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Chalcone derivatives as novel,potent and selective inhibitors against human Notum:Structure–activity relationships and biological evaluations

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Chinese Chemical Letters 2024年第3期35卷 321-325页

作者： jin-Hui Shi Bei Zhao li-lin Song Yu-qing Song Meng-Ru Sun Tian Tian Hong-Yu Chen Yun-qing Song Jian-Ming Sun Guang-Bo Ge Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Dalian Engineering Research Center for Carbohydrate Agricultural Preparations Liaoning Provincial Key Laboratory of CarbohydratesDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine Shanghai 200137China

Human Notum(hNotum)inhibitors could be used for treating Wnt signalling-associated diseases including colorectal ***,two series of chalcone derivatives were designed and synthesized aiming to find selective and potent hNotum ***–activity relationship(SAR)studies showed that 2-methoxyl and 5-bromine substitutions on A-ring significantly enhanced anti-hNotum effect,while 4’-ethoxyl and 3’-alkyl substitutions on B-ring were beneficial for hNotum *** all tested chalcones,B11 displayed the most potent anti-Notum effect(IC_(50)=3.6 nmol/L),good selectivity,excellent chemical stability and suitable metabolic *** investigations showed that B11 acted as a competitive inhibitor of hNotum,while this agent(5μmol/L)significantly weaken the migration abilities of colorectal cancer ***,this study deciphers the SARs of chalcones as hNotum inhibitors and reports a novel and potent hNotum inhibitor with the anti-migration effect on colorectal cancer cells,which offers a promising lead compound to develop novel anti-cancer agents.

关键词： Human notum(hNotum) Chalcone Computer-assisted drug discovery Structure–activity relationship(SAR) Anti-colorectal cancer agent

Dt1-SWEET10a partner:Photoperiodic control of seed weight in soybean

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Molecular Plant 2024年第6期17卷 839-841页

作者： li-qing Chen Lalit Dev Tiwari Department of Plant Biology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA DOE Center for Advanced Bioenergy and Bioproducts Innovation University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Institute for Sustainability Energyand EnvironmentUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Seed weight and size are critical agronomic traits essential for determining yield and composition,receiving significant attention throughout domestication(Meyer et al.,2012).Seed weight serves as a reliable indicator of average seed size due to their positive *** of seed weight involves both developmental and environmental cues,affecting cell proliferation or expansion(li et al.,2019).

关键词： soybean SWEET1 weight

Recent progress on the synthesis of defective UiO-66 for thermal catalysis

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Nano Research 2024年第10期17卷 8653-8670页

作者： qing Feng Caoyu Yang lin Chang Guodong li Zhiyong Tang CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China

Zirconium terephthalate UiO-66 has aroused great interest in catalysis since it exhibits significant flexibility and compatibility for accommodating a high number of defects as well as exceptional thermal and chemical *** now,many works have focused on the modulations of the Zr6-oxo clusters in UiO-66 in terms of diverse synthesis,advanced characterizations,and their catalytic *** achieve high catalytic efficiency,it is still highly desired for rationally constructing and modulating the Zr6-oxo clusters with exposed catalytic sites and diverse microenvironments for advanced *** this review,we provide a comprehensive summary of recent progress on the synthesis of defective UiO-66,qualitative and quantitative characterizations,as well as a logical overview of heterogeneous catalytic applications over the past few ***,the outlooks for the research paradigm of defective UiO-66 are discussed.

关键词： defective UiO-66 de novo synthesis post-synthetic treatment characterization thermal catalysis

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一套红外池测定精四氯化钛中二氯氧钛的含量

光谱学与光谱分析 2015年第12期35卷 3427-3430页

作者：宋光林罗运军李晋庆李青谭红北京理工大学材料学院北京100081 贵州省分析测试研究院贵州贵阳550002

钛材质量控制的关键是控制精TiCl_4中杂质含量。精TiCl_4是海绵钛生产的关键环节,海绵钛中杂质与精TiCl4中杂质含量成4倍富集关系。需要分析氧杂质的来源,对精TiCl_4中氧杂质进行严格控制。精TiCl_4中TiOCl_2含量的测定具有重要意义。Ti... 详细信息

钛材质量控制的关键是控制精TiCl_4中杂质含量。精TiCl_4是海绵钛生产的关键环节,海绵钛中杂质与精TiCl4中杂质含量成4倍富集关系。需要分析氧杂质的来源,对精TiCl_4中氧杂质进行严格控制。精TiCl_4中TiOCl_2含量的测定具有重要意义。TiOCl2具有红外吸收谱线,因而能够利用红外光谱实现测定,然而精TiCl_4与空气中水气接触极易发生水解反应,生成强腐蚀性的盐酸烟雾,不能使用常规的红外吸收池进行测定。根据Lambert-Beer定律,被测组分浓度(cx)与吸光度(A)~样品光程(L)曲线的斜率成正比,利用波长范围7 800~440cm^(-1)的硒化锌窗片(Φ10×1mm)和玻璃池体(22,12,7和4mm光程)组装成一套红外吸收池,采用加标法测定精TiCl_4中TiOCl_2杂质含量。实验得出TiOCl_2的检出限为17.8mg·kg^(-1),样品回归方程Y=1.0118 X,相关系数r为0.996 3,加标TiOCl_2样品的回归方程Y=1.940 0 X,相关系数r为0.997 0,线性关系较好。测定精TiCl4中TiOCl_2含量为833.8 mg·kg^(-1),标准偏差(SD)为40.0 mg·kg^(-1),方法精密度相对标准偏差(RSD)在0.95~1.94之间,加标回收率在88.5%~93.1%之间。此红外吸收池安全简便、容易拆洗、可重复使用,通过一次加标样品定量分析精TiCl_4中TiOCl_2含量,可满足精TiCl_4中TiOCl_2分析的要求。

关键词：红外池测定四氯化钛二氯氧钛

Exceptional points enhance sensing in silicon micromechanical resonators

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Microsystems & Nanoengineering 2024年第1期10卷 17-25页

作者： Man-Na Zhang Lei Dong li-Feng Wang qing-An Huang Key Laboratory of MEMS of the Ministry of Education Southeast UniversityNanjing 210096China

Exceptional points(EPs)have recently emerged as a new method for engineering the response of open physical systems,that is,systems that interact with the *** systems at the EPs exhibit a strong response to a small ***,we show a method by which the sensitivity of silicon resonant sensors can be enhanced when operated at *** our experiments,we use a pair of mechanically coupled silicon micromechanical resonators constituting a parity-time(PT)-symmetric *** perturbations introduced on the mechanically coupled spring cause the frequency to split from the EPs into the PT-symmetric regime without broadening the two spectrum linewidths,and this frequency splitting scales with the square root of the perturbation *** overall signal-tonoise ratio is still greatly enhanced,although the measured noise spectral density of the EP sensing scheme has a slight increase comparable to the traditional *** results pave the way for resonant sensors with ultrahigh sensitivity.

关键词： resonant symmetric points

Day-ahead P2P Energy Sharing Strategy Among Energy Hubs Considering Flexibility of Energy Storage and Loads

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1105-1118页

作者： Penghua li Wanxing Sheng qing Duan Jun liang Cunhao Zhu China Electric Power Research Institute Beijing 100192China School of Engineering Cardiff UniversityUK IEEE

Multi-energy systems are one of the key technologies to tackle energy crisis and environmental *** energy hub(EH)is a minimum multi-energy *** of multiple EHs through energy routers(ERs)can realize mutual energy *** paper proposes a peer-to-peer(P2P)energy sharing strategy between EHs including ERs in an interconnected system,which is divided into two *** the lower level,a method of determining the charging/discharging constraints of energy storage devices is *** on the Lyapunov optimization method,virtual queues are used to model the energy storage devices and flexible loads in the *** objective is to minimize the overall operating cost of the interconnected *** the upper level,a non-cooperative game model is introduced to minimize the cost of purchasing power from other EHs for each EH.A best response-based method is adapted to find the Nash *** simulation outcomes demonstrate that application of the proposed strategy can reduce operating costs of an interconnected system and each *** basis of a real-world dataset of interconnected EHs,both analytical and numerical results show the effectiveness of the proposed strategy.

关键词： Energy hub energy router Lyapunov optimization non-cooperative game peer to peer virtual queue

Dual template-induced construction of three-dimensional porous SiO2/NC/Co-CNTs heterostructure with highly dispersed active sites for efficient oxygen evolution reaction

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Tungsten 2024年第3期6卷 585-595页

作者： Hai-Qi Zhang Xiao-Jun Zeng qing-qing Zhang Zu-liang Zhang Chu-Long jin Rong-Hai Yu School of Materials Science and Engineering Jingdezhen Ceramic University School of Materials Science and Engineering Beihang University

The development and exploration of efficient and economical electrocatalysts for oxygen evolution reaction（OER） represents the main bottleneck to unlocking a sustainable energy scenario based on elec trocataly tic water *** scale integration of three-dimensional（3D） porous heterostructure with highly dispersed active sites and good structural stability is ***,a dual template route is developed to construct the 3D porous SiO2/nitrogen-doped carbon（NC）/Co-carbon nano tubes（CNTs） hetero ***,the hard template（SiO2nano spheres） contributes to 3D porous structure,increases the specific surface area,and promotes the contact area of the *** the same time,the soft template（basic zinc carbonate） can control the growth of 1D CNTs and facilitate the exposure of the active ***,3D porous SiO2/NC/Co-CNTs hetero structure inherits highly dispersed Co nanoparticles coated by *** conductive channels and abundant N hetero atoms doping are reasonably constructed by a dual template ***,SiO2/NC/Co-CNTs catalyst provides an extraordinary activity for the OER in alkaline media,with a low overpotential of 298 mV at a current density of 10 mA·***,SiO2/NC/Co-CNTs hetero structure enables excellent long-term durability with a 10 mV decay in overpotential after 3000 cyclic voltammetry cycles,and 97% remain in current density over 20 *** is believed that this dual template strategy can provide a new and simple way to construct a highly dispersed active site in electrocatalysts.

关键词： Dual template High dispersion Porous heterostructure Conductive channels Oxygen evolution reaction

Optimal Strategy for Aircraft Pursuit-evasion Games via Self-play Iteration

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Machine Intelligence Research 2024年第3期21卷 585-596页

作者： Xin Wang qing-Lai Wei Tao li Jie Zhang State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing100049China Institute of Systems Engineering Macao University of Science and TechnologyMacao999078China

In this paper,the pursuit-evasion game with state and control constraints is solved to achieve the Nash equilibrium of both the pursuer and the evader with an iterative self-play *** the condition where the Hamiltonian formed by means of Pontryagin’s maximum principle has the unique solution,it can be proven that the iterative control law converges to the Nash equilibrium ***,the strong nonlinearity of the ordinary differential equations formulated by Pontryagin’s maximum principle makes the control policy difficult to figured *** the system dynamics employed in this manuscript contains a high dimensional state vector with *** practical applications,such as the control of aircraft,the provided overload is ***,in this paper,we consider the optimal strategy of pursuit-evasion games with constant constraint on the control,while some state vectors are restricted by the function of the *** address the challenges,the optimal control problems are transformed into nonlinear programming problems through the direct collocation ***,two numerical cases of the aircraft pursuit-evasion scenario are given to demonstrate the effectiveness of the presented method to obtain the optimal control of both the pursuer and the evader.

关键词： Differential games pursuit-evasion games nonlinear control optimal control Nash equilibrium solution

The prognostic value of collateral circulation in coronary chronic total occlusion underwent percutaneous coronary intervention

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Journal of Geriatric Cardiology 2024年第2期21卷 232-241页

作者： Xiao-Ying HU Wei-Xian YANG Chang-Dong GUAN li-Hua XIE Ke-Fei DOU Yong-Jian WU jin-qing YUAN Jie QIAN Yue-jin YANG Shu-Bin QIAO Lei SONG Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina National Clinical Research Center for Cardiovascular Diseases BeijingChina Catheterization Laboratories Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

BACKGROUND The prognostic value of coronary collateral circulation(CC)in patients undergoing chronic total occlusion(CTO)percutaneous coronary intervention(PCI)is *** purpose of the study was to assess the prognostic value of current two CC grading systems and their association with long-term outcomes in patients with CTO underwent *** We consecutively enrolled patients with single-vessel CTO underwent PCI between January 2010 and *** patients were categorized into well-developed or poor-developed collaterals group according to angiographic Werner's CC(grade 2 *** 0–1)or Rentrop(grade 3 *** 0–2)grading *** primary endpoint was 5-year cardiac *** Of 2452 enrolled patients,the overall technical success rate was 74.1%.Well-developed collaterals were present in686 patients(28.0%)defined by Werner's CC grade 2,and in 1145 patients(46.7%)by Rentrop grade *** to Werner's CC grading system,patients with well-developed collaterals had a lower rate of 5-year cardiac death compared with those with poordeveloped collaterals(1.6%vs.3.3%,P=0.02),those with suboptimal recanalization was associated with higher rate of 5-year cardiac death compared with optimal recanalization(4.7%vs.0.8%,P=0.01)and failure patients(4.7%vs.1.6%,P=0.12).However,the similar effect was not shown in Rentrop grading *** In patients with the single-vessel CTO underwent PCI,well-developed collaterals by Werner's CC definition were associated with lower rate of 5-year cardiac ***'s CC grading system had a greater prognostic value than Rentrop grading system in patients with CTO underwent PCI.

关键词： coronary collateral occlusion