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Revascularization and outcomes in Veterans with moderate to severe ischemia on myocardial perfusion imaging

Military Medical Research 2017年第3期4卷 127-131页

作者： David E.Winchester Alexander j.Bolanos Anita Wokhlu Rebecca j.Beyth leslee j.shaw Malcom Randall VAMC North Florida/South Georgia Veterans Health System Division of Cardiovascular Medicine University of Florida College of Medicine Malcom Randall VAMC Department of Medicine University of Florida College of Medicine Division of General Internal Medicine University of Florida College of Medicine Division of Cardiology Emory University School of Medicine

Background： The prevalence of ischemia on nuclear myocardial perfusion imaging （MPI） has been decreasing. Recent research has questioned the benefit of invasive revascularization for patients with moderate to severe ischemia. We hypothesized that patients with moderate to severe ischemia could routinely undergo successful revascularization. Methods： We analyzed data from 544 patients who underwent an MPI at a single academic Veterans Affairs Medical Center. Patients with moderate to severe ischemia, defined as a summed difference score （SDS） 8 or greater, were compared to the rest of the cohort. Results： Of the total cohort （n=544）, 39 patients had MPI studies with resultant moderate to severe ischemia. Patients with ischemia were more likely to develop coronary artery disease （74.4% versus 38.8%, P〈0.0001） and have successful revascularization （38.5% versus 4.0%, P〈0.0001） during the following year. Revascularization was attempted in 31 patients with moderate to severe ischemia, though only 15（47%） of these attempts were successful, Ischemia was predictive of myocardial infarction （5.1% versus 0.8%, P=0.01） within I year. Conclusion： Moderate to severe ischemia is an uncommon finding in a contemporary nuclear laboratory. Among patients with ischemia, revascularization is typically attempted but is frequently unsuccessful. Trial registration： This trial does not appear on a registry as it is neither randomized nor prospective.

关键词： Myocardial ischemia Nuclear myocardial perfusion imaqinq Veterans Revascularization

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SARS-CoV-2 triggers Dickkopf-1(Dkk-1)modulation of T helper cells and lung pathology in mice

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Genes & Diseases 2024年第4期11卷 9-12页

作者： Yifan Wu Freedom M.Green Stephen A.shaw Lauren j.Bonilla Shannon E.Ronca Maria Elena Bottazzi Farrah Kheradmand jill E.Weatherhead Department of Pathology&Immunology One Baylor PlazaHoustonTX 77030USA Department of Pediatrics One Baylor PlazaHoustonTX 77030USA Department of Medicine One Baylor PlazaHoustonTX 77030USA National School of Tropical Medicine One Baylor PlazaHoustonTX 77030USA Molecular Virology&Microbiology One Baylor PlazaHoustonTX77030USA Biologyof Inflammation Center Baylor College of MedicineOne BaylorPlazaHoustonTX77030USA Michael E.DeBakey VA Center for Translational Research on Inflammatory Diseases HoustonTX 77030USA

Severe acute respiratory syndrome coronavirus 2(SARSCov-2)is the etiologic agent of the coronavirus disease 19(COVID-19)*** viral infections like SARS-CoV-2,a robust anti-viral type 1 immune response,including upregulation of type 1 CD4+T helper cells(Th1),is required for effective viral clearance while minimizing end-organ pathology and collateral tissue damage.

关键词： pathology acute respiratory

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janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis

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Translational Neurodegeneration 2023年第1期12卷 225-241页

作者： Peter j.Richardson Daniel P.Smith Alex de Giorgio Xenia Snetkov joshua Almond-Thynne Sara Cronin Richard j.Mead Christopher j.McDermott Pamela j.shaw BenevolentAI 4-8 Maple StreetLondon W1T 5HDUK BenevolentAI 15 MetroTech Centre8th FLBrooklynNY 11201USA Sheffield Institute for Translational Neuroscience Faculty of MedicineDentistry and HealthUniversity of SheffieldSheffieldUK NIHR Sheffield Biomedical Research Centre University of Sheffield and Sheffield Teaching Hospitals NHS Foundation TrustSheffieldUK

Amyotrophic lateral sclerosis(ALS)is a poorly treated multifactorial neurodegenerative disease associated with multiple cell types and subcellular *** with other multifactorial diseases,it is likely that drugs will need to target multiple disease processes and cell types to be *** review here the role of janus kinase(jAK)/Signal transducer and activator of transcription(STAT)signalling in ALS,confirm the association of this signalling with fundamental ALS disease processes using the BenevolentAI Knowledge Graph,and demonstrate that inhibitors of this pathway could reduce the ALS pathophysiology in neurons,glia,muscle fibres,and blood ***,we suggest that inhibition of the jAK enzymes by approved inhibitors known as jakinibs could reduce STAT3 activation and modify the progress of this *** of the jakinibs highlights baricitinib as a suitable candidate due to its ability to penetrate the central nervous system and exert beneficial effects on the immune ***,we recommend that this drug be tested in appropriately designed clinical trials for ALS.

关键词： janus kinase STAT3 Amyotrophic lateral sclerosis

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Nursing and mHealth

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International journal of Nursing Sciences 2014年第4期1卷 330-333页

作者： Catherine Samples Zhao Ni Ryan j.shaw School of Nursing Duke UniversityDurhamNC 27710USA

Innovations in mobile health(mHealth)technology offer applications to promote wellness management and health behavior change outside of formal clinical *** can help to move mHealth into mainstream health care by understanding its potential to change the landscape of health intervention delivery,incorporating mHealth into patients'day to day preventive care strategies,and supporting the science of mHealth's effectiveness.

关键词： Mobile health mHealth Nursing

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Mobile technology for health care in rural China

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International journal of Nursing Sciences 2014年第3期1卷 323-324页

作者： Zhao Ni Bei Wu Catherine Samples Ryan j.shaw School of Nursing Duke UniversityDurhamNC 27710USA

With the proliferation of mobile technologies in China,the Chinese mobile medical applications market is growing *** may be particularly useful for Chinese rural populations who have limited access to quality medical care where mobile technologies can reach across geographic and socioeconomic boundaries and potentially increase access to care and improve health outcomes.

关键词： China Mobile health mHealth Rural

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Accumulation sequence of Chinese loess and climatic records of Greenland ice core during the last 130 ka

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Chinese Science Bulletin 1995年第15期40卷 1272-1276页

作者：安芷生孙东怀张小曳周卫建 S.C.Porter j.shaw 张代州 Xi'an Laboratory of Loess and Quaternary Geology. Chinese Academy of Sciences. Xi'an 710061 China Quaternary Research Centre. University of Washington. Seattle. USA Geomagnetism Laboratory. University of Liverpool UK Department of Geophysics. Peking University. Beijing 100871 China

The present winter climate of continental China is associated with cold air *** cold air forming Siberian high pressure comes from the Northern Barents *** Kara Sea and Northern Atlantic Ocean (fig.1). in other words,... 详细信息

关键词： winter monsoon GRIP core and Chinese loess.

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RECENT PROGRESS IN STUDY OF THE QUATERNARY OF QAIDAM BASIN, QINGHAI

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Chinese Science Bulletin 1986年第4期31卷 252-256页

作者：王靖泰张勇 E.DERBYSHIRE j.shaw Lanzhou Institute of Glaciology and Cryopedology Academia Sinica First Hydrological Team of Geological Bureau of Qinghai Province Department of Geography University of Keel UK Department of Geology University Gollege Cardiff UK series of mountain systems and intermountane basins extend across the northern and western China. The largest of the basins are those of Tarim Junggar and Qaidam. A thick sedimentary sequence has been deposited in these basins during the Cenozoic. Accordingly the region has great potential for the study of the Quaternary stratigraphy. However information on the Quaternary sedimentology and chronostratigraphy of this huge region is sparse.

A series of mountain systems and intermountane basins extend across the northern and western China. The largest of the basins are those of Tarim, junggar and Qaidam. A thick sedimentary sequence has been deposited in these basins during the Cenozoic. Accordingly, the region has great potential for the study of the Quaternary stratigraphy. However, information on the Quaternary sedimentology and chronostratigraphy of this huge region is sparse.

关键词： sedimentary Quaternary stratigraphy Cenozoic thick PROGRESS folding borehole sparse abundant

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辽西四合屯含化石层古地磁极性年龄的初步确定

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科学通报 2001年第8期46卷 680-684页

作者：潘永信朱日祥 j.shaw 周烑秀中国科学院地质与地球物理研究所北京100101 Geomagnetism Laboratory 国土资源部航空物探遥感中心北京100083

对辽西四合屯剖面合化石层及其下伏和上覆玄武岩进行了较为详细的岩石磁学和古地磁学研究，结果表明含化石的沉积岩层段和下伏玄武岩段具有正极性，上覆玄武岩则具有负极性．结合最新的同位素测年结果可知，含化石层段的古地磁极性年龄... 详细信息

对辽西四合屯剖面合化石层及其下伏和上覆玄武岩进行了较为详细的岩石磁学和古地磁学研究，结果表明含化石的沉积岩层段和下伏玄武岩段具有正极性，上覆玄武岩则具有负极性．结合最新的同位素测年结果可知，含化石层段的古地磁极性年龄为早白垩世Ｂａｒｒｅｍｉａｎ阶Ｍ３ｎ极性时．岩石磁学参数测量结果揭示出该湖相沉积岩中夹有数层火山凝灰质沉积物，这可能说明由火山活动等地球深部动力学过程引起的剧烈环境变化与古湖区生物的剧生剧灭有关．

关键词：磁性地层年龄下义县组早白垩世四合屯剖面辽宁

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Astrocyte Function and Role in Motor Neuron Disease:A Future Therapeutic Target?

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神经损伤与功能重建 2009年第5期4卷 351-362页

作者： DANIEL BLACKBURN SIRANUSH SARGSYAN PETER N.MONK PAMELA j.shaw Academic Neurology Unit Sheffield Care and Research Centre for Motor Neuron DisordersUniversity of Sheffield

星形胶质细胞是中枢神经系统中数量最多的细胞,从引导轴突、突触支持到控制血-脑脊液屏障及脑血流,发挥多种作用。发挥这些作用需要通过大量不同类型的星形胶质细胞进行。本文对星形胶质细胞的功能,尤其是保持突触平衡、调节神经元信号... 详细信息

星形胶质细胞是中枢神经系统中数量最多的细胞,从引导轴突、突触支持到控制血-脑脊液屏障及脑血流,发挥多种作用。发挥这些作用需要通过大量不同类型的星形胶质细胞进行。本文对星形胶质细胞的功能,尤其是保持突触平衡、调节神经元信号传导、保护氧化损伤下的神经元和决定内源性神经前体细胞分化方面的作用进行综述。本文还重点讨论近年星形胶质细胞在运动神经元病(MND)中的作用方面的研究,强调其在细胞替代治疗中作为治疗靶标和治疗剂的潜能。在20%家族性MND中涉及到的铜锌超氧化物歧化酶(SOD1)基因,其必须表达在胶质细胞和运动神经元中来诱导小鼠疾病模型的疾病状态。在星形胶质细胞中选择性减少突变SOD1(mSOD1)不会影响疾病发作,可延缓疾病进展;但减少运动神经元中的mSOD1可推迟疾病发作,延缓早期病程,对寿命无影响。这提示胶质细胞在MND中可作为潜在的治疗靶标。然而,对星形胶质细胞特异性标志物、前体细胞、亚型的认识缺乏意味着对其发育/分化、应对损伤的了解落后于对其功能的认识。只有深入理解这些问题才能有效运用星形胶质细胞靶向或替代治疗慢性中枢神经系统疾病,如MND。

关键词：星形胶质细胞星形胶质细胞增生胶质纤维酸性蛋白运动神经元病

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埃及神话

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2018年

作者： (英)加里·j. 肖(Garry j. shaw)

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