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医学生不确定心理压力对学习成绩的影响——基于全国50所大学的实证研究

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中国高等医学教育 2023年第12期 60-63页

作者：章伟芳戴佳丹王慧慧陈乐怡蒋姝函杨廷忠浙江大学医学院附属口腔医院浙江大学口腔医学院浙江省口腔疾病临床医学研究中心浙江省口腔生物医学研究重点实验室浙江大学癌症研究院口腔生物材料与器械浙江省工程研究中心浙江杭州310000 浙江中医药大学人文与管理学院浙江杭州311402 浙江大学医学院附属妇产科医院浙江杭州310006

目的:旨在探讨不确定性压力对大学生学习成绩的影响。方法:研究样本为11954名医科大学生,他们系从50所大学多阶段抽样调查获取。数据分析采用未调整和调整logistic回归方法。结果:学习成绩不良率为15.1%。多元分析显示不确定心理压力对... 详细信息

目的:旨在探讨不确定性压力对大学生学习成绩的影响。方法:研究样本为11954名医科大学生,他们系从50所大学多阶段抽样调查获取。数据分析采用未调整和调整logistic回归方法。结果:学习成绩不良率为15.1%。多元分析显示不确定心理压力对学习具有显著影响。结论:本研究提供了不确定心理压力对于学习成绩影响的直接证据。这一信息有助于考虑处理学生学习问题的政策和干预。

关键词：学习成绩不确定心理压力医学生

Robust n-type doping of WSe2 enabled by controllable proton irradiation

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Nano Research 2023年第1期16卷 1220-1227页

作者： Haidong Liang Yue Zheng leyi Loh Zehua Hu Qijie Liang cheng Han Michel Bosman Wei chen Andrew A.Bettiol Centre for Ion Beam Applications(CIBA) Department of PhysicsNational University of SingaporeSingapore 117542Singapore International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China Department of Physics National University of SingaporeSingapore 117551Singapore Department of Materials Science and Engineering National University of SingaporeSingapore 117575Singapore Department of Chemistry National University of SingaporeSingapore 117543Singapore Division of Physics and Applied Physics School of Physical and Mathematical ScienceNanyang Technological UniversitySingapore 637371Singapore Songshan Lake Materials Laboratory Songshan Lake Mat LabDongguan 523808China National University of Singapore(Suzhou)Research Institute 377 Lin Quan StreetSuzhou Industrial ParkSuzhou 215123China

Two-dimensional(2D)transition metal dichalcogenides(TMDs)are considered to be promising building blocks for the next generation electronic and optoelectronic *** doping schemes and work function engineering techniques have been explored to overcome the intrinsic performance limits of 2D ***,a reliable and long-time air stable doping scheme is still lacking in this *** this work,we utilize keV ion beams of H2+to irradiate layered WSe2 crystals and obtain efficient n-type doping effect for all irradiated crystals within a fluence of 1×1014 protons·cm−2(1e14).Moreover,the irradiated WSe2 remains an n-type semiconductor even after it is exposed to ambient conditions for a *** ion irradiation with a focused beam can directly pattern on the sample to make high performance homogenous p-n junction *** and photoluminescence(PL)spectra demonstrate that the WSe2 crystal lattice stays intact after irradiation within *** attribute the reliable electrondoping to the significant increase in Se vacancies after the proton irradiation,which is confirmed by our scanning transmission electron microscope(STEM)*** work demonstrates a reliable and long-term air stable n-type doping scheme to realize high-performance electronic TMD devices,which is also suitable for further integration with other 2D devices.

关键词： WSe2 proton beam irradiation n-type doping long-time air stable Se vacancies

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颈项功治疗颈型颈椎病60例的疗效观察

中医临床研究 2024年第3期16卷 82-85页

作者：陈佳费乐怡余谦单婉青吕立江浙江中医药大学浙江杭州310053

目的:通过对颈型颈椎病患者进行锻炼干预,比较颈项功和常规米字操治疗颈型颈椎病的临床疗效及对颈痛、压痛阈(Pressure Pain Threshold,PPT)的影响。方法:选择2020年11―12月浙江中医药大学纳入的60例颈型颈椎病患者,应用随机数字表法... 详细信息

目的:通过对颈型颈椎病患者进行锻炼干预,比较颈项功和常规米字操治疗颈型颈椎病的临床疗效及对颈痛、压痛阈(Pressure Pain Threshold,PPT)的影响。方法:选择2020年11―12月浙江中医药大学纳入的60例颈型颈椎病患者,应用随机数字表法将60例颈型颈椎病患者分为功法组和常规米字操组,每组各30例。功法组患者采用功法“仙鹤点水”锻炼,常规米字操组患者采用常规米字操锻炼,两组患者每天早晚各锻炼1次,以锻炼4周为一个疗程。锻炼前对两组患者进行压痛点筛查,结果得到两组患者压痛点多在肩井穴和C3夹脊穴,并以此作为PPT值的采集点。观察各组患者在锻炼前后的视觉模拟评分法(Visual Analogue Scale,VAS)评分、Northwick Park颈痛量表(Northwick Park Neck-pain Questionnaire,NPQ)评分及肩井穴和C3夹脊穴的PPT值,并综合评定各组的临床疗效。结果:锻炼4周后两组患者的VAS评分和NPQ评分均较锻炼前降低(P 0.05)。功法组的总有效率为86.67%(26/30),优于常规米字操组的63.33%(19/30)(P <0.05)。结论:功法和常规米字操均能改善颈型颈椎病患者的颈部疼痛和压痛,但功法的疗效更加显著。

关键词：颈椎病功法颈痛量表评分压痛阈视觉模拟评分法评分

叠后地质统计学反演在H地区储层预测中的应用

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石油地质与工程 2024年第3期38卷 36-41页

作者：刘灵徐乐意陈人杰朱焕谢雨邴琦杨帆中海石油(中国)有限公司深圳分公司研究院广东深圳518054

H地区A3层是珠江口盆地惠州凹陷寻找岩性圈闭最有利的地区之一,但A3层砂岩厚度薄,叠后地震资料和常规叠后确定性反演结果纵向分辨率低,难以准确识别砂岩的尖灭位置和平面展布。采用叠后地质统计学反演方法,利用地质、测井、地震等信息... 详细信息

H地区A3层是珠江口盆地惠州凹陷寻找岩性圈闭最有利的地区之一,但A3层砂岩厚度薄,叠后地震资料和常规叠后确定性反演结果纵向分辨率低,难以准确识别砂岩的尖灭位置和平面展布。采用叠后地质统计学反演方法,利用地质、测井、地震等信息和贝叶斯概率密度函数建立统计学模型,同时结合马尔科夫链-蒙特卡洛算法进行随机模拟,得到了高精度、高分辨率的反演阻抗体和岩性体;相比于常规确定性反演,地质统计学反演结果高频细节更清晰,分辨率提高了一倍,有效识别出了A3层薄层砂岩的走向和尖灭位置,为H地区岩性油藏的储层预测提供了重要依据。

关键词：地质统计学反演贝叶斯理论 MCMC随机模拟薄层砂体识别

Development of 3-mercaptopropyltrimethoxysilane(MPTS)-modified bone marrow mononuclear cell membrane chromatography for screening anti-osteoporosis components from Scutellariae Radix

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Acta Pharmaceutica Sinica B 2020年第10期10卷 1856-1865页

作者： Yanqiu Gu Xiao chen Yao Wang Yue Liu leyi Zheng Xiaoqun Li Rong Wang Shaozhan Wang Shengnan Li Yifeng Chai Jiacan Su Yongfang Yuan Xiaofei chen Department of Pharmacy Shanghai Ninth People’s HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 201999China School of Pharmacy Second Military Medical UniversityShanghai 200433China Department of Orthopedic Trauma Shanghai Changhai HospitalSecond Military Medical UniversityShanghai 200433China

Osteoporosis is a bone metabolic disease caused by the imbalance between osteoblasts and osteoclasts due to excess osteoclastogenesis,manifesting in the decrease of bone density and bone *** Radix shows good anti-osteoporosis activity,but the effective component is still *** membrane chromatography(CMC)is a biological affinity chromatography with membrane immobilized on a silica carrier as the stationary *** can realize a dynamical simulation of interactions between drugs and receptors on cell membrane,which is suitable for screening active compounds from complex *** this study,the components of Scutellariae Radix with potential anti-osteoporosis activity through inhibiting the differentiation from bone marrow mononuclear cells(BMMCs)to osteoclast were screened by a BMMC/CMC analytical ***,a new3-mercaptopropyltrimethoxysilane(MPTS)-modified BMMC/CMC stationary phase was developed to realize covalent binding with cell membrane *** investigating the retention time(tR)of the positive drug,the life span of the MPTS-modified CMC columns was significantly improved from 3 to 12 ***,6 components of Scutellariae Radix were screened to show affinity to membrane receptors on BMMCs by a two-dimensional BMMC/CMC-TOFMS analytical *** them,tectochrysin demonstrated the best anti-osteoporosis effect in vitro,which has never been *** found that tectochrysin could inhibit the differentiation of BMMCs into osteoclasts induced by receptor activator of nuclear factor-κB ligand(RANKL)and macrophage colony-stimulating factor(M-CSF)in a concentration-dependent manner in *** vivo,it significantly reduced the loss of bone trabeculae in ovariectomized mice,and decreased the level of C-terminal cross-linking telopeptides of type 1 collagen(CTX-1),tartrate-resistant acid phosphatase 5 b(TRAP-5 b),interleukin 6(IL-6)in *** conclusion,tectochrysin serves as a potential candidate in the treatment of os

关键词： 3-Mercaptopropyltrimethoxysilane-modifiedsilica Two-dimensional cell membrane chromatography Scutellariae Radix Anti-osteoporosis Tectochrysin

Bilirubin inhibits the anticancer activity of sorafenib by blocking MCL-1 degradation in hepatocellular carcinoma cells

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Cancer Biology & Medicine 2022年第7期19卷 1061-1077页

作者： leyi Yao Qian Zhao Ding Yan Ziying Lei Yali Hao Jinghong chen Qian Xue Xiaofen Li Qingtian Huang Daolin Tang QPing Dou Xin chen Jinbao Liu Affiliated Cancer Hospital&Institute of Guangzhou Medical University Guangzhou 510095China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation State Key Laboratory of Respiratory DiseaseSchool of Basic Medical SciencesGuangzhou Medical UniversityGuangzhou 511436China Institute of Digestive Disease of Guangzhou Medical University The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518China School of Public Health Guangzhou Medical UniversityGuangzhou511436China Department of Surgery UT Southwestern Medical CenterDallasTX 75390USA Barbara Ann Karmanos Cancer Institute and Departments of Oncology Pharmacology&PathologySchool of MedicineWayne State UniversityDetroitMI 48201USA

Objective:Sorafenib is a first-line drug for advanced hepatocellular carcinoma(HCC).Unfortunately,most patients with HCC do not respond to sorafenib,mainly because of the frequent development of drug *** is an end metabolite of heme catabolism and an indicator of liver function,but its direct role in regulating the anticancer activity of sorafenib in HCC cells is *** the current study,we aimed to investigate the mechanism of action of bilirubin in sorafenib-mediated tumor suppression in ***:A retrospective observational cohort of 100 patients receiving sorafenib was conducted to evaluate the potential role of bilirubin in predicting the prognosis of patients with *** HCC cell lines were treated with sorafenib in the absence or presence of bilirubin,and cell proliferation,apoptosis,and signaling pathways were *** antagonistic effect of bilirubin toward sorafenib was assessed in nude mice bearing HCC ***:Serum levels of bilirubin(including total,direct,and indirect bilirubin)negatively correlated with the overall survival of patients with HCC treated with sorafenib(P<0.05).Both in vitro and in vivo analyses demonstrated that bilirubin significantly abrogated sorafenib-mediated proliferation inhibition and apoptosis induction in HCC cells(P<0.05).Mechanically,bilirubin inhibited sorafenib-induced activation of GSK-3βand subsequent downstream MCL-1 ***:Our study provides experimental evidence of the antagonistic effect of bilirubin toward sorafenib-mediated anticancer activity in HCC,and it suggests that bilirubin could be used to predict the efficacy of sorafenib treatment.

关键词： Apoptosis bilirubin hepatocellular carcinoma MCL-1 sorafenib

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半干旱区2种雪茄烟叶发酵后差异代谢物分析

干旱地区农业研究 2024年第4期42卷 22-28页

作者：陆岸芷张乐毅王平平陈新颖杜姗姗李先锋王辉张强艾绥龙张立新西北农林科技大学生命科学学院陕西杨凌712100 陕西省烟草科学研究所陕西西安710000 陕西省烟草公司汉中市公司陕西汉中723000

通过比较2个雪茄品种‘海研103’和‘青雪204’发酵后烟叶的代谢产物,探究不同品种烟叶间代谢组的差异。采用超高效液相色谱-四极杆飞行时间质谱联用技术(UHPLC-QTOF-MS),对2个雪茄品种烟叶化学成分进行了非靶向代谢组学分析。结果表明... 详细信息

通过比较2个雪茄品种‘海研103’和‘青雪204’发酵后烟叶的代谢产物,探究不同品种烟叶间代谢组的差异。采用超高效液相色谱-四极杆飞行时间质谱联用技术(UHPLC-QTOF-MS),对2个雪茄品种烟叶化学成分进行了非靶向代谢组学分析。结果表明:‘海研103’和‘青雪204’的代谢物相对含量存在明显差异。2个雪茄品种烟叶共筛选鉴定出179个差异代谢物,‘海研103’较‘青雪204’有114个代谢物显著上调,有65个显著下调。对前40个主要差异代谢物用PLS-DA法进行分析,鉴定为有机酸10种、氨基酸7种、酚酸类4种、核苷酸及类似物4种、碳水化合物3种、黄酮类3种、木脂素和香豆素3种,其他6种。结合KEGG通路分析,发现12条2个品种显著富集的代谢通路。

关键词：雪茄品种烟叶非靶向代谢组学差异代谢物半干旱区

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Controlling phase transition in WSe_(2) towards ideal n-type transistor

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Nano Research 2021年第8期14卷 2703-2710页

作者： Yue Zheng Du Xiang Jialin Zhang Rui Guo Wenhui Wang Tao Liu leyi Loh Yanan Wang Jing Gao cheng Han Michel Bosman Zhenhua Ni Wei chen SZU-NUS Collaborative Innovation Center for Optoelectronic Science&Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationInstitute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China Department of Physics National University of SingaporeSingapore 117551Singapore Department of Chemistry National University of SingaporeSingapore 117543Singapore School of Physics and the Key Laboratory of MEMS of the Ministry of Education Southeast UniversityNanjing 210096China Department of Materials Science and Engineering National University of Singapore Singapore 117575Singapore Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207China National University of Singapore(Suzhou)Research Institute 377Lin Quan StreetSuzhou Industrial ParkSuzhou 215123China

Two-dimensional(2D)transition metal dichalcogenides(TMDs)have been rapidly established as promising building blocks for versatile atomic scale circuits and multifunctional ***,the high contact resistance in TMDs based transistors seriously hinders their applications in complementary *** this work,we show that an Ohmic homojunction n-type tungsten diselenide(WSe_(2))transistor is realized through spatially controlling cesium(Cs)doping region near the *** find that the remarkable electron doping effect of Cs stimulates a semiconductor to metal(2H to 1T')phase transition in WSe_(2),and hence the formation of 2H-1T’hetero-phase *** method significantly optimizes the WSe_(2) transport behavior with a perfect low subthreshold swing of-61 mV/dec and ultrahigh current on/off ratio exceeding-10^(9).Meanwhile,the electron mobility is enhanced by nearly 50 *** elucidate that the ideal n-type behavior originates from the negligible Schottky barrier height of~19 meV and low contact resistance of-0.9Ωk·μm in the 2H-1T’homojunction ***,based on the Ohmic hetero-phase configuration,a WSe_(2) inverter is achieved with a high gain of~270 and low power consumption of-28 *** findings envision Cs functionalization as an effective method to realize ideal Ohmic contact in 2D WSe_(2) transistors towards high performance complementary electronic devices.

关键词： WSe_(2) Cs intercalation semiconductor to metal phase transition ideal hetero-phase transistor high gain homo-inverter

Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis

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International Journal of Oral Science 2023年第3期15卷 489-501页

作者： Jianfan chen Xueqing Xu Song chen Ting Lu Yingchun Zheng Zhongzhi Gan Zongrui Shen Shunfei Ma Duocai Wang leyi Su Fei He Xuan Shang Huiyong Xu Dong chen Leitao Zhang Fu Xiong Department of Medical Genetics Experimental Education/Administration CenterSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Experimental Department of Obstetrics and Gynecology Institute The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Precision Medicine Shenzhen HospitalSouthern Medical UniversityShenzhenChina Department of Stomatology Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Stomatology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Guangdong Provincial Key Laboratory of Single Cell Technology and Application GuangzhouChina Department of Fetal Medicine and Prenatal Diagnosis Zhujiang HospitalSouthern Medical UniversityGuangzhouChina

Hereditary gingival fibromatosis(HGF)is a rare inherited condition with fibromatoid hyperplasia of the gingival tissue that exhibits great genetic *** distinct loci related to non-syndromic HGF have been identified;however,only two diseasecausing genes,SOS1 and REST,inducing HGF have been identified at two loci,GINGF1 and GINGF5,***,based on a family pedigree with 26 members,including nine patients with HGF,we identified double heterozygous pathogenic mutations in the ZNF513(c.C748T,p.R250W)and KIF3C(c.G1229A,p.R410H)genes within the GINGF3 locus related to *** studies demonstrated that the ZNF513 p.R250W and KIF3C p.R410H variants significantly increased the expression of ZNF513 and KIF3C in vitro and in ***513,a transcription factor,binds to KIF3C exon 1 and participates in the positive regulation of KIF3C expression in gingival ***,a knock-in mouse model confirmed that heterozygous or homozygous mutations within Zfp513(p.R250W)or Kif3c(p.R412H)alone do not led to clear phenotypes with gingival fibromatosis,whereas the double mutations led to gingival hyperplasia *** addition,we found that ZNF513 binds to the SOS1 promoter and plays an important positive role in regulating the expression of ***,the KIF3C p.R410H mutation could activate the PI3K and KCNQ1 potassium ***513 combined with KIF3C regulates gingival fibroblast proliferation,migration,and fibrosis response via the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK *** summary,these results demonstrate ZNF513+KIF3C as an important genetic combination in HGF manifestation and suggest that ZNF513 mutation may be a major risk factor for HGF.

关键词： gingival KIF hereditary