Dianzi UniversityHangzhou 310018Zhejiang ProvinceChina School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 611731Sichuan ProvinceChina School of Engineering Lebanese American UniversityByblos 11022801Lebanon

Electrochemical biosensors have emerged as a promising technology for cancer detection due to their high sensitivity,rapid response,low cost,and capability for non-invasive detection.Recent advances in nanomaterials like nanoparticles,graphene,and nanowires have enhanced sensor performance to allow for cancer biomarker detection,like circulating tumor cells,nucleic acids,proteins and metabolites,at ultra-low concentrations.However,several challenges need to be addressed before electrochemical biosensors can be clinically implemented.These include improving sensor selectivity in complex biological media,device miniaturization for implantable applications,integration with data analytics,handling biomarker variability,and navigating regulatory approval.This editorial critically examines the prospects of electrochemical biosensors for efficient,low-cost and minimally invasive cancer screening.We discuss recent developments in nanotechnology,microfabrication,electronics integration,multiplexing,and machine learning that can help realize the potential of these sensors.However,significant interdisciplinary efforts among researchers,clinicians,regulators and the healthcare industry are still needed to tackle limitations in selectivity,size constraints,data interpretation,biomarker validation,toxicity and commercial translation.With committed resources and pragmatic strategies,electrochemical biosensors could enable routine early cancer detection and dramatically reduce the global cancer burden.

关键词： Electrochemical sensors Cancer biomarkers Nanomaterials Point-of-care diagnostics Microfabrication Machine learning

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Förster resonance energy transfer reveals phillygenin and swertiamarin concurrently target AKT on different binding domains to increase the anti-inflammatory effect

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Chinese Chemical Letters 2024年第5期35卷 207-212页

作者： Xiaoyao Ma Jinling Zhang Ge Fang He Gao Jie Gao li fu Yuanyuan Hou Gang Bai State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300000China College of life Health Dalian UniversityDalian 116622China Dalian fusheng Pharmaceutical Co. Ltd.Dalian 116000China

The clinical benefit of combination therapy is significant,but it is not easy to define the mechanism of complexity and diversity.Previous studies illustrate that phillygenin(Phi)binds in the allosteric inhibit pocket of protein kinase B(AKT),and swertiamarin(Swe)acts on the pleckstrin homology(PH)domain of AKT.However,the combined synergistic effect of relieving the inflammatory response has yet to be elucidated.Based on high sensitivity,specificity and fast-responsibility fluorescent sensors,the Förster resonance energy transfer(FRET)technique offers a route to provide clear insights into physiological and pathological processes.In the study,molecular docking,the fluorescent probes of Phi and Swe for FRET were designed and synthesized.FRET analysis shown that Swe and Phi concurrently acted on the PH domain and allosterically inhibited pocket of AKT,respectively.The combination of Swe and Phi significantly increased the heat stability of AKT and decreased protease-induced degeneration.In lipopolysaccharides(LPS)-induced mice and cells,the combination arrested AKT activation,nuclear factor kappa-B(NF-κB)phosphorylation,and the expression of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-8.In conclusion,FRET revealed Phi and Swe concurrently targeted AKT on different domains and the combination of Phi and Swe enhanced the anti-inflammatory effect.

关键词： FRET Swertiamarin Phillygenin AKT Anti-inflammation Combinatorial drug

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A mitochondria-targeted H_(2)S-activatable fluorogenic probe for tracking hepatic ischemia-reperfusion injury

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Chinese Chemical Letters 2024年第6期35卷 370-375页

作者： Bin Fang Jiaqi Yang limin Wang Haoqin li Jiaying Guo Jiaxin Zhang Qingyuan Guo Bo Peng Kedi liu Miaomiao Xi Hua Bai li fu lin li School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging Facility Huazhong University of Science and TechnologyWuhan 430074China TANK Medicinal Biology Institute of Xi’an Xi’an 710032China

Hepatic ischemia-reperfusion injury(HIRI)is the cause of postoperative hepatic dysfunction and failure,and even death.As an important biological effector molecule,hydrogen sulfide(H_(2)S)of mitochondria as a gasotransmitter that is usually used to protect against acute HIRI injury.However,the exact relationship between HIRI and mitochondrial H_(2)S remains tangled due to the lack of an effective analytical method.Herein,we have fabricated a mitochondria-targeted H_(2)S-activatable fluorogenic probe(Mito-GW)to explore the stability of mitochondrial H_(2)S and track the changes of mitochondrial H_(2)S during the HIRI.By virtue of pyridinium electropositivity and its amphiphilicity,Mito-GW could accumulate in mitochondria.It goes through an analyte-prompted immolation when reacts with H_(2)S,resulting in the releasing of the fluorophore(GW).Therefore,the extent of Mito-GW conversion to GW can be used to evaluate the changes of mitochondrial H_(2)S level in living cells and tissues.As proof-of-principle,we have used MitoGW to demonstrate the mitochondria H_(2)S-levels increase and then decrease during HIRI in vitro and in vivo.Our research highlights the tremendous potential of Mito-GW as a mitochondrial H_(2)S fluorogenic probe in elucidating the pathogenesis of HIRI,providing a powerful tool for promoting future research on hepatology.

关键词： Mitochondria-targeted Bioimaging H2S-activatable Fluorogenic probe Hepatic ischemia-reperfusion injury(HIRI)

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Multi-Granularity Neighborhood fuzzy Rough Set Model on Two Universes

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Journal of Intelligent Learning Systems and Applications 2024年第2期16卷 91-106页

作者： Ju Wang Xinghu Ai li fu School of Mathematics and Statistics Qinghai Nationalities University Xining China Xining Big Date Center Xining China

The two universes multi-granularity fuzzy rough set model is an effective tool for handling uncertainty problems between two domains with the help of binary fuzzy relations. This article applies the idea of neighborhood rough sets to two universes multi-granularity fuzzy rough sets, and discusses the two-universes multi-granularity neighborhood fuzzy rough set model. Firstly, the upper and lower approximation operators are defined in the two universes multi-granularity neighborhood fuzzy rough set model. Secondly, the properties of the upper and lower approximation operators are discussed. Finally, the properties of the two universes multi-granularity neighborhood fuzzy rough set model are verified through case studies.

关键词： fuzzy Set Two Universes Multi-Granularity Rough Set Multi-Granularity Neighborhood fuzzy Rough Set

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F?rster resonance energy transfer reveals phillygenin and swertiamarin concurrently target AKT on different binding domains to increase the anti-inflammatory effect

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Chinese Chemical Letters 2024年第5期 233-238页

作者： Xiaoyao Ma Jinling Zhang Ge Fang He Gao Jie Gao li fu Yuanyuan Hou Gang Bai State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University College of life Health Dalian University Dalian fusheng Pharmaceutical Co. Ltd.

The clinical benefit of combination therapy is significant, but it is not easy to define the mechanism of complexity and diversity. Previous studies illustrate that phillygenin(Phi) binds in the allosteric inhibit pocket of protein kinase B(AKT), and swertiamarin(Swe) acts on the pleckstrin homology(PH) domain of AKT. However, the combined synergistic effect of relieving the inflammatory response has yet to be elucidated. Based on high sensitivity, specificity and fast-responsibility fluorescent sensors, the F?rster resonance energy transfer(FRET) technique offers a route to provide clear insights into physiological and pathological processes. In the study, molecular docking, the fluorescent probes of Phi and Swe for FRET were designed and synthesized. FRET analysis shown that Swe and Phi concurrently acted on the PH domain and allosterically inhibited pocket of AKT, respectively. The combination of Swe and Phi significantly increased the heat stability of AKT and decreased protease-induced degeneration. In lipopolysaccharides(LPS)-induced mice and cells, the combination arrested AKT activation, nuclear factor kappa-B(NF-κB)phosphorylation, and the expression of tumor necrosis factor-α(TNF-α), interleukin(IL)-6 and IL-8. In conclusion, FRET revealed Phi and Swe concurrently targeted AKT on different domains and the combination of Phi and Swe enhanced the anti-inflammatory effect.

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Increased Risk of Neonatal Pneumonia in Pregnant Women with Atypical Pre-Labor Rupture of Membrane Assessed at Pregnancy Week 39

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Open Journal of Obstetrics and Gynecology 2024年第4期14卷 528-534页

作者： li fu Haiyan Pei Yuefeng Wang Dan Zhang Xiaodan liu Huaizhong Hu Xinghui liu Department of Gynecology Pengzhou People&#8217s Hospital Chengdu China Department of Ultrasound Examination Pengzhou People&#8217s Hospital Chengdu China Origissay Diagnostics Ltd. Chengdu China Department of Obstetrics and Gynecology Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University Chengdu China Ministry of Education West China Second University Hospital of Sichuan University Chengdu China

Purpose: Neonatal pneumonia is a major newborn disease with a high morbidity rate. We aimed to evaluate whether atypical prelabor rupture of membranes (PROM) is a high-risk factor for causing neonatal pneumonia in a prospective real-world study. Patients and Methods: A total of 250 pregnant women at pregnancy week 39 were non-selectively recruited. All were examined by PROM and neonatal pneumonia related clinical, bedside and lab tests, including body temperature, blood pressure, increased vagina discharge, posterior vault pooling, abdominal tenderness, WBC count, nitrazine test, amniotic fluid index, Leakection (a sICAM-1 based lateral flow immunoassay) and vagina streptococcus examinations. Increased vagina discharge with a Leakection positivity was adopted as a working criterium for identifying atypical PROM. Neonatal pneumonia was diagnosed based on the clinical presentation and lab tests. Results: Twenty cases of neonatal pneumonia (8.0%) were diagnosed after the deliveries of the 250 pregnant women. In these neonatal pneumonia cases, 12 (16.7%) occurred in 72 deliveries with atypical PROM, 2 (16.7%) in 12 deliveries with typical PROM, and 6 (3.6%) in 166 deliveries with non-PROM. Conclusion: In this real-world study, we find that a systematic screening at pregnancy week 39 was very meaningful in revealing atypical PROM. Moreover, atypical PROM is a major risk factor for neonatal pneumonia. Therefore, an early diagnosis and intervention on atypical PROM could potentially reduce the occurrence of neonatal pneumonia.

关键词： Atypical Prelabor Rupture of Membranes Neonatal Pneumonia Soluble Intercellular Adhesion Molecule-1

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Meta label associated loss for fine-grained visual recognition

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Science China(Information Sciences) 2024年第6期67卷 230-247页

作者： Yanchao li fu XIAO Hao li Qun li Shui YU School of Computer Science Nanjing University of Posts and Telecommunications School of Network Engineering Zhoukou Normal University School of Computer Science University of Technology Sydney

Recently, intensive attempts have been made to design robust models for fine-grained visual recognition, most notably are the impressive gains for training with noisy labels by incorporating a reweighting strategy into a meta-learning framework. However, it is limited to up or downweighting the contribution of an instance for label reweighting approaches in the learning process. To solve this issue, a novel noise-tolerant method with auxiliary web data is proposed. Specifically, first, the associations made from embeddings of well-labeled data with those of web data and back at the same class are measured. Next, its association probability is employed as a weighting fusion strategy into angular margin-based loss, which makes the trained model robust to noisy datasets. To reduce the influence of the gap between the well-labeled and noisy web data, a bridge schema is proposed via the corresponding loss that encourages the learned embeddings to be coherent. Lastly, the formulation is encapsulated into the meta-learning framework, which can reduce the overfitting of models and learn the network parameters to be noise-tolerant. Extensive experiments are performed on benchmark datasets, and the results clearly show the superiority of the proposed method over existing state-of-the-art approaches.

关键词： label associated loss weighting noisy samples fine-grained visual recognition noise-tolerant learning meta-learning

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Trace formula of the integro-differential operator on a quantum graph

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 311-318页

作者： WEI li-xiao YANG Chuan-fu School of Mathematics and Statistics Nanjing University of Science and TechnologyNanjing 210094China.

In this paper we study the eigenvalue problem for integro-differential operators on a lasso graph.The trace formula of the operator is established by applying the residual technique in complex analysis.

关键词： integro-differential operators eigenvalue trace formula

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Analysis of amino acid enantiomers in ambient aerosols:Effects and removal of coexistent aerosol matrix

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Journal of Environmental Sciences 2024年第3期137卷 732-740页

作者： Ying li Xiaoying li libin Wu Luhan Shi ShanWang Pingqing fu Yingyi Zhang Senchao Lai The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationSchool of Environment and EnergySouth China University of TechnologyGuangzhou 510006China Institute of Surface-Earth System Science School of Earth System ScienceTianjin UniversityTianjin 300072China now at Hong Kong University of Science and Technology Hong Kong 00852China

Amino acids(AAs)including D-and L-enantiomers are a group of organic nitrogen species in ambient aerosol.Due to the low abundances of AAs(level of ng/m^(3))and the matrix effects by coexistent components,it is challenging to quantify AA enantiomers in ambient aerosols especially under pollution conditions.In this study,we present an optimized method for analyzing AA enantiomers in atmospheric aerosol samples including a pretreatment process and the detection by high performance liquid chromatography coupled to a fuorescence detector(HPLC-FLD).Matrix effects caused by coexistent chemicals on AA enantiomers analysis in ambient aerosol samples were investigated especially for those collected in pollution episodes.The results revealed that the determination of AA enantiomers is significantly affected by the coexistent organic carbon(as a proxy of organic matter)and water-soluble ion of NH_(4)^(+).To remove the matrix effects,we applied a pretreatment using the solid phase extraction column coupled with alkaline adjustment to sample extract.After pretreatment,18 AAs including 6 pairs of D-and L-enantiomers(i.e.,leucine,isoleucine,valine,alanine,serine,and aspartic acid)can be successfully separated and quantified in aerosol samples by HPLC-FLD.The recoveries are in the range of 67%-106%.This method was successfully applied to the urban aerosol samples from pollution and non-pollution periods for AA enantiomers determination.We suggest that the concentrations of D-AAs and the ratio of D-AA/L-AA are indicative of the contribution of bacterial sources and the infuence of biomass burning.

关键词： Amino acid enantiomers Atmospheric aerosol Organic carbon Ammonia Chiral ratio

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Tissue adhesive,ROS scavenging and injectable PRP-based‘plasticine’for promoting cartilage repair

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Regenerative Biomaterials 2024年第1期3卷 94-107页

作者： Shiao li Dawei Niu Haowei Fang Yancheng Chen Jinyan li Kunxi Zhang Jingbo Yin Peiliang fu Department of Orthopedics Shanghai Changzheng HospitalNaval Medical UniversityShanghai 200003P.R.China Department of Polymer Materials School of Materials Science and EngineeringShanghai UniversityShanghai 200444P.R.China

Platelet-rich plasma(PRP)that has various growth factors has been used clinically in cartilage repair.However,the short residence time and release time at the injury site limit its therapeutic effect.The present study fabricated a granular hydrogel that was assembled from gelatin microspheres and tannic acid through their abundant hydrogen bonding.Gelatin microspheres with the gelatin concentration of 10wt%and the diameter distribution of 1-10 lm were used to assemble by tannic acid to form the granular hydrogel,which exhibited elasticity under low shear strain,but flowability under higher shear strain.The viscosity decreased with the increase in shear rate.Meanwhile,the granular hydrogel exhibited self-healing feature during rheology test.Thus,granular hydrogel carrying PRP not only exhibited well-performed injectability but also performed like a‘plasticine’that possessed good plasticity.The granular hydrogel showed tissue adhesion ability and reactive oxygen species scavenging ability.Granular hydrogel carrying PRP transplanted to full-thickness articular cartilage defects could integrate well with native cartilage,resulting in newly formed cartilage articular fully filled in defects and well-integrated with the native cartilage and subchondral bone.The unique features of the present granular hydrogel,including injectability,plasticity,porous structure,tissue adhesion and reactive oxygen species scavenging provided an ideal PRP carrier toward cartilage tissue engineering.

关键词： cartilage regeneration granular hydrogel gelatin tannic acid PRP

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