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World Journal of Gastroenterology 2014年第47期20卷 17993-18000页

作者： Shajan Peter leona Council Ji Young Bang Helmut Neumann Klaus mnkemüller Shyam Varadarajulu Charles melbern Wilcox Division of Gastroenterology and Hepatology University of AlabamaBirminghamAL 35294-0012United States Department of Pathology University of Alabama at BirminghamBirminghamAL 35294-0012United States Department of medicine 1 University of Erlangen-Nuremberg91054 ErlangenGermany

AIm: To compare the interpretation of probe-based confocal laser endomicroscopy (pCLE) findings between endoscopists and gastrointestinal (GI)-pathologists.

关键词： Confocal endomicroscopy Gastointestinal Interobserver variation

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用电话线传输视频图像的新技术

电子与仪表 1991年第1期 15-16页

作者： leona.,m 仲实

Hepatic decompensation/serious adverse events in post-liver transplantation recipients on sofosbuvir for recurrent hepatitis C virus

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World Journal of Gastroenterology 2016年第9期22卷 2844-2854页

作者： Neal Patel Kian Bichoupan Lawrence Ku Rachana Yalamanchili Alyson Harty donald Gardenier michel Ng David motamed Viktoriya Khaitova Nancy Bach Charissa Chang Priya Grewal meena Bansal Ritu Agarwal Lawrence Liu Gene Im Jennifer Leong leona Kim-Schluger Joseph Odin Jawad Ahmad Scott Friedman douglas Dieterich Thomas Schiano Ponni Perumalswami Andrea Branch Division of Liver Diseases Icahn School of Medicine at Mount Sinai Recanati miller Transplant Institute Icahn School of Medicine at Mount Sinai

AIm: To determine the safety profile of new hepatitis C virus (HCV) treatments in liver transplant (LT) recipients with recurrent HCV ***: Forty-two patients were identified with recurrent HCV infection that underwent LT at least 12 mo prior to initiating treatment with a Sofosbuvir-based regimen during December 2013-June 2014. Cases were patients who experienced hepatic decompensation and/or serious adverse events (SAE) during or within one month of completing treatment. Controls had no evidence of hepatic decompensation and/or SAE. HIV-infected patients were excluded. Cumulative incidence of decompensation/SAE was calculated using the Kaplan meier method. Exact logistic regression analysis was used to identify factors associated with the composite ***: median age of the 42 patients was 60 years [Interquartile Range (IQR): 56-65 years], 33% (14/42) were female, 21% (9/42) were Hispanic, and 9% (4/42) were Black. The median time from transplant to treatment initiation was 5.4 years (IQR: 2.1-8.8 years). Thirteen patients experienced one or more episodes of hepatic decompensation and/or SAE. Anemia requiring transfusion, the most common event, occurred in 62% (8/13) patients, while 54% (7/13) decompensated. The cumulative incidence of hepatic decompensation/SAE was 31% (95%CI: 16%-41%). Risk factors for decompensation/SAE included lower pre-treatment hemoglobin (OR = 0.61 per g/dL, 95%CI: 0.40-0.88, P mated glomerular filtration rate (OR = 0.95 per mL/min per 1.73 m2, 95%CI: 0.90-0.99, P = 0.01), and higher baseline serum total bilirubin (OR = 2.43 per mg/dL, 95%CI: 1.17-8.65, P management of anemia remains an important clinical challenge.

关键词： Hepatitis C virus Sofosbuvir Ribavirin Anemia Hepatic decompensation Serious adverse event Liver transplant

Utility of the low-accelerating-dose regimen in 182 liver recipients with recurrent hepatitis C virus

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World Journal of Gastroenterology 2015年第20期21卷 6236-6245页

作者： Kieron BL Lim Hamid R Sima m Isabel Fiel Viktoriya Khaitova John T doucette maria Chernyiak Jawad Ahmad Nancy Bach Charissa Chang Priya Grewal leona Kim-Schluger Lawrence Liu Joseph Odin Ponni Perumalswami Sander S Florman Thomas D Schiano Division of Liver Diseases Icahn School of Medicine at Mount Sinai Division of Gastroenterology and Hepatology National University Center for Organ TransplantationNational University Hospital Lillian and Henry m Stratton-Hans Popper Department of Pathology Icahn School of Medicine at Mount Sinai Recanati-miller Transplantation Institute Icahn School of Medicine at Mount Sinai Department of Preventive medicine Icahn School of Medicine at Mount Sinai

AIm: To describe our experience using a low-acceleratingdose regimen(LADR) with pegylated interferon alpha-2a and ribavirin in treatment of hepatitis C virus(HCV) recurrence. mETHODS: From 2003, a protocolized LADR strategy was employed to treat liver transplant(LT) recipients with recurrent HCV at our institution. medical records of 182 adult patients with recurrent HCV treated with LADR between 1/2003 and 1/2011 were reviewed. Histopathology from all post-LT liver biopsies were reviewed in a blinded fashion. Paired recipient and donor IL28 B status were assessed. A novel technique was employed to ascertain recipient and donor IL28B(rs12979860) Gt data using DNA extracted from archival FFPE tissue from explanted native livers and donor gallbladders respectively. The primary endpoint was SVR; secondary endpoints examined include(1) patient and graft survival;(2) effect of anti-viral therapy on liver histology(fibrosis and inflammation);(3) incidence of on-treatment development of ACR, CDR, or PCH;(4) association of recipient and donor IL28 B genotype with SVR; and(5) incidence of antiviral therapy-associated adverse events(anemia, leukopenia, thrombocytopenia, depression) and hepatic ***: The overall SVR rate was 38%(29% Gt1, 67% Gt2, 86% Gt3 and 58% Gt4). HCV Gt(P donor age(P = 0.003), cytomegalovirus mismatch(P = 0.001), baseline serum bilirubin(P = 0.002), and baseline viral load(P = 0.04) were independent predictors for SVR. SVR rates were significantly higher in the recipient-CC/donor-non CC pairs(P = 0.007). Neither baseline fibrosis nor change in fibrosis stage after anti-viral therapy were associated with SVR. Fibrosis progressed in 72% of patients despite SVR. median graft survival was 91 mo. Five-year patient survival was superior in patients who achieved SVR(97% vs 82%, P = 0.001). Pre-treatment ALP ≥ 150 U/L(P = 0.01), total bilirubin ≥ 1.5 mg/d L(P = 0.001) and creatinine ≥ 2 mg/d L(P = 0.001) were independently associated

关键词： Hepatitis C recurrence Liver transplant Low accelerating dose regimen Peginterferon α-2a IL28B

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电动—射流多芯片控制器组件

电子与仪表 1994年第2期 6-6页

作者： leona.,m 楚旭

Functional groups of Sahelian trees in a semiarid agroforestry system of Senegal

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Journal of Plant Ecology 2018年第3期11卷 375-384页

作者： Joseph S.Diémé mayécor Diouf Cristina Armas Graciela mRusch Francisco I.Pugnaire Estación Experimental de ZonasÁridas Consejo Superior de Investigaciones CientíficasCtra.de Sacramento s/n04120 La CañadaAlmeríaSpain Centre National de Recherches Forestières Institut Sénégalais de Recherches Agricoles(CNRF/ISRA)DakarSenegal Norwegian Institute for Nature Research TrondheimNorway

Aims Addressing plant responses to water stress is critical to understand the structure of plant communities in water-limited environments and to forecast their resilience to future changes in *** a semiarid agroforestry system in the Sahelian savannah of leona(Senegal),we selected nine common tree species and explored their stress-resistance *** species represent a variety of life forms and are of high regional socio-economic *** hypothesized that different species would show different suites of traits to cope with water stress and expected to identify functional groups differing in strategies to withstand water *** Along a dry and a wet season,we monitored four traits reflecting above-and below-ground strategies of resource acquisition such as predawn leaf water potential(ψpd),specific leaf area(SLA),leaf thickness and leaf area index(LAI).We also measured two mor-phological traits:trunk diameter and tree *** andψpd were measured six times during the dry and rainy seasons,and the other traits were measured *** Findings We identified two functional classes subdivided into two func-tional groups of each *** first class included deciduous and semi-deciduous species that generally had large SLA,low leaf thickness and small-to-intermediate inter-seasonal varia-tions inψ*** second class included evergreen species of two functional groups that differ in SLA,leaf thickness and the mag-nitude of inter-seasonal variations ofψpd throughout the *** four functional groups identified in this study represent plant strategies differing in their response to changing environmental conditions.

关键词： Acacia tortilis Adansonia digitata Balanites aegyptiaca Celtis integrifolia Combretum glutinosum Faidherbia albida functional traits Neocarya macrophyla Sclerocarya birrea Tamarindus indica water stress

Clinical approach to indeterminate biliary strictures:Clinical presentation,diagnosis,and workup

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世界胃肠病学杂志:英文版 2023年第36期29卷 5198-5210页

作者： Sujani Yadlapati Ramzi mulki Sergio A Sánchez-Luna Ali m Ahmed Kondal Rao Kyanam Kabir Baig Shajan Peter Department of Gastroenterology and Hepatology Indiana University HospitalIndianapolisIN 46202USA Department of Gastroenterology and Hepatology University of Alabama at BirminghamBirminghamAL 35294USA

Despite advances in cross-sectional imaging and endoscopic technology,bile duct strictures remain a challenging clinical *** is crucial to make an early determination of benign or malignant nature of biliary *** diagnosis not only helps with further management but also minimizes mortality and morbidity associated with delayed *** imaging and endoscopic techniques,particularly endoscopic retrograde cholangiopancreatography(ERCP)and tissue sampling techniques play a key in establishing a *** biliary strictures(IDBSs)have no definite mass on imaging or absolute histopathological diagnosis and often warrant utilization of multiple diagnostics to ascertain an *** this review,we discuss possible etiologies,clinical presentation,diagnosis,and management of *** on available data and expert opinion,we depict an evidence based diagnostic algorithm for management of *** of focus include use of traditional tissue sampling techniques such as ERCP with brush cytology,intraductal biopsies,fluorescence in situ hybridization and flow *** also describe the role of endoscopic ultrasound(EUS)-guided fine needle aspiration and biopsies,cholangioscopy,confocal laser endomicroscopy,and intraductal EUS in management of IDBSs.

关键词： Biliary strictures Indeterminate strictures Biliary sampling Cholangioscopy Benign strictures malignant strictures Indeterminate biliary strictures

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse

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Bone Research 2020年第2期8卷 157-168页

作者： Tobias Schwerd Freia Krause Stephen R.F.Twigg dominik Aschenbrenner Yin-Huai Chen Uwe Borgmeyer miryam müller Santiago manrique Neele Schumacher Steven A.Wall Jonathan Jung Timo Damm Claus-Christian Glüer Jürgen Scheller Stefan Rose-John E.Yvonne Jones Arian Laurence Andrew O.m.Wilkie Dirk Schmidt-Arras Holm H.Uhlig Translational Gastroenterology Unit John Radcliffe HospitalUniversity of OxfordOxfordUK Department of Pediatrics Dr von Hauner Children’s HospitalLMU MunichMunichGermany Christian-Albrechts-University Kiel Institute of BiochemistryKielGermany Clinical Genetics Group MRC Weatherall Institute of Molecular MedicineUniversity of OxfordJohn Radcliffe HospitalOxfordUK Center for molecular Neurobiology Hamburg(ZmNH) University Medical Center Hamburg-EppendorfHamburgGermany Division of Structural Biology Wellcome Trust Centre for Human GeneticsUniversity of OxfordOxfordUK Craniofacial Unit Department of Plastic and Reconstructive SurgeryOxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxfordUK Section Biomedical Imaging Department of Radiology and NeuroradiologyUniversity Medical Center Schleswig-HolsteinKielGermany Institute of Biochemistry and molecular Biology Ⅱ Medical FacultyHeinrich-Heine-UniversityDüsseldorfGermany Department of Paediatrics University of OxfordOxfordUK NIHR Oxford Biomedical Research Centre OxfordUK The Beatson Institute for Cancer Research GlasgowUK School of medicine University of GlasgowGlasgowUK

The GP130 cytokine receptor subunit encoded by IL6ST is the shared receptor for ten cytokines of the IL-6 family. We describe a homozygous non-synonymous variant in IL6 ST(p.R281 Q) in a patient with craniosynostosis and retained deciduous teeth. We characterize the impact of the variant on cytokine signaling in vitro using transfected cell lines as well as primary patient-derived cells and support these findings using a mouse model with the corresponding genome-edited variant Il6 st p.R279 Q. We show that human GP130 p.R281 Q is associated with selective loss of IL-11 signaling without affecting IL-6, IL-27, OSm, LIF, CT1, CLC, and CNTF signaling. In mice Il6 st p.R279 Q lowers litter size and causes facial synostosis and teeth abnormalities. The effect on IL-11 signaling caused by the GP130 variant shows incomplete penetrance but phenocopies aspects of IL11 RA deficiency in humans and mice. Our data show that a genetic variant in a pleiotropic cytokine receptor can have remarkably selective defects.

关键词： IL11 cytokine facial

Corneal epithelial defects following vitreoretinal surgery:incidence and outcomes from the DISCOVER study

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 83-88页

作者： Kubra Sarici Daniel Petkovsek Alison martin Alex Yuan Jeffrey m.Goshe Sunil K.Srivastava Jamie L.Reese Justis P.Ehlers The Tony and leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research Cole Eye InstituteCleveland ClinicClevelandOH 44195USA Vitreoretinal Service Cole Eye InstituteCleveland ClinicClevelandOH 44195USA Cornea Service Cole Eye InstituteCleveland ClinicClevelandOH 44195USA

AIm:To investigate the incidence,risk factors,clinical course,and outcomes of corneal epithelial defects(CED)following vitreoretinal surgery in a prospective study ***:This was a post-hoc analysis of all participants in DISCOVER intraoperative optical coherence tomography *** with CED 1 d after surgery without intraoperative corneal debridement was defined as the postoperative CED *** who underwent intraoperative debridement were defined as intraoperative debridement *** were matched 2:1 with controls(eyes without postoperative CED)for comparative *** primary outcomes were the incidence of CED on postoperative day one and the incidence of required intraoperative *** outcomes included time to defect closure,delayed healing(>2 wk),visual acuity(VA)and presence of scarring at one year and cornea ***:This study included 856 eyes that underwent vitreoretinal *** corneal debridement was performed to 61(7.1%)subjects and postoperative CED developed spontaneously in 94(11.0%)*** factors associated with postoperative CED included prolonged surgical duration(P=0.003),diabetes mellitus(P=0.04),postoperative ocular hypotension(Pme(>2 wk)was associated with corneal scar formation at the end of the 1 y in all epithelial defect subjects(Pmy was 1.8%.CONCLUSION:Prolonged duration of surgery is the strongest factor associated with both intraoperative debridement and spontaneous postoperative *** defect closure is associated with a greater risk of corneal scarring at one *** overall rate of corneal scarring following vitrectomy is low at<2%.

关键词： corneal epithelial defect vitreoretinal surgery intraoperative optical coherence tomography

Consolidation of AA 7075-2 wt% ZrO2 Composite Powders by Severe Plastic Deformation via ECAP

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Acta metallurgica Sinica(English Letters) 2016年第10期29卷 895-901页

作者： S. E. Hernandez-martinez J. J. Cruz-Rivera R. martinez-Sanchez C. G. Garay-Reyes J. A. mufioz-Bolanos J. m. Cabrera J.L.Hernández-Rivera Instituto de metalurgia Universidad Autonoma de San Luis Potosi Sierra Leona 550 78210 San Luis Potosi Mexico Centro de Investigacion en materiales Avanzados (CImAV) Miguel de Cervantes 120 31109 Chihuahua Mexico Departamento de Ciencia de materiales e Ingenieria metalurgica Universitat Politecnica de Catalunya Av Diagonal 647 08028 Barcelona Spain Fundacion CTm Centro Tecnologico Plaza de la Ciencia 208243 Manresa Spain CONACYT Research Fellow-Instituto de metalurgia Universidad Autonoma de San Luis Potosi- Sierra Leona 550 78210 San Luis Potosf Mexico

The powders of the AA 7075-ZRO2 were mixed by mechanical milling, but it was found that the system presents a few disadvantages when processed by conventional sintering and hot extrusion, since intermetallic phases between ZrO2 particles and alloying elements were formed. Equal channel angular pressing （ECAP） processing was proposed as an alternative method to consolidate the composite where there is no intermetallic formation. The analysis of the ECAP process showed that the intermediate temperature （220℃） produced a higher consolidation level than conventional sintering and hot extrusion （400 and 500℃, respectively）. This fact was supported by relative density analysis. In the case of the sintered and hot-extruded sample, the relative density exhibited a value of 0.95, while ECAP sample showed a value of 0.98. Hardness values show that microstructural refinement obtained during mechanical milling was preserved during ECAP processing even when it was carded out at 220℃.

关键词： metal matrix composites (mmCs) Powder consolidation Severe plastic deformation (SPD)