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Subjective Cognitive Concerns and Attitudes toward Genetic Testing Are Associated with Depressive Symptoms and Quality of Life after Genetic Testing for the Cerebral Cavernous Malformation Common Hispanic Mutation (CCM1)

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Journal of Behavioral and Brain Science 2020年第2期10卷 118-127页

作者： Richard Campbell Christine L.Petranovich Savannah Cheek leslie morrison Blaine Hart Department of Psychiatry and Behavioral Sciences University of New Mexico Health Sciences CenterAlbuquerqueNMUSA Department of Rehabilitation Medicine Children’s Hospital Colorado and the School of MedicineUniversity of Colorado DenverAuroraCOUSA University of New Mexico AlbuquerqueNMUSA Department of Neurology and Pediatrics University of New Mexico Health Sciences CenterAlbuquerqueNMUSA Department of Radiology University of New Mexico Health Sciences CenterAlbuquerqueNMUSA

Purpose: This study aimed to characterize mood and quality of life and to examine the associations of these areas with subjective cognitive concerns and attitudes toward genetic testing for the Common Hispanic Mutation, a gene that has been associated with increased risk for CCM1. Method: Fifty-four adults with previous genetic testing for the Common Hispanic Mutation completed a mail survey that included assessments of the above identified areas. Results: Self-reported depressive symptoms and quality of life did not differ between those with positive and negative genetic test results. The negative group expressed a more favorable attitude toward genetic testing (p p = 0.06). Using generalized linear regression, more subjective cognitive concerns were associated with poorer quality of life and more depressive symptoms (p p Conclusions: Subjective cognitive concerns and negative attitudes toward genetic testing may influence emotional well-being after genetic testing for the Common Hispanic Mutation. Additional research is needed that uses objective neuropsychological measures to understand the associations of subjective cognitive concerns, emotional well-being, and cognitive test performance in individuals with CCM1. There is also a need for research that focuses on protective factors and resiliency following genetic testing for CCM1 and the development of mental health interventions to preempt psychosocial difficulties.

关键词： Quality of Life Depression Genetic Testing Subjective Cognitive Concerns

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Rough singular integrals associated to surfaces of revolution on product spaces

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Acta Mathematica Sinica,English Series 2025年

作者： Hussain AL-QASSEM leslie CHENG Yibiao PAN Mathematics Program Department of Mathematics Statistics and Physics College of Arts and Sciences Qatar University Department of Mathematics Bryn Mawr College Department of Mathematics University of Pittsburgh

We study the Lpboundedness of singular integral operators along surfaces of revolution on product spaces. The Lpboundedness for these operators are obtained under very weak conditions on kernels. Our results are new and they improve several previously known results. Furthermore, they are natural extensions of many known results on singular integrals in the one-parameter setting and they subsume many other corresponding results on the product space setting.

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Start-Ups Seek to Accelerate Path to Nuclear Fusion Mitch leslie

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Engineering 2022年第5期8卷 6-8页

作者： Mitch leslie 机构不祥

In September 2021,the world’s most powerful high-temperature superconducting magnet passed its first test,generating a 20 T magnetic field during a 5 h trial[1].The 3 m tall,9000 kg device(Fig.1)is the centerpiece of an ambitious plan by the start-up Commonwealth Fusion Systems,headquartered in Cambridge,MA,USA,to build a fusion reactor that produces more energy than it requires to stimulate and sustain its nuclear reactions[2,3].None of the experimental fusion approaches that scientists have tested has come close to that *** the multi-billion USD International Thermonuclear Experimental Reactor(ITER),the massive project sponsored by 35 countries that is under construction in southern France(Fig.2),is not projected to pass the breakeven point until the mid-2030s at the earliest[2,4].But Commonwealth Fusion Systems aims to have a pilot plant operating by 2025.

关键词： generating massive Commonwealth

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脑海绵状血管畸形临床诊疗指南概要：血管瘤联盟科学咨询委员会临床专家组基于系统文献评价的共识推荐

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国际脑血管病杂志 2017年第7期25卷 577-591页

作者： Amy Akers Rustam Al-Shahi Salman Issam A. Awad Kristen Dahlem Kelly Flemming Blaine Hart Helen Kim Ignacio Jusue-Torres Douglas Kondziolka Cornelia Lee leslie morrison Daniele Rigamonti Tania Rebeiz Elisabeth Toumier-Lasserve Darrel Waggoner Kevin Whitehead 鄂同舟雷宇倪伟顾宇翔 Angioma Alliance Norfolk Virginia Centre for Clinical Brain Sciences University of Edinburgh Edinburgh United Kingdom Neurovascular Surgery Program Section of Neurosurgery" University of Chicago Medicine" and Biological Sciences Chicago Illinois Department of Neurology Mayo Clinic Rochester Minnesota Department of Radiology University of New Mexico Albuquerque New Mexico Department of Anesthesia and Perioperative Care Department of Epidemiology and Biostatistics University of California San Francisco San Francisco California Department of Ncurosurgery Johns Hopkins Medicine Baltimore Maryland Departments of Neurosurgery and Radiation Oncology NYU Langone Medical Center New York City New York Departments of Neurology and Pediatrics University of New Mexico Albuquerque New Mexico Department of Genetics INSERM UMR 1161 Pads France Department of Human Genetics and Pediatrics University of Chicago Medicine and Biological Sciences Chicago Illinois Department of Cardiovascular Medicine University of Utah Salt Lake City Utah 复旦大学附属华山医院神经外科上海200040

背景尽管脑海绵状血管畸形（cerebral cavernous malformation, CCM）的相关研究文献已相当丰富，但在诊断和治疗策略方面仍存在着争议。目的制订CCM诊疗指南。方法作为代表CCM患者和研究的患者支持团体，血管瘤联盟（***）召集了一个包... 详细信息

背景尽管脑海绵状血管畸形（cerebral cavernous malformation, CCM）的相关研究文献已相当丰富，但在诊断和治疗策略方面仍存在着争议。目的制订CCM诊疗指南。方法作为代表CCM患者和研究的患者支持团体，血管瘤联盟（***）召集了一个包括CCM临床专家在内的多学科写作组来帮助总结现有的CCM临床诊疗相关文献，重点关注5个主题：（1）流行病学和自然病程；（2）遗传检测和咨询；（3）诊断标准和影像学标准；（4）神经外科注意事项；（5）神经内科注意事项。写作组根据预定方案进行了文献回顾和证据评价，最终制定推荐意见，并且确立了共识、争议和知识空白。结果根据方法学标准从1983年1月1日至2014年9月31日期间公开发表的1 270篇文献中筛选出98篇，并确定了另外38篇近期或相关的文献。各主题作者利用这些文献总结了现有知识并形成了23项共识诊疗推荐，同时根据美国心脏协会/美国卒中协会标准进行了推荐强度（效应量）和证据水平（确定性估计）评级。其中，尚无A级证据（因为缺乏随机对照试验），B级证据11项（48%），C级证据12项（52%）；Ⅰ级推荐8项（35%），Ⅱ级推荐10项（43%），Ⅲ级推荐5项（22%）。结论现有证据支持对CCM诊疗的推荐，但这些证据的级别和推荐强度普遍较低，因此需要进一步研究来帮助进行更好的临床实践并更新这些推荐。完整的推荐文档包括引用文献的纳入标准、关于各项推荐更详尽的评判标准以及各种争议和知识空白的总结，同样通过了同行评议并可在线获取（***/CCMGuidelines）。

关键词：海绵状血管瘤血管畸形指南推荐

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Charting Disaster Recovery via Google Street View: A Social Science Perspective on Challenges Raised by the Fukushima Nuclear Disaster

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International Journal of Disaster Risk Science 2016年第2期7卷 175-185页

作者： leslie Mabon School of Applied Social Studies Robert Gordon University

There is increasing interest in using Google Street View(GSV) for research purposes, particularly with regard to ‘‘virtually auditing'' the built environment to assess environmental quality. Research in this field to date generally suggests GSV is a reliable means of understanding the ‘‘real world'' environment. But limitations around the dates and resolution of images have been identified. An emerging strand within this literature is also concerned with the potential of GSV to understand recovery post-disaster. Using the GSV data set for the evacuated area around the Fukushima Dai'ichi nuclear power plant as a case study, this article evaluates GSV as a means of assessing disaster recovery in a dynamic situation with remaining uncertainty and a significant value and emotive dimension. The article suggests that GSV does have value in giving a high-level overview of the postdisaster situation and has potential to track recovery and resettlement over time. Drawing on social science literature relating to Fukushima, and disasters more widely, the article also argues it is imperative for researchers using GSV to reflect carefully on the wider socio-cultural contexts that are often not represented in the photo montage.

关键词： Digital representation of place Fukushima nuclear disaster Google Street View Post-disaster recovery Social dimensions of energy

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Add-on Renewables Aim to Decrease Impact and Increase Benefits

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Engineering 2024年第6期37卷 10-12页

作者： Mitch leslie Senior Technology Writer

In the South Boulder Canal near Denver,CO,USA,turbine blades that resemble the mixers used to stir cake batter in kitchens(Fig.1)spin in the rushing water[1].Each of the turbines,manufactured by Emrgy of Atlanta,GA,USA,generates up to 25 kW of electricity for the area’s grid[2].In an orchard in southern Italy,an arcade of solar panels stands above rows of citron trees,which are valuable for the essential oils in their fruits[3].The solar panels not only produce electricity for local homes,but also protect the trees from the sun,reducing their water use by 70%[3].These are two examples of a clean energy trend:integrating power-generation with other *** the approach called agrivoltaics,for example,farmers and ranchers grow crops or raise livestock around and beneath solar panels(Fig.2)[4].Experts hope that such add-on strategies can spare farmland,cut the environmental costs of clean energy development,supply extra income to landowners,and furnish other benefits[5,6].

关键词： income beneath integrating

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Farmers Reap Right to Repair Agricultural Equipment

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Engineering 2023年第8期27卷 8-10页

作者： Mitch leslie Senior Technology Writer

A farmer is ready to harvest the winter wheat crop when his combine harvester breaks *** if the problem would be relatively simple to remedy,the farmer probably cannot make the repair himself or get help from an independent shop because manufacturers have restricted access to the tools,documentation,and other requirements for fixing their equipment[1].Instead,the farmer will likely have to turn to one of the manufacturer’s dealers,which could mean waiting days or even weeks for a service call from a company technician[2].In the meantime,the farmer’s crop sits unharvested,vulnerable to damage or destruction by bad weather[2].

关键词： dealer harvest likely

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Can Giant Microchips Become a Big Deal?

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Engineering 2024年第5期36卷 6-8页

作者： Mitch leslie Senior Technology Writer

For decades,manufacturers have boasted about how small they can make microchip *** have shrunk by about 1000-fold over the last 50 years,for example[1].But Cerebras Systems,*** Sunnyvale,CA,USA takes pride in how big its chips *** from a single silicon wafer,its Wafer-Scale Engine(WSE)-2 chips measure 46225 mm^(2),56 times the size of a standard Nvidia microprocessor(Fig.1)[2].

关键词： microprocessor Microchip Engine

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Commercial Moon Landings Multiply

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Engineering 2023年第11期30卷 10-12页

作者： Mitch leslie Senior Technology Writer

Along with its familiar impact craters,the surface of the Moon sports numerous pale whorls and streaks known as lunar swirls[1].Likened to the pattern produced when someone pours cream into a cup of black coffee[2],the swirls can extend for more than 50 km and have puzzled researchers for centuries[3].Adding to their mystery,the features are associated with regions of magnetized rocks,an unusual attribute because the Moon lacks a magnetic field[3].Researchers do not know how the swirls are related to the magnetic fields or how they formed.

关键词： someone unusual Moon

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Signaling the Future, Cell Phones Gain Limited Satellite-Link Capabilities

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Engineering 2023年第9期28卷 4-6页

作者： Mitch leslie Senior Technology Writer

On 13 December 2022,a couple was driving through the Angeles National Forest near Los Angeles,CA,USA,when their car slid off the road,plowed 100 m down a steep hillside,and landed upside down at the bottom of a canyon[1].Although the couple suffered only minor injuries,they were trapped in the canyon,and in the remote area the passenger could not get any reception on her iPhone 14 cellular ***,she was able to send an SOS through a new feature on the phone that routes such messages via satellites[2].Rescuers alerted to the couple’s location airlifted them out of the canyon later the same day.

关键词： Rescue injuries driving

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