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Creatine Supplementation Improves Physical Performance,Without Negative Effects on Health Markers,in Young Weightlifters

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Journal of Science in Sport and Exercise 2022年第3期4卷 255-265页

作者： Douglas Almeida Rafael Pereira Elvis Q.Borges Eric S.Rawson leonardo silva rocha Marco Machado Laboratory of Physiology and Biokinetic Faculty of Biological Sciences and HealthUNIG Campus VItaperuna 28300-000Brazil Departmment of Health Nutritionand Exercise ScienceMessiah UniversityMechanicsburgPA 17837USA Integrative Physiology Research Center Department of Biological SciencesUniversidade Estadual Do Sudoeste da Bahia(UESB)ItaperunaRJ 28300-000Brazil Research Group in Neuromuscular Physiology Department of Biological SciencesUniversidade Estadual Do Sudoeste da Bahia(UESB)JequiéBA 45210-506Brazil Laboratory of Human Movement Studies University Foundation of ItaperunaItaperuna 28300-000Brazil

Purpose The safety of creatine supplementation has been investigated,however,the safety of a high-dose/short-term or low-dose/long-term supplementation dosing scheme,combined with a resistance training program,a commonly used dosing scheme,has not yet *** aim of this study was to evaluate physical performance and the safety of the cited creatine supplementation dosing scheme in a double-blind placebo-controlled study by assessing blood and urine health indicators in subjects undertaking resistance *** Thirty-four healthy male subjects were randomly assigned to creatine supplement(CREA/7 days,0.3 g/kg body mass+21 days,0.03 g/kg)or placebo(PLA)group and both groups participated in a resistance training intervention(6 exercises,3 sets of 8-12 repetitions per exercise at 85%of 1RM,3 d/week).Blood and urine samples were collected pre-,7 and 30 days *** blood(26 parameters)and urine markers(15),between-group differences were calculated by using 2 groups(CREA and PLA)×2 measures(“POST7 minus PRE”and“POST30 minus PRE”)*** The CREA group exhibited significant body weight and 1RM increase(POST30 minus PRE)of all evaluated exercises,when compared to PLA *** the blood and urine health markers,only hematocrit,LDL,Uric Acid,Phosphatase Alkaline and Creatinine exhibited between-group differences,but with small magnitude of differences and maintained into the range of clinical reference *** Our data suggest that creatine supplementation the used dosing scheme,concomitantly with resistance training,improves physical performance with no evident risk or protection to health for young weightlifters.

关键词： Supplement Exercise performance Resistance exercise Kidney Liver Safety

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King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

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World Journal of Transplantation 2025年第1期15卷 124-134页

作者： Bruno da silva Athanasio Antonio Marcio de Faria Andrade Vivian Vasconcelos Costa Juliano Felix Castro Silverio leonardo Macedo Garcia Mauro Martins Teixeira Daniele da Gloria Souza Paula Vieira Teixeira Vidigal Cristiano Xavier Lima Department of Surgery Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Liver Transplantation Unit Felicio Rocho HospitalBelo Horizonte 30110-934Minas GeraisBrazil Department of Morphology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Pathology Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Acute liver failure(ALF)is a severe condition characterized by rapid deterioration of liver function in individuals without preexisting liver *** transplantation(LT)is the most impactful *** fever(YF)is an infectious disease that primarily affects the liver and has a high mortality ***,LT can be a viable option for treating rare cases with extensive liver ***,the criteria for assessing the severity of ALF and determining the indications for transplantation have not been specifically validated for cases caused by *** To present necessary adjustments to established scoring systems for ALF secondary to *** This was an observational,retrospective,single-center *** consecutive patients with confirmed ALF due to YF were monitored in the intensive care unit by a specialized liver transplant team during a three-month epidemic outbreak in *** hospitalization,general supportive therapeutic measures were implemented,and the patients were regularly assessed using the King's College criteria and the Clichy-Villejuif criteria to determine the severity of liver *** is considered a viable measure for patients with signs of end-stage liver *** Eight of 14(57%)patients developed severe neurological alterations within the first 96 hours after hospital *** patients underwent emergency LT,and despite a moderate viral infection of the graft after transplantation,the 5-year survival rate was 50%.Although the King's College criteria and the Clichy-Villejuif criteria are the main scoring systems for ALF,they are insufficient for predicting the risk of mortality in this context,primarily because of low serum bilirubin levels in the final stage of the disease and significant disparities between coagulation abnormalities and patient *** To ensure good applicability in cases of YF-induced ALF,the authors suggest adaptations to the King's College and Clichy-Vill

关键词： Yellow fever Acute liver failure Liver transplantation King's College criteria Clichy-Villejuif criteria

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Preliminary results of a new intrastromal corneal ring segment as a tissue saving procedure in photorefractive keratectomy to correct moderate to high myopia

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1955-1960页

作者： Sandro Coscarelli Pablo Rodrigues Guilherme rocha leonardo Torquetti Ennio Coscarelli Eye Clinic Belo Horizonte 30140-001Brazil Escola Paulista de Medicina Sao Paulo 04023-062Brazil Hospital de Olhos de Brasilia Brasilia 70200-670Brazil Center of Excellence in Ophthalmology Para de Minas 35660-051Brazil

AIM:To evaluate the clinical results after implantation of a new intrastromal corneal ring segment(ICRS)associated with photorefractive keratectomy(PRK)to correct high myopia(HM)patients with thin ***:We evaluated 42 eyes of 23 HM patients that had ICRS implantation followed by *** mean age of patients was 29.1±7.12 y(range 18 to 40 years old).Uncorrected visual acuity(UCVA),best corrected visual acuity(BCVA),keratometry,spherical equivalent,pachymetry,and aberrometry were compared using ANOVA with repeated measurements evaluated preoperatively and at last follow-up visit after the *** refractive predictability and simulated/real corneal ablation were also ***:The mean follow-up time after PRK was 6.8±1.6 *** mean preoperative UCVA improved from 20/800 preoperative to 20/100 after ICRS and 20/35 after *** mean preoperative BCVA was 20/25(range from 20/30 to 20/20)and remained unchanged after ICRS *** the PRK the mean BCVA was 20/25(range from 20/30 to 20/20).The mean spherical equivalent decreased from-7.25±1.12(range-5.00 to-9.00)preoperatively to-3.32±1.0(range-2.00 to-5.00)postoperatively(P<0.001)after ICRS implantation and decreased from-2.44±1.51 preoperatively to 0.32±0.45(range-0.625 to 0.875)postoperatively(P<0.001)after *** change in BCVA and topographic astigmatism was statistically significant(P<0.0001).CONCLUSION:ICRS in HM associated with PRK can be a tissue saving procedure and an alternative surgical option for correction of moderate to high myopia.

关键词： high myopia intrastromal corneal ring segments photorefractive keratectomy

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Toxicological effects of mining hazard elements

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Energy Geoscience 2022年第3期3卷 255-262页

作者： leonardo Lucas da silva-Rego leonardo Augusto de Almeida Juciano Gasparotto Instituto de Ciencias Biomedicas-Universidade Federal de Alfenas AlfenasMinas GeraisRua Gabriel Monteiro da Silva700CEP:37130-001Centro-Alfenas/MGBrazil

Mining plays a prominent role in the economy worldwide since human efforts have been more concentrated in extraction than recycling of natural *** composed of various minerals vary according to the geological *** are raw materials for the conventional industries or fossil fuels for power *** can also be used in new *** mining industry triggers intense environmental *** exposure to multiple small particles from mining effluent,such as dust,uranium,iron,lead,zinc,silicon,titanium,sulfur,nitrogen,platinum,chromium,vanadium,manganese,and mercury,is a health *** elements can have several pathological effects,such as respiratory and cardiovascular,multiple chronic inflammation,and neurodegenerative ***,mining results in severe soil,water(surface and aquifer),and air contamination,reaching large areas far away from the *** of mining companies,with the recovery of ancient mined areas during the early development of environmental laws and regulations,compromises environmental integrity for more extended periods,increasing coverage of the affected *** review evaluates the toxicological effects on humans exposed to the mining wastes and the impact of these compounds on the *** results of our evaluation can be used by the government,manufacturers,scientists,private environmental organizations,decision-makers,and readers from different areas of knowledge to explore the potential risk of mining to the ecosystem and human health.

关键词： Mining operation Toxicology Environmental impact Ecosystem Human health

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The road to sustainable use and waste management of plastics in Portugal

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Frontiers of Environmental Science & Engineering 2022年第1期16卷 91-106页

作者： Joana C.Prata Ana LPatrício silva Armando CDuarte Teresa rocha-Santos Centre for Environmental and Marine Studies(CESAM)&Department of Chemistry University of Aveiro3810-193 AveiroPortugal Centre for Environmental and Marine Studies(CESAM)&Department of Biology University of Aveiro3810-193 AveiroPortugal

As a European Union(EU)member,Portugal must comply with reductions in plastic *** Portugal,the 330 items/100 m of beach litter,comprising up to 3.9 million pieces and of which 88%is plastic,is higher than the EU median(149 items/100 m)and must be reduced to 20 items/100 m(94%).Integrative measures are needed to reduce littering and improve plastics’use and disposal under the circular *** this 414 kt of plastic packaging waste,163 kt were declared plastic packaging,140 kt subjected to recycling,and 94 kt to energy *** current recycling rate of plastic packaging(34%)should be improved to reach EU recycling averages(42%)and goals and to provide widespread benefits,considering revenues of 167€/*** a net importer of waste,Portugal could benefit from the valorization of imported *** increased recycling,pyrolysis and gasification could provide short-term alternatives for producing value-added substances from plastic waste,such as hydrogen,consistent with the National Plan of Hydrogen and improving ongoing regulations on single-use *** manuscript provides an integrative view of plastics in Portugal,from use to disposal,providing specific recommendations under the circular economy.

关键词： Single-use plastics Plastic packaging Plastic waste Waste management Waste shipment Lightweight plastic bags

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The Global Leprosy Assessment Index(GLAI):A new approach for measuring the severity of disease in Brazil

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Infectious Medicine 2023年第2期2卷 128-135页

作者： Lucas silva Thiago rocha Dalson Figueiredo Filho Department of Medicine Universidade Estadual de Ciências da Saúde do Estado de AlagoasMaceio 57010-382ALBrazil Department of Political Science Universidade Federal de PernambucoRecife 50670-901PEBrazil

Background:In Brazil,the Ministry of Health(MH)monitors leprosy using 15 indicators,with the aim of imple-menting and evaluating evidence-based public ***,an excessive number of variables can compli-cate the definition of objectives and verification of epidemiological ***:In this paper,we develop the Global Leprosy Assessment Index(GLAI),a composite measure that integrates two key dimensions for the control the disease:epidemiological and *** a confirmatory factor analysis model to examine 2020 state-level data,we have standardized GLAI to a range of 0 to ***:Higher values within this range indicate a greater severity of the *** mean value of the GLAI was 0.67,with a standard deviation of *** has the highest value,followed by Paraíba with 0.88 while Tocantins records the lowest value of the indicator,followed by Mato Grosso with *** epidemiological and operational indicators have a positive but statistically insignificant correlation(r=0.25;p-value=0.20).Conclusions:The development of evidence-based public policies depends on the availability of valid and reliable *** GLAI presented in this paper is easily reproducible and can be used to monitor the disease with disaggregated ***,the GLAI has the potential to serve as a more robust parameter for evaluating the impact of actions designed to eradicate leprosy in Brazil.

关键词： Leprosy Transmissible disease control Public health policy Health indicator Factor analysis

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Horizontally Solidified Al-3 wt%Cu-(0.5 wt%Mg)Alloys:Tailoring Thermal Parameters,Microstructure,Microhardness,and Corrosion Behavior

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Acta Metallurgica Sinica(English Letters) 2019年第6期32卷 695-709页

作者： Andre Barros Clarissa Cruz Adrina P.silva Noe Cheung Amauri Garcia Otavio rocha Antonio Moreira Institute of Technology Federal University of Para-UFPABelemPA 66075-110Brazil Federal Institute of Education Science and Technology of Para-IFPABelemPA 66093-020Brazil Department of Manufacturing and Materials Engineering University of Campinas-UNICAMPCampinasSP 13083-860Brazil

In the present experimental investigation,Al–3 wt%Cu and Al–3 wt%Cu–0.5 wt%Mg alloys castings are produced by a horizontal solidification technique with a view to examining the interrelationship among growth rate(GR),cooling rate(CR),secondary dendrite arm spacing(λ2),Vickers microhardness(HV),and corrosion behavior in a 0.5 M NaCl *** intermetallic phases of the as-solidified microstructures,that is,h-Al2Cu,S–Al2CuMg,and x-Al7Cu2 Fe,are subjected to a comprehensive characterization by using calculations provided by computational thermodynamics software,optical microscopy,and scanning electron microscopy/energy-dispersive ***,electrochemical impedance spectroscopy and potentiodynamic polarization tests have been applied to analyze the corrosion performance of samples of both alloys ***–Petch-type equations are proposed to represent the HV dependence onλ*** is shown that the addition of Mg to the Al–Cu alloy has led to a considerable increase in HV;however,the Al–Cu binary alloy is shown to have lower corrosion current density(icorr)as well as higher polarization resistance as compared to the corresponding results of the Al–Cu–Mg ternary alloy.

关键词： Aluminum alloys Solidification Dendritic microstructure Intermetallic phases Microhardness Corrosion resistance

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Diabetes and obesity:A debate on bariatric interventions and its implications

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World Journal of Diabetes 2024年第11期15卷 2157-2161页

作者： JoséC Tatmatsu-rocha Marcos R Lima da silva College of Medicine Postgraduate Program in Physiotherapy and FunctionalityDepartment of PhysiotherapyFederal University of Ceará-UFCFortaleza 60430-450CearáBrazil

In this editorial,we comment on an article by Tang et al published in the World Journal of *** and diabetes are two pathological situations that are intrinsically *** lifestyle changes nor pharmacological treatments have achieved diabetes *** this perspective,bariatric surgery has been widely used as an approach for weight loss in obese patients and as a strategy to promote metabolic *** main effects of bariatric surgery involve direct action in improving cardiovascular function and endothelial function and reducing insulin resistance,leading to diabetes remission in the short term following *** this context,it has been observed that hormones from the gastrointestinal tract and endothelium play a prominent role in this *** reversing endothelial dysfunction,it is possible to balance pro-inflammatory cytokine production,improving the availability of nitric oxide and inhibiting vascular oxidative ***,it can be considered an efficient anti-inflammatory strategy,alleviating interferon-gamma-mediated adipose tissue *** current challenge must be to unravel the pathophysiological mechanisms and potential targets for treating metabolic diseases.

关键词： Bariatric surgery Diabetes mellitus Oxidative stress Endothelial dysfunction Obesity

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Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis

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World Journal of Gastroenterology 2014年第28期20卷 9458-9467页

作者： Bruno César da silva Andre Castro Lyra Raquel rocha Genoile Oliveira Santana Post-graduate Program in Medicine and Health Federal University of Bahia Gastroenterology Department of the University Hospital Professor Edgard Santos Federal University of Bahia Gastro-Hepatology Service of Hospital S?o Rafael Department of Sciences of Nutrition School of NutritionFederal University of Bahia

Ulcerative colitis(UC)is a chronic disease characterized by diffuse inflammation of the mucosa of the colon and *** hallmark clinical symptom of UC is bloody *** clinical course is marked by exacerbations and remissions,which may occur spontaneously or in response to treatment changes or intercurrent *** is most commonly diagnosed in late adolescence or early adulthood,but it can occur at any *** incidence of UC has increased worldwide over recent decades,especially in developing *** contrast,during this period,therapeutic advances have improved the life expectancy of patients,and there has been a decrease in the mortality rate over *** is important to emphasize that there is considerable variability in the phenotypic presentation of *** this context,certain clinical and demographic characteristics are useful in identifying patients who tend to have more severe evolution of the disease and a poor *** this group of patients,better clinical surveillance and more intensive therapy may change the natural course of the *** aim of this article was to review the epidemiology and demographic characteristics of UC and the factors that may be associated with its clinical prognosis.

关键词： Ulcerative colitis Incidence Prevalence Risk factors Predictive factors

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Induced pluripotent stem cells, a giant leap for mankind therapeutic applications

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World Journal of Stem Cells 2019年第7期11卷 421-430页

作者： JoséBraganca Joao AndréLopes leonardo Mendes-silva Joao Miguel Almeida Santos Department of Biomedical Sciences and Medicine University of AlgarveFaro 8005-139Portugal Centre for Biomedical Research(CBMR) University of AlgarveFaro 8005-139Portugal

Induced pluripotent stem cells(iPSC)technology has propelled the field of stem cells biology,providing new cells to explore the molecular mechanisms of pluripotency,cancer biology and aging.A major advantage of human iPSC,compared to the pluripotent embryonic stem cells,is that they can be generated from virtually any embryonic or adult somatic cell type without destruction of human *** addition,iPSC can be generated from somatic cells harvested from normal individuals or patients,and used as a cellular tool to unravel mechanisms of human development and to model diseases in a manner not possible *** these fundamental aspects of human biology and physiology that are revealed using iPSC or iPSC-derived cells,these cells hold an immense potential for cell-based therapies,and for the discovery of new or personalized pharmacological treatments for many ***,we review some of the current challenges and concerns about iPSC *** introduce the potential held by iPSC for research and development of novel health-related *** briefly present the efforts made by the scientific and clinical communities to create the necessary guidelines and regulations to achieve the highest quality standards in the procedures for iPSC generation,characterization and long-term ***,we present some of the audacious and pioneer clinical trials in progress with iPSC-derived cells.

关键词： Induced pluripotent stem cells Reprogramming Cell-based therapy Stem cell banking Disease modelling

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