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The Interrelation of Urban Health Indicators and COVID-19:A Study of Passo Fundo/RS

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Journal of Civil Engineering and Architecture 2021年第10期15卷 534-540页

作者： Letícia Müller Thaísa Leal da silva Wilson Levy braga da silva Neto Postgraduate Program in Architecture and Urbanism(PPGARQ-IMED) Passo Fundo/RS 99070-220Brazil Postgraduate Program in Smart and Sustainable Cities(PPG-CIS-UNINOVE) São Paulo/SP 03155-000Brazil

The COVID-19(Coronavirus Disease 19)pandemic has demonstrated that cities are at the center of major contemporary *** epidemiological crisis has highlighted the importance of the urban environment,challenging public managers on managing *** initiative that aims to assist in this management process is the concept of Smart Cities,which uses ICT(Information and Communication Technology)as tools for transforming urban dynamics,and through urban indicators,measures information about ***,the research aimed to analyze the health indicators of Passo Fundo/RS,seeking to analyze the interrelationship of these indicators with the epidemiological data from *** the methodology,multi-method procedures were applied,using the indicators of the Connected Smart Cities Ranking as reference,as well as a regional selection of medium-sized cities in the southern region of *** results show that the health indices of Passo Fundo are,for the most part,lower than those of the analyzed cities,with the indicator related to Population Coverage of the Family Health team as the main ***,it also presents satisfactory indices as is the case of the indicator of Beds/1,000 *** the epidemiological picture of COVID-19,Passo Fundo had a high lethality rate when compared to the other analyzed cities.

关键词： Smart cities COVID-19 urban health indicators resilience.

Prediction of hospital mortality in intensive care unit patients from clinical and laboratory data: A machine learning approach

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World Journal of Critical Care Medicine 2022年第5期11卷 317-329页

作者： Elena Caires Silveira Soraya Mattos Pretti Bruna Almeida Santos Caio Fellipe Santos Correa leonardo Madureira silva Fabricio Freire de Melo Multidisciplinary Institute of Health Federal University of BahiaVitória da Conquista 45-029094Brazil

BACKGROUND Intensive care unit(ICU)patients demand continuous monitoring of several clinical and laboratory parameters that directly influence their medical progress and the staff’s *** data are vital in the assistance of these patients,being already used by several scoring *** this context,machine learning approaches have been used for medical predictions based on clinical data,which includes patient *** To develop a binary classifier for the outcome of death in ICU patients based on clinical and laboratory parameters,a set formed by 1087 instances and 50 variables from ICU patients admitted to the emergency department was obtained in the“WiDS(Women in data Science)datathon 2020:ICU Mortality Prediction”*** For categorical variables,frequencies and risk ratios were *** variables were computed as means and standard deviations and Mann-Whitney U tests were *** then divided the data into a training(80%)and test(20%)*** training set was used to train a predictive model based on the Random Forest algorithm and the test set was used to evaluate the predictive effectiveness of the *** A statistically significant association was identified between need for intubation,as well predominant systemic cardiovascular involvement,and hospital death.A number of the numerical variables analyzed(for instance Glasgow Coma Score punctuations,mean arterial pressure,temperature,pH,and lactate,creatinine,albumin and bilirubin values)were also significantly associated with death *** proposed binary Random Forest classifier obtained on the test set(n=218)had an accuracy of 80.28%,sensitivity of 81.82%,specificity of 79.43%,positive predictive value of 73.26%,negative predictive value of 84.85%,F1 score of 0.74,and area under the curve score of *** predictive variables of the greatest importance were the maximum and minimum lactate values,adding up to a predictive importance of 15.54%.CONCLUSIO

关键词： Hospital mortality Machine learning Patient outcome assessment Routinely collected health data Intensive care units Critical care outcomes

Reserpine-Induced Progressive Parkinsonism in Mice Predisposed and Non-Predisposed to Depressive-Like Behavior

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Journal of Behavioral and Brain Science 2021年第11期11卷 267-279页

作者： Manuela B. L. Soares leonardo B. Lopes-silva Marcela Becegato Vinicius S. Bioni Alvaro C. Lima Gabriela M. Ferreira Ywlliane Meurer Regina H. silva Behavioral Neuroscience Laboratory Department of Pharmacology Federal University of S&atilde o Paulo S&atilde o Paulo Brazil Memory and Cognition Studies Laboratory Post-Graduate Program of Cognitive Neuroscience and Behavior Department of Psychology Federal University of Paraíba Jo&atilde o Pessoa Brazil

Parkinson’s disease (PD) is a progressive degenerative condition that mainly affects the elderly. The disease comprises motor symptoms such as tremors at rest, loss of voluntary movement, decreased muscle strength, propensity to lean forward and acceleration of the walking pace. These signs are related to the degeneration of the nigrostriatal dopaminergic pathway. Patients also have non-motor symptoms, among which sleep alterations, cognitive deficits, fatigue, pain and depression stand out. Although depression has been described as the most prevalent non-motor symptom, it is not clear whether this mood disorder is due to PD or patients would already have a greater predisposition. The present study evaluated the relationship between the predisposition to depressive-like behavior and the development of motor alterations in a progressive pharmacological model of PD in mice. Mice were classified into groups of depressive-like propensities and submitted to the pharmacological model. Reserpine was administrated at 0.1 mg/kg on alternate days for 40 days. The catalepsy and oral movement tests were used to evaluate motor alterations, the sucrose preference test was used to evaluate anhedonia, and the open field test was applied to evaluate general activity. Reserpine promoted parkinsonian motor impairments, and there were no differences between animals from different depressive-like behavior profiles. Thus, it was not possible to find a relationship between parkinsonism and the propensity to depression based on the basal sucrose preference test. More studies with other evaluations of depressive-like behavior are needed to confirm the results found in our study.

关键词： Parkinson’s Disease Depression Reserpine Mice

Luminescent polymer electrolytes based on chitosan and containing europium triflate

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Journal of Rare Earths 2016年第7期34卷 661-666页

作者： R.Alves A.S.S.de Camargo A.Pawlicka M.M.silva Center of Chemistry University of MinhoGualtar4710-057 BragaPortugal Sao Carlos Institute of Physics University of Sao Paulo13566-590 Sao Carlos-SPBrazil Sao Carlos Institute of Chemistry University of Sao Paulo13566-590 Sao Carlos-SPBrazil

Solid polymer electrolytes based on chitosan and europium triflate were prepared by solvent casting and characterized by X-ray diffraction, scanning electron microscopy （SEM）, atomic force microscopy （AFM）, and photoluminescence spectroscopy. The X-ray diffraction exhibited that the samples were essentially amorphous with organized regions over the whole range of the salt content studied. The AFM analysis demonstrated that the smoother sample had roughness of 4.39 nm. Surface visualization through SEM revealed good homogeneity without any phase separation for more conductive samples and the less conductive showed some im- perfections on the surface. The emission and excitation spectra displayed the characteristic bands of Eu（CF3SO3）3 in addition to broad bands corresponding to the polymer host. The excited state 5D0 lifetime values ranged from 0.29-0.37 ms for the studied samples.

关键词： solid polymer electrolytes natural polymers photoluminescence spectroscopy rare earths

Elevated calprotectin levels are associated with mortality in patients with acute decompensation of liver cirrhosis

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World Journal of Hepatology 2022年第11期14卷 1964-1976页

作者： Camila Matiollo Elayne Cristina de Morais Rateke Emerita Quintina de Andrade Moura Michelle Andrigueti Fernanda Cristina de Augustinho Tamara Liana Zocche Telma Erotides silva Lenyta Oliveira Gomes Mareni Rocha Farias Janaina Luz Narciso-Schiavon leonardo Lucca Schiavon Clinical Analysis Laboratory Unit University HospitalFederal University of Santa CatarinaFlorianopolis 88040-900Brazil Division of Gastroenterology University HospitalFederal University of Santa CatarinaFlorianópolis 88040-900Brazil Department of Pharmaceutical Sciences Health Sciences Center Federal University of Santa CatarinaFlorianópolis 88040-370Brazil Division of Gastroenterology Department of Internal MedicineFederal University of Santa CatarinaFlorianopolis 88040-900SCBrazil

BACKGROUND Acute decompensation(AD)of cirrhosis is related to systemic inflammation and elevated circulating *** this context,biomarkers of inflammation,such as calprotectin,may be of prognostic *** To evaluate serum calprotectin levels in patients hospitalized for complications of *** This is a prospective cohort study that included 200 subjects hospitalized for complications of cirrhosis,20 outpatients with stable cirrhosis,and 20 healthy *** calprotectin was measured by enzyme-linked immunosorbant *** Calprotectin levels were higher among groups with cirrhosis when compared to healthy *** median calprotectin was related to Child-Pugh C,ascites,and hepatic *** calprotectin was related to acute-on-chronic liver failure(ACLF)and infection in the bivariate,but not in multivariate *** was not associated with survival among patients with ACLF;however,in patients with AD without ACLF,higher calprotectin was associated with a lower 30-d survival,even after adjustment for chronic liver failure-consortium(CLIF-C)AD score.A high-risk group(CLIF-C AD score≥60 and calprotectin≥580 ng/mL)was identified,which had a 30-d survival(27.3%)similar to that of patients with grade 3 ACLF(23.3%).CONCLUSION Serum calprotectin is associated with prognosis in patients with AD without ACLF and may be useful in clinical practice to early identify patients with a very low short-term survival.

关键词： Inflammation Liver cirrhosis Acute-on-chronic liver failure

Current advances in solid free-form techniques for osteochondral tissue engineering

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Bio-Design and Manufacturing 2018年第3期1卷 171-181页

作者： Joao Bebiano Costa Joana silva-Correia Rui Luis Reis Joaquim Miguel Oliveira B's Research Group I3Bs - Research Institute onBiomaterials Biodegradables and Biomimetics University ofMinho Headquarters of the European Institute of Excellenceon Tissue Engineering and Regenerative Medicine AveParkParque de Ciencia e Tecnologia Zona Industrial da Gandra4805-017 Barco Guimaraes Portugal ICVS/3B's-PT Government Associate Laboratory Braga Guimarfies Portugal The Discoveries Centre for Regenerative and PrecisionMedicine Headquarters at University of MinhoAvepark 4805-017 Barco Guimaraes Portugal

Osteochondral （OC） lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds＇ processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form （SFF） techniques. These techniques allow tuning different properties at the micro-macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.

关键词： Solid free-form Osteochondral Tissue engineering Scaffolds

Joannesia princeps： Evaluation of Aqueous Extracts Genotoxicity Utilizing Allium cepa Assay and Micronucleus Test

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Journal of Life Sciences 2013年第12期7卷 1249-1254页

作者： Viviane Moreira de Lima Jessica Tamara dos Santos Teixeira Jennifer Vieira Gomes Lelio Kallut Almeida Netto leonardo Oliveira Bastos Hataanderson Luiz Cabral dos Santos Lenicio Gongalves Francisco de Assis da silva Bruno Pereira Berto Helcio Resende Borba Department of Animal Biology Federal Rural University of Rio de Janeiro Seropddica Rio de Janeiro 23890000 Brazil

Evaluation of the genotoxic and cytotoxic potentials is a part of the analysis process where plant products with therapeutic properties must be submitted for being safely employed, mainly through long time points, doannesia princeps, also known as ＂cotieira＂ has been used on popular medicine as laxative and several diseases treatment. Aiming to analyze genotoxic potential ofd. princeps leaves extract, Allium cepa assay and micronucleus test were employed. No genotoxic activity presented J. princeps leaves extract; however, extracts cytotoxic activity over A. cepa meristematic cells and mice marrow cells was observed. J. princeps leaves extract presented antiproliferative activity at concentrations and systems employed indicating their therapeutic potential for cellular cycle inhibition. Moreover, results showed that in regard to its mutagenic effect, usage of J. princeps leaves tea on popular medicine has been a safe procedure, as well.

关键词： Cytotoxicity genotoxicity Allium cepa assay micronucleus Joannesia princeps.

Cell-based therapeutic strategies for treatment of spinocerebellar ataxias:an update

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Neural Regeneration Research 2023年第6期18卷 1203-1212页

作者： Joana Sofia Correia Sara Duarte-silva António JoséSalgado Patrícia Maciel Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s–PT Government Associate Laboratory BragaGuimarãesPortugal

Spinocerebellar ataxias are heritable neurodegenerative diseases caused by a cytosine-adenine-guanine expansion,which encodes a long glutamine tract(polyglutamine)in the respective wild-type protein causing misfolding and protein *** features of polyglutamine spinocerebellar ataxias include neuronal aggregation,mitochondrial dysfunction,decreased proteasomal activity,and autophagy *** polyglutamine protein aggregates accumulate within neurons and cause neural dysfunction and death in specific regions of the central nervous *** ataxias are mostly characterized by progressive ataxia,speech and swallowing problems,loss of coordination and gait *** the past decade,efforts have been made to ameliorate disease symptoms in patients,yet no cure is *** studies have been proposing the use of stem cells as promising tools for central nervous system tissue *** far,pre-clinical trials have shown improvement in various models of neurodegenerative diseases following stem cell transplantation,including animal models of spinocerebellar ataxia types 1,2,and ***,contrasting results can be found in the literature,depending on the animal model,cell type,and route of administration ***,clinical trials using cellular implants into degenerated brain regions have already been applied,with the expectation that these cells would be able to differentiate into the specific neuronal subtypes and re-populate these regions,reconstructing the affected neural ***,the question of how feasible it is to continue such treatments remains unanswered,with long-lasting effects being still *** establish the value of these advanced therapeutic tools,it is important to predict the actions of the transplanted cells as well as to understand which cell type can induce the best outcomes for each *** studies are needed to determine the best route of administration,without neglec

关键词： cell transplantation engraftment induced pluripotent stem cells mesenchymal stem cells neural progenitor cells neuroprotection polyglutamine spinocerebellar ataxias secretome spinocerebellar ataxia stem cell therapy

Recognition of esophagitis in endoscopic images using transfer learning

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World Journal of Gastrointestinal Endoscopy 2022年第5期14卷 311-319页

作者： Elena Caires Silveira Caio Fellipe Santos Corrêa leonardo Madureira silva Bruna Almeida Santos Soraya Mattos Pretti Fabrício Freire de Melo Multidisciplinary Institute of Health Federal University of BahiaVitória da Conquista 45029-094BahiaBrazil

BACKGROUND Esophagitis is an inflammatory and damaging process of the esophageal mucosa,which is confirmed by endoscopic visualization and may,in extreme cases,result in stenosis,fistulization and esophageal *** use of deep learning(a field of artificial intelligence)techniques can be considered to determine the presence of esophageal lesions compatible with *** To develop,using transfer learning,a deep neural network model to recognize the presence of esophagitis in endoscopic *** Endoscopic images of 1932 patients with a diagnosis of esophagitis and 1663 patients without any pathological diagnosis provenient from the KSAVIR and HyperKSAVIR datasets were splitted in training(80%)and test(20%)and used to develop and evaluate a binary deep learning classifier built using the DenseNet-201 architecture,a densely connected convolutional network,with weights pretrained on the ImageNet image set and fine-tuned during *** classifier model performance was evaluated in the test set according to accuracy,sensitivity,specificity and area under the receiver operating characteristic curve(AUC).RESULTS The model was trained using Adam optimizer with a learning rate of 0.0001 and applying binary cross entropy loss *** the test set(n=719),the classifier achieved 93.32%accuracy,93.18%sensitivity,93.46%specificity and a 0.96 *** for spatial predictive relevance in esophagitis endoscopic images from the test set were also *** face of the obtained results,the use of dense convolutional neural networks with pretrained and fine-tuned weights proves to be a good strategy for predictive modeling for esophagitis recognition in endoscopic *** addition,adopting the classification approach combined with the subsequent plotting of heat maps associated with the classificatory decision gives greater explainability to the *** It is opportune to raise new studies involving transfer learning for the analysis of en

关键词： Esophagitis Endoscopy Artificial intelligence Deep learning Transfer learning