^(1)O_(2)-activatable Eu^(3+)-afterglow nanoprobe for highly sensitive detection of porphyria in whole blood

作     者：Jia Liu Jiamiao Yin Hang Yuan Yiyang Zhao Shihua Luo Fuyou Li Jia Liu;Jiamiao Yin;Hang Yuan;Yiyang Zhao;Shihua Luo;Fuyou Li

作者机构：Department of ChemistryState Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai 200433China Hangzhou Foreign Languages SchoolHangzhou 310023China Department of TraumatologyRuijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China 

出 版 物：《Journal of Rare Earths》 (稀土学报（英文版）)

年 卷 期：2022年第40卷第9期

页      面：1382-1388,I0002页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 10[医学] 

基　　金：Project supported by the National Key R&D Program of China(2017YFA0205100) the National Natural Science Foundation of china(21937003 21874027) 

主　　题：Porphyria Afterglow Nanoprobe Europium luminescence Whole blood detection Rare earths 

摘      要：High-sensitivity detection of porphyrin in blood is very important for the early diagnosis and treatment of *** on the advantages of longer luminescence lifetime and lower background interference,organic afterglow molecular porphyrin detection probes were developed,but these probes show poor water solubility and insufficient luminescence ***,we present an afterglow nanoprobe(Eu-NP)for porphyria detection in whole *** luminescent substance(europium complex)and the organic vinyl co mpound reacted with singlet oxygen(^(1)O_(2))were selected for encapsulation in polystyrene ***-NP can respond to^(1)O_(2)produced by porphyrins,and the detection signals can be obtained by the emission of the afterglow Eu^(3+)-emissive ***-NP can achieve high-sensitivity detection of porphyrin,and the lowest detection limit reaches 0.29μmol/*** porphyrin detection in whole blood samples is consistent with clinical diagnosis *** with the organic afterglow molecule,the Eu-NPs constructed in this work show a higher signal-to-noise ratio and sensitivity of porphyria detection.