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AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation

SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 281页

作者： Dai, Dan-ling Xie, Chu Zhong, Lan-Yi liu, Shang-Xin Zhang, Le-Le Zhang, Hua Wu, Xing-Ping Wu, Zhou-Ming Kang, Kexin li, Yan Sun, Ya-Meng Xia, Tian-liang Zhang, Chen-Song Zhang, Ao Shi, Ming Sun, Cong Chen, Mei-ling Zhao, Ge-Xin Bu, Guo-Long liu, Yuan-Tao Huang, kui-Yuan Zhao, Zheng li, Shu-Xin Zhang, Xiao-Yong Yuan, Yun-Fei Wen, Shi-Jun Zhang, lingqiang li, bin-kui Zhong, Qian Zeng, Mu-Sheng Sun Yat Sen Univ Guangdong Prov Clin Res Ctr Canc Dept Expt Res State Key Lab Oncol South ChinaCanc Ctr Guangzhou Peoples R China Sun Yat sen Univ Sch Med Shenzhen Key Lab Syst Med inflammatory Dis Shenzhen Campus Shenzhen Guangdong Peoples R China Sun Yat sen Univ Collaborat Innovat Ctr Canc Med Dept Clin Lab State Key Lab Oncol South ChinaCanc CtrGuangdong Guangzhou Peoples R China Tsinghua Univ Tsinghua Peking Ctr Life Sci Sch Life Sci State Key Lab Membrane Biol Beijing Peoples R China Sun Yat Sen Univ Guangdong Prov Clin Res Ctr Canc Dept Pathol State Key Lab Oncol South ChinaCanc Ctr Guangzhou Peoples R China Xiamen Univ Sch Life Sci State Key Lab Cellular Stress Biol Xiamen Fujian Peoples R China Sun Yat Sen Univ Guangdong Prov Clin Res Ctr Canc Dept Liver Surg State Key Lab Oncol South ChinaCanc Ctr Guangzhou Peoples R China Sun Yat sen Univ Guangdong Prov Clin Res Ctr Canc Dept Nucl Med State Key Lab Oncol South ChinaCanc Ctr Guangzhou Peoples R China Southern Med Univ Guangdong Prov Key Lab Viral Hepatitis Res State Key Lab Organ Failure Res Dept Infect DisNanfang Hosp Guangzhou Peoples R China Sun Yat sen Univ Med Synthet Chem Ctr Guangdong Prov Clin Res Ctr Canc Dept Expt ResCanc Ctr Guangzhou Peoples R China Beijing Inst lifeom Natl Ctr Prot Sci Beijing State Key Lab Med Prote Beijing Peoples R China

Axis inhibition protein 1 (AXIN1), a scaffold protein interacting with various critical molecules, plays a vital role in determining cell fate. However, its impact on the antiviral innate immune response remains largely unknown. Here, we identify that AXIN1 acts as an effective regulator of antiviral innate immunity against both DNA and RNA virus infections. In the resting state, AXIN1 maintains the stability of the transcription factor interferon regulatory factor 3 (IRF3) by preventing p62-mediated autophagic degradation of IRF3. This is achieved by recruiting ubiquitin-specific peptidase 35 (USP35), which removes lysine (K) 48-linked ubiquitination at IRF3 K366. Upon virus infection, AXIN1 undergoes a phase separation triggered by phosphorylated TANK-binding kinase 1 (TBK1). This leads to increased phosphorylation of IRF3 and a boost in IFN-I production. Moreover, KYA1797K, a small molecule that binds to the AXIN1 RGS domain, enhances the AXIN1-IRF3 interaction and promotes the elimination of various highly pathogenic viruses. Clinically, patients with HBV-associated hepatocellular carcinoma (HCC) who show reduced AXIN1 expression in pericarcinoma tissues have low overall and disease-free survival rates, as well as higher HBV levels in their blood. Overall, our findings reveal how AXIN1 regulates IRF3 signaling and phase separation-mediated antiviral immune responses, underscoring the potential of the AXIN1 agonist KYA1797K as an effective antiviral agent.

关键词： IRF3 immunity separation

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变速超空泡航行体壳结构的动力响应分析

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振动与冲击 2013年第4期32卷 138-141页

作者：李魁彬王安稳邓磊海军工程大学理学院武汉430033

通过对变速超空泡水下航行体壳结构受力模型的分析,建立了恒定推力下航行体的平面运动方程,确定了变速过程中的阻力和冲击力。利用有限元方法,进行了结构响应计算,分析了减速过程中节点时域上的最大应力值在轴向的分布情况及典型节点处... 详细信息

通过对变速超空泡水下航行体壳结构受力模型的分析,建立了恒定推力下航行体的平面运动方程,确定了变速过程中的阻力和冲击力。利用有限元方法,进行了结构响应计算,分析了减速过程中节点时域上的最大应力值在轴向的分布情况及典型节点处的响应。结果表明:航行体所需推力和所受应力较大,对其结构强度要求较高;运动过程中,节点时域上的最大应力在空间域上的极大值主要分布在首尾端部和柱壳中部;存在一些振动频率对航行体结构响应影响显著。结果对超空泡航行体壳结构受力和强度分析以及优化设计有着重要的指导意义。

关键词：变速运动超空泡航行体有限元法动力响应

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LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma

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World Journal of Gastroenterology 2010年第16期16卷 2046-2054页

作者： Huang, Guo-liang li, bin-kui Zhang, Mei-Yin Zhang, Hui-Zhong Wei, Rong-Rong Yuan, Yun-Fei Shi, Ming Chen, Xiao-Qian Huang, Long li, An-Hua Huang, Bi-Jun li, Hong-Hua Wang, Hui-Yun Sun Yat Sen Univ Ctr Canc State Key Lab Oncol S China Guangzhou 510060 Guangdong Peoples R China Sun Yat Sen Univ Ctr Canc Dept Hepatobiliary Oncol Guangzhou 510060 Guangdong Peoples R China Sun Yat Sen Univ Ctr Canc Dept Pathology Guangzhou 510060 Guangdong Peoples R China Sun Yat Sen Univ Ctr Canc Dept Ultrasound & Electrocardiogram Guangzhou 510060 Guangdong Peoples R China UMDNJ Robert Wood Johnson Med Sch Canc Inst New Jersey Dept Microbiol Mol Genet & Immunol Piscataway NJ 08854 USA

AIM:To investigate genes around the locus D4S2964 affected by loss of heterozygosity(LOH) and their clinical ***:Four hundred and forty single nucleotide polymorphisms(SNPs) located at 49 genes around D4S2964 were selected from the National Center for Biotechnology Information website for the SNPs microarray *** of SNPs markers in 112 cases of hepatocellular carcinoma(HCC) tissues and paired adjacent liver tissues were investigated by the SNPs *** correlation between allelic losses with clinicopathological features and overall survival was ***:A f ine map of LOH of SNPs in genes around D4S2964 was *** average frequency of LOH in genes was 0.39.A correlation between cirrhosis and the FAL index(fractional allelic loss) was found(P = 0.0202).Larger tumor size was found to be signif icantly associated with LOH in genes ADP-ribosyltransferase 3(ART3),nucleoporin 54 kDa(NUP54),scavenger receptor class B,member 2(SCARB2) and coiled-coil domain containing 158(CCDC158)(P = 0.043,P = 0.019,P = 0.001,P = 0.037,respectively).Kaplan-Meier analysis showed that patients with LOH in ARD1 homolog B(ARD1B) and septin 11(SEPT11) had a significantly lower survival rate than those with retention(P = 0.021 and P = 0.004,respectively).A Cox regression model suggested that LOH in ARD1B and SEPT11,respectively,were predictors of the overall survival in HCC(P = 0.006 and P = 0.026,respectively).CONCLUSION:LOH in genes around D4S2964 may play an important role in HCC development and *** in ARD1B and SEPT11 could serve as novel prognostic predictors in HCC patients.

关键词： ARD1 homolog B Hepatocellular carcinoma Loss of heterozygosity Septin 11 Single nucleotide polymorphism

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Resistance of Cement-based Grouting Materials with Nano- SiO_(2) Emulsion to Chloride Ion Penetration

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 114-119页

作者： li Shuiping CHENG Jian WEI Chao YUAN bin YU Chengxiao College of Architectural Science and Engineering Yangzhou UniversityYangzhou 225127China

The chloride penetration resistance of cement-based grout materials was improved by nano-silica *** of mixtures containing different nano-silica particles or emulsions were exposed in sodium chloride solutions of specific concentrations with different test *** properties of the mixes were assessed in terms of weight loss and compressive strength.X-ray diffraction(XRD)and scanning electron microscopy(SEM)of mixes were performed to analysis the phase evolution and *** results demonstrated that the introduction of nano-SiO_(2) emulsion significantly decreased the compressive strength loss and calcium hydroxide(CH)crystal content of hydration production,and then enhanced the resistance of cement-based grouting materials to chloride ion *** improvement derives from the filling and pozzolanic effects of nano-SiO_(2) particles,which were incorporated via an emulsion and attributed to a well dispersion in grouting matrix.

关键词： grouting materials nano-SiO_(2)emulsion chloride ion penetration,weight loss strength loss

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方孔蜂窝夹层板在爆炸载荷下的吸能特性

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振动与冲击 2012年第17期31卷 186-189页

作者：邓磊王安稳毛柳伟李魁彬海军工程大学理学院武汉430033

通过有限元数值模拟方法,对方孔蜂窝夹层板在爆炸冲击载荷下的变形机理和吸能特性进行了分析。在单位面积质量以及夹层板芯层薄壁间距、高度给定的情况下,通过对不同夹芯层相对密度下夹层板的吸能率以及上、下面板最大变形的比较,得出... 详细信息

通过有限元数值模拟方法,对方孔蜂窝夹层板在爆炸冲击载荷下的变形机理和吸能特性进行了分析。在单位面积质量以及夹层板芯层薄壁间距、高度给定的情况下,通过对不同夹芯层相对密度下夹层板的吸能率以及上、下面板最大变形的比较,得出了最优的夹芯层相对密度。在此相对密度下,夹芯层吸能率最高,下面板变形最小,夹层板的抗冲击性能最优。同时还讨论了夹层板芯层薄壁间距、厚度、高度以及面板厚度对其各部分吸能率的影响,以得到最优化的夹层板结构。

关键词：夹层板爆炸载荷能量吸收有限元模拟

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Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai Shan Guoliang li Xuechun Chen Wen Zhao bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

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Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin Chen Jinghong Xu bin Jiang Lei li Yawei li Yuliang Dai bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

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复合材料层合板的动力响应和横向应力分析

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船舶力学 2008年第5期12卷 778-784页

作者：胡明勇王安稳姜伟李魁彬海军工程大学船舶与动力学院武汉430033 海军工程大学理学院武汉430033 海军航空工程学院青岛分院航空机械系青岛266041

基于分层理论并在板厚方取二次位移插值函数推导出正交层合板的动力学方程,得到了简支层合板的振动频率,且能够计算出协调的横向应力。在低阶模态振动下,横向剪应力是造成层合板脱层的主要原因;而在高阶模态振动下,横向正应力在脱层破... 详细信息

基于分层理论并在板厚方取二次位移插值函数推导出正交层合板的动力学方程,得到了简支层合板的振动频率,且能够计算出协调的横向应力。在低阶模态振动下,横向剪应力是造成层合板脱层的主要原因;而在高阶模态振动下,横向正应力在脱层破坏中起主要作用。采用适当模量材料的层合板能有效地降低横向应力,特别是横向正应力。结果表明文中所采用的算法、算式及所编写的程序是可靠的。

关键词：分层理论振动频率层间应力动力响应

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基于Logvinovich原理射弹超空泡形态解析解研究

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弹道学报 2013年第1期25卷 103-106页

作者：李魁彬王安稳施连会邓磊海军工程大学理学院武汉430033

为快捷、简便地分析运动射弹的超空泡形态,利用Logvinovich原理、Riabouchinsky空泡闭合模型和射弹动力学方程,推导了射弹运动过程中空泡形态解析解和空泡参数的计算公式,得到了自然超空泡扩展的一些规律。计算结果与经验公式比较,吻合... 详细信息

为快捷、简便地分析运动射弹的超空泡形态,利用Logvinovich原理、Riabouchinsky空泡闭合模型和射弹动力学方程,推导了射弹运动过程中空泡形态解析解和空泡参数的计算公式,得到了自然超空泡扩展的一些规律。计算结果与经验公式比较,吻合较好。算例分析表明:首尾压差对射弹速度影响较小,当射弹速度不小于100m/s,射弹在水中的深度不大于100m时,压差的影响可以忽略;完整空泡扩展时间非常短,且随着射弹运动时间增大而减小,逐渐趋于平缓;空泡数0.06、射弹速度60m/s左右时,超空泡开始蜕化为局部空泡。

关键词：超空泡射弹独立性原理空泡形态解析解

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超空泡航行体刚柔耦合动力响应有限元分析

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海军工程大学学报 2015年第2期27卷 20-23,56页

作者：苗海李魁彬孙炜邓磊海军工程大学动力工程学院武汉430033 海军指挥学院后勤与装备系南京210016

考虑航行体大范围转动,根据哈密顿原理推导了超空泡航行体在一次近似模型变形下的刚柔耦合动力响应方程,定性分析了其与零次近似模型下方程的区别,并对方程进行了定量计算。结果表明:一次近似模型相比零次近似模型下的横向振动方程,刚... 详细信息

考虑航行体大范围转动,根据哈密顿原理推导了超空泡航行体在一次近似模型变形下的刚柔耦合动力响应方程,定性分析了其与零次近似模型下方程的区别,并对方程进行了定量计算。结果表明:一次近似模型相比零次近似模型下的横向振动方程,刚度矩阵项增大;所推导方程能够用于定量分析和直观描述超空泡航行体刚柔耦合下的变形。

关键词：超空泡水下航行体有限元刚柔动力性

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