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Comparative proteomic profiles of resistant/susceptible cucumber leaves in response to downy mildew infection

Horticultural Plant Journal 2021年第4期7卷 327-340页

作者： Chengzhen Sun Xiaofei Song Jinshuang Zheng xiaoli li Zhihong Feng liying Yan Hebei Key Laboratory of Horticultural Germplasm Excavation and Innovative Utilization QinhuangdaoHebei 066004China College of Horticulture Science and Technology Hebei Normal University of Science and TechnologyQinhuangdaoHebei 066004China

Downy mildew is a serious disease in cucumber production worldwide,which is caused by Pseudoperonospora cubensis(Berk.&Curt.)*** the mechanism of cucumber response to downy mildew infection is important for breeding improvement and production;however,the research remains largely elusive.A comparative proteomic approach was used to reveal the differential accumulation of the proteomes from leaves of cucumber(susceptible line and resistant line)that were inoculated with *** or not by two-dimensional electrophoresis and MALDI-TOF/TOF MS.A total of 76 protein spots were successfully identified with significant changes in abundance(>2-fold,Pline and resistant *** the functional annotation,these proteins were classified into 8 groups including photosynthesis(29%),energy and metabolism(29%),cell rescue and defense(17%),and protein biosynthesis,folding and degradation(13%),unclassified(7%),nucleotide metabolism(3%),signal transduction(1%)and cellular process(1%).Among the 17 differentially expressed proteins between the resistant and susceptible cucumber line,most of the protein spots were concentrated in cell rescue and defense(4)and energy and metabolism(4).Moreover,a schematic diagram containing majority of the metabolic pathways of cucumber leaves in response to downy mildew was *** network revealed the positive effect of several functional components in cucumber seedlings’resistant to downy mildew such as accumulation of energy supply and resistance-related proteins,hastened protein metabolism and photorespiratory,inhibited photosynthesis,and triggered photosystem repair and programmed cell *** together,these results have advanced a further understanding of the key metabolic pathways of cucumber resistance to downy mildew and pathogen control in the proteomic level.

关键词： Defense response Downy mildew Proteomics Cucumber

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Palmitic acid reduces the methylation of the FOXO1 promoter to suppress the development of diffuse large B-cell lymphoma via modulating the miR-429/DNMT3A axis

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Chinese Journal of Natural Medicines 2024年第6期22卷 554-567页

作者： li Weiming GAO Ming XUE Weili li xiaoli CHANG Yu ZHANG Kaixin WEN Chenyu ZHANG Mingzhi Department of Oncology Henan University of Traditional Chinese MedicineZhengzhou 450000China Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China

Diffuse large B-cell lymphoma(DLBCL)is characterized by significant treatment *** acid(PA)has shown promising antitumor *** study aims to elucidate the molecular mechanisms by which PA influences DLBCL *** quantified the expression levels of microRNAs(miRNAs),Forkhead box protein O1(FOXO1),and DNA methyltransferase 3A(DNMT3A)in both untreated and PA-treated DLBCL tumors and cell *** were made of cell viability,apoptosis,and autophagy-related protein expression following PA *** analyses among miR-429,DNMT3A,and FOXO1 were conducted using luciferase reporter assays and methylation-specific(MSP)Polymerase chain reaction(PCR).After transfecting the miR-429 inhibitor,negative control(NC)inhibitor,shRNA against DNMT3A(sh-DNMT3A),shRNA negative control(sh-NC),over-expression vector for DNMT3A(oe-DNMT3A),or overexpression negative control(oe-NC),we evaluated the effects of miR-429 and DNMT3A on cell viability,mortality,and autophagy-related protein expression in PA-treated DLBCL cell *** efficacy of PA was also tested in vivo using DLBCL tumor-bearing mouse ***-429 and FOXO1 expression levels were downregulated,whereas DNMT3A was upregulated in DLBCL compared to the control *** treatment was associated with enhanced autophagy,mediated by the upregulation of miR-429 and downregulation of *** luciferase reporter assay and MSP confirmed that miR-429 directly inhibits DNMT3A,thereby reducing FOXO1 *** experiments demonstrated that PA promotes autophagy and inhibits DLBCL progression by upregulating miR-429 and modulating the DNMT3A/FOXO1 *** vivo PA signific-antly reduced the growth of xenografted tumors through its regulatory impact on the miR-429/DNMT3A/FOXO1 *** acid may modulate autophagy and inhibit DLBCL progression by targeting the miR-429/DNMT3A/FOXO1 signaling pathway,suggesting a novel therapeutic target for DLBCL management.

关键词： Palmitic acid Diffuse large B-cell lymphoma MiR-429 DNMT3A FOXO1 Autophagy

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Mechanical Properties and Network Structure of Hydrophobic Association Hydrogels Prepared from Octylphenol Polyoxyethylene（7） Acrylate and Sodium Dodecyl Sulfate

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Chemical Research in Chinese Universities 2015年第4期31卷 633-639页

作者： liANG Zi GAO Tingting XU Jianan li Zhiying liU xiaoli liU Fengqi College of Chemistry Jilin University Changchun 130012 P. R. China

Hydrophobic association hydrogels（HA-gels） with high mechanical strength were prepared by free radical micellar copolymerization in aqueous solutions of acrylamide（AM）, anion surfactant sodium dodecyl sulfate（SDS） and a small amount of hydrophobic monomer octylphenol polyoxyethylene（7） acrylate（OP-7-AC）. We found that the molar ratio of SDS to OP-7-AC has a great effect on the tensile strength and other mechanical property parameters. The best ratio point R＇ was determined. On the basis of Mooney theory and statistical theory, the critical tensile ratios and critical tensile strengths of the hydrogels were obtained, elastic parameters C1 and C2 were calculated via uniaxial tensile equation and structural parameters, such as the effective network chain density and the averaged molecular weight of the chain between cross-linking points of all the hydrogels were evaluated. The results indicate that the variation of mechanical property parameters depends on the number of effective cross-linking points and the match degree of long and short chains.

关键词： Hydrophobic association Cross-linking point Distribution of chain Surfactant

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The great triangular seismic region in eastern Asia:Thoughts on its dynamic context

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Geoscience Frontiers 2011年第1期2卷 57-65页

作者： Xianglin Gao Xiaojing Ma xiaoli li Institute of Geology China Earthquake Administration Beijing 100029 China

A huge triangle-shaped tectonic region in eastern Asia plays host to numerous major earth- quakes. The three boundaries of this region, which contains plateaus, mountains, and intermountain basins, are roughly the Himalayan arc, the Tianshan-Baikal, and longitude line -105°E. Within this trian- gular region, tectonism is intense and major deformation occurs both between crustal blocks and within most of them. Outside of this region, rigid blocks move as a whole with relatively few major earthquakes and relatively weak Cenozoic deformation. On a large tectonic scale, the presence of this broad region of intraplate deformation results from dynamic interactions between the Indian, Philippine Sea-West Pacific, and Eurasian plates, as well as the influence of deep-level mantle flow. The Indian subcontinent, which continues to move northwards at -40 mm/a since its collision with Eurasia, has plunged beneath Tibet, resulting in various movements and deformations along the Himalayan arc that diffuse over a long distance into the hinterland of Asia. The northward crustal escape of Asia from the Himalayan collisional zone turns eastwards and southeastwards along 95°-100°E longitude and defines the eastern Himalayan syntaxis. At the western Himalayan syntaxis, the Pamirs continue to move into central Asia, leading to crustal deformation and earthquakes that are largely accommodated by old EW or NW trending faults in the bordering areas between China, Mongolia, and Russia, and are restricted by the stable landmass northwest of the Tianshan-Altai-Baikal region. The subduction of the Philippine and Pacific plates under the Eurasian continent has generated a very long and narrow seismic zone along trenches and island arcs in the marginal seas while imposing only slight horizontal compression on the Asian continent that does not impede the eastward motion of eastern Asia. In the third dimension, there may be southeastward deep mantle flow beneath most of Eurasia that reaches the ma

关键词： Eastern Asian tectonics Huge triangular seismicregion India plate Philippine Sea-WestPacific region Eurasian mantle flow

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LSDA-APF:A Local Obstacle Avoidance Algorithm for Unmanned Surface Vehicles Based on 5G Communication Environment

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Computer Modeling in Engineering & Sciences 2024年第1期138卷 595-617页

作者： xiaoli li Tongtong Jiao Jinfeng Ma Dongxing Duan Shengbin liang School of Software Henan UniversityKaifeng475004China

In view of the complex marine environment of navigation,especially in the case of multiple static and dynamic obstacles,the traditional obstacle avoidance algorithms applied to unmanned surface vehicles(USV)are prone to fall into the trap of local ***,this paper proposes an improved artificial potential field(APF)algorithm,which uses 5G communication technology to communicate between the USV and the control *** algorithm introduces the USV discrimination mechanism to avoid the USV falling into local optimization when the USV encounter different obstacles in different *** the various scenarios between the USV and other dynamic obstacles such as vessels in the process of performing tasks,the algorithm introduces the concept of dynamic artificial potential *** the multiple obstacles encountered in the process of USV sailing,based on the International Regulations for Preventing Collisions at Sea(COLREGS),the USV determines whether the next step will fall into local optimization through the *** local potential field of the USV will dynamically adjust,and the reverse virtual gravitational potential field will be added to prevent it from falling into the local optimization and avoid *** objective function and cost function are designed at the same time,so that the USV can smoothly switch between the global path and the local obstacle *** simulation results show that the improved APF algorithm proposed in this paper can successfully avoid various obstacles in the complex marine environment,and take navigation time and economic cost into account.

关键词： Unmanned surface vehicles local obstacle avoidance algorithm artificial potential field algorithm path planning collision detection

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The BHLH Transcriptional Factor PIF4 Competes with the R2R3-MYB Transcriptional Factor MYB75 to Fine-Tune Seeds Germination under High Glucose Stress

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Phyton-International Journal of Experimental Botany 2021年第5期90卷 1387-1400页

作者： xiaoli li Shiyan Lu Yaru Yang Wenjie Wei Jiali Wei Xiaojun Yuan Ping li Shanghai Key Laboratory of Bio-Energy Crops School of Life SciencesShanghai UniversityShanghai200444China

It is known that the high level of sugar including glucose suppresses seed germination through ABA ***5 is an essential component to mediate ABA-dependent seed germination inhibition,but underlying mechanism needs more *** study demonstrated the PIF4 activated the expression of ABI5 to suppress seed germination in *** we reported that PIF4 also mediated the seed germination inhibition through ABI5 under high concentration of glucose ***,we found that PIF4 interacted with PAP1,the central factor to control anthocyanin *** interaction was confirmed in vitro and in *** and physiological analysis revealed that PAP1 bond the promoter of ABI5 to suppress its expression,thus enhanced seed germination under high concentration of glucose ***,PAP1 competed with PIF4 to antagonize the activation of PIF4 on ABI5 expression,thus promoted seed germination under high glucose *** these,we uncover a novel role for PIF4 and PAP1 in controlling seed germination under high glucose treatment,and reveal their antagonistic mechanism by which coordinates ABI5 expression to control seed germination in response to the glucose signal.

关键词： Seeds germination glucose MYB75 PIF4 ABI5

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S-Nitrosoglutathion Reductase Activity Modulates the Thermotolerance of Seeds Germination by Controlling ABI5 Stability under High Temperature

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Phyton-International Journal of Experimental Botany 2021年第4期90卷 1075-1087页

作者： Wenjie Wei Yulan Hu Wenjuan Yang xiaoli li Jiali Wei Xiangyang Hu Ping li Shanghai Key Laboratory of Bio-Energy Crops School of Life SciencesShanghai UniversityShanghai200444China

Seed germination or dormancy status is strictly controlled by endogenous phytohormone and exogenous environment *** acid(ABA)is the important phytohormone to suppress seed *** high temperature(HT)also suppressed seed germination,or called as secondary seed dormancy,through upregulating ABI5,the essential component of ABA signal *** result shows that appropriate nitric oxide(NO)breaks seed dormancy through triggering S-nitrosoglutathion reductase(GSNOR1)-dependent S-nitrosylation modification of ABI5 protein,subsequently inducing the degradation of *** we found that HT induced the degradation of GSNOR1 protein and reduced its activity,thus accumulated more reactive nitrogen species(RNS)to damage seeds ***,HT increased the S-nitrosylation modification of GSNOR1 protein,and triggered the degradation of GSNOR1,therefore stabilizing ABI5 to suppress seed ***,the ABI5 protein abundance was lower in the transgenic line overexpressing GSNOR1,but higher in the gsnor mutant after HT *** analysis showed that GSNOR1 affected seeds germination through ABI5 under *** together,our data reveals a new mechanism by which HT triggers the degradation of GSNOR1,and thus stabilizing ABI5 to suppress seed germination,such mechanism provides the possibility to enhance seed germination tolerance to HT through genetic modification of GNSOR1.

关键词： Seed germination ambient high temperature GSNOR1 S-nitrosoglutathion ABI5

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Interface characterization of the discontinuously reinforced metal matrix composites based on wavelet analysis of acoustic emission behaviour

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Chinese Science Bulletin 1998年第9期43卷 791-792页

作者： Cui, Yan li, xiaoli Peng, Huaxin Yao, Zhongkai National Key Laboratory of Advanced Composites Beijing Institute of Aeronautical Materials Beijing China Harbin Institute of Technology Harbin China Beijing Science and Technology University Beijing China

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The Chemical Trees with Minimum Inverse Symmetric Division Deg Index

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Journal of Mathematical Research with Applications 2023年第4期43卷 399-408页

作者： xiaoli li Yanling SHAO Yubin GAO Department of Mathematics North University of China

Let G be a graph with vertex set V(G) and edge set E(G). The inverse symmetric division deg index of G is defined as ■ where duand dvare the degrees of u and v, respectively. A tree T is a chemical tree if du≤4 for each vertex u ∈ V(T).In this paper, we characterize the structure of chemical trees with minimum inverse symmetric division deg index among all chemical trees of order n.

关键词： graph inverse symmetric division deg index chemical tree

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Dioscin from Polygonatum sibiricum induces apoptosis and autophagy in Ishikawa human endometrial cancer cell and in vivo

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Food Science and Human Wellness 2024年第5期13卷 2601-2616页

作者： xiaoli li Runhui Ma Zhijing Ni Wei Wang Kiran Thakur Jianguo Zhang Zhaojun Wei School of Biological Science and Engineering North Minzu UniversityYinchuan 750021China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China School of Public Health Anhui University of Science and TechnologyHuainan 232001China

With an aim to comprehend the precise regulatory mechanism of dioscin against endometrial carcinoma(EC), we firstly extracted the components from Polygonatum sibiricum followed by identification and structural characterization. The anti-EC activity of dioscin was initially determined based on the inhibition of Ishikawa cell proliferation and tumor growth. The high-throughput sequencing data indicated that dioscin not only promoted apoptosis, including decrease of poly ADP-ribose polymerase(PARP) and B-cell lymphoma-2(Bcl-2) and increase of c-PARP and Bcl-2-associcated agonist of cell death(Bad), but also induced autophagy, including increase of autophagic lysosomes and LC3Ⅱ/LC3Ⅰ ratio. Mechanistic exploration suggested that dioscin induced autophagy and apoptosis through inhibition of PI3K/AKT/mTOR signaling pathway. Besides, the dioscin-regulated p53 pathway was mainly involved in autophagy induction. Furthermore, inhibition of Ishikawa cell autophagy was linked to dioscin-induced apoptosis. Our data suggest the immense potential of dioscin for the development of functional food for EC and related medical application.

关键词： Dioscin Ishikawa cell Apoptosis Autophagy PI3K/AKT p53

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