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A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

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Military Medical Research 2024年第2期11卷 228-267页

作者： Miguel A.Ortega Oscar Fraile-Martinez Cielo García-Montero Sergio Haro Miguel Ángel Álvarez-Mon diego de leon-Oliva Ana M.Gomez-Lahoz Jorge Monserrat Mar Atienza-Pérez david díaz Elisa Lopez-dolado Melchor Álvarez-Mon department of Medicine and Medical Specialities University of Alcala28801 Alcala de HenaresSpain Ramón y Cajal Institute of Sanitary Research(IRYCIS) 28034 MadridSpain department of Psychiatry and Mental Health Hospital Universitario Infanta Leonor28031 MadridSpain Service of Rehabilitation National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Immune System diseases‑Rheumatology Service and Internal Medicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this ***(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a *** initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and *** the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are ***,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.

关键词： Spinal cord injury(SCI) Psychoneuroimmunoendocrinology(PNIE) Secondary injury Immunoinflammatory dysfunction Gut microbiota Translational opportunities

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Giant photoinduced reflectivity modulation of nonlocal resonances in silicon metasurfaces

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Advanced Photonics 2023年第6期5卷 83-91页

作者： Andrea Tognazzi Paolo Franceschini Olga Sergaeva Luca Carletti Ivano Alessandri Giovanni Finco osamu takayama Radu Malureanu Andrei V.Lavrinenko Alfonso C.Cino domenico de Ceglia Costantino de Angelis University of Palermo Department of EngineeringPalermoItaly National Institute of Optics-National Research Council PalermoItaly University of brescia Department of Information EngineeringPalermoItaly ITMO University School of Physics and EngineeringSaint-PetersburgRussia ETH Zurich Institute for Quantum ElectronicsDepartment of PhysicsOptical Nanomaterial GroupZurichSwitzerland Technical University of denmark Department of Electrical and Photonics EngineeringKongens LyngbyDenmark

Metasurfaces offer a unique playground to tailor the electromagnetic field at subwavelength scale to control polarization,wavefront,and nonlinear *** of the optical response of these structures is challenging due to the nanoscale size of their constitutive elements.A long-sought solution to achieve tunability at the nanoscale is all-optical modulation by exploiting the ultrafast nonlinear response of ***,the nonlinear response of materials is inherently very weak,and,therefore,requires optical excitations with large values of *** show that by properly tuning the equilibrium optical response of a nonlocal metasurface,it is possible to achieve sizable variation of the photoinduced out-ofequilibrium optical response on the picosecond timescale employing fluences smaller than 250μJ∕cm^(2),which is 1 order of magnitude lower than previous studies with comparable reflectivity variations in silicon *** results pave the way to fast devices with large modulation amplitude.

关键词： nonlocal metasurface nanophotonics ultrafast modulation Fano resonance

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Statin-induced Liver Injury Patterns: A Clinical Review

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Journal of Clinical and Translational Hepatology 2022年第3期10卷 543-552页

作者： leon.d.Averbukh Alla Turshudzhyan david C.Wu George Y.Wu department of Medicine Division of Gastroenterology-HepatologyAllegheny Health NetworkPittsburghPAUSA department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Since their introduction in 1987,hydroxymethyl glutaryl coenzyme A reductase(HMG-CoA)inhibitors,more commonly known as statins,have become some of the most widely prescribed medications in the *** generally considered to be safe and well tolerated,statins have been associated with several side effects including mild liver dysfunction manifested by increases in ***,statins have been noted to induce more serious hepatic injury,including liver injury with autoimmune *** literature supports statin induced liver injury presenting in either hepatocellular or cholestatic patterns,though with the former being the prevailing pattern of ***,severe liver injury is uncommon with statin use and is generally reversible without any intervention other than offending statin *** evaluating cases of suspected statininduced liver injury,a complete medical history,laboratory tests including a complete metabolic panel,autoimmune markers,and viral panel,as well as hepatic imaging,are crucial for a complete causality analysis with validated tools such as Roussel Uclaf Causality Assessment *** aim of this review is to review the current evidence for statininduced liver injury and cholestasis.

关键词： drug-induced liver injury Statin Cholestatic liver injury Hepatocellular liver injury Cholestasis Autoimmune hepatitis

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The “July Effect” in the intensive care units revisited:A bi-institutional 6-year experience of 57,160 patients

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World Journal of Emergency Medicine 2022年第3期13卷 215-218页

作者： leon Naar Ander d.Gallastegi Raghu R.Seethala b.Christian Renne Michael E.billington Jasmine Kannikal Haytham M.A.Kaafarani Jarone Lee division of Trauma Emergency Surgery&Surgical Critical CareDepartment of SurgeryMassachusetts General HospitalHarvard Medical SchoolBoston 02114-2696USA division of Emergency Critical Care Medicine Department of Emergency MedicineBrigham and Women's HospitalHarvard Medical SchoolBoston 02115-6195USA department of Emergency Medicine Massachusetts General HospitalHarvard Medical SchoolBoston 02115-6195USA

July coincides with the beginning of the academic year in teaching hospitals across the United States of America (USA).The increased responsibility assumed by trainees transitioning to a higher role in the healthcare team is hypothesized to lead to poorer patient outcomes,termed the“July Effect”.The consequence of a“July Effect”might be more severe in critical care settings,where the complexity of patients requires a higher level of experience and *** only studies evaluating the“July Effect”in the ICU were published in the early 2000’s.;Since that time,several resident work-hour regulations have been implemented by the Accreditation Council for Graduate Medical Education (ACGME).;These regulations have resulted in more frequent sign-outs,reduced continuity of care,and less clinical time for trainees,which in theory could increase the risk of errors among young trainees at the time they are most vulnerable.

关键词： sized academic assumed

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2-d localization system utilizing M-sequence encoded laser beam scanning

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仪器仪表学报 2007年第3期28卷 408-413页

作者： Shinji Ohyama Kiyoshi Tanaka Junya takayama Graduate School of Science and Engineering Tokyo Institute of Technology 2-12-1 O-okayama Meguro-ku Tokyo 152-8552 Japan

In this paper, as the active position measurement system, a novel method for a two-dimensional localization system using M-sequence signal is proposed. The feature of this system is to realize a position measurement only by scanning the encoded laser beams from fixing points to a measurement field, and by observing it. First, both the system configuration and encoding method were practically considered, and an order and an initial value of M-sequence signal were selected for encoding. This method is based on discrete angle measurement therefore the resolution has its own limitation. To overcome this limitation, analogue phase shift detecting method was introduced. System design was performed and applied to position measurement experiments. The experimental results show that the measurement error of the analogue method is 1/3 of that of the discrete method.

关键词：激光电子束扫描位置测量二维定位系统 M序列离散法

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Evidence for Viral Induction of biliary Atresia: A Review

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Journal of Clinical and Translational Hepatology 2018年第4期6卷 410-419页

作者： leon.d.Averbukh George Y.Wu department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

biliary atresia(bA)is a childhood disease which manifests with abnormal narrowing,blockage or complete absence of bile ducts within the *** possible etiologies have been reported for the development of bA,including congenital,perinatal and acquired *** the 1970's,there has been increasing evidence linking bA development to viral perinatal *** viral vectors most commonly implicated include members of the herpesviridae family(cytomegalovirus and Epstein-barr virus)as well as those of the reoviridae family(reovirus and rotavirus).While extensive work has been done on a murine model of disease,the current review focuses primarily on evidence from human studies of viral vectors in children afflicted with bA.

关键词： biliary atresia Cytomegalovirus Epstein-barr virus Reovirus Rotavirus

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Role of biologics in the development of Autoimmune Hepatitis: A Review

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Journal of Clinical and Translational Hepatology 2018年第4期6卷 402-409页

作者： leon.d.Averbukh George Y.Wu department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Autoimmune hepatitis(AIH)is a cause of chronic,immunemediated liver injury which without treatment may progress to end-stage liver *** disease state,characterized by elevations in liver enzymes,autoantibodies,and interface hepatitis on histology,has been noted to be induced by a wide range of ***,most commonly minocycline and nitrofurantoin,have long been established as potential inducers of ***,biologics,powerful immune-modulators,have also been reported to induce *** conclude that there is an association between administration of biologics in the development of AIH,and whether the relationship is causal will require appropriate studies in the future.

关键词： Autoimmune hepatitis TNF alpha inhibitors biologics Hepatitis Infliximab Adalimumab Etanercept

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Highlights for dental Care as a Hepatitis C Risk Factor:A Review of Literature

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Journal of Clinical and Translational Hepatology 2019年第4期7卷 346-351页

作者： leon.d.Averbukh George Y.Wu department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterCTUSA

Hepatitis C(HCV)is a viral infection that affects an estimated 71 million people worldwide,with over 1 million new infec-tions *** medical treatments exist,HCV continues to be a significant public health *** prevention and transmission risk factor identification remain key in helping decrease disease *** intravenous drug use,healthcare exposure(*** transfusions and surgical care),and body modification(*** and piercings)are well accepted risk factors for HCV transmission,others remain *** dental practice is often asso-ciated with procedures and bleeding,the possibility of HCV transmission seemed reasonable to ***,we review the evidence for dental care as a potential risk factor for HCV *** identified a total of 1,180 manu-scripts related to HCV and dental care,of which 26 manu-scripts were included in the study after exclusionary criteria were *** per our review of the available literature,in the developing world,the improper use of sterile technique and lack of provider education likely increases the risk of HCV transmission during dental *** developed nations,on the other hand,general dental care does not appear to be a significant risk factor for HCV transmission in non-intravenous drug user patients;although,the improper use and reuse of anesthetics during procedures poses a rare potential risk for viral transmission.

关键词： Hepatitis C Oral care dental care Risk factors Hepatitis

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AdCP application for long-term monitoring of coastal water

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Acta Oceanologica Sinica 2005年第1期24卷 95-100页

作者： YOSHIOKA Hiroshi takayama Tomotsuka SERIZAWA Shigeatsu Faculty of Information Science and Technology Aichi Prefectural University Aichi 480-1198 JapanDisaster Prevention Research Institute Kyoto-University Kyoto 611-0011 JapanDisaster Prevention Research Institute Kyoto-University Kyoto 611-0011 Japan

Three kind of application of AdCP is reported for long-term monitoring in coastal sea.(1)The routine monitoring of water qualities. The water quality and AdCP echo data (600 kHz) observed in the long-term are analgzed at MT (Marine Tower) Station of Kansai International Airport in the Osaka bay, Japan. The correlation between the turbidity and echo intensity in the surface layer is not good because air bubbles generated by breaking wave are not detected by the turbidity meter, but detected well by AdCP. When estimating the turbidity consists of plankton population from echo intensity, the effect of bubbles have to be eliminated. (2) Monitoring stirring up of bottom sediment. The special observation was carried out by using following two AdCP in the Osaka bay, One AdCP was installed upward on the sea. The other AdCP was hanged downward at the gate type stand about 3 m above from the bottom. At the spring tide, high echo intensities indicating the stirring up of bottom sediment were observed. (3) The monitoring for the boundary condition of water mixing at an estuary. In summer season, the AdCP was set at the mouth of Tanabe bay in Wakayama Prefecture, Japan. during the observation, water temperature near the bottom showed remarkable falls with interval of about 5-7 d. When the bottom temperature fell, the inflow current with low echo intensity water appears at the bottom layer in the AdCP record. It is concluded that when occasional weak northeast wind makes weak coastal upwelling at the mouth of the bay, the combination of upwelling with internal tidal flow causes remarkable water exchange and dispels the red tide.

关键词： AdCP echo intensity monitoring coastal water red tide stirring up

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Comparative study of the effect of solvents on the efficacy of neonicotinoid insecticides against malaria vector populations across Africa

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Infectious diseases of Poverty 2022年第2期11卷 23-31页

作者： Magellan Tchouakui Tatiane Assatse leon M.J.Mugenzi benjamin d.Menze daniel Nguifo-Nguete Williams Tchapga Jonathan Kayondo Francis Watsenga Emile Zola Manzambi Michael Osae Charles S.Wondji Centre for Research in Infectious diseases(CRId) P.O.Box 13501YaoundeCameroon Parasitology and Ecology Laboratory Department of Animal Biology and PhysiologyFaculty of ScienceUniversity of Yaounde 1P.O.Box 812YaoundeCameroon Institut National de Recherche biomedicale KinshasaDemocratic Republic of Congo Radiation Entomology and Pest Management Centre Biotechnology and Nuclear Agriculture Research InstituteGhana Atomic Energy CommissionP.O.Box LG80Legon-AccraGhana department of Vector biology Liverpool School of Tropical MedicinePembroke PlaceLiverpool L35QAUK International Institute of Tropical Agriculture(IITA) P.O.Box 2008YaoundeCameroon Entomology department Uganda Virus Research Institute(UVRI)P.O.Box 49EntebbeUganda.

background:New insecticides with a novel mode of action such as neonicotinoids have recently been recommended for public health by *** monitoring of such novel insecticides requires a robust protocol to monitor the development of resistance in natural *** this study,we comparatively used three different solvents to assess the susceptibility of malaria vectors to neonicotinoids across ***:Mosquitoes were collected from May to July 2021 from three agricultural settings in Cameroon(Njombe-Penja,Nkolondom,and Mangoum),the democratic Republic of Congo(Ndjili-brasserie),Ghana(Obuasi),and Uganda(Mayuge).Using the CdC bottle test,we compared the effect of three different solvents(ethanol,acetone,MERO)on the efficacy of neonicotinoids againstAnopheles gambiae *** addition,TaqMan assays were used to genotype key pyrethroid-resistant markers *** and odds ratio based on Fisher exact test were used to evaluate potential cross-resistance between pyrethroids and ***:Lower mortality was observed when using absolute ethanol or acetone alone as solvent for clothianidin(11.4-51.9% mortality in Nkolondom,31.7-48.2% in Mangoum,34.6-56.1% in Mayuge,39.4-45.6% in Obuasi,83.7-89.3% in Congo and 71.1-95.9% in Njombe pendja)compared to acetone+MERO for which 100% mortality were observed for all the *** observations were done for imidacloprid and *** assays(PbO,dEM and dEF)with clothianidin revealed a significant increase of mortality suggesting that metabolic resistance mechanisms are contributing to the reduced susceptibility.A negative association was observed between the L1014F-kdr mutation and clothianidin resistance with a greater frequency of homozygote resistant mosquitoes among the dead than among survivors(OR=0.5;P=0.02).However,the I114T-GSTe2 was in contrast significantly associated with a greater ability to survive clothianidin with a higher frequency of homozygote resistant among surv

关键词： Malaria Anopheles Insecticide resistance Neonicotinoids Clothianidin Cross-resistance

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