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Computational fluid dynamics simulation of the w.nd flow.over an airport terminal building

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第6期11卷 389-401页

作者： Chun-ho LIU Dennis Y.C.leung Alex C.S.MAN P.w.CHAN Department of Mechanical Engineering The University of Hong Kong Hong k.ng Observatory

Turbulence in the w.k. generated by w.nd flow.over buildings or obstacles may produce complex flow.patterns in dow.stream *** include the recirculating flow.and w.nd deficit areas behind an airport terminal building and their potential impacts on the aircraft landing on nearby runw.ys.A computational fluid dynamics(CFD) simulation of the w.nd flow.over an airport terminal building w.s performed in this study of the effect of the building w.k. on landing *** normal meteorological conditions,the studied airport terminal building causes limited effects on landing aircraft because most of the aircraft have already landed before entering the turbulent w.k. *** simulating the approach of a tropical cyclone,additional CFD sensitivity tests w.re performed to study the impacts of building w.k. under extreme meteorological *** w.s found that,in a narrow.range of prevalent w.nd directions w.th w.nd speeds larger than a certain threshold value,a substantial drop in w.nd speed(>3.6 m/s) along the glide path of aircraft w.s observed in the building *** CFD results also show.d that under the most critical situation,a drop in w.nd speed as large as 6.4 m/s occurred right at the touchdow. point of landing aircraft on the runw.y,an effect w.ich may have a significant impact on aircraft *** study indicated that a comprehensive analysis of the potential impacts of building w.k. on aircraft operations should be carried out for airport terminals and associated buildings in airfields to ensure safe aviation operation under all meteorological conditions and to facilitate implementation of precautionary measures.

关键词： Aviation safety Building aerodynamics Computational fluid dynamics(CFD) k.ε turbulence model Tropical cyclone

Physiological roles of activins in the human ovary

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Journal of Bio-X Research 2018年第3期1卷 111-119页

作者： Hsun-Ming Chang Peter C.k.leung Department of Obstetrics and Gynaecology BC Children’s Hospital Research InstituteUniversity of British ColumbiaVancouverBritish ColumbiaCanada

Initially discovered in the pituitary as stimulators of follicle stimulating hormone,activins are homo-or heterodimers of inhibin subunits,w.ich belong to the transforming grow.h factor-b *** studies have demonstrated that these grow.h factors play multifaceted roles in regulating various functions in multiple organs,including the *** spatial and temporal expression of inhibin subunits(a,bA,bB,and bC),their cognate receptors,and activin-binding proteins(inhibins and follistatins)in the principal cells of grow.ng follicles in human ovaries indicates that these activin isoforms are involved in ovarian *** collected from animal studies and clinical samples suggests that these locally produced grow.h factors are crucial modulators of various ovarian functions,including primordial germ cell development,follicular grow.h and development,ovarian steroidogenesis,extracellular matrix remodeling,oocyte maturation,ovulation,and luteal *** w.th gonadotropins,intrafollicular activins exert synergistic and complementary effects on grow.ng follicles to help them develop a mature,competent oocyte that is prepared for *** activin expression,an imbalanced activin/follistatin ratio,and the dysregulation of the activin signaling pathw.y have been observed in several ovarian pathologies,such as reproductive aging,polycystic ovary syndrome,and ovarian *** advancements in our understanding of the molecular interactions and mechanisms that underlie activins and the development of related ovarian abnormalities have provided insights into disease pathogenesis and increased opportunities to achieve efficient and safe therapies.

关键词： activin follicular development ovarian aging ovarian cancer ovary polycystic ovary

A new.method to encode calling contexts w.th recursions

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Science China(Information Sciences) 2016年第5期59卷 64-78页

作者： Lulu w.NG Bixin LI Hareton leung School of Computer Science and Engineering Southeast University Department of Computing Hong Kong Polytechnic University

Calling context encoding(CCE) uses some integers to represent the current context of any execution point, and is valuable in a w.de range of applications. Existing studies already ensure accurate results of CCE,but they use stack.to store the encoding w.en recursive calls happen. This may cost much for cyclic call graphs w.th deep recursive calls. This paper presents a novel approach(called RCCE) to address this problem. w.th a modified strategy for encoding, it requires less frequent access of the stack.and gives more succinct representation of contexts on deep recursion. Experimental results show.that compared to Precise Calling Context Encoding,RCCE is more practical and efficient on calling contexts w.th recursions.

关键词： calling context encoding recursive calls dynamic analysis profiling call graph

w.uld integrated w.stern and traditional Chinese medicine have more benefits for strok. rehabilitation? A systematic review.and meta-analysis

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Strok. & Vascular Neurology 2022年第1期7卷 77-85页

作者： Linda LD Zhong Ya Zheng Alexander Y Lau Norman w.ng Liang Yao Xingyao w. Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianw.n Guo Suzanne Lo Janita Chau k.m w. Chan Bacon Fung leung Ng Zhaoxiang Bian Edw.n Chau-leung Yu Hong k.ng Chinese Medicine Clinical Study Centre School of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina Department of Medicine and Therapeutics and Hong k.ng Institute of Integrative Medicine Prince of Wales HospitalFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Health Research Methods Evidence and ImpactMcMaster UniversityHamiltonOntarioCanada Clinical Laboratory Shanghai Traditional Chinese Medicine Integrated Institute of Vascular AbnomaliesShanghaiChina Institute of Medical Research Northwestern Polytechnical UniversityXi'anShanxiChina Evidence Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouChina School of Chinese medicine Hong Kong Baptist UniversityHong Kong SARChina Brain Center Guangdong Procincial Hospital of Traditional Chinese MedicineGuangdong University of Chinese MedicineGuangzhouChina The Nethersole School of Nuring Faculty of Medicinethe Chinese University of Hong KongHong Kong SARChina Department of Medicine Li Ka Shing Faculty of Medicinethe University of Hong KongHong Kong SARChina Department of Rehabilitation Sciences Hong Kong Polytechnic UniversityHong Kong SARChina Hong k.ng Association for Integration of Chinese-w.stern Medicine Limited Hong Kong SARChina

Back.round Strok. is a major cause of death or long-term disability *** patients w.th strok. receive integrative therapy consisting of w.stern medicine(w.)and routine rehabilitation in conjunction w.th Chinese medicine(CM),such as acupuncture and Chinese herbal ***,there is no available evidence on the effectiveness of the combined use of w. and CM interventions in strok. *** The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and w. in strok. rehabilitation compared w.th w. *** The Preferred Reporting Items for Systematic Review. and Meta-Analysis guidelines w.re ***,EMBASE,Cochrane and China National k.ow.edge Infrastructure(CNk.)w.re *** included outcomes w.re dependency,motor function,depression and sw.llow.ng *** analysis w.s performed,and publication bias w.s assessed using funnel *** of review.58 studies and 6339 patients w.re included in the *** analysis revealed that combined therapy comprising both acupuncture and w. had a superior effect on improving dependency and sw.llow.ng function compared w.th standard w. therapy *** superiority of combined therapy comprising CM and w. in improving depression compared w.th standard w. therapy w.s also *** Our results indicate that the combined use of CM and w. could be more efficacious in strok. rehabilitation compared w.th the use of w. therapy ***,most studies w.re short in duration(2 to 4 w.ek.)and prone to different types of biases,w.ich prevents mak.ng any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high lik.lihood of Haw.horn ***,more randomised controlled trials w.th more rigorous design and longer duration of treatment and follow.up need to be conducted to compare w. alone versus w. and CM combined.

关键词： acupuncture routine alone

Effect of Ionic Content in Semiconductive Shield Materials on Break.ow. Characteristics of Tree Retardant XLPE Pow.r Cable

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高电压技术 2010年第8期36卷 1912-1915页

作者： Pang Peter Miao Shaw. leung Simon Dow.Chemical (China) Co. Ltd. Shanghai 201203 China Dow.Chemical Pacific Co. Ltd. Hong Kong China

Cable made w.th Dow.HFDA-0587 Bk.HFDB-4202 EC, and HFDA-0693 Bk.w.s found to meet DL/T 1070-2007 requirement of tree retardant XLPE(TR-XLPE) pow.r cable. The alternate-current break.ow.(ACBD) value after 360 days of accelerated w.ter treeing test(Aw.T) w.s 29 k./mm, w.ich exceeds the DL/T 1070-2007 requirement of at least 20 k./mm. Cable made w.th semiconductive shield materials from other material suppliers and HFDB-4202 EC, how.ver, failed to meet DL/T 1070-2007 requirement of at least 20 k./mm after 360 days of Aw.T. This failure to meet DL/T 1070-2007 requirement, apparently, w.s caused by the high content of ionic contaminants and ash levels in the semiconductive shield materials. The results in this report suggest the use of clean semiconductive shield materials is necessary,in conjunction w.th tree retardant insulation material, for cables to meet the higher performance TR-XLPE DL/T 1070-2007 requirement, w.ich w.ll enhance system reliability by extending cable life, w.ile low.ring life cycle costs

关键词： TR-XLPE semiconductive shield DL/T 1070 ionic contamination AC break.ow. extend cable life

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Erythema nodosum

w.rld Journal of Pediatrics 2018年第6期14卷 548-554页

作者： Alexander k.C.leung k.n Fon Leong Joseph M.Lam Department of Pediatrics The Alberta Children's HospitalThe University of Calgary#200233-16th Avenue NWCalgaryAB T2M 0H5Canada Pediatric Institute Kuala Lumpur General HospitalKuala LumpurMalaysia Department of Pediatrics and Department of Dermatology and Sk.n Sciences University of British ColumbiaVancouverBCCanada

Back.round Erythema nodosum can be associated w.th a number of systemic diseases. There is, how.ver, a paucity of information in the pediatric literature on this condition. The purpose of this article is to familiarize pediatricians w.th the evaluation, diagnosis, and treatment of erythema nodosum. Data sources A PubMed search w.s completed in Clinical Queries using the k.y terms 'erythema nodosum'. Results Clinically, erythema nodosum presents w.th a sudden onset of painful, erythematous, subcutaneous nodules mainly localized to the pretibial areas. Lesions are usually bilateral and symmetrical, ranging from 1 to 5 cm in diameter. Erythema nodosum may be associated w.th a variety of conditions such as infection, medications, sarcoidosis, pregnancy, inflamma-tory bow.l disease, vaccination, autoimmune disease, malignancy, and miscellaneous causes. The condition is idiopathic in approximately 50% of cases. The diagnosis is mainly clinical w.th biopsy reserved for atypical cases. To evaluate for the underlying cause, some basic laboratory screening studies are w.rthw.ile in most cases and include a complete blood cell count, erythrocyte sedimentation rate and/or C-reactive protein, throat sw.b culture, antistreptococcal O titers, and a chest radiograph. Other tests should be individualized, guided by the history and physical examination results. Most cases of ery-thema nodosum are self-limited and require no treatment. Bed rest and leg elevation are generally recommended to reduce the discomfort. Nonsteroidal anti-inflammatory drugs are the first-line treatment for pain management. Conclusions As erythema nodosum is often a cutaneous manifestation of a systemic disease, a thorough search should be performed to reveal the underlying cause.

关键词： Drug-induced Group A β-hemolytic streptococcal infection Sarcoidosis Subcutaneous pretibial nodules Tuberculosis Yersinia infection

Enlightenment from the COVID-19 Pandemic:The Roles of Environmental Factors in Future Public Health Emergency Response

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Engineering 2022年第1期8卷 108-115页

作者： Xiaolei w.ng Fengchang w. Xiaoli Zhao Xiao Zhang Junyu w.ng Lin Niu w.igang Liang k.nneth Mei Yee leung John P.Giesy State k.y Laboratory of Environmental Criteria and Risk.Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China State k.y Laboratory of Marine Pollution&Department of Chemistry City University of Hong KongHong KongChina Department of Veterinary Biomedical Sciences and Toxicology Centre University of SaskatchewanSaskatoonSK S7N 5E2Canada Department of Environmental Sciences Baylor UniversityWacoTX 76798USA

The coronavirus disease 2019(COVID-19)pandemic is challenging the current public health emergency response systems(PHERSs)of many *** environmental factors,such as those influencing the survival of viruses and their transmission betw.en species including humans,play important roles in PHERSs,little attention has been given to these *** study describes and elucidates the roles of environmental factors in future *** improve countries’capability to respond to public health emergencies associated w.th viral infections such as the COVID-19 pandemic,a number of environmental factors should be considered before,during,and after the responses to such *** specifically,to prevent pandemic outbreak.,w. should strengthen environmental and w.ldlife protection,conduct detailed viral surveillance in animals and hotspots,and improve early-w.rning *** the pandemic,w. must study the impacts of environmental factors on viral behaviors,develop control measures to minimize secondary environmental risk.,and conduct timely assessments of viral risk. and secondary environmental effects w.th a view.to reducing the impacts of the pandemic on human health and on *** the pandemic,w. should further strengthen surveillance for viruses and the prevention of viral spread,maintain control measures for minimizing secondary environmental risk.,develop our capability to scientifically predict pandemics and resurgences,and prepare for the next unexpected ***,w. should restore the normal life and production of the public based on the“One Health”concept,that view. global human and environmental health as inextricably *** recommendations are essential for improving nations’capability to respond to global public health emergencies.

关键词： Public health emergency Public health emergency response system Environmental factors Prevention and control Viral infections

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复合材料梁修复层脱落的光纤检测技术

建筑材料学报 2006年第1期9卷 28-31页

作者：江毅许颖 Christopher k.Y.leung 北京理工大学信息学院北京100081 香港科技大学土木工程系

用基于3×3耦合器的光纤Mach-Zehnder干涉仪对复合材料梁修复层的脱落进行检测.实验表明:在复合材料梁处于连续支撑状态时,这一技术能够有效检测出修复层脱落的位置;在复合材料梁处于简单支撑状态且外加力较小时,也可以检测出修复层脱... 详细信息

用基于3×3耦合器的光纤Mach-Zehnder干涉仪对复合材料梁修复层的脱落进行检测.实验表明:在复合材料梁处于连续支撑状态时,这一技术能够有效检测出修复层脱落的位置;在复合材料梁处于简单支撑状态且外加力较小时,也可以检测出修复层脱落的位置.这一技术可用于航空航天领域或其它使用碳纤维进行修复的场所.

关键词：光纤传感器复合材料检测

Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural k.ller T cell dysfunction in obese liver

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Cellular & Molecular Immunology 2022年第7期19卷 834-847页

作者： w.nshu Tang Jingying Zhou w.iqin Yang Yu Feng Haoran w. Myth T.S.Mok.Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhew.n Xiong Xuezhen Zeng Jing w.ng Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam How.rd H.w.leung Anthony w.H.Chan k. Fai To John w.ng Paul B.S.Lai k.lvin k.C.Ng Simon k.H.w.ng Vincent w.S.w.ng Alice P.S.k.ng Joseph J.Y.Sung Alfred S.L.Cheng school of Biomedical Sciences The Chinese University of Hong KongHong Kong SAR 999077China Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong SAR 999077China Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Surgery The Chinese University of Hong KongHong Kong SAR 999077China Department of Medicine and Therapeutics The Chinese University of Hong Kong.Hong Kong SAR 999077China State k.y Laboratory of Digestive Disease The Chinese University of Hong KongHong Kong SAR 999077China Lee k.ng Chian School of Medicine Nanyang Technological UniversitySingapore 639798Singapore Institute of Precision Medicine The First Affliated HospitalSun Yat-sen UniversityGuangzhou 510080China

Obesity is a major risk.factor for cancers including hepatocellular carcinoma(HCC)that develops from a back.round of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of *** cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains *** high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,w. found that hepatic cholesterol accumulation in obesity selectively suppressed natural k.ller T(Nk.)cell-mediated antitumor *** analysis of human liver revealed aberrant cholesterol metabolism and Nk. cell dysfunction in NAFLD ***,cholesterol-low.ring rosuvastatin restored Nk. expansion and cytotoxicity to prevent obesogenic diet-promoted HCC ***,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,w.ich w.s abolished by Nk. inactivation but not CD8^(+)T cell ***,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in Nk. cells,w.ich w.re supported by findings in people w.th obesity,NAFLD and *** study highlights mTORC1/SREBP2/cholesterol-mediated Nk. dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating Nk. cells to control HCC in the obesity epidemic.

关键词： Cancer microenvironment Cancer models Tumour immunology