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Cutaneous Dengue Virus Inoculation Triggers Strong B Cell Reactions but Contrastingly Poor T Cell Responses

Virologica Sinica 2020年第5期35卷 575-587页

作者： Edith Marcial-Juárez Julio García-Cordero Raúl Antonio Maqueda-Alfaro Rafael Eduardo Saucedo-López Luvia Enid Sánchez-Torres Leticia Cedillo-Barrón leopoldo flores-romo Department of Cell Biology Center for Advanced Research(CINVESTAV-IPN)The National Polytechnic Institute07360 Mexico CityMexico Department of Molecular Biomedicine Center for Advanced Research(CINVESTAV-IPN)The National Polytechnic Institute07360 Mexico CityMexico Immunology Department The National School of Biological Sciences(ENCB-IPN)The National Polytechnic Institute11340 Mexico CityMexico

Dengue is a global health problem without current specific treatment nor safe vaccines *** severe dengue is related to pre-existing non-neutralizing dengue virus(DENV)antibodies,the role of T cells in protection or pathology is *** cutaneous DENV infection in immunocompetent mice we previously showed the generation of PNA+germinal centers(GCs),now we assessed the activation and proliferation of B and T cells in draining lymph nodes(DLNs).We found a drastic remodelling of DLN compartments from 7 to 14 days post-infection(dpi)with greatly enlarged B cell follicles,occupying almost half of the DLN area compared to*24%in na?ve *** clusters of proliferating(Ki-67+)cells inside B follicles were found 14 dpi,representing*33%of B cells in DLNs but only*2%in noninfected *** GCs,we noticed an important recruitment of tingle body macrophages removing apoptotic *** contrast,the percentage of paracortex area and total T cells decreased by 14–16 dpi,compared to *** randomly distributed Ki-67+T cells were found,similar to non-infected ***69 expression by CD4+and CD8+T cells was minor,while it was remarkable in B cells,representing 1764.7%of change from basal levels 3 *** apparent lack of T cell responses cannot be attributed to apoptosis since no significant differences were observed compared to noninfected *** study shows massive B cell activation and proliferation in DLNs upon DENV *** contrast,we found very poor,almost absent CD4+and CD8+T cell responses.

关键词： Dengue virus(DENV) B and T cells proliferation Lymphocyte activation Lymph nodes In vivo cutaneous infection Immunocompetent mice

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Dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

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Cluster Partition Function and Invariants of 3-Manifolds

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Chinese Annals of Mathematics,Series B 2017年第4期38卷 937-962页

作者： Mauricio romo School of-Natural Sciences Institute for Advanced Study Princeton NJ 08540 USA.

The author reviews some recent developments in Chern-Simons theory on a hyperbolic 3-manifold M with complex gauge group G. The author focuses on the case of G = SL(N, C) and M being a knot complement: M = S^3\ K. The main result presented in this note is the cluster partition function, a computational tool that uses cluster algebra techniques to evaluate the Chern-Simons path integral for G = SL(N, C). He also reviews various applications and open questions regarding the cluster partition function and some of its relation with string theory.

关键词： Chern-Simons theory Knots Cluster algebras

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Matching dependencies： semantics and query answering

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Frontiers of Computer Science 2012年第3期6卷 278-292页

作者： Jaffer GARDEZI leopoldo BERTOSSI Iluju KIRINGA School of Information Technology and Engineering University of Ottawa Ottawa ON K1N 6N5 Canada School of Computer Science Carleton University Ottawa ON KIS 5B6 Canada

Matching dependencies （MDs） are used to declaratively specify the identification （or matching） of cer- tain attribute values in pairs of database tuples when some similarity conditions on other values are satisfied. Their en- forcement can be seen as a natural generalization of entity resolution. In what we call the pure case of MD enforce- ment, an arbitrary value from the underlying data domain can be used for the value in common that is used for a match- ing. However, the overall number of changes of attribute val- ues is expected to be kept to a minimum. We investigate this case in terms of semantics and the properties of data clean- ing through the enforcement of MDs. We characterize the in- tended clean instances, and also the clean answers to queries, as those that are invariant under the cleaning process. The complexity of computing clean instances and clean query an- swering is investigated. Tractable and intractable cases de- pending on the MDs are identified and characterized.

关键词： databases data cleaning duplicate and entityresolution integrity constraints matching dependencies

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In-plane transversal normal stresses in the concrete face of CFRD induced by the first-dam reservoir filling

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Frontiers of Structural and Civil Engineering 2018年第1期12卷 81-91页

作者： Neftali SARMIENTO-SOLANO Miguel P. romo l Institute of Engineering National University of Mexico Mexico City 0451 O Mexico

To evaluate the effects of dam height, valley narrowness and width of concrete slabs on the first-dam reservoir filling in-plane transversal normal stresses in the concrete face of CFRD＇s, 3D finite difference analyses were carried out. Behavior of rockfiU dams considered in this study was defined from the monitoring of a number of 3D sets of pressure cells and extensometers installed in three large dams in Mexico. The 3D analyses results show that high in-plane transversal compressive stresses develop within the concrete panels located in the central concrete face zone upon dam reservoir filling loading. Likewise, in-plane induced tensile transversal stresses in the zones near the abutments increase the potential of slabs cracking and damaging the waterstops in-between the vertical and perimetral joints. From the results of the 3D finite difference analyses, a simple method to estimate in-plane normal stresses in the concrete face is advanced and through comparisons with the results of a 3D case numerical study, its accuracy assessed.

关键词： concrete face CFR dams reservoir filling slab in-plane stresses

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Dynamic in-plane transversal normal stresses in the concrete face of CFRD

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Frontiers of Structural and Civil Engineering 2019年第1期13卷 135-148页

作者： Neftali SARMIENTO-SOLANO Miguel P.romo Institute of Engineering National University of MexicoMexico City04510Mexico

Severe earthquakes can induce damages to Concrete Face Rocldill Dams (CFRDs)such as concrete cracking and joint's water stops distressing where high in-plane transversal normal stresses *** these damages rarely jeopardize the dam safety,they cause large water reservoir leakages that hinder the dam *** issue can be addressed using well know numerical methods;however,given the wide range of parameters involved,it would seem appropriate to develop a simple yet reliable procedure to get a close understanding how their interaction affects the CFRD's overall ***,once the physics of the problem is better understood one can proceed to perform a detailed design of the various components of the *** this end an easy-to-use procedure that accounts for the dam height effects,valley narrowness,valley slopes,width of concrete slabs and seismic excitation characteristics was *** procedure is the dynamic complement of a method recently developed to evaluate in-plane transversal normal stresses in the concrete face of CFRD's due to dam reservoir filling [1].Using these two procedures in a sequential manner,it is possible to define the concrete slab in-plane normal stresses induced by the reservoir filling and the action of orthogonal horizontal seismic excitations acting at the same time upstream-downstream and cross *** procedures were developed from a data base generated using nonlinear static and dynamic three-dimensional numerical analyses on the same group of CFRD'***,the results were interpreted with the Buckingham Pi theorem and various relationships were *** the above reference,the method to evaluate the concrete face in-plane transversal normal stresses caused by the first reservoir filling was *** this paper,the seismic procedure is first developed and then through an example the whole method (dam construction,reservoir filling plus seismic loading)of analysis is assessed.

关键词： CFR dams dynamic analysis in-plane normal stresses concrete face

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Assessment of an alternative to deep foundations in compressible clays： the structural cell foundation

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Frontiers of Structural and Civil Engineering 2018年第1期12卷 67-80页

作者： Sergio A. MARTINEZ-GALVAN Miguel P. romo Institute of Engineering National University of Mexico Mexico City 04510 Mexico

The new type of deep foundation for buildings on saturated, compressible-low strength clayey soil deposits, branded structural cell essentially consists of a rigid concrete top slab, structurally connected to reinforced concrete peripheral walls （diaphragms） that enclose the natural soil. Accordingly, as the initial volume of the confined soft clays within the lateral stiff diaphragms will remain constant upon loading, the hollowed structural cell will be ＂transformed＂ into a very large cross-section pillar of unit weight slightly higher than that of the natural soft clayey soil. This type of foundation seems to be a highly competitive alternative to the friction pile-box foundations （widely used in Mexico City clays）, due to its economic and environmental advantages. Economies result, for example, from the absence of huge excavations hence sparing the need of earth retaining structures. Further savings result from appreciably smaller concrete volumes required for building the structural cell than the friction pile-box foundation; moreover, the construction time of the former is much shorter than that of the latter. Regarding the impact to the environment, less air contamination follows from the fact that both traffic jams and soil excavation lessen appreciably. Considering these facts and others regarding scheduling, it was decided to replace 48-friction pile-box foundations specified in the master plan project by this new type of foundation. The overall behavior of these cell foundations over a five-year period is fared from close visual observations and their leveling during the first three years after their construction.

关键词： deep foundations bearing capacity resistant moment structural cell 3D numerical modeling

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Ligand effects on the structure and vibrational properties of the thiolated Au18 cluster

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Progress in Natural Science:Materials International 2016年第5期26卷 510-515页

作者： Alfredo Tlahuice-flores CICFIM-Facultad de Ciencias Físico-Matemáticas Universidad Autónoma de Nuevo León

Most of the studies devoted to thiolated gold clusters suppose that their core and Au-S framework do not suffer from distortion independently of the protecting ligands（-SR） and it is assumed as correct to simplify the ligand as SCH3. In this work is delivered a systematic study of the structure and vibrational properties（IR and Raman）of the Au18（SR）14cluster. The pursued goal is to understand the dependency of the displayed vibrational properties of the thiolated Au18cluster with the ligands type. A set of six ligands was considered during calculations of the vibrational properties based on density functional theory（DFT） and in its dispersioncorrected approach（DFT-D）.

关键词： Gold cluster Ligand effects Structure Vibration Au18(SR)14 Density functional theory

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Curcuma longa L. extract improves the cortical neural connectivity during the aging process

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Neural Regeneration Research 2017年第6期12卷 875-880页

作者： Gonzalo flores Laboratorio de Neuropsiquiatría Instituto de Fisiología Benemérita Universidad Autónoma de Puebla

Turmeric or Curcuma is a natural product that has anti-inflammatory, antioxidant and anti-apoptotic pharmacological properties. It can be used in the control of the aging process that involves oxidative stress, inflammation, and apoptosis. Aging is a physiological process that affects higher cortical and cognitive functions with a reduction in learning and memory, limited judgment and deficits in emotional control and social behavior. Moreover, aging is a major risk factor for the appearance of several disorders such as cerebrovascular disease, diabetes mellitus, and hypertension. At the brain level, the aging process alters the synaptic intercommunication by a reduction in the dendritic arbor as well as the number of the dendritic spine in the pyramidal neurons of the prefrontal cortex, hippocampus and basolateral amygdala, consequently reducing the size of these regions. The present review discusses the synaptic changes caused by the aging process and the neuroprotective role the Curcuma has through its anti-inflammatory, antioxidant and anti-apoptotic actions.

关键词： Curcuma longa cortical curcumin hippocampus synaptic antioxidant spine connectivity cortex

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