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Synthesis of NaYF_4:Nd@NaLuF_4@SiO_2@PS colloids for fluorescence imaging in the second biological window

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Journal of Rare Earths 2018年第2期36卷 113-118页

作者： Dongpeng Yang Cong Cao Wei Feng Chunhui Huang fuyou li Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersInstitutes of Biomedical Sciences & Collaborative Innovation Center of Chemistry for Energy Materials Fudan University

Nd doped nanoparticles is commonly used as bioimaging agents but presents poor stability. Here, a polymer coating is applied to NaYF4：Nd nanoparticles using a versatile step-by-step coating strategy. The as-synthesized NaYF_4：Nd@NaLuF_4@SiO_2@PS colloids show good stability in various polar solvent and are very stable in water at least for 6 months. These NaYF_4：Nd@NaLuF_4@SiO_2@PS colloids can exhibit strong down converting photoluminescence when excited by 808 nm lasers. Moreover, these NaYF_4：Nd@NaLuF_4@SiO_2@PS colloids accumulate in liver of mice when used as bio-imaging agents. which exhibit strong fluorescence luminescence in NIR Ⅱ window.

关键词： Neodymium Polystyrene Stability Bioimaging Rare earths

^(1)O_(2)-activatable Eu^(3+)-afterglow nanoprobe for highly sensitive detection of porphyria in whole blood

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Journal of Rare Earths 2022年第9期40卷 1382-1388,I0002页

作者： Jia liu Jiamiao Yin Hang Yuan Yiyang Zhao Shihua Luo fuyou li Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai 200433China Hangzhou Foreign Languages School Hangzhou 310023China Department of Traumatology Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China

High-sensitivity detection of porphyrin in blood is very important for the early diagnosis and treatment of *** on the advantages of longer luminescence lifetime and lower background interference,organic afterglow molecular porphyrin detection probes were developed,but these probes show poor water solubility and insufficient luminescence ***,we present an afterglow nanoprobe(Eu-NP)for porphyria detection in whole *** luminescent substance(europium complex)and the organic vinyl co mpound reacted with singlet oxygen(^(1)O_(2))were selected for encapsulation in polystyrene ***-NP can respond to^(1)O_(2)produced by porphyrins,and the detection signals can be obtained by the emission of the afterglow Eu^(3+)-emissive ***-NP can achieve high-sensitivity detection of porphyrin,and the lowest detection limit reaches 0.29μmol/*** porphyrin detection in whole blood samples is consistent with clinical diagnosis *** with the organic afterglow molecule,the Eu-NPs constructed in this work show a higher signal-to-noise ratio and sensitivity of porphyria detection.

关键词： Porphyria Afterglow Nanoprobe Europium luminescence Whole blood detection Rare earths

Two birds with one stone:Amine-functionalized MSNs@Eu(OH)CO_(3) nanoprobe for efficient dissolution-enhanced afterglow bioassay

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Nano Research 2022年第9期15卷 8360-8366页

作者： Fuying Zhang Donghao Hu Xianlong Su Zhengdao Hong Wei Feng Ming Xu fuyou li Department of Chemistry&State Key Laboratory of Molecular Engineering of Polymers&Institute of Biomedicine Science Fudan UniversityShanghai 200433China

ABSTRACT The efficient detection of tumor markers is crucial to early cancer diagnosis and ***,we propose a unique“two birds with one stone”dissolution-enhanced afterglow bioassay based on amino-functionalized mesoporous SiO2 nanoparticles(MSNs-NH2)encapsulated Eu(OH)CO_(3)*** nanoprobes(i)stably conjugate to the antibody and(ii)are highly soluble in the acidic enhancer solution,and provide a high Eu3+*** released Eu3+ions further activate the photochemical afterglow system to determine the alpha-fetoprotein(AFP)levels in clinical serum *** the use of a real-time excitation source,the interference of autofluorescence and scattering from blood can be *** demonstrated limit of detection(LOD)for AFP was as low as 0.12 ng·mL^(−1).This covalently connected dissolution-enhanced luminescent bioassay(DELBA)and novel afterglow system shows tremendous potential for ultrasensitive and rapid clinical diagnosis.

关键词： bioassay photochemical afterglow mesoporous SiO2 nanoparticles(MSNs) nanocomposites dissolution-enhanced

A luminescent metal-organic framework with an open cubic cage and eight-coordinate cadmium nodes

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Science China Chemistry 2010年第10期53卷 2079-2082页

作者： WANG ChuanFeng ZHANG ZhengXing ZHANG lili li fuyou ZHOU XiGeng Department of Chemistry Fudan UniversityShanghai 200433China Department of Chemistry Taizhou CollegeLinhai 317000China

Self-assembly of cadmium ions and the rigid bridging ligand 4,4′-methylenebis(3-hydroxy-2-naphthoic acid) (pamoic acid, H4PA) leads to a one-dimensional metal-organic framework with open cube-like M2(H2PA)2 cages wit... 详细信息

关键词： framework eight-coordinate cadmium cubic cage fluorescence pamoic acid

Luminescence interference-free lifetime nanothermometry pinpoints in vivo temperature

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Science China Chemistry 2021年第6期64卷 974-984页

作者： Mengya Kong Yuyang Gu Yingjie Chai Jiaming Ke Yulai liu Xincheng Xu Zhanxian li Wei Feng fuyou li Department of Chemistry Institutes of Biomedical SciencesState Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai 200433China Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China

Luminescence nanothermometry makes non-invasive and real-time temperature readings possible in living ***,the spectral fluctuation in tissues and fluids,as well as the interaction between fluorophores and environment hinders accuracy of the ***,we report a luminescence lifetime-based nanothermometry which specifically addresses this problem.A temporal based calibration(lifetime sensing)in the NIR range,an endogenous thermal response as well as a polymer encapsulation evading environmental factors,altogether help to pinpoint temperature in *** to the highly condensed NdYb ions in a well-protected tiny core-shell nanocrystal(overall 11 nm),a temperature sensitivity about 2.07%K^(-1)(with 5%Yb^(3+)doped nanoparticles)and an accuracy of 0.27 K(with 25%Yb^(3+)doped nanoparticles)in biological fluids are ***,combining thermally activated energy transfer nanothermometer with anti-interference lifetime thermometry would provide a more accurate temperature measurement for biological and preclinical studies.

关键词： luminescence nanothermometry NIR lifetime imaging lanthanide-doped nanocrystals thermal sensing

Lanthanide-containing persistent luminescence materials with superbright red afterglow and excellent solution processability

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Science China Chemistry 2021年第12期64卷 2125-2133页

作者： Ming Xu Jia liu Xianlong Su Qianwen Zhou Hang Yuan Yue Wen Yihang Cheng fuyou li Department of Chemistry&State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai200433China Shanghai Taywell Biotechnology Co. Ltd.Shanghai200438China

Lanthanide-containing persistent luminescence materials are promising candidates for a wide range of applications by virtue of splendid superiorities in afterglow ***,it is a crucial challenge to achieve high-quality afterglow materials at the attractive nanoscale,with uniform size,controllable morphology,and satisfying ***,a bottom-up approach was developed to construct the high-quality afterglow nanoparticles,incorporating luminescent lanthanide complex and organic molecular ingredients under mild *** nanoparticles exhibited intrinsic lanthanide luminescence with superbright red afterglow(>10 cd m^(−2))in a homogeneous *** afterglow solution with excellent processability can serve as ideal building blocks for the on-demand fabrication of functional ***-dispersible afterglow nanoparticles with state-of-the-art high brightness were uniformly constructed to perform whole-blood lateral flow assay of procalcitonin with a naked-eye detection limit of 0.5 ng mL^(−1),promoting the point-of-care testing development.

关键词： persistent luminescence lanthanide photochemical afterglow solution processing point-of-care testing

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Engineering single-molecule fluorescence withasymmetric nano-antennas

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light(Science & Applications) 2021年第5期10卷 858-866页

作者： Wenqi Zhao Xiaochaoran Tian Zhening Fang Shiyi Xiao Meng Qiu Qiong He Wei Feng fuyou li Yuanbo Zhang Lei Zhou Yan-Wen Tan State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200433China Shanghai Institute for Advanced Communication and Data Science Shanghai UniversityShanghai 200444China Key Laboratory of Specialty Fiber Optics and Optical Access Networks Joint International Research Laboratory of Specialty Fiber Optics and Advanced CommunicationShanghai UniversityShanghai 200444China Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200433China Institute for Nanoelectronic Devices and Quantum Computing Fudan UniversityShanghai 200433China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China Multiscale Research Institute of Complex Systems Fudan UniversityShanghai 200433China

As a powerful tool for studying molecular dynamics in bioscience,single-molecule fluorescence detection providesdynamical information buried in ensemble *** in the near-infrared(NIR)is particularly usefulbecause it offers higher signal-to-noise ratio and increased penetration depth in tissue compared with *** low quantum yield of most NIR fluorophores,however,makes the detection of single-moleculefluorescence ***,we use asymmetric plasmonic nano-antenna to enhance the fluorescence intensity ofAlEE1000,a typical NIR dye,by a factor up to *** asymmetric nano-antenna achieve such an enhancement mainlyby increasing the quantum yield(to~80%)rather than the local field,which degrades the molecules'*** coupled-mode-theory analysis reveals that the enhancements stem from resonance-matching between antennaand molecule and,more importantly,from optimizing the coupling between the near-and far-ield modes withdesigner asymmetric *** work provides a universal scheme for engineering single-molecule fluorescence inthe near-infrared regime.

关键词： stability. asymmetric quantum