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CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1029-1045页

作者： Wen-Qian Ma Ming-Chang Miao Ping-An Ding Bi-Bo Tan Wen-Bo liu Shuo Guo li-mian Er Zhi-Dong Zhang Qun Zhao Department of Endoscopy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer Shijiazhuang 050011Hebei ProvinceChina Department of Radiotherapy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Third Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND CALD1 has been discovered to be abnormally expressed in a variety of malignant tumors,including gastric cancer(GC),and is associated with tumor progression and immune infiltration;however,the roles and mechanisms of CALD1 in epithe-lial-mesenchymal transition(EMT)in GC are *** To investigate the role and mechanism of CALD1 in GC progression,invasion,and *** In this study,the relationship between CALD1 and GC,as well as the possible network regulatory mechanisms of CALD1,was investigated by bioinformatics and validated by ***1-siRNA was synthesized and used to trans-fect GC *** activity was measured using the CCK-8 method,cell migration and invasive ability were measured using wound healing assay and Transwell assay,and the expression levels of relevant genes and proteins in each group of cells were measured using qRT-PCR and Western blot.A GC cell xenograft model RESULTS Bioinformatics results showed that CALD1 was highly expressed in GC tissues,and CALD1 was significantly higher in EMT-type GC tissues than in tissues of other types of *** prognosis of patients with high expression of CALD1 was worse than that of patients with low expression,and a prognostic model was constructed and *** experimental results were consistent with the results of the bioinformatics *** expression level of CALD1 in GC cell lines was all higher than that in gastric epithelial cell line GES-1,with the strongest expression found in AGS and MKN45 *** activity was significantly reduced after CALD1-siRNA trans-fection of AGS and MKN45 *** ability of AGS and MKN45 cells to migrate and invade was reduced after CALD1-siRNA transfection,and the related mRNA and protein expression was *** to bioinfor-matics findings in GC samples,the CALD1 gene was significantly associated with the expression of members of the PI3K-AKT-mTOR signaling pathway as well as the EMT signaling pathway,and was closely rel

关键词： Gastric tumor CALD1 Epithelial-mesenchymal transition Gene disruption Invasion Migration Bioinformatics

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“双减”背景下中小学办学质量评价体系构建

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中国考试 2024年第3期 28-36页

作者：李勉北京师范大学北京100875

将“双减”政策要求转化为中小学办学质量评价内容并建立与之相适应的评价机制,是当前教育评价改革面临的一项重要课题。学校办学质量评价应遵循质量为本、注重增值、尊重差异、多元参与的原则,通过细化指标形成测评点、研发适用于不同... 详细信息

将“双减”政策要求转化为中小学办学质量评价内容并建立与之相适应的评价机制,是当前教育评价改革面临的一项重要课题。学校办学质量评价应遵循质量为本、注重增值、尊重差异、多元参与的原则,通过细化指标形成测评点、研发适用于不同主体的测评工具、确定评价标准、构建学校办学质量指数等技术路径开展评价;同时还要建立政府部门协同联动、专业机构提供支撑、学校积极参与的组织管理机制,构建评价—反馈—改进—追踪的政策闭环,发挥以评促建的作用。

关键词：教育评价学校评价学校办学质量 “双减”政策教育指数

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无机材料的“化学剪刀”结构编辑策略

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无机材料学报 2024年第2期39卷 115-128页

作者：丁浩明陈科李勉李友兵柴之芳黄庆中国科学院宁波材料技术与工程研究所先进能源材料工程实验室宁波315201 宁波杭州湾新材料研究院宁波315336 苏州大学苏州医学院放射医学与防护学院苏州215123

受到生物基因工程中“基因剪刀”的启发,“化学剪刀”作为一种重要的研究工具在材料结构编辑及应用研究中发挥着重要作用。本文对“化学剪刀”在材料结构编辑及应用方面的研究进展进行了评述。首先,介绍了“化学剪刀”的概念和基本原理... 详细信息

受到生物基因工程中“基因剪刀”的启发,“化学剪刀”作为一种重要的研究工具在材料结构编辑及应用研究中发挥着重要作用。本文对“化学剪刀”在材料结构编辑及应用方面的研究进展进行了评述。首先,介绍了“化学剪刀”的概念和基本原理,即指在保持初始材料主结构不变的条件下,通过化学反应敲除、置换、修复或重构目标原子或结构单元,从而定制化编辑材料晶格中的组成元素、晶体结构以及微观形貌,最终实现特定的材料结构与功能。随后,详细回顾了“化学剪刀”在材料结构编辑中的具体应用,即如何利用化学剪切、化学修饰、化学合成和化学刻蚀与化学插层等结构编辑方法对材料结构进行精确调控和功能设计。最后,对“化学剪刀”未来在材料结构编辑及应用的研究方向进行了展望。本评述详细介绍了“化学剪刀”在材料结构编辑及应用研究方面的研究进展和巨大潜力,为探索和开发“化学剪刀”在材料领域的应用提供了有力的理论和实验支撑,并有望推动相关材料领域的发展。

关键词：化学剪刀无机材料结构编辑专题评述

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Early-life famine exposure,adulthood obesity patterns,and risk of low-energy fracture

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Frontiers of Medicine 2024年第1期18卷 192-203页

作者： Hongyan Qi Chunyan Hu Jie Zhang lin lin Shuangyuan Wang Hong lin Xiaojing Jia Yuanyue Zhu Yi Zhang Xueyan Wu mian li Min Xu Yu Xu Tiange Wang Zhiyun Zhao Weiqing Wang Yufang Bi Meng Dai Yuhong Chen Jieli Lu Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People’s Republic of ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China

Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains *** study included 5323 community-dwelling subjects aged⩾40 years from ***-life famine exposure was identified based on the participants’birth *** obesity was assessed using the body mass index(BMI),and abdominal obesity was evaluated with the waist-to-hip ratio(WHR).Low-energy fracture was defined as fracture occurring after the age of⩾40 typically caused by falls from standing height or *** to the nonexposed group,the group with fetal,childhood,and adolescence famine exposure was associated with an increased risk of fracture in women with odds ratios(ORs)and 95%confidence intervals(CIs)of 3.55(1.57–8.05),3.90(1.57–9.71),and 3.53(1.05–11.88),respectively,but not in *** interactions were observed between fetal famine exposure and general obesity with fracture among women(P for interaction=0.0008).Furthermore,compared with the groups with normal BMI and WHR,the group of women who underwent fetal famine exposure and had both general and abdominal obesity had the highest risk of fracture(OR,95%CI:3.32,1.17–9.40).These results indicate that early-life famine exposure interacts with adulthood general obesity and significantly increases the risk of low-energy fracture later in life in women.

关键词： famine obesity body mass index waist-to-hip ratio low-energy fracture

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国际教育质量测评项目的数字化进展

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比较教育学报 2024年第3期 89-100页

作者：李勉葛兴蕾北京师范大学中国基础教育质量监测协同创新中心北京100875 北京航空航天大学人文社会科学学院北京航空航天大学民族教育质量监测研究基地北京100191

借鉴国际先进经验创新测评技术方法、推进我国教育质量监测的数字化发展是当前深化教育评价改革的必然要求。通过对PISA、NAEP、TIMSS等国际教育质量测评项目分析发现,其在数字化方面呈现出如下特点:采用情境化、交互式、自适应工具设计... 详细信息

借鉴国际先进经验创新测评技术方法、推进我国教育质量监测的数字化发展是当前深化教育评价改革的必然要求。通过对PISA、NAEP、TIMSS等国际教育质量测评项目分析发现,其在数字化方面呈现出如下特点:采用情境化、交互式、自适应工具设计,提供数字工具辅助学生作答,深入测查学生的高阶认知能力;借助自动化程序和数据管理系统实施自动评分、数据清理和质量控制,提高数据管理的效率和质量;分析学生过程性数据,揭示学生认知过程中的“黑箱”;基于读者的个性需求,有针对性地呈现测评结果,提高数据结果的可视化程度。借鉴国际测评经验,建议我国教育质量监测推进人机交互式测评任务的研发,加强数字化测评的基础性研究;发挥我国特色领域的数字化测评技术优势,利用人工智能及其协同技术推动数据分析方法的更新;加强监测结果报告的顶层设计,探索自动化、可视化的监测结果呈现形式。

关键词：数字化数字化测评教育质量监测

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英格兰基础教育增值评价的发展与经验

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清华大学教育研究 2024年第4期45卷 121-130页

作者：王亚玲李勉北京外国语大学国际教育学院北京师范大学中国基础教育质量监测协同创新中心

增值评价作为衡量学校效能更为公平合理的方法，已被多个国家用于深化基础教育改革。英格兰在基础教育增值评价上积累了二十余年的理论与实践经验，先后经历了简单增值评价、背景性增值评价、预期进步评价和进步评价四个发展阶段。英格... 详细信息

增值评价作为衡量学校效能更为公平合理的方法，已被多个国家用于深化基础教育改革。英格兰在基础教育增值评价上积累了二十余年的理论与实践经验，先后经历了简单增值评价、背景性增值评价、预期进步评价和进步评价四个发展阶段。英格兰增值评价的主要特点包括：坚持评价初衷，把握技术理性；关注核心要义，变化比较对象；取舍复杂算法，平衡社会效益；强化教育问责，督促学校改进。我国增值评价的开展可借鉴英格兰的经验，在国家层面做好增值评价实施的统筹规划，鼓励地方组织试点；基于区域教育质量监测积累增值数据，逐步建立符合中国实际的增值数据系统；确保增值评价技术方法的科学性，同时兼顾现实可操作性；强化增值评价的诊断功能，做好面向学校、教师、家长等群体的宣传普及和培训工作。

关键词：增值评价基础教育学校效能英格兰

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乡村振兴背景下湖南省农民大学生创新创业系统的政策保障研究

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湖北开放职业学院学报 2024年第13期37卷 17-19,36页

作者：李冕湖南开放大学湖南长沙410004

近年来,乡村创新创业日益成为国家创新转型战略的重要“战场”。大学生通过乡村振兴政策参与农村经济发展,实现社会价值,有关部门在充分落实相关政策扶持措施的同时,为大学生创业群体提供广阔的平台。湖南省农民大学生创新创业是近年来... 详细信息

近年来,乡村创新创业日益成为国家创新转型战略的重要“战场”。大学生通过乡村振兴政策参与农村经济发展,实现社会价值,有关部门在充分落实相关政策扶持措施的同时,为大学生创业群体提供广阔的平台。湖南省农民大学生创新创业是近年来得到广泛关注和支持的一项工作。农民大学生作为优秀农村青年的代表,具备自主创新和创业的潜力和动力。本文分析了乡村振兴背景下湖南省农民大学生创新创业中政府政策的支持和落实情况,以及目前农民大学生所面临的优势与困难。然后,进一步研究农民大学生创新创业政策保障。如此,既能缓解当前农村科技创新人才短缺的局面,又能改善农民大学生就业创业的出路,也是加快建设和发展社会主义新农村的新途径。

关键词：乡村振兴农民大学生乡村经济创新创业政策

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“互联网+”赋能农民大学生创新创业的机制与策略

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继续教育研究 2024年第11期 81-85页

作者：李冕湖南开放大学马克思主义学院湖南长沙410004

基于“互联网+”先进理念与技术,探索建立农民大学生创新创业的赋能机制,以期建立和完善针对农民大学生的创新创业体系及其支持措施,解决当前农民大学生创新创业活动存在的各类问题,从而提升农民大学生创新创业的成功率,全面推进乡村振... 详细信息

基于“互联网+”先进理念与技术,探索建立农民大学生创新创业的赋能机制,以期建立和完善针对农民大学生的创新创业体系及其支持措施,解决当前农民大学生创新创业活动存在的各类问题,从而提升农民大学生创新创业的成功率,全面推进乡村振兴战略。研究发现:(1)“互联网+”时代农民大学生创新创业需求集中在三个方面,即信息技术与网络平台的应用创新、新型业态与产业模式的探索创新、政策支持与资源整合的服务创新;(2)结合“互联网+”时代特点与乡村振兴战略推进方向,综合考虑政府部门、高校、社会团体、行业企业等多方主体利益联结关系,构建一个包含政策引领、能力提升、资源汇聚与服务配套等多个层面的创新创业机制;(3)科学提出政府、高校与社会等三个层面的提升策略,即强化政策引导与主体联结作用、完善产教融合与产学研用体系、建立资源共享与双创赋能机制。

关键词： “互联网+” 农民大学生创新创业机制

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Concomitant and sequential administration of nirmatrelvir-ritonavir and azvudine in patients with COVID-19 caused by the Omicron variant: Safety and efficacy

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iLABMED 2024年第2期2卷 88-97页

作者： Guang-Bin Chen You-Rou Zheng Yun-Ni Yu li-mian liang Chao Chen Ying-Xia liu Hong-Zhou Lu Department of Clinical Pharmacy Third People's Hospital of ShenzhenShenzhenGuangdongChina National Clinical Research Center for Infectious Diseases Division of Infectious DiseasesThe Third People's Hospital of ShenzhenShenzhenGuangdongChina

Background:This study assessed the safety and efficacy of nirmatrelvir-ritonavir(Paxlovid®)and azvudine when administered sequentially or concomitantly in patients with coronavirus 2019(COVID-19)caused by the Omicron ***:Ninety-three patients confirmed to be infected with the Omicron variant by nucleic acid detection were retrospectively ***-tion was collected on general health status,medication,and adverse drug reactions(ADRs)according to whether nirmatrelvir-ritonavir and azvudine were administered sequentially or *** on times of onset,clinical manifestations,and outcomes of ADRs and on conversion to a nega-tive nucleic acid test were also ***:Possible ADRs were recorded in 41 patients(44.1%).There were 22 gastrointestinal reactions in 18 patients and 18 hematological abnormalities in 16 after sequential or concomitant treatment with nirmatrelvir-ritonavir and *** enzyme levels increased in nine cases and creatinine clearance decreased in *** of atrial fibrillation(n=1),sleep disorder(n=2),rash(n=2),dizziness(n=1),and weakness(n=5)were also *** vomiting,poor appetite,diarrhea,xerostomia,bitter taste,and rash were considered probable ADRs;others were thought to be possible *** all cases,the nucleic acid test did not turn negative after the first antiviral was *** nucleic acid test of 28 patients did not turn negative before *** remaining 65 patients(69.9%)returned a negative nucleic acid test after receiving the second antiviral ***:Treatment with nirmatrelvir-ritonavir and azvudine is safe and effective whether administered sequentially or concomitantly in patients with COVID-19 caused by the Omicron variant.

关键词： adverse drug reactions azvudine efficacy nirmatrelvir-ritonavir Omicron variant safety

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Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

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Frontiers of Medicine 2024年第2期18卷 303-314页

作者： Yi Ding Xiaoli Xu Zhuojun Xin Qiuyu Cao Jiaojiao Huang Xianglin Wu Yanan Huo Qin Wan Yingfen Qin Ruying Hu lixin Shi Qing Su Xuefeng Yu li Yan Guijun Qin Xulei Tang Gang Chen Min Xu Tiange Wang Zhiyun Zhao Zhengnan Gao Guixia Wang Feixia Shen Zuojie Luo li Chen Qiang li Zhen Ye Yinfei Zhang Chao liu Youmin Wang Tao Yang Huacong Deng Lulu Chen Tianshu Zeng Jiajun Zhao Yiming Mu Shengli Wu Yuhong Chen Jieli Lu Weiqing Wang Guang Ning Yu Xu Yufang Bi mian li Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang330000China Department of Endocrinology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310000China Department of Endocrinology Affiliated Hospital of Guiyang Medical UniversityGuiyang550000China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200000China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou510000China Department of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Endocrinology The First Hospital of Lanzhou UniversityLanzhou730000China Fujian Provincial Hospital Fujian Medical UniversityFuzhou350000China Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian116000China Department of Endocrinology The First Hospital of Jilin UniversityChangchun130000China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Qilu Hospital of Shandong University Jinan250000China Department of Endocrinology The Second Affiliated Hospital of Harbin Medical UniversityHarbin150000China Department of Endocrinology Cen

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with *** included 104538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life *** isotemporal substitution models,we found that substituting 1 h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD ***-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working *** stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long *** pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active *** U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical *** divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

关键词： sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern

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