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Dysglycemia and arrhythmias

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World Journal of Diabetes 2023年第8期14卷 1163-1177页

作者： Dong-Kun Sun Nan Zhang Ying Liu Jiu-Chun Qiu Gary Tse Guang-Ping Li leonardo Roever Tong Liu Department of Cardiology Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular DiseaseTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjin 300211China Kent and Medway Medical School Kent CT27NTCanterburyUnited Kingdom School of Nursing and Health Studies Metropolitan UniversityHong Kong 999077China Department of Clinical Research Federal University of UberlândiaUberlândia38400384MGBrazil

Disorders in glucose metabolism can be divided into three separate but interrelated domains,namely hyperglycemia,hypoglycemia,and glycemic *** glycemic control in patients with diabetes might increase the risk of hypoglycemic incidents and glucose *** three dysglycemic states occur not only amongst patients with diabetes,but are frequently present in other clinical settings,such as during critically ill.A growing body of evidence has focused on the relationships between these dysglycemic domains with cardiac arrhythmias,including supraventricular arrhythmias(primarily atrial fibrillation),ventricular arrhythmias(malignant ventricular arrhythmias and QT interval prolongation),and bradyarrhythmias(bradycardia and heart block).Different mechanisms by which these dysglycemic states might provoke cardiac arrhythmias have been identified in experimental studies.A customized glycemic control strategy to minimize the risk of hyperglycemia,hypoglycemia and glucose variability is of the utmost importance in order to mitigate the risk of cardiac arrhythmias.

关键词： Dysglycemia Hyperglycemia Hypoglycemia Glucose variability Cardiac arrhythmia

TLBO with variable weights applied to shop scheduling problems

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CAAI Transactions on Intelligence Technology 2019年第3期4卷 148-158页

作者： leonardo Ramos Rodrigues Joao Paulo Pordeus Gomes Electronics Division Institute of Aeronautics and SpacePraca Marechal Eduardo Gomes50Sao Josedos Campos 12228-904Brazil Computer Science Department Federal University of CearaRua Campus do PiciSnFortaleza 60440-554Brazil

The teaching–learning-based optimisation (TLBO) algorithm is a population-based metaheuristic inspired on the teaching–learning process observed in a classroom. It has been successfully used in a wide range of applications. In this study, the authors present a variant version of TLBO. In the proposed version, different weights are assigned to students during the student phase, with higher weights being assigned to students with better solutions. Three different approaches to assign weights are investigated. Numerical experiments with benchmark instances of the flow-shop and the job-shop scheduling problems are carried out to investigate the performance of the proposed approaches. They compare the proposed approaches with the original TLBO algorithm and with two variants of TLBOs proposed in the literature in terms of solution quality, convergence speed and simulation time. The results obtained by the application of a Friedman statistical test showed that the proposed approaches outperformed the original version of TLBO in terms of convergence, with no significant losses in the average makespan. The additional simulation time required by the proposed approaches is small. The best performance was achieved with the approach of assigning a fixed weight to half the students with the best solutions and assigning zero to other students.

关键词： TLBO variable weights shop scheduling problems

Subterranean termites （Isoptera： Rhinotermitidae）： Exploitation of equivalent food resources with different forms of placement

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Insect Science 2012年第3期19卷 412-418页

作者： Juliana Toledo Lima Ana Maria Costa-leonardo Departamento de Biologia Instituto de BiocienciasUNESP-Univ Estadual PaulistaRio Claro-SPBrazil

Coptotermes gestroi and Heterotermes tenuis have been described as important urban pests in Brazil. The establishment of control technologies using baits that consider the social behavior of termites requires a better knowledge of their foraging behavior. Thus, this study analyzed the feeding behavior of these species with three different forms of food placement： food on the surface of a substrate and food either partially or completely buried in the substrate. Experimental arenas were composed of a central chamber connected to three food chambers. Each central chamber contained 550 foragers of C. gestroi or 517 foragers of 11. tenuis. Blocks of Pinus elliottii were placed in the different food chambers. After 28 days, the consumption of each wood block and the percentage of foraging individuals recruited for food chambers were verified in relation to the total survival rate obtained for each one of the 20 replicates. Results showed that completely buried food was most consumed for H. tenuis and presented a higher recruitment rate of workers and soldiers for both species. Although the consumption had non-significant differences for C. gestroi, these termites exhibited a tendency to prefer completely buried food. In these conditions, it can be concluded that the forms of food placement used in the present research influenced the recruitment of individuals for both species. Data also suggests that when the foraging subterranean termites find food resources in the tunneling substrate, they tend to concentrate their efforts on it, a behavior regime that reduces exposure to external environment.

关键词： Coptotermes gestroi feeding behavior foraging behavior Heterotermes tenuis

Which octogenarian patients are at higher risk after cholecystectomy for symptomatic gallstone disease? A single center cohort study

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World Journal of Clinical Cases 2022年第24期10卷 8556-8567页

作者： Fabrizio D'Acapito leonardo Solaini Daniela Di Pietrantonio Francesca Tauceri Maria Teresa Mirarchi ElenaAntelmi Francesca Flamini Alessio Amato Massimo Framarini Giorgio Ercolani Department of General and Oncologic Surgery Morgagni-Pierantoni HospitalAUSL RomagnaForlì47121Italy Department of Medical and Surgical Sciences University of BolognaBologna 40126Italy

BACKGROUND Incidence of gallstones in those aged≥80 years is as high as 38%-53%.The decision-making process to select those oldest old patients who could benefit from cholecystectomy is *** To assess the risk of morbidity of the“oldest-old”patients treated with cholecystectomy in order to provide useful data that could help surgeons in the decision-making process leading to surgery in this *** A retrospective study was conducted between 2010 and *** variables were collected and compared between patients who had postoperative complications.A model was created and tested to predict severe postoperative *** The 269 patients were included in the study(193 complicated).The 9.7%of complications were grade 3 or 4 according to the Clavien-Dindo *** levels were lower in patients who did not have any postoperative *** Society of Anesthesiologists scale 4 patients,performing a choledocholithotomy and bilirubin levels were associated with Clavien-Dindo>2 complications(P<0.001).The decision curve analysis showed that the proposed model had a higher net benefit than the treating all/none options between threshold probabilities of 11%and 32%of developing a severe *** Patients with American Society of Anesthesiologists scale 4,higher level of bilirubin and need of choledocholithotomy are at the highest risk of a severely complicated postoperative *** endoscopic or percutaneous treatments should be considered in this subgroup of octogenarians.

关键词： Cholecystitis Gallstones Choledocholithotomy Elderly Post-operative complications

Creatine Supplementation Improves Physical Performance,Without Negative Effects on Health Markers,in Young Weightlifters

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Journal of Science in Sport and Exercise 2022年第3期4卷 255-265页

作者： Douglas Almeida Rafael Pereira Elvis Q.Borges Eric S.Rawson leonardo Silva Rocha Marco Machado Laboratory of Physiology and Biokinetic Faculty of Biological Sciences and HealthUNIG Campus VItaperuna 28300-000Brazil Departmment of Health Nutritionand Exercise ScienceMessiah UniversityMechanicsburgPA 17837USA Integrative Physiology Research Center Department of Biological SciencesUniversidade Estadual Do Sudoeste da Bahia(UESB)ItaperunaRJ 28300-000Brazil Research Group in Neuromuscular Physiology Department of Biological SciencesUniversidade Estadual Do Sudoeste da Bahia(UESB)JequiéBA 45210-506Brazil Laboratory of Human Movement Studies University Foundation of ItaperunaItaperuna 28300-000Brazil

Purpose The safety of creatine supplementation has been investigated,however,the safety of a high-dose/short-term or low-dose/long-term supplementation dosing scheme,combined with a resistance training program,a commonly used dosing scheme,has not yet *** aim of this study was to evaluate physical performance and the safety of the cited creatine supplementation dosing scheme in a double-blind placebo-controlled study by assessing blood and urine health indicators in subjects undertaking resistance *** Thirty-four healthy male subjects were randomly assigned to creatine supplement(CREA/7 days,0.3 g/kg body mass+21 days,0.03 g/kg)or placebo(PLA)group and both groups participated in a resistance training intervention(6 exercises,3 sets of 8-12 repetitions per exercise at 85%of 1RM,3 d/week).Blood and urine samples were collected pre-,7 and 30 days *** blood(26 parameters)and urine markers(15),between-group differences were calculated by using 2 groups(CREA and PLA)×2 measures(“POST7 minus PRE”and“POST30 minus PRE”)*** The CREA group exhibited significant body weight and 1RM increase(POST30 minus PRE)of all evaluated exercises,when compared to PLA *** the blood and urine health markers,only hematocrit,LDL,Uric Acid,Phosphatase Alkaline and Creatinine exhibited between-group differences,but with small magnitude of differences and maintained into the range of clinical reference *** Our data suggest that creatine supplementation the used dosing scheme,concomitantly with resistance training,improves physical performance with no evident risk or protection to health for young weightlifters.

关键词： Supplement Exercise performance Resistance exercise Kidney Liver Safety

cAMP:A second messenger involved in the mechanism of midgut alkalinization in Lutzomyia longipalpis

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Insect Science 2022年第4期29卷 1059-1070页

作者： Denise Barguil Nepomuceno Grasielle Caldas D’Ávila Pessoa leonardo Barbosa Koerich Marcos Horácio Pereira Mauricio Roberto Viana Sant'Anna Ricardo Nascimento Araújo Nelder Figueiredo Gontijo Laboratório de Fisiologia de Insetos Hematófagos Departamento de Parasitologia/ICBUniversidade Federal de Minas GeraisBelo HorizonteMGBrazil

The sand fly Lutzomyia longipalpis is the main vector of Leishmania infantum in the *** sand flies ingest sugar-rich solutions and blood,which are digested in the *** of nutrients is an essential function performed by digestive enzymes,which require appropriate physiological *** of the main aspects that influence enzymatic activity is the gut pH,which must be tightly *** second messengers are frequently involved in the coordination of tightly regulated physiological events,we investigated if the second messenger cAMP would participate in the process of alkalinization in the abdominal midgut of female *** midguts containing the indicator dye bromothymol-blue,cAMP stimulated the alkalinization of the midgut *** another technique based on the use of fluorescein as a pH indicator,we propose that cAMP is involved in the alkalinization of the midgut by activating HCO3-transport from the enterocyte's cytoplasm to the *** results strongly suggested that the carrier responsible for this process would be a HCO3−/Cl−antiporter located in the enterocytes’apical *** promotes the release of alkalinizing hormones in the hemolymph;however,when the enzyme adenylyl cyclase,responsible for cAMP production,was inhibited,we observed that the hemolymph from blood-fed ***’females did not stimulate midgut *** result indicated that hormone-stimulated alkalinization is mediated by *** the present study,we provide evidences that cAMP has a key role in the control of intestinal pH.

关键词： abdominal midgut alkalinization cAMP HCO_(3)^(-)/Cl^(-)antiport hormone Lulcomyia longipalpis

Robot-assisted kidney transplantation:Is it getting ready for prime time?

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World Journal of Transplantation 2022年第7期12卷 163-174页

作者： Vincenzo Li Marzi Alessio Pecoraro Maria Lucia Gallo leonardo Caroti Adriano Peris Graziano Vignolini Sergio Serni Riccardo Campi Department of Minimally Invasive and Robotic Urologic Surgery Careggi University HospitalUniversity of FlorenceFlorence 50134Italy Nephrology Unit Careggi HospitalFlorence 50134Italy Intensive Care Unit and Regional ECMO Referral Centre Careggi HospitalFlorence 50134Italy Department of Minimally Invasive and Robotic Urologic Surgery University of FlorenceFlorence 50134Italy Department of Experimental and Clinical Medicine University of FlorenceFlorence 50134Italy

Kidney transplantation(KT)is the treatment of choice for patients with end-stage renal disease,providing a better survival rate and quality of life compared to *** the progress in the medical management of KT patients,from a purely surgical standpoint,KT has resisted innovations during the last 50 ***,robot-assisted KT(RAKT)has been proposed as an alternative approach to open surgery,especially due to its potential benefits for fragile and immunocompromised *** was not until 2014 that the role of RAKT has found value thanks to the pioneering Vattikuti Urology Institute-Medanta collaboration that conceptualized and developed a new surgical technique for RAKT following the Idea,Development,Exploration,Assessment,Long-term follow-up recommendations for introducing surgical innovations into real-life *** the last years,mirroring the Vattikuti-Medanta technique,several centers developed RAKT program worldwide,providing strong evidence about the safety and the feasibility of this ***,the majority of RAKT are still performed in the living donor setting,as an“eligible”procedure,while only a few centers have realized KT through a robotic approach in the challenging scenario of cadaver *** addition,despite the spread of minimally-invasive(predominantly robotic)surgery worldwide,many KTs are still performed in an open *** of the type of incision employed by surgeons,open KT may lead to nonnegligible risks of wound complications,especially among obese ***,the assessment for KT should consider not only the added surgical technical challenges but also the higher risk of postoperative *** this context,robotic surgery could offer several benefits,including providing a better exposure of the surgical field and better instrument maneuverability,as well as the possibility to integrate other technological nuances,such as the use of intraoperative fluorescence vascular imagi

关键词： Deceased donors Living donors Kidney transplantation Minimally invasive surgery Robotics

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MPEG-Past and Future

通信学报 1995年第5期16卷 46-59页

作者： leonardo Chiariglione (CSELT, Italy) CSEL T 意大利

ＭＰＥＧ－ＰａｓｔａｎｄＦｕｔｕｒｅ￥ＬｅｏｎａｒｄｏＣｈｉａｒｉｇｌｉｏｎｅ（ＣＳＥＬＴ，Ｉｔａｌｙ）Ａｂｓｔｒａｃｔ：Ｔｈｅｄｒｅａｍｏｆｄｉｇｉｔａｌａｕｄｉｏａｎｄｖｉｄｅｏａｎｄ，ｏｆｌａｔｅ，ｍｕｌｔｉｍ... 详细信息

ＭＰＥＧ－ＰａｓｔａｎｄＦｕｔｕｒｅ￥ＬｅｏｎａｒｄｏＣｈｉａｒｉｇｌｉｏｎｅ（ＣＳＥＬＴ，Ｉｔａｌｙ）Ａｂｓｔｒａｃｔ：Ｔｈｅｄｒｅａｍｏｆｄｉｇｉｔａｌａｕｄｉｏａｎｄｖｉｄｅｏａｎｄ，ｏｆｌａｔｅ，ｍｕｌｔｉｍｅｄｉａｉｎｆｏｒｍａｔｉｏｎｆｒ...

关键词： international standards MPEG Uideo coding audio coding

Melting behavior and globular microstructure formation in semi-solid CoCrCuxFeNi high-entropy alloys

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Journal of Materials Science & Technology 2020年第17期52卷 207-217页

作者： Kaio Niitsu Campo Caio Chaussêde Freitas leonardo Fanton Rubens Caram University of Campinas School of Mechanical EngineeringSPBrazil

High-entropy alloys can be compelling raw materials for semi-solid *** the present study,the influence of the Cu content on the melting behavior and semi-solid microstructure of CoCrCuxFeNi(x=0,1,2,3)alloys was ***-melted samples were cross-rolled at room temperature and then isothermally treated at 1175℃in the semi-solid state for 300 *** characterization showed that the alloys containing Cu were formed by two fcc ***,the increase in Cu content also led to an increase in the volumetric fraction of the Cu-rich *** solidification,this phase,which is the last to form,nucleates and epitaxially grows on the Cu-lean *** the studied CoCrCuFeNi alloys exhibited the same melting *** Cu-rich phase melts at approximately 1120℃,whereas the Culean phase melts at approximately 1350℃,providing a suitable processing temperature range of more than 200℃.The semi-solid microstructures were considerably refined and globular regardless of the alloy composition,being suitable for semi-solid ***,each fcc phase exhibited roughly the same composition under the different processing *** Cu content in the Cu-lean phase was approximately 10 at.%,while Co,Cr,Fe,and Ni were in an approximately equiatomic ***,the Cu content was between 80 at.%and 86 at.%in the Cu-rich *** isothermal treatment of the CoCrCu3FeNi alloy at a higher temperature(1300℃)only caused the globules to *** conclusion,this work showed that these alloys can be potential candidates for semi-solid processing.

关键词： Semi-solid processing Thixoforming High-entropy alloys Microstructure