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Crowdfunding Effort Identifies the Causative Mutation in a Patient with Nystagmus,Microcephaly,Dystonia and Hypomyelination

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Journal of Genetics and Genomics 2015年第2期42卷 79-81页

作者： Ofer Isakov Dorit lev Lubov Blumkin Gershon Celniker Esther Leshinsky-Silver Noam Shomron Sackler School of Medicine Tel Aviv University Metabolic-Neurogenetic Clinic Wolfson Medical Center Institute of Medical Genetics Wolfson Medical Center Pediatric Neurology Unit Wolfson Medical Center Molecular Genetic Laboratory Wolfson Medical Center

Crowdfunding refers to the online gathering of finance via numerous small donations from individual supporters （the ＂crowd＂） in order to fund a service, project or cause from various fields including business, arts, medicine and science （Sisler, 2012; Cameron et al., 2013; Weigmann, 2013; Wheat et al., 2013）. Crowdfunding platforms facilitate the interaction between organizations soliciting funding for their projects and the people who wish to support them. As prices of molecular testing plummet, utilizing crowdfunding in order to support genetic research becomes increasingly feasible （Cameron et al., 2013）. Whole Exome Sequencing （WES） has been used extensively for the purpose of identifying the genetic cause of rare mendelian diseases, uncovering novel mutations in previously implicated genes or identifying new disease- causing genes （Ng et al., 2009; Bamshad et al., 2011; Gilissen et al., 2011）.

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The Siberian Craton and its evolution in terms of the Rodinia hypothesis

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Episodes 2006年第3期29卷 169-174页

作者： Dmitry Gladkochub Sergei Pisarevsky Tatiana Donskaya lev Natapov Anatoliy Mazukabzov Arkadiy Stanevich Eugene Sklyarov Institute of the Earth＇s Crust Siberian Branch Russian Academy of Science Lermontov Ave. 128 664033 Irkutsk Russia Tectonics Special Research Centre School of Earth and Geographical Sciences The University of Western Australia 35 Stirling Highway Crawley WA 6009 Australia GEMOS ARC Key Centre Department of Earth and Planetary Sciences Macquarie University Sydney NSW 2109 Australia

Recent geochronological studies in southern Siberia support a Siberian assembly between 2.1 and 1.8 Ga. This broadly coincides with major orogenic events in most other Precambrian continents including Laurentia. In the Mesoproterozoic, Siberia was mainly an area of stable platform sedimentation whereas Laurentia underwent a continental growth from southeast. Lack of traces of the Grenville orogeny in Siberia suggests its peripheral position in Rodinia. The eastern （Uchur- Maya area） and western （Yenisei area） Siberian margins probably faced oceans during the Meso- and Neoproterozoic. Recent geological, geochronological, geochemical and paleomagnetic data suggest integrity of Siberia and Laurentia in the Meso- and early Neoproterozoic with the Siberian southern margin close to the northern margin of Laurentia. However, some ‘intervening＇ continental blocks were probably located between these two cratons. The 750-720 Ma igneous event was probably related to the rifting between Siberia and Laurentia and the opening of the Paleo-Asian Ocean, causing the development of a passive margin sedimentary succession in southern Siberia.

关键词：西伯利亚地质年代学切向压缩力前寒武纪沉降

Phase transitions and degradation/oxidation mechanisms in lead-free CsSnI_(3) halide perovskites

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Clean Energy 2024年第3期8卷 109-115页

作者： Alexandra Ivanova Margarita Golikova lev Luchnikov Pavel Gostishchev Igor Shetinin Victor Voronov Danila Saranin Vladimir Khovaylo National University of Science and Technology MISIS(NUST MISIS) Leninsky av.4Moscow119049Russia Belgorod State University Pobedy st.85Belgorod308015Russia

Halide perovskites possess ultra-low thermal conductivity and show high potential for thermoelectric *** chemical properties and molecular structure of halide perovskite materials are not completely stable under ambient conditions,which hinders their use in thermoelectric *** in the properties of bulk halide perovskite thermoelectrics are accompanied by partial phase transitions and surface oxidation *** this paper,we conducted a comprehensive study of the transport and structural properties of CsSnI_(3),which were pristine by vacuum melting followed by spark plasma *** research results on the electrical transport of these materials revealed that exposure to an inert atmosphere does not deteriorate stability and the properties of the materials remain ***,prolonged exposure to air leads to a significant degradation of the electrical transport *** to thin-film samples,the shift to the double perovskite structure from the perovskite one is limited to a specific surface *** change significantly influences the electrical transport of the material while maintaining the essential properties of both perovskite types.

关键词： halide perovskites degradation oxidation transport properties surface

Random Search Algorithm for the Generalized Weber Problem

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Journal of Software Engineering and Applications 2012年第12期5卷 59-65页

作者： lev Kazakovtsev Department of Information Technologies Siberian State Aerospace University Krasnoyarsk Russian Federation

In this paper, we consider the planar multi-facility Weber problem with restricted zones and non-Euclidean distances, propose an algorithm based on the probability changing method (special kind of genetic algorithms) and prove its efficiency for approximate solving this problem by replacing the continuous coordinate values by discrete ones. Version of the algorithm for multiprocessor systems is proposed. Experimental results for a high-performance cluster are given.

关键词： Discrete Optimization Weber Problem Random Search Genetic Algorithms Parallel Algorithm

Factors associated with surgery in patients with intra-abdominal fistulizing Crohn's disease

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World Journal of Gastroenterology 2016年第47期22卷 10380-10387页

作者： Shaul Yaari Ariel Benson Eyal Aviran Naama lev Cohain Ran Oren Jacob Sosna Eran Israeli IBD Unit Institute of Gastroenterology and Liver Diseases Hadassah-Hebrew University Medical Center Department of Radiology and Medical Imaging Hadassah-Hebrew University Medical Center

AIM To characterize radiological and clinical factors associated with subsequent surgical intervention in Crohn's disease(CD) patients with intra-abdominal *** From a cohort of 1244 CD patients seen over an eight year period(2006 to 2014), 126 patients were identified as having intra-abdominal fistulae, and included in the study. Baseline patient information was collected from the medical records. Imaging studies were assessed for: anatomic type and number of fistulae; diameter of the inflammatory conglomerate; length of diseased bowel; presence of a stricture with pre-stenotic dilatation; presence of an abscess; lymphadenopathy; and the degree of bowel enhancement. Multivariate analysis for the prediction of abdominal surgery was calculated via Generalized Linear *** In total, there were 193 fistulae in 132 patients, the majority(52%) being entero-enteric. Fifty-nine(47%) patients underwent surgery within one year of the imaging study, of which 36(29%) underwent surgery within one month. Radiologic features that were associated with subsequent surgery included: multiple fistulae(P = 0.009), presence of stricture(P = 0.02), and an entero-vesical fistula(P = 0.01). Evidence of an abscess, lymphadenopathy, or intense bowel enhancement as well as C-reactive protein levels was not associated with an increased rate of surgery. Patients who were treated after the imaging study with combination immunomodulatory and anti-TNF therapy had significantly lower rates of surgery(P = 0.01). In the multivariate analysis, presence of a stricture [RR 4.5(1.23-16.3), P = 0.02] was the only factor that increased surgery *** A bowel stricture is the only factor predicting an increased rate of surgery. Radiological parameters may guide in selecting treatment options in patients with fistulizing CD.

关键词： Crohn’s disease Fistula Cross-sectional imaging Intra-abdominal surgery Magnetic resonance imaging Computed tomography-scan

A Grain as Big as Hen's Egg

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青苹果 2004年第2期 36-38页

作者： lev Tolstoy

One day some children found in a valley a thing shaped like a grain ofCorn but as large as a hen’s egg.A traveller passing by saw the thing,boughtit from the children for a penny,and taking it to town,sold it to the ... 详细信息

关键词： A Grain as Big as Hen’s Egg

Semantic Keys and Reading

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宏观语言学 2016年第2期4卷 1-10页

作者： Zev bar-lev San Diego State University USA

Semantic Keys are elements (word-parts) of written language that give an iconic,general representation of the whole word’s meaning. In written Sino-Japanese the “radical”or semantic components play this role. For example, the character meaning 'woman,female’ is the Semantic Key of the character for Ma 'Mama’ (alongside the phonetic component Ma, which means 'horse’ as a separate character). The theory of semantic Keys in both graphic and phonemic aspects is called qTheory or *** most innovative aspect of the present article is the hypothesis that, in languages using alphabetic writing systems, the role of Semantic Key is played by consonants, more specifically the first consonant. Thus, L meaning 'Lif t ’ is the Semantic Key of English L f,Ladle, Lofty, aLps，elevator，oLympus; Spanish leva, Lecantarse，aLto，Lengua; Arabic aLLah, and Hebrew? aeL-0aL ‘upto-above’ （the Israeli airline), Polish Lot ‘flight’ （the Polish airline); Hebrew aeL, aeLohim ‘God’， and haLLeluyah ‘praise-ye God’ （using Parallels, 'Lift up God’). Evidence for the universality of the theory is shown by many examples drawn from various languages, including Indo-European Semitic, Chinese and Japanese. The theory reveals hundreds of relationships within and between languages,related and unrelated, that have been “Hiding in Plain Sight”, to mention just one example:the Parallel between Spanish Pan 'bread’ and Mandarin Fan 'rice’.

关键词： Lexicon Semantic Theory Key-letters ambiguity

Supersymmetry in the Geometric Representation of the Early Universe Wave Function

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Journal of Modern Physics 2023年第6期14卷 777-789页

作者： Bohdan I. lev Bogolyubov Institute for Theoretical Physics NAS of Ukraine Kyiv Ukraine Condensed Matter Physics Department J. Stefan Institute Ljubljana Slovenia Faculty of Mathematics and Physics University of Ljubljana Ljubljana Slovenia

The main goal of this article is to present a new result of a possible approach to the geometrical description of the birth and evolution of the universe. The novelty of the article is that it is possible to explain the nature of supersymmetry in terms of the geometric representation of the wave function and to propose a mechanism of spontaneous symmetry breaking of the excitation of the universe with different degrees of freedom. It is under such conditions that the well-known spontaneous symmetry breaking occurs and individual excitation acquires mass. At the same time, a phase transition of the first kind occurs with the formation of a new phase.

关键词： Clifford Algebra Wave Function Early Universe Supersymmetry Spontaneous Symmetry Breaking

Dislocations in Cosserat Plates

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Journal of Applied Mathematics and Physics 2022年第11期10卷 3369-3384页

作者： Roman Kvasov lev Steinberg Department of Mathematics University of Puerto Rico at Aguadilla Puerto Rico USA Department of Mathematics University of Puerto Rico at Mayaguez Puerto Rico USA

This article provides the numerical modeling of the dislocations in the Cosserat elastic plates based on the Cosserat Plates Theory developed by the authors. The dislocation is modeled by a sequence of domains that converge to the point of the dislocation and by a residual force distributed around that point. The plate deformation caused by the dislocation is calculated using the Finite Element Method. We also discuss the effect of the dislocation on the cavities present in the Cosserat plates.

关键词： Dislocation Cosserat Plates Cosserat Materials