检索结果-南通市图书馆

Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei liu dai li Xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

引用

Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan liao Zhenyu Yin Xintong Ge dai li Rongrong Zhong Qiang liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic output feedback control of systems with event-driven control inputs

引用

Science China(Information Sciences) 2020年第5期63卷 24-37页

作者： Jinhui ZHANG Hao XU li dai Yuanqing XIA School of Automation Beijing Institute of Technology

In this paper, a dynamic output feedback control problem is investigated for systems with eventdriven control inputs. With both continuous and sampled output measurements in the systems, two types of dynamic output feedback controllers are designed based on a predefined event-driven scheduler for the control signals, respectively. With the proposed event-driven control scheme, the Zeno behavior can be avoided, and the states of closed-loop systems are also guaranteed to be globally uniformly ultimately bounded. Detailed parameters of the event-driven controllers are constructed under the stabilizable conditions of the closedloop systems. Finally, both the effectiveness and merits of the proposed design techniques are verified by the numerical examples.

关键词： networked control systems NCSs event-driven control dynamic output feedback control

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Finite-Time Stabilization for Constrained Discrete-time Systems by Using Model Predictive Control

引用

IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1656-1666页

作者： Bing Zhu Xiaozhuoer Yuan li dai Zhiwen Qiang IEEE the Seventh Research Division Beihang UniversityBeijing 100191China the School of Automation Beijing Institute of TechnologyBeijing 100081China

In this paper, a model predictive control(MPC)framework is proposed for finite-time stabilization of linear and nonlinear discrete-time systems subject to state and control constraints. The proposed MPC framework guarantees the finite-time convergence property by assigning the control horizon equal to the dimension of the overall system, and only penalizing the terminal cost in the optimization, where the stage costs are not penalized explicitly. A terminal inequality constraint is added to guarantee the feasibility and stability of the closed-loop *** feasibility can be improved via augmentation. The finite-time convergence of the proposed MPC is proved theoretically,and is supported by simulation examples.

关键词： Constraints deadbeat control finite-time stabilization model predictive control(MPC)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental investigation on the gravity driven discharge of cohesive particles from a silo with two outlets

引用

Particuology 2024年第6期89卷 11-21页

作者： li dai Zhulin Yuan Fengxian Fan Conghui Gu School of Energy and Power Engineering University of Shanghai for Science and TechnologyShanghai 200093China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China Shanghai Key Laboratory of Multiphase Flow and Heat Transfer in Power Engineering University of Shanghai for Science and TechnologyShanghai 200093China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212100China

An experimental study on the gravity driven discharge of cohesive particles from a silo with two outlets was *** discharge behaviors under the conditions that a single outlet was open and two outlets were open were investigated by varying the moisture content of the particles and the filling height of the particles in the *** results show that the discharge rate of the cohesive particles increases gradually at the beginning,then almost keeps constant,and finally drops *** discharge rate in case of two openings is around 1.1–1.6 times that in case of a single *** filling height leads to lower discharge rate in case of a single opening but results in higher discharge rate in case of two ***,the avalanche dynamics in case of a single opening was examined,and the mixing behavior of the cohesive particles was *** is observed that the discharge flow is promoted by the avalanche phenomenon in the silo,generating a general trend that the normalized mass of discharge increases with the filling height at higher moisture *** case of a single opening,the transition from mass flow to funnel flow favors the particle mixing,resulting in an increasing mixing index as the moisture content *** general,a better performance of mixing can be achieved in case of a single opening compared with in case of two *** study provides vital information for fundamental understanding of the gravity driven discharge of cohesive particles from the silo with multiple outlets.

关键词： Cohesive particles Moisture content Discharge rate Avalanche Mixing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Auditory-model-based Feature Extraction Method for Mechanical Faults Diagnosis

引用

Chinese Journal of Mechanical Engineering 2010年第3期23卷 391-397页

作者： li Yungong ZHANG Jinping dai li ZHANG Zhanyi liU Jie Sehool of Mechanical Engineering and Automation Northeastern University Shenyang 110004 China School of Mechanical Engineering Shenyang University of Chemical Technology Shenyang 110142 China

It is well known that the human auditory system possesses remarkable capabilities to analyze and identify signals. Therefore, it would be significant to build an auditory model based on the mechanism of human auditory systems, which may improve the effects of mechanical signal analysis and enrich the methods of mechanical faults features extraction. However the existing methods are all based on explicit senses of mathematics or physics, and have some shortages on distinguishing different faults, stability, and suppressing the disturbance noise, etc. For the purpose of improving the performances of the work of feature extraction, an auditory model, early auditory（EA） model, is introduced for the first time. This auditory model transforms time domain signal into auditory spectrum via bandpass filtering, nonlinear compressing, and lateral inhibiting by simulating the principle of the human auditory system. The EA model is developed with the Gammatone filterbank as the basilar membrane. According to the characteristics of vibration signals, a method is proposed for determining the parameter of inner hair cells model of EA model. The performance of EA model is evaluated through experiments on four rotor faults, including misalignment, rotor-to-stator rubbing, oil film whirl, and pedestal looseness. The results show that the auditory spectrum, output of EA model, can effectively distinguish different faults with satisfactory stability and has the ability to suppress the disturbance noise. Then, it is feasible to apply auditory model, as a new method, to the feature extraction for mechanical faults diagnosis with effect.

关键词： faults diagnosis feature extraction auditory model early auditory model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Flocculation process of fine-grained sediments by the combined effect of salinity and humus in the Changjiang Estuary

引用

Acta Oceanologica Sinica 2007年第1期26卷 140-149页

作者： liU Qizhen li Jiufa dai Zhijun li Daoji State Key Laboratory of Estuarine and Coastal Research East China Normal University Shanghai 200062 China

For the great amount of organic compounds and the variation of salinity in the Changjiang Estuary, the study on the flocculation process of fine-grained sediments by the combined effect of salinity and humus in the high-turbid system is of critical significance for the understanding of the mechanism of the formation of the turbidity maximum （TM） . For the great amount of organic compounds and the variation of salinity in the Changjiang Estuary, the study on the flocculation process of fine-grained sediments by the combined effect of salinity and humus in the high-turbid system is of critical significance for the understanding of the mechanism of the formation of the turbidity maximum （TM） . The effects of salinity and humus on the fine-grained sediments have been analyzed through the synthetic study of the aspects of flocculation/coagulation power （ F）, diameter （D） and zeta potential （Z）. And the microcosmic configuration of the flocs has been analyzed by using a scan electron microscope and Fourier Transform Infrared Spectrometry. The results show that：（ 1 ） with the increase of salinity, F and D become greater and Z becomes smaller, and with the increase of the concentration of humus, F becomes smaller, but D and Z become greater; （2） the microcosmic configuration of the flocculation shows that humus packs on the fine sediments in the form of salt, and the flocculation model of C - P - OM （C stands for clay; P cations; OM organic materials） can successfully demonstrate the mechanism of the formation of the finegrained sediments in the high-turbid area of the Changjiang Estuary.

关键词： Changjiang Estuary fine-grained sediment floceulation salinity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Complete Composition Tunability of Cu(Ni)-Ti-Zr Alloys for Bulk Metallic Glass Formation

引用

Journal of Materials Science & Technology 2009年第1期25卷 39-47页

作者： Ze-xiu Zhang Chun-li dai Jian Xu Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences 72 Wenhua Road Shenyang 110016 China

In the Cu-Zr-Ti ternary system, a new composition zone of bulk metallic glasses （BMGs） formation was discovered, locating at the 55-57 at. pct Cu, 30-31 at. pct Ti and 13-14 at. pct Zr, and near Cu-Ti binary subsystem rather than the Cu-Zr binary. For these alloys, BMG rods of 2 mm in diameter can be fabricated by using copper mould casting. It is expected that these 13MG-forming alloys correlate with （L →CuTi＋Cu2TiZr＋Cu51Zr14） eutectic reaction that the undercooled melt undergoes during solidification. Adopting ＂3D pinpointing approach＂, compositional dependence of glass-forming ability （GFA） in Cu（Ni）-Ti-Zr pseudo ternary system was revisited. Optimized BMG-forming composition is located at Cu50.4Ni5.6Ti31Zr13, with a critical diameter of 6 mm for complete BMG formation. Its GFA is significantly superior to Vit 101 （Cu47Ni8Ti34Zr11） previously developed by Caltech group. The effect that the GFA of the ternary base alloy was improved by substitution of Ni for Cu is attributed to a role of retarding the crystallization of Cu51Zr14 intermetallics.

关键词： Bulk metallic glasses Amorphous alloys Eutectic Copper

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Design and preliminary experimental investigation of a 4K Stirling-type pulse tube cryocooler with precooling

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第9期10卷 1277-1284页

作者： Zhi-hua GAN Zhuo-pei li Jie CHEN li dai li-min QIU Institute of Refrigeration and Cryogenics Zhejiang University Hangzhou 310027 China

A Stirling-type pulse tube cryocooler （PTC） with precooling was designed and manufactured to investigate its performance at 4 K. Numerical simulation was carried out based on the well-known regenerator model REGEN with an emphasis on the performance of a 4 K stage regenerator of the Stifling-type PTC as influenced by the warm end temperature, pressure ratio, frequency and average pressure with helium-4 and helium-3 as the working fluid respectively. This study demonstrates that the use of a cold inertance tube can significantly improve the efficiency of a 4 K Stirling-type PTC. A preliminary experimental investigation was carried out with helium-4 as the working fluid and a refrigeration temperature of 4.23 K was achieved. The experimental results show that the operating frequency has a significant influence on the performance of the Stirling-type PTC and a relatively low average pressure is favorable for decreasing the loss associated with the real gas effects of a 4 K Stirling-type PTC.

关键词： Stirling-type pulse tube cryocooler (PTC) Regenerator Helium-3 Cold inertance tube 4 K

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermal Characterization and Decomposition Kinetics of Free Anthraquinones from Rhubarb

引用

Chinese Chemical Letters 2006年第5期17卷 699-702页

作者： li Ming ZHANG Xia li Yu Jie dai College of Bioengineering Tianjin University of Science ＆ Technology Tianjin 300222

The thermal behaviour of aloe-emodin, chrysophanol and physcion and their kinetics have been investigated under non-isothermal conditions by means of differential thermal analysis （DTA） and thermogravimetry （TG）. The thermal characteristics have been determined using the DTA and TG-DTG curves. The non-isothermal kinetic data were analyzed by means of the Achar method and the Madhusudanan-Krishnan-Ninan （MKN） method. The possible reaction mechanisms have been investigated by comparing the kinetic parameters. The kinetic equation for aloe-emodin, chrysophanol and physcion can be expressed as dα/dt=Aexp（-E/RT）1/3（1-α）[-In（1-α]2. The activation energy E （kJ mol^-1） of the three free anthraquinones are 78.09, 89.54, and 107.5 and their InA/s^-1 are 22.98, 36.85 and 43.60, respectively.

关键词： Aloe-emodin chrysophanol physcion thermogravimetry (TG) differential thermoanalysis (DTA) non-isothermal kinetics.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：