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Flexible nanoimprint lithography enables high-throughput manufacturing of bioinspired microstructures on warped substrates for efficient III-nitride optoelectronic devices

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Science Bulletin 2024年第13期69卷 2080-2088页

作者： Siyuan Cui Ke Sun Zhefu Liao Qianxi Zhou leonard jin Conglong jin Jiahui Hu Kuo-Sheng Wen Sheng Liu Shengjun Zhou Center for Photonics and Semiconductors School of Power and Mechanical EngineeringWuhan UniversityWuhan 430072China The Institute of Technological Sciences Wuhan UniversityWuhan 430072China Department of Mechanical and Mechatronics Engineering University of WaterlooWaterloo ONN2L 3G1Canada Jiangxi SMTC Semiconductor Co. Ltd.Nanchang 330096China

III-nitride materials are of great importance in the development of modern optoelectronics,but they have been limited over years by low light utilization rate and high dislocation densities in heteroepitaxial films grown on foreign substrate with limited refractive index contrast and large lattice ***,we demonstrate a paradigm of high-throughput manufacturing bioinspired microstructures on warped substrates by flexible nanoimprint lithography for promoting the light extraction *** design a flexible nanoimprinting mold of copolymer and a two-step etching process that enable high-efficiency fabrication of nanoimprinted compound-eye-like Al2O3 microstructure(NCAM)and nanoimprinted compound-eye-like SiO_(2)microstructure(NCSM)template,achieving a 6.4-fold increase in throughput and 25%savings in economic costs over stepper projection *** to NCAM template,we find that the NCSM template can not only improve the light extraction capability,but also modulate the morphology of AlN nucleation layer and reduce the formation of misoriented GaN grains on the inclined sidewall of microstructures,which suppresses the dislocations generated during coalescence,resulting in 40%reduction in dislocation *** study provides a low-cost,high-quality,and high-throughput solution for manufacturing microstructures on warped surfaces of III-nitride optoelectronic devices.

关键词： Flexible nanoimprint lithography Bioinspired Micro-and nano-manufacturing III-nitride epitaxy Optoelectronic devices

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柔性纳米压印技术在翘曲衬底上制造仿生微结构及其在Ⅲ族氮化物半导体光电器件中的应用（英文）

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Science Bulletin 2024年第13期 2080-2088页

作者：崔思远孙珂廖喆夫周千禧 leonard jin 金从龙胡加辉文国昇刘胜周圣军 Center for Photonics and Semiconductors School of Power and Mechanical Engineering Wuhan University Department of Mechanical and Mechatronics Engineering University of Waterloo Jiangxi SMTC Semiconductor Co. Ltd. The Institute of Technological Sciences Wuhan University

Ⅲ-nitride materials are of great importance in the development of modern optoelectronics, but they have been limited over years by low light utilization rate and high dislocation densities in heteroepitaxial films grown on foreign substrate with limited refractive index contrast and large lattice mismatches. Here, we demonstrate a paradigm of high-throughput manufacturing bioinspired microstructures on warped substrates by flexible nanoimprint lithography for promoting the light extraction capability. We design a flexible nanoimprinting mold of copolymer and a two-step etching process that enable high-efficiency fabrication of nanoimprinted compound-eye-like Al2O3microstructure（NCAM） and nanoimprinted compound-eye-like SiO2microstructure（NCSM） template, achieving a 6.4-fold increase in throughput and 25% savings in economic costs over stepper projection lithography. Compared to NCAM template,we find that the NCSM template can not only improve the light extraction capability, but also modulate the morphology of AlN nucleation layer and reduce the formation of misoriented GaN grains on the inclined sidewall of microstructures, which suppresses the dislocations generated during coalescence, resulting in40% reduction in dislocation density. This study provides a low-cost, high-quality, and high-throughput solution for manufacturing microstructures on warped surfaces of Ⅲ-nitride optoelectronic devices.

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Reconfigurable intelligent surface:design the channel-a new opportunity for future wireless networks

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Digital Communications and Networks 2022年第2期8卷 87-104页

作者： Miguel Dajer Zhengxiang Ma leonard Piazzi Narayan Prasad Xiao-Feng Qi Baoling Sheen jin Yang Guosen Yue Wireless Access Lab Futurewei TechnologiesInc.BridgewaterNJ08807USA

In this paper,we survey state-of-the-art research outcomes in the burgeoning field of Reconfigurable Intelligent Surface(RIS),given its potential for significant performance enhancement of next-generation wireless communication networks by means of adapting a propagation *** has been placed on several aspects gating the commercial viability of future network *** summaries are provided for practical hardware design considerations and broad implications of artificial intelligence techniques,as are in-depth outlooks on the salient aspects of system models,use cases,and physical layer optimization techniques.

关键词： Reconfigurable intelligent surface MIMO Channel estimation Beamforming Reflectarray Transmitarray Machine learning Deep learning

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High-precision transfer-printing and integration of vertically oriented semiconductor arrays for flexible device fabrication

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Nano Research 2014年第7期7卷 998-1006页

作者： Mark Triplett Hideki Nishimura Matthew Ombaba V. J. Logeeswarren Matthew Yee Kazim G. Polat jin Y. Oh Takashi Fuyuki Francois leonard M. Saif Islam Center for Nano and Micro Manufacturing and Department of Electrical and Computer Engineering University of California Davis CA 95616 USA Department of Physics University of California Davis CA 95515 USA Sandia National Laboratories Livermore CA 94551 USA Microelectronic Device Science Laboratory Nara Institute of Science and Technology Japan

Flexible electronics utilizing single crystalline semiconductors typically require post-growth processes to assemble and incorporate the crystalline materials onto flexible substrates. Here we present a high-precision transfer-printing method for vertical arrays of single crystalline semiconductor materials with widely varying aspect ratios and densities enabling the assembly of arrays on flexible substrates in a vertical fashion. Complementary fabrication processes for integrating transferred arrays into flexible devices are also presented and characterized. Robust contacts to transferred silicon wire arrays are demonstrated and shown to be stable under flexing stress down to bending radii of 20 mm. The fabricated devices exhibit a reversible tactile response enabling silicon based, nonpiezoelectric, and flexible tactile sensors. The presented system leads the way towards high-throughput, manufacturable, and scalable fabrication of flexible devices.

关键词： transfer printing nanowires flexible electronics printable electronics nanoscale devices

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Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer

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Acta Pharmaceutica Sinica B 2019年第2期9卷 443-454页

作者： Bing Cui Patrick A. Eyers leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu jinmei Yu Zhuowei Hu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Department of Biochemistry Institute of Integrative Biology University of Liverpool Division of Molecular Biology and Biochemistry School of Biological Sciences University of Missouri-Kansas City School of Biological Sciences Nanyang Technological University Lee Kong Chian School of Medicine Nanyang Technological University Institute of Molecular and Cell Biology KK Women's and Children Hospital Biochemistry Department School of Biomedical Sciences University of Otago Centre for Biomedical Research (CBMR) University of Algarve Campus de Gambelas Department of Biomedical Sciences and Medicine University of Algarve Algarve Biomedical Center (ABC) University of Algarve Campus de Gambelas Department of Infection Immunity and Cardiovascular Disease University of Sheffield Paul O'Gorman Leukaemia Research Centre Institute of Cancer Sciences University of Glasgow Division of Carcinogenesis The Cancer Institute Japanese Foundation for Cancer Research Department of Pathology and Laboratory Medicine Abramson Family Cancer Research Institute Perelman School of Medicine at the University of Pennsylvania Centre de Recherche en Transplantation et Immunologie (ou CRTI) Inserm Université de Nantes Nantes France Institut de Transplantation Urologie Néphrologie (ou ITUN) CIC bioGUNE CIBERONC Ikerbasque Basque Foundation for Science Biochemistry and Molecular Biology Department University of the Basque Country (UPV/EHU) Institute for Diabetes and Cancer IDC Helmholtz Center Munich Joint Heidelberg-IDC Translational Diabetes Program University Hospital Heidelberg Molecular Metabolic Control Medical Faculty Technical University Munich German Center for Diabetes Research (DZD) Division of Cardiology Department of Medicine Columbia University Irving Medical Center School of Sport and Health Sciences Cardiff Metropolitan Universit

The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases.

关键词： Tribbles Immunology Metabolism Cell biology Kinase inhibitor Tumorigenesis Metastasis TRIB1 TRIB2 TRIB3 Pseudokinase Inflammation Atomic structure Protein quality control Ubiqutin

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贝多芬《第九交响曲》第二三乐章的指挥处理与版本比较

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黄钟（武汉音乐学院学报） 2012年第2期 159-163,172页

作者：周进美国南卡罗莱纳大学武汉430064

《第九交响曲》作为贝多芬的晚期创作,显示出了创作的独创性。文章是继作者《贝多芬〈第九交响曲〉第一乐章指挥版本比较》一文后,对贝多芬《第九交响曲》的第二三乐章的速度、配器、反复记号、个性化处理等做的较详尽的指挥分析。文章... 详细信息

《第九交响曲》作为贝多芬的晚期创作,显示出了创作的独创性。文章是继作者《贝多芬〈第九交响曲〉第一乐章指挥版本比较》一文后,对贝多芬《第九交响曲》的第二三乐章的速度、配器、反复记号、个性化处理等做的较详尽的指挥分析。文章旨在通过对不同指挥家录音和总谱版本的诠释分析,揭示与继承这部伟大的作品从创作构思到表演实践的一些规律与传统。

关键词：贝多芬第九交响曲第二三乐章指挥总谱版本配器个性化处理诠释

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贝多芬《第九交响曲》第一乐章指挥版本比较

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黄钟（武汉音乐学院学报） 2011年第4期 376-383页

作者：周进美国南卡罗来纳大学音乐学院武汉音乐学院作曲系

文章主要探讨了贝多芬《第九交响曲》第一乐章的指挥实践中应该注意的几个技术环节,通过对比不同历史时期、不同类型的指挥家的艺术处理,挖作品中的内涵,起到作为指挥诠释交响乐作品的的参考作用。文章论述了不同指挥家对第一乐章的速... 详细信息

文章主要探讨了贝多芬《第九交响曲》第一乐章的指挥实践中应该注意的几个技术环节,通过对比不同历史时期、不同类型的指挥家的艺术处理,挖作品中的内涵,起到作为指挥诠释交响乐作品的的参考作用。文章论述了不同指挥家对第一乐章的速度、配器、句法、平衡以及弓法的使用等方面。作者试图对这部交响曲总谱的不同版本、不同指挥家录音的艺术处理与音响对比,指挥诠释作品的传统与当代诠释风格作对比,从中得出合理有效演出这部作品的方法和经验,继承与发扬贝多芬交响曲的指挥传统。

关键词：贝多芬第九交响曲指挥魏因加特纳马可维奇艾利西.克莱伯托斯卡尼尼富特文格纳弗里克塞索尔蒂、约胡姆卡拉扬伯恩斯坦重新配器

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Bendamustine treatment of Chinese patients with relapsed indolent non-Hodgkin lymphoma: a multicenter, open-label, single-arm, phase 3 study

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Chinese Medical Journal 2021年第11期134卷 1299-1309页

作者： Yuan-Kai Shi Xiao-Nan Hong Jian-Liang Yang Wei Xu Hui-Qiang Huang Xiu-Bin Xiao Jun Zhu Dao-Bin Zhou Xiao-Hong Han Jian-Qiu Wu Ming-Zhi Zhang Jie jin Xiao-Yan Ke Wei Li De-Pei Wu Shen-Miao Yang Xin Du Yong-Qian Jia Ai-Chun Liu Dai-Hong Liu Zhi-Xiang Shen Lian-Sheng Zhang leonard James Edward Hellriegel Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200030China Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Department of Medical Oncology 307 Hospital of Chinese People’s Liberation ArmyBeijing 100071China Department of Lymphoma Peking University Cancer Hospital&InstituteBeijing 100142China Department of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Oncology Jiangsu Cancer Hospital&Jiangsu Institute of CancerNanjingJiangsu 210009China Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Hematology The First Affiliated Hospital of Zhejiang University College of MedicineHangzhouZhejiang 310003China Department of Hematology Peking University Third HospitalBeijing 100191China Department of Oncology Jilin University First Affiliated HospitalChangchunJilin 130021China Department of Hematology Jiangsu Institute of HematologyThe First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006China Department of Hematology Peking University Institute of HematologyPeking University People’s HospitalBeijing 100044China Department of Hematology Guangdong General HospitalGuangzhouGuangdong 510062China Department of Hematology and Research Laboratory of Hematology West China Hospital of Sichuan UniversityChengduSichuan 610041China Department of Medical Oncology Harbin Medical University Cancer HospitalHarbinHeilongjiang 150001China Department of Hematolo

Background:Bendamustine was approved in China on May 26th,2019 by the National Medical Product Administration for the treatment of indolent B-cell non-Hodgkin lymphoma(NHL).The current study was the registration trial and the first reported evaluation of the efficacy,safety,and pharmacokinetics of bendamustine in Chinese adult patients with indolent B-cell NHL following relapse after chemotherapy and rituximab ***:This was a prospective,multicenter,open-label,single-arm,phase 3 study(NCT01596621;C18083/3076)with a 2-year follow-up *** patients received bendamustine hydrochloride 120 mg/m2 infused intravenously on days 1 and 2 of each 21-day treatment cycle for at least six planned cycles(and up to eight cycles).The primary endpoint was the overall response rate(ORR);and secondary endpoints were duration of response(DoR),progression-free survival(PFS),safety,and *** were classified according to their best overall response after initiation of *** of patients in each response category(complete response[CR],partial response[PR],stable disease,or progressive disease)were summarized along with a twosided binomial exact 95%confidence intervals(CIs)for the ***:A total of 102 patients were enrolled from 20 centers between August 6th,2012,and June 18th,*** the time of the primary analysis,the ORR was 73%(95%CI:63%–81%)per Independent Review Committee(IRC)including 19%CR and 54%*** the follow-up period,the median DoR was 16.2 months by IRC and 13.4 months by investigator assessment;the median PFS was 18.6 months and 15.3 months,*** most common non-hematologic adverse events(AEs)were gastrointestinal toxicity,pyrexia,and *** 3/4 neutropenia was reported in 76%of *** AEs were reported in 29 patients and five patients died during the *** analysis indicated that the characteristics of bendamustine and its metabolites M3 and M4 were generally consistent

关键词： Bendamustine Non-Hodgkin lymphoma B-cell malignancy Relapsed disease Clinical trial

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Mutation of kri1l causes ribosomopathy-like hematopoiesis failure via excessive autophagy

Mutation of kri1l causes ribosomopathy-like hematopoiesis fa...

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第二届全国发育生物学大会

作者： Xiao-E Jia Ke Ma Tao Xu Changbin jing Lei Gao Cong Fu Wenjuan Zhang Shuang Wu Mei Dong Chunguang Ren Yi Chen Yi jin Min Deng Li Li Lingfei Luo Jun Zhu leonard I.Zon Yi Zhou Saijuan Chen Weijun Pan Key Laboratory of Stem Cell Biology Institute of Health SciencesShanghai Institutes for Biological SciencesChinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine State Key Laboratory for Medical Genomics Shanghai Institute of HematologyRuiJin HospitalShanghai Jiao Tong University School of Medicine Key Laboratory of Freshwater Fish Reproduction and Development Ministry of EducationLaboratory of Molecular Developmental BiologySchool of Life SciencesSouthwest University CNRS LIA Shanghai Institute of HematologyRui Jin Hospital Stem Cell Program Hematology/Oncology Program at Children's Hospital BostonHarvard Medical SchoolBostonMA02114USA

Dysregulation of ribosome biogenesis called ribosomopathies causes human diseases,such as Diamond-Blackfan anemia(DBA)or 5q minus(5q-)*** mechanism of blood disorder in these diseases remains *** genetic cloning and mechanism characterization of zebrafish mutant,we report a novel connection between ribosomal dysfunction and excessive autophagy in regulation of hematopoietic stem and progenitor cells(HSPCs).This mutant carries a recessive lethal mutation in kril1 gene that encodes an essential component of rRNA small subunit *** showed that Krill function was required for normal ribosome biogenesis,expansion of definitive HSPCs and subsequent lineage *** of Bcl2,but not p53 inhibition,could fully rescue hematopoietic defects in *** rescue is distinguished from cell apoptosis regulated by p53 in other *** live imaging and biochemical studies,we found loss of Kri11 function induced excessive autophagy in *** with autophagy inhibitors(3-MA,Baf A1)markedly restored HSPCs function and recovered hematopoietic lineages in *** of autophagy may provide clinical benefits to anemic or ribosomopathy patients with increased autophagy in HSPCs.

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表面活性剂聚集体--从实验室到工业应用(续完)

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日用化学品科学 2022年第7期45卷 5-10页

作者：肖进新北京氟乐邦表面活性剂技术研究所北京100096

1.4药物传输系统在过去几十年,表面活性剂用于构建药物载体或靶向体系一直是药物科学家关注的主要问题[57]。在表面活性剂体系中配制药物配方,其最严重的问题是缺乏合适的、可生物降解的商业表面活性剂。leonard等对于选定的多糖即右旋... 详细信息

1.4药物传输系统在过去几十年,表面活性剂用于构建药物载体或靶向体系一直是药物科学家关注的主要问题[57]。在表面活性剂体系中配制药物配方,其最严重的问题是缺乏合适的、可生物降解的商业表面活性剂。leonard等对于选定的多糖即右旋糖酐进行化学修饰,通过生成醚键共价连接碳氢基团[58]。疏水改性右旋糖酐被证明是特定的药物输送体系候选项。

关键词：表面活性剂右旋糖酐疏水改性药物载体聚集体药物传输系统药物配方化学修饰

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