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Relationship between hepatitis B virus DNA levels and liver histology in patients with chronic hepatitis B

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World Journal of Gastroenterology 2007年第14期13卷 2104-2107页

作者： Jie Shao Lai Wei Hao Wang Yan Sun Lan-Fang Zhang Jing li jian-qiang Dong Department of Hepatic Disease People's Hospital Peking University Beijing 100034 China

AIM： To study the relationship between hepatitis B virus （HBV） DNA levels and liver histology in patients with chronic hepatitis B （CHB） and to determine the prevalence and characteristics of hepatitis B e antigen （HBeAg） negative patients.METHODS： A total of 213 patients with CHB were studied, and serum HBV DNA levels were measured by the COBAS Amplicor HBV Monitor test. All patients were divided into two groups according to the HBeAg *** correlation between serum HBV DNA levels and liver damage （liver histology and biochemistry） was explored.RESULTS： Of the 213 patients with serum HBV DNA levels higher than 10^5 copies/mL, 178 （83.6%） were HBeAg positive, 35 （16.4%） were HBeAg negative. The serum HBV DNA levels were not correlated to the age,history of CHB, histological grade and stage of liver disease in either HBeAg negative or HBeAg positive patients. There was no correlation between serum levels of HBV DNA and alanine aminotransferanse （ALT）,aspartate aminotrans-ferase （AST） in HBeAg positive patients. In HBeAg negative patients, there was no correlation between serum levels of HBV DNA and AST,while serum DNA levels correlated with ALT （r = 0.351, P = 0.042）. The grade （G） of liver disease correlated with ALT and AST （P 〈 0.05, r = 0.205, 0.327 respectively）in HBeAg positive patients. In HBeAg negative patients,correlations were shown between ALT, AST and the G （P 〈 0.01, and r = 0.862, 0.802 respectively）. HBeAg negative patients were older （35 ± 9 years vs 30 ±9 years, P 〈 0.05 ） and had a longer history of HBV infection （8 ± 4 years vs 6 ± 4 years, P 〈 0.05） and a lower HBV DNA level than HBeAg positive patients （8.4± 1.7 Log HBV DNA vs 9.8 ± 1.3 Log HBV DNA, P 〈0.001）. There were no significant differences in sex ratio,ALT and AST levels and liver histology between the two groups.CONCLUSION： Serum HBV DNA level is not correlated to histological grade or stage of liver disease in CHB patients with HBV DNA more than 10^5 copies/*** to HB

关键词： Hepatitis B virus Hepatitis B virus DNA Chronic hepatitis B liver histology

Gastric adenomyoma presenting as melena: A case report and literature review

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World Journal of Gastroenterology 2010年第15期16卷 1934-1936页

作者： Zhu, Hui-Neng Yu, jiang-Ping Luo, Juan jiang, You-Hua li, jian-qiang Sun, Wen-Yong Zhejiang Canc Hosp Dept Pathol Hangzhou 310022 Zhejiang Peoples R China Zhejiang Canc Hosp Dept Thoracicoabdominal Surg Hangzhou 310022 Zhejiang Peoples R China

Gastric adenomyoma (AM) is a rare benign tumor characterized by glandlike structures embedded within a smooth muscle stroma. We report a case of a 68yearold man with gastric AM admitted to our hospital for melana. Endoscopic examination revealed a gastric mass of about 4 cm in diameter, located in the antrum. Histologic examination of the excised specimen showed irregularly arranged glands and interlacing smooth muscle bundles surrounding the glandular elements. Although gastric AM is rare, it should be considered in differential diagnosis of extramucosal gastric tumor.

关键词： Adenomyoma Stomach Melana Histopathology Endoscopic examination

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开口桩中土芯形成、影响因素及判别方法研究

岩土力学 2008年第2期29卷 449-454页

作者：李剑强周建浙江大学岩土工程研究所

开口桩打桩过程中桩端土体进入桩管内形成土芯,土芯在大直径钢管桩、新研发的大直径现浇混凝土薄壁筒桩的作用不容忽视,通过闭塞效应土芯会提高开口桩的承载力,减小桩的沉降量。比较分析了目前国际上两种土芯闭塞效应定义方法,研究认为... 详细信息

开口桩打桩过程中桩端土体进入桩管内形成土芯,土芯在大直径钢管桩、新研发的大直径现浇混凝土薄壁筒桩的作用不容忽视,通过闭塞效应土芯会提高开口桩的承载力,减小桩的沉降量。比较分析了目前国际上两种土芯闭塞效应定义方法,研究认为,从土芯破坏机制出发定义土芯是否产生闭塞效应更为合理;并从土芯的形成出发,探讨了影响土芯形成及闭塞效应的各种因素,如桩径、桩端土的承载力、土芯与桩内壁的摩阻力等,此外还应考虑桩端土体侧向水平应力的影响。最后讨论了ICP方法中砂土及黏土中开口桩土芯闭塞效应的判别方式,认为该判别方式过于粗略,不能很好地反映土芯闭塞情况。

关键词：土芯闭塞效应土芯破坏机制

Research of Mechanism on the Impact of Local Governmental Competition on Farmland Conversion

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Asian Agricultural Research 2011年第1期3卷 104-107,111页

作者： CHEN Shi-cong li jian-qiang College of Economics and Management Sichuan Agricultural University Ya’an 625014 China

In the perspective of local governmental competition, the impact of local governmental competition on farmland conversion is analyzed in terms of political competition, factors competition and products competition, and the empirical analysis is conducted according to the provincial data from 2002 to 2007. The results show that the endowment of land resources correlates negatively with the scale of farmland conversion, and the population, the tendency of exceeding capital investment and the competition of research and development input correlate positively with the scale of farmland conversion. According to these research results, corresponding policies and countermeasures are put forward: we should overhaul the system of performance evaluation of local governmental officials; we should normalize the local governmental competitive behavior.

关键词： Local governmental competition Farmland Farmland c

Emerging progress: photochemical transformation of nitroso compounds

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Science China Chemistry 2025年第1期68卷 118-133页

作者： Ze-Le Chen qiang-qiang li Armido Studer Jun Xuan Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials School of Chemistry & Chemical Engineering Anhui University Organisch-Chemisches Institut Universitat Münster

Nitroso compounds have emerged as highly valuable reaction partners or reagents in organic synthesis due to their rich *** versatile profile of these compounds allows them to function as electrophiles, nucleophiles, diradicals, and radical acceptors in diverse transformations. In recent years, notable progress has been made in harnessing photochemical reactions with nitroso compounds to prepare N,O-containing structures using mild and eco-friendly conditions. Various nitroso compounds like nitrosoarenes, acyloxy nitroso compounds, N-nitrosoamines and nitrites have received significant attention for their ability to introduce NO moieties into complex molecules that are otherwise difficult to access. In this review, we provide an overview of the recent advancements in the visible light-induced conversion of nitroso compounds, with particular emphasis on their role as bifunctional reagents and acceptors of radicals, carbenes and nitrenes.

关键词： nitroso compounds photochemistry radical reaction carbene transformation nitrosoarenes

Poly(aryl ether nitrile)s containing flexible side-chain-type quaternary phosphonium cations as anion exchange membranes

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Science China Materials 2020年第4期63卷 533-543页

作者： Chenyi Wang Zhengwang Tao Xiaoyan Zhao jian li and qiang Ren jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering Jiangsu Key Laboratory of Environmentally Friendly Polymeric MaterialsSchool of Materials Science and EngineeringChangzhou UniversityChangzhou 213164China

In order to effectively improve the properties of anion exchange membrane(AEM)materials,a series of novel poly(aryl ether nitrile)s with flexible side-chain-type quaternary phosphonium cations(PAEN-TPP-x)were designed and prepared on the basis of considering the influences of polymer backbone,cationic group species and the connection way between the cations and polymer *** synthetic method,structure and ion-exchange capacity,water absorption,swelling,hydroxide conductivity and alkaline stability of the obtained AEMs were studied.A comparative study with other reported AEMs was also performed for further exploration of the relationship between the structure and *** AEMs with flexible side-chain-type quaternary phosphonium cations displayed good comprehensive *** water uptakes and swelling ratios were in the range of 11.6%–22.7%and 4.4%–7.8%at 60℃,*** had hydroxide conductivity in the range of 28.6–45.8 mS cm^-1 at 60℃.Moreover,these AEMs also exhibited improved alkaline stability,and the hydroxide conductivity for PAEN-TPP-0.35 could remain 82.1%and 80.6%of its initial value at 60 and 90℃in 2 mol L^-1 NaOH solution for480 h,respectively.

关键词： anion exchange membrane poly(aryl ether nitrile)s quaternary phosphonium cations alkaline stability

Prognostic values of serum cystatin C and β2 microglobulin, urinary β2 microglobulin and N-acetyl-β-D-glucosaminidase in early acute renal failure after liver transplantation

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Chinese Medical Journal 2008年第14期121卷 1251-1256页

作者： HEI Zi-qing li Xiao-yun SHEN Ning PANG Hong-yu ZHOU Shao-li GUAN jian-qiang Department of Anesthesiology Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510630 China

Background Acute renal failure （ARF） after liver transplantation is associated with high mortality and morbidity. Early therapeutic or preventive intervention is hampered by the lack of early effective prognostic factors. Recent studies indicated that serum levels of cystatin C and β2-microglobulin （β2 MG） as well as urinary β2 MG and N-acetyI-β-D- glucosaminidase （NAG） would increase in patients with early and mild renal impairment. In this study, these factors were detected during the different stages in patients who accepted orthotopic liver transplantation （OLT）, and their feasibilities to predict early ARF after OLT were also analyzed. Methods Sixty patients with normal blood urea nitrogen （BUN） and serum creatinine （SCr） who received modified piggyback liver transplantation without veno-venous bypass were prospectively studied. Blood samples were drawn from patients for the determination of serum β2 MG（n=60）, SCr （n=60） and serum Cystatin C （n=39） at following 5 intervals： before operation （TO）, 20 minutes before anhepatic phase （T1）, 25 minutes in anhepatic （T2）, 60 minutes after reperfusion （T3） and at the end of operation（T4）. Urinary B2 MG （n=60） and NAG （n=60） were also examined at following 3 intervals： before operation （TO）, 60 minutes after reperfusion （T3） and at the end of operation （T4）. According to the Rimola A criteria of ARF in 24 hours after operation, all the patients were divided into two groups： ARF group and non-ARF group. The data were statistically analyzed to evaluate the feasibiliy of regarding these factors as prognostic factors for early ARF after liver transplantation in patients with normal SCr and BUN before operation. Results Ten of sixty cases showed ARF（16.7%）. The Logistic regression analysis showed that the levels of serum and urinary β2 MG as well as serum cystatin C before operation were correlated with early ARF after liver transplantation （P 〈0.05）, while only serum levels of cystatin C and Cr at the end of operation c

关键词： liver transplantation acute renal failure cystatin C β2-microglobulin

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麦饭石中微量元素的加罩电极光谱分析

冶金分析 2006年第2期26卷 73-75页

作者：李建强鲁毅强姜伟北京科技大学应用科学学院北京100083 北京科技大学应用科学学院

采用加罩电极发射光谱法测定了来自不同地区麦饭石样品和地质标样中36种痕量元素,对测定的最佳条件进行了系统研究。通过选择合适的曝光条件、内标元素和分析线对,连续测定了易挥发、中等挥发和难挥发元素。标样的测定值与认定值一致,... 详细信息

采用加罩电极发射光谱法测定了来自不同地区麦饭石样品和地质标样中36种痕量元素,对测定的最佳条件进行了系统研究。通过选择合适的曝光条件、内标元素和分析线对,连续测定了易挥发、中等挥发和难挥发元素。标样的测定值与认定值一致,标准偏差小于21%。对不同地区的样品测定结果表明:麦饭石中对人体有益的痕量元素含量高,而对人体有害的元素如砷、镉、铬、汞和铅等含量低。

关键词：麦饭石痕量元素加罩电极发射光谱

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竞争条件下公共交通最优出行方式选择

公路交通科技 2019年第10期36卷 121-127页

作者：李建强同济大学道路与交通工程教育部重点实验室

多种交通方式共线运行为出行者提供了便利,但也使得出行者面临最优出行方式选择问题.为了在竞争条件下对出行者的出行方式选择进行科学的引导,提高出行者的出行效率并实现交通资源的最优配置,引入固定出行成本和可变出行成本概念,对步... 详细信息

多种交通方式共线运行为出行者提供了便利,但也使得出行者面临最优出行方式选择问题.为了在竞争条件下对出行者的出行方式选择进行科学的引导,提高出行者的出行效率并实现交通资源的最优配置,引入固定出行成本和可变出行成本概念,对步行、共享单车、常规公交和轨道交通4类常用出行方式的成本问题进行研究.具体方法为:分别将4类出行方式的成本量化为出行距离的函数,然后分析平均出行成本(即出行效益)随出行距离的变化规律,分别建立了单一方式与多种方式组合联运条件下的最优出行方式优化模型,最后以成都市某轨道交通枢纽周边区域为例对模型进行了验证.实证结果表明:当出行距离增加时,共享单车、常规公交、轨道交通的平均出行成本具有规模效应,即出行距离增加时,其出行单位出行成本降低;在研究区域内,按照出行距离递增的顺序,考虑出行成本因素下出行者最优出行方式依次为步行、共享单车、常规公交、轨道交通;在常规公交最优选择区间,轨道交通平均成本与其差距不大,形成了很大竞争.因此,为了实现资源高效利用,应提高常规公交竞争活力,如提升舒适性,减小发车间隔.

关键词：交通工程出行方式选择规模效应出行成本竞争条件