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A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia

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Animal Models and experimental Medicine 2024年第3期7卷 367-376页

作者： Lauren S.Kelly Jennifer A.Munley erick e.Pons Kolenkode B.Kannan elizabeth M.Whitley letitia e.bible Philip A.efron Alicia M.Mohr Department of Surgery and Sepsis and Critical Illness Research Center University of Florida College of MedicineGainesvilleFloridaUSA Pathogenesis LLCGainesvilleFloridaUSA

Background:Severe trauma is associated with systemic inflammation and organ *** rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human *** aim of this study was to create a rat model of multicompartmental injury which recreates profound traumatic ***:Male Sprague-Dawley rats were subjected to unilateral lung contusion and hemorrhagic shock(LCHS),multicompartmental polytrauma(PT)(unilateral lung contusion,hemorrhagic shock,cecectomy,bifemoral pseudofracture),or na?ve ***,plasma toll-l ike receptor 4(TLR4),hemoglobin,spleen to body weight ratio,bone marrow(BM)erythroid progenitor(CFU-GeMM,BFU-e,and CFU-e)growth,plasma granulocyte colony-stimulating factor(G-CSF)and right lung histologic injury were assessed on day 7,with significance defined as p valuesesults:Polytrauma resulted in markedly more profound inhibition of weight gain compared to LCHS(p=0.0002)along with elevated plasma TLR4(per hemoglobin(penlarged spleen to body weight ratios(p=0.004).Both LCHS and PT demonstrated suppression of CFU-e and BFU-e growth compared to naive(pelevated in PT compared to both na?ve and LCHS(pemonstrated significant histologic right lung injury with poor alveolar wall integrity and interstitial ***:Multicompartmental injury as described here establishes a reproducible model of multicompartmental injury with worsened anemia,splenic tissue enlargement,weight loss,and increased inflammatory activity compared to a less severe *** may serve as a more effective model to recreate profound traumatic injury to replicate the human inflammatory response postinjury.

关键词： anemia i nflammation polytrauma pseudofracture shock

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汉语孤独谱系障碍儿童早期特殊疑问句习得的眼动研究

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现代外语 2022年第2期45卷 183-194页

作者：苏怡肖洁 letitia R.Naigles 中南大学外国语学院厦门大学康涅狄格大学

本研究采用多通道优先注视范式眼动实验对比了36名3~6岁孤独谱系障碍(ASD)儿童和28名1~3岁典型发展(TD)儿童的早期特殊疑问句习得。结果表明TD儿童可高效稳定地理解宾语特殊疑问句和主语特殊疑问句,而ASD儿童对特殊疑问句的理解比TD儿... 详细信息

本研究采用多通道优先注视范式眼动实验对比了36名3~6岁孤独谱系障碍(ASD)儿童和28名1~3岁典型发展(TD)儿童的早期特殊疑问句习得。结果表明TD儿童可高效稳定地理解宾语特殊疑问句和主语特殊疑问句,而ASD儿童对特殊疑问句的理解比TD儿童显著延迟,且仅理解了宾语特殊疑问句,对主语特殊疑问句的理解存在困难。跨语言对比研究表明汉语ASD儿童与英语ASD儿童早期特殊疑问句的习得模式相似,对宾语特殊疑问句的习得均比主语特殊疑问句更具优势。研究结果表明不同语言ASD儿童的特殊疑问句习得遵循典型发展轨迹,受到普遍语法WH-移位原则和参数的制约,提示人类语言习得机制对ASD儿童核心语法习得的可能贡献。同时,研究也为多通道优先注视眼动装置在汉语学龄前ASD儿童语言评估中的应用提供了依据。

关键词：孤独谱系障碍儿童特殊疑问句普遍语法原则和参数语言习得机制多通道优先注视

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Psychosocial stress and liver disease status

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World Journal of Gastroenterology 2009年第24期15卷 2980-2986页

作者： Cristin Constantin Vere Costin Teodor Streba letitia Maria Streba Alin Gabriel Ionescu Felix Sima 1st Department of Internal Medicine Emergency County Hospital of Craiova University of Medicine and Pharmacy of Craiova 3rd Department of Internal Medicine "Filantropia" University Hospital of Craiova

"Psychosocial stress" is an increasingly common concept in the challenging and highly-demanding modern society of today. Organic response to stress implicates two major components of the stress system, namely the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Stress is anamnestically reported by patients during the course of disease, usually accompanied by a decline in their overall health status. As the mechanisms involving glucocorticoids and catecholamines have been deciphered, and their actions on immune cell function deeper understood, it has become clear that stress has an impact on hepatic inflam-matory response. An increasing number of articles have approached the link between psychosocial stress and the negative evolution of hepatic diseases. This article reviews a number of studies on both human populations and animal models performed in recent years, all linking stress, mainly of psychosocial nature, and the evolution of three important liver-related pathological entities: viral hepatitis, cirrhosis and hepatocellular carcinoma.

关键词：心理压力肝脏疾病社会状态交感神经系统糖皮质激素病毒性肝炎组成部分

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New episode in PV Trade Dispute

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China International Business 2012年第12期 46-47页

作者： letitia CHeNG

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When Publishing Meets Digitalization

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China International Business 2013年第5期 44-46页

作者： letitia CHeNG

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Henan One of the Biggest Provinces Finally Takes off--Crouching Tiger in the Central Plains

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China International Business 2011年第12期 57-60页

作者： letitia CHeNG

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A New Deal for Movies

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China International Business 2012年第4期 38-40页

作者： letitia CHeNG

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Welcome to the American Footbal

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China International Business 2013年第5期 36-37页

作者： letitia CHeNG

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A Dream of Stone

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China International Business 2013年第5期 40-41页

作者： letitia CHeNG

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Assessment of Air Pollution,by the Urban Traffic,in University Campus of Bucharest

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Journal of environmental Protection 2017年第8期8卷 884-897页

作者： Razvan Stefan Popescu Lelia letitia Popescu Technical University of Civil engineering of Bucharest BucharestRomania

This study aims to measure traffic-related air pollution of vehicles with internal combustion, the main source of emissions of BTeX, organic compounds and NOx, NO2, NO, O3, CO, SO2, PM10 and PM2.5, inorganic compounds, in three sites of the University campus, surrounded by residential areas. According to the University data, around 8000 students are being exposed daily to the measured level of pollution, in all 3 studied places of campus. A mobile laboratory was used, which continuously measures above mentioned pollutants and mete-orological parameters. The diurnal variation of BTeX, in a sunny and rainy day showed two peaks of BTeX concentration in the morning and evening. In the rainy days, the non-polar (hydrophobic) compounds as BTeX are mechanically trained by rain into the ground, where either they enter into the groundwater, or volatilized and re-enter in the air. Particulate matter such as PM10 and PM2.5 is, in a large part, carried by the rain into the soil. The polar compounds (hydrophilic, NOx, SO2) dissolves in the rainwater and are absorbed in the soil (increasing soil acidity) and evaporated towards the clouds (leading to acid rain). In our study, BTeX compounds removed by the rain varied between 62% - 75%, NOx and SO2, 80% and 77% respectively. Particulate matters were washed out up to 68% for PM10, and 42% for PM2.5. In the sunny days the air pollution with measured concentrations of O3 (121.66 ± 7.02, 123.56 ± 4.89 μg/m3) remained for 7 hours close to the limit value (120 μg/m3). The maximum of solar radiation, with corresponding low concentrations in NOx and xylene, corresponds to photochemical reactions in the atmosphere, generating photochemical smog. In a sunny day and high traffic, we found the maximum value 5.4 μg/m3 for benzene, for 30 min., a known human carcinogen, exceeding the annual limit value de 5 μg/m3. The average background, from benzene, in three University campuses daily visited by around 8000 students was 0.97 μg/m3, exposed to 1

关键词： University Campus Outdoor Air Quality BTeX Mobile Laboratory PM10 PM2.5

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