Subjective Cognitive Concerns and Attitudes toward Genetic Testing Are Associated with Depressive Symptoms and Quality of Life after Genetic Testing for the Cerebral Cavernous Malformation Common Hispanic Mutation (CCM1)

作     者：Richard Campbell Christine L.Petranovich Savannah Cheek Leslie Morrison Blaine Hart 

作者机构：Department of Psychiatry and Behavioral SciencesUniversity of New Mexico Health Sciences CenterAlbuquerqueNMUSA Department of Rehabilitation MedicineChildren’s Hospital Colorado and the School of MedicineUniversity of Colorado DenverAuroraCOUSA University of New MexicoAlbuquerqueNMUSA Department of Neurology and PediatricsUniversity of New Mexico Health Sciences CenterAlbuquerqueNMUSA Department of RadiologyUniversity of New Mexico Health Sciences CenterAlbuquerqueNMUSA 

出 版 物：《Journal of Behavioral and Brain Science》 (行为与脑科学期刊（英文）)

年 卷 期：2020年第10卷第2期

页      面：118-127页

学科分类：0502[文学-外国语言文学] 050201[文学-英语语言文学] 05[文学] 

主　　题：Quality of Life Depression Genetic Testing Subjective Cognitive Concerns 

摘      要：Purpose: This study aimed to characterize mood and quality of life and to examine the associations of these areas with subjective cognitive concerns and attitudes toward genetic testing for the Common Hispanic Mutation, a gene that has been associated with increased risk for CCM1. Method: Fifty-four adults with previous genetic testing for the Common Hispanic Mutation completed a mail survey that included assessments of the above identified areas. Results: Self-reported depressive symptoms and quality of life did not differ between those with positive and negative genetic test results. The negative group expressed a more favorable attitude toward genetic testing (p p = 0.06). Using generalized linear regression, more subjective cognitive concerns were associated with poorer quality of life and more depressive symptoms (p p Conclusions: Subjective cognitive concerns and negative attitudes toward genetic testing may influence emotional well-being after genetic testing for the Common Hispanic Mutation. Additional research is needed that uses objective neuropsychological measures to understand the associations of subjective cognitive concerns, emotional well-being, and cognitive test performance in individuals with CCM1. There is also a need for research that focuses on protective factors and resiliency following genetic testing for CCM1 and the development of mental health interventions to preempt psychosocial difficulties.