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钠-葡萄糖共转运蛋白2抑制剂在心血管疾病中的抗炎作用及机制

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中国新药与临床杂志 2024年第3期43卷 177-181页

作者：王悦李冰清陈余文李文倩万少枝李册兴孙培媛吕建峰三峡大学附属仁和医院心血管内科湖北宜昌443000

钠-葡萄糖共转运蛋白(SGLT)-2抑制剂是一类新型口服降血糖药,主要通过抑制肾脏近端小管葡萄糖的重吸收,促进尿糖排泄,降低血糖。大量临床研究发现SGLT-2抑制剂具有良好的心血管保护作用。同时,众多基础研究发现多种SGLT-2抑制剂在细胞... 详细信息

钠-葡萄糖共转运蛋白(SGLT)-2抑制剂是一类新型口服降血糖药,主要通过抑制肾脏近端小管葡萄糖的重吸收,促进尿糖排泄,降低血糖。大量临床研究发现SGLT-2抑制剂具有良好的心血管保护作用。同时,众多基础研究发现多种SGLT-2抑制剂在细胞及动物模型中表现出良好的抗炎活性,SGLT-2抑制剂的心血管保护机制可能与抑制炎症反应密切相关。如卡格列净通过提高AMP活化蛋白激酶(AMPK)、内皮型一氧化氮合酶(eNOS)等抗炎信号传导抑制炎症反应;达格列净可显著降低白细胞介素(IL)-1β、IL-6及肿瘤坏死因子(TNF)-α等炎症因子的表达,促进巨噬细胞向抗炎表型的极化;恩格列净可以减少糖尿病心肌病、高血压和心力衰竭模型中的心脏炎症。

关键词：钠-葡萄糖共转运蛋白2抑制剂心血管系统炎症药理作用分子作用机制

Pipeline Defect Detection Cloud System Using Role Encryption and Hybrid Information

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Computers, Materials & Continua 2019年第9期61卷 1245-1260页

作者： ce li Xinyu Shang liguo Zhang Feng Yang Jing Zheng Xianlei Xu State Key Laboratory of Coal Resources and Safe Mining China University of Mining&TechnologyBeijing100083China School of Mechanical Electronic&Information Engineering China University of Mining&TechnologyBeijing100083China Computer Science&Engineering Harbin Engineering UniversityHarbin150001China Computer Science&Engineering Hong Kong University of Science and TechnologyHong Kong Stanford University Palo AltoCA 94305-6104USA

Pipeline defect detection systems collect the videos from cameras of pipeline robots,however the systems always analyzed these videos by offline systems or humans to detect the defects of potential security *** existing systems tend to reach the limit in terms of data access anywhere,access security and video processing on *** is in need of studying on a pipeline defect detection cloud system for automatic pipeline *** this paper,we deploy the framework of a cloud based pipeline defect detection system,including the user management module,pipeline robot control module,system service module,and defect detection *** the system,we use a role encryption scheme for video collection,data uploading,and access security,and propose a hybrid information method for defect *** experimental results show that our approach is a scalable and efficient defection detection cloud system.

关键词： Defect detection cloud computing data encryption hybrid information

Abnormal Event Detection based on Deep Autoencoder fusing optical flow

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Abnormal Event Detection based on Deep Autoencoder fusing op...

Constraint-induced movement therapy promotes motor function recovery and downregulates phosphorylated extracellular regulated protein kinase expression in ischemic brain tissue of rats

第36届中国控制会议

作者： Meina Qiao Tian Wang Jiakun li ce li Zhiwei lin Hichem Snoussi School of Automation Science and Electrical Engineering Beihang University College of Electrical and Information Engineering Lanzhou University of Technology School of Computing Ulster University Institute Charles Delaunay-LM2S-UMR STMR 6279 CNRS University of Technology of Troyes

ISBN: (纸本)9781538629185

As an important research topic in computer vision,abnormal detection has gained more and more *** order to detect abnormal events effectively,we propose a novel method using optical flow and deep *** our model,optical flow of the original video sequence is calculated and visualized as optical flow image,which is then fed into a deep *** the deep autoencoder extract features from the training samples which are compressed to low dimension ***,the normal and abnormal samples gather separately in the coordinate *** the evaluation,we show that our approach outperforms the existing methods in different scenes,in terms of accuracy.

关键词： Abnormal event detection Deep autoencoder Optical flow

来源： cnki会议评论

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Neural Regeneration Research 2015年第12期10卷 2004-2010页

作者： Bei Zhang Qiang He Ying-ying li ce li Yu-long Bai Yong-shan Hu Feng Zhang Department of Rehabilitation Medicine Huashan HospitalFudan University State Key Laboratory of Medical Neurobiology Fudan University Department of Rehabilitation the Third Hospital of Hebei Medical University

Motor function impairment is a common outcome of ***-induced movement therapy（CIMT）involving intensive use of the impaired limb while restraining the unaffected limb is widely used to overcome the effects of＇learned non-use＇and improve limb function after ***,the underlying mechanism of CIMT remains *** the present study,rats were randomly divided into a middle cerebral artery occlusion（model）group,a CIMT＋model（CIMT）group,or a sham *** of the affected limb by plaster cast was performed in the CIMT and sham *** with the model group,CIMT significantly improved the forelimb functional performance in *** western blot assay,the expression of phosphorylated extracellular regulated protein kinase in the bilateral cortex and hippocampi of cerebral ischemic rats in the CIMT group was significantly lower than that in the model group,and was similar to sham group *** data suggest that functional recovery after CIMT may be related to decreased expression of phosphorylated extracellular regulated protein kinase in the bilateral cortex and hippocampi.

关键词： nerve regeneration constraint-induced movement therapy mitogen-activated proteinkinase signaling system brain ischemia locomotion recovery cortex hippocampus middle cerebralartery occlusion foot fault test balance beam walking rats NSFC grants neural regeneration

Van der Waals materials-based floating gate memory for neuromorphic computing

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Chip 2023年第4期2卷 27-44页

作者： Qianyu Zhang Zirui Zhang ce li Renjing Xu Dongliang Yang linfeng Sun centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quan-tum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing 100081China Beijing Key Lab of Nanophotonics&Ultra-fine Optoelectronic Systems School of PhysicsBeijing Institute of TechnologyBeijing 100081China Thrust of Microelectronics of Function Hub The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China

With the advent of the“Big Data Era”,improving data storage density and computation speed has become more and more urgent due to the rapid growth in different types of *** memory with a floating gate(FG)structure is attracting great attention owing to its advantages of miniaturization,low power consumption and reli-able data storage,which is very effective in solving the problems of large data capacity and high integration ***,the FG memory with charge storage principle can simulate synaptic plasticity perfectly,breaking the traditional von Neumann computing ar-chitecture and can be used as an artificial synapse for neuromorphic computations inspired by the human *** many candidate materials for manufacturing devices,van der Waals(vdW)materials have attracted widespread attention due to their atomic thickness,high mobility,and sustainable miniaturization *** to the arbitrary stacking ability,vdW heterostructure combines rich physics and potential 3D integration,opening up various possibilities for new functional integrated devices with low power consumption and flexible *** paper provides a comprehensive review of memory devices based on vdW materials with FG structure,including the working principles and typical structures of FG structure devices,with a focus on the introduction of various highperformance FG memories and their versatile applications in neuro-morphic ***,the challenges of neuromorphic devices based on FG structures are also *** review will shed light on the design and fabrication of vdW material-based memory devices with FG engineering,helping to promote the development of practical and promising neuromorphic computing.

关键词： Van der Waals materials Floating gate memory Memristor Neuromorphic computing

Luminescent nanoparticle-arrays synthesized via polymer pen lithography

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Nano Research 2023年第2期16卷 3125-3129页

作者： Ping Wang Shuyi Bao Shuqian Qiao ce li Zhang Jiang Hao Song Yilin Wang Qiuqiang Zhan ling Huang Institute of Advanced Materials Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech UniversityNanjing 211816China centre for Optical and Electromagnetic Research Guangdong Provincial Key Laboratory of Optical Information Materials and TechnologyNational Centre for International Research on Green OptoelectronicsSouth China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China College of Chemistry State Key Laboratory of the Chemistry and Utilization of Carbon Based EnergiesXinjiang UniversityUrumqi 830046China

We report a high-throughput approach to generating lanthanide-doped upconversion nanoparticle(UCNP)arrays through polymer pen lithography(PPL),where instead of the expensive block co-polymer,two types of polymers are employed with one working as ink carrier,e.g.,polyethylene glycol-400(PEG-400)to facilitate smooth transfer from the tip to the substrate and the other,e.g.,polyvinyl pyrrolidone(PVP),as chelator to ensure successful patterning of metal *** strong coordination of PVP with rare earth ions(RE^(3+))is the key for weakening the interaction between RE3+ions and the carrier PEG-400 so that the good mobility of ink can be *** experimental results have shown that besides PVP,small molecules with functional groups that can coordinate with RE^(3+)ions,such as oleic acid,can also serve the same role as PVP,which greatly enriches the ink library for *** 1 cm^(2)area arrays comprising individual UCNP can be reliably generated with characteristic upconversion *** strategy not only allows reliable production of individual UCNP arrays,it also paves new avenue to the precise synthesis of multifunctional NPs for lasing,imaging,encryption,and anticounterfeiting.

关键词： polymer pen lithography upconversion luminescence nanoparticle array ligand

习近平总书记关于“理想信念”的重要论述融入大学生理想信念教育研究

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教育教学论坛 2024年第30期 31-34页

作者：李俊策张宝亮张垚瑶毛安琪山东建筑大学土木工程学院山东济南250101

理想信念对于个人成长成才、国家发展进步、民族伟大复兴有着重要的精神价值。习近平总书记高度重视理想信念,多次提及,并作出重要论述。理想因其远大而为理想,信念因其执着而为信念。青年一代是国家的未来和民族的希望,更应坚定理想信... 详细信息

理想信念对于个人成长成才、国家发展进步、民族伟大复兴有着重要的精神价值。习近平总书记高度重视理想信念,多次提及,并作出重要论述。理想因其远大而为理想,信念因其执着而为信念。青年一代是国家的未来和民族的希望,更应坚定理想信念,努力成长为堪当民族复兴重任的时代新人。高校承担着落实立德树人根本任务的重担,在开展理想信念教育时应该从习近平总书记关于“理想信念”的重要论述中汲取经验,让大学生理想信念教育能有的放矢、有路可走、有章可循。

关键词：理想信念教育大学生教育研究

需要层次理论下的大学生理想信念教育路径研究

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教育教学论坛 2024年第30期 181-184页

作者：张宝亮李俊策王培森徐崇山东建筑大学土木工程学院山东济南250101

国际错综复杂形势背景下,西方多元文化价值观与多样性思想文化给处于“扣好人生第一粒扣子”这一关键阶段的大学生带来严重冲击,导致他们在理想认知、信念实践等方面产生困惑。高校应高度重视理想信念教育在立德树人方面的重要作用,引... 详细信息

国际错综复杂形势背景下,西方多元文化价值观与多样性思想文化给处于“扣好人生第一粒扣子”这一关键阶段的大学生带来严重冲击,导致他们在理想认知、信念实践等方面产生困惑。高校应高度重视理想信念教育在立德树人方面的重要作用,引导学生树立正确的“三观”。当前,在推进理想信念教育过程中应注重用“缺失性需要”增加学生的黏性,引导学生坚定“四个自信”;用“成长性需要”促进学生发展,着力培养肩负中华民族伟大复兴重任的新青年。

关键词：需要层次理论大学生理想信念教育路径

An integrated strategy of UPLC-Q-TOF/MS and HPTLC/PAD-DESI-MSI for the analysis of chemical variations:A case study of Tibetan medicine Tiebangchui

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Journal of Pharmaceutical Analysis 2024年第4期14卷 615-618页

作者： Yue liu Mengjia li Xing Fu Yi Zhang ce Tang State Key Laboratory of Southwestern Chinese Medicine Resources School of Ethnic MedicineChengdu University of Traditional Chinese MedicineChengdu611137China Meishan Hospital of Chengdu University of Traditional Chinese Medicine MeishanSichuan620010China Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese MedicineChengdu611137China

The dried roots of Aconitum pendulum Busch are the major source of a commonly used Tibetan medicine,namely Tiebangchui(TBC)(Fig.S1).However,raw TBC contains a large amount of high toxic diester-diterpenoid alkaloids(DDAs),and the improper use would cause arrhythmia,irreversible cardiovascular damages,and even death.“Paozhi”,an appropriate processing method,is the essential prerequisite for the safe clinical application of ***-decocting and sand-frying are commonly used processing methods for toxicity attenuation and efficacy preservation for TBC.

关键词： dried irreversible roots