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A novel model of photo-carrier screening effect on the GaN-based p-i-n ultraviolet detector

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Science China(Physics,Mechanics & Astronomy) 2010年第5期53卷 793-801页

作者： GAO Bo,LIU HongXia,KUANG QianWei,ZHOU Wen & cao lei School of Microelectronics,Xidian University,Key Laboratory of Wide Band-Gap Semiconductor Materials and Devices,Xi’an 710071,China School of Microelectronics Xidian University Key Laboratory of Wide Band-Gap Semiconductor Materials and Devices Xi’an China

The photo-carrier density in the depletion region of the GaN-based p-i-n ultraviolet(UV) detector is calculated by solving the photo-carrier continuity equation,and the photo-carrier screening electric field is calculated according to Poisson's *** the numerical calculation method,a novel model of photo-carrier screening effect is *** the influence of photo-carrier screening effect on the distribution of photo-carrier density in the depletion region of p-i-n detector is *** influence of incident power,bias voltage and carrier life time on the photo-carrier screening effect is also *** is concluded that the influence of photo-carrier screening effect on the performance of GaN-based p-i-n UV detector is non-monotone,the maximum of carrier drift velocity and the minimum of response time can be realized by adjusting the applied ***,the incident light duration has strong impact on the photo-carrier screening effect.

关键词： GaN p-i-n ultraviolet detector photo-carrier screening effect

抗氧化剂抑制血色素蛋白介导的脂质氧化的研究进展

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食品工业科技 2022年第10期43卷 434-441页

作者：曹珈荣雷雪晴秦志伟刘玲沈阳农业大学食品学院辽宁沈阳110866

脂质氧化是导致肉类食品质量下降的主要原因,其中血色素蛋白介导的脂质氧化不仅可以引发肉的异味和变色,还会进一步增强血红素蛋白的促氧化活性。在肉制品的加工和储藏过程中,抗氧化剂抑制肉制品氧化速度、最大限度地保留肉制品的风味... 详细信息

脂质氧化是导致肉类食品质量下降的主要原因,其中血色素蛋白介导的脂质氧化不仅可以引发肉的异味和变色,还会进一步增强血红素蛋白的促氧化活性。在肉制品的加工和储藏过程中,抗氧化剂抑制肉制品氧化速度、最大限度地保留肉制品的风味并延长其货架期。本文从肉制品中血红素蛋白和脂质在贮藏加工中的氧化过程,抗氧化剂抑制血红素蛋白介导的脂质氧化机理,抗氧化剂在肉制品中的应用几个方面进行综述,为抗氧化剂在肉制品中的机理研究和实践应用提供依据。

关键词：抗氧化剂脂质氧化血红素蛋白

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大口径空间光学遥感器辐射散热器的设计及应用

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北京航空航天大学学报 2023年第12期49卷 3293-3302页

作者：阳明王磊于峰罗世魁宋欣阳赵振明北京空间机电研究所北京100094

为满足大口径空间光学遥感器高效率、低密度散热的需求,提出一种基于高导热石墨膜的空间辐射散热器。对高导热石墨膜的基础物理性能、结构成分、力学性能、热性能、空间环境适应性等进行较全面的测试分析。将高导热石墨膜与热管、蜂窝... 详细信息

为满足大口径空间光学遥感器高效率、低密度散热的需求,提出一种基于高导热石墨膜的空间辐射散热器。对高导热石墨膜的基础物理性能、结构成分、力学性能、热性能、空间环境适应性等进行较全面的测试分析。将高导热石墨膜与热管、蜂窝板等结合起来解决高导热石墨膜应用中常见的厚度方向导热系数低、力学强度低、硬度低、厚度薄、单块尺寸小的难题。对散热器和2种传统空间辐射散热器进行对比仿真分析,仿真分析结果表明:同等散热能力下,高导热石墨辐射散热器的质量仅为传统铝合金板散热器的约1/3,仅为传统铝蜂窝板辐射散热器的约1/2。通过热平衡实验和在轨飞行应用对散热器的散热性能进行验证,验证结果表明:仿真值与在轨值具有良好的一致性,散热器具有优异的力、热性能及显著的减重优势,可广泛应用于各种航天器的散热及均温。

关键词：高导热石墨辐射散热器大口径空间光学遥感器轻量化热设计

Review of Chinese Journal of Traumatology in the year 2016

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Chinese Journal of Traumatology 2017年第1期20卷 18-19页

作者： Yuan-Yuan Peng Li-Ping Huang Gui-E Liu Shuang-ming Song Yuan Tian Si-Yang Zeng lei Li Editorial Office of Chinese Journal of Traumatology Research Institute of Surgery/Daping Hospital Third Military Medical University Chongqing 400042 China

A total of 89 papers were published in Chinese Journal of Traumatology (CJT) in the year 2016, among which brain injury, road traffic injury, blast injury, 3D bioprinting and eye injury were discussed. The articles reported the latest research trends and progress in the field of trauma care. The present study gives a retrospective review on the special topics.

关键词： Review Chinese Journal Traumatology

Toripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma:a single-center,single-arm,phase 2 study

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1983-1992页

作者： Guo-ming Shi Xiao-Yong Huang Dong Wu Hui-Chuan Sun Fei Liang Yuan Ji Yi Chen Guo-Huan Yang Jia-Cheng Lu Xian-Long Meng Xin-Ying Wang lei Sun Ning-Ling Ge Xiao-Wu Huang Shuang-Jian Qiu Xin-Rong Yang Qiang Gao Yi-Feng He Yang Xu Jian Sun Zheng-Gang Ren Jia Fan Jian Zhou Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Department of Radiology Zhongshan HospitalFudan UniversityShanghaiChina Department of Statistics Zhongshan HospitalFudan UniversityShanghaiChina Department of Pathology Zhongshan HospitalFudan UniversityShanghaiChina Department of Hepatic Oncology Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Tianjin Medical Laboratory BGI-TianjinBGI ShenzhenTianjinChina

Advanced intrahepatic cholangiocarcinoma(ICC)has a dismal ***,we report the efficacy and safety of combining toripalimab,lenvatinib,and gemcitabine plus oxaliplatin(GEMOX)as first-line therapy for advanced *** patients with pathologically confirmed advanced ICC received intravenous gemcitabine(1 g/m2)on Days 1 and 8 and oxaliplatin(85 mg/m2)Q3W for six cycles along with intravenous toripalimab(240 mg)Q3W and oral lenvatinib(8 mg)once daily for one *** expression of programmed death-ligand 1(PD-L1)and genetic status was investigated in paraffin-embedded tissues using immunohistochemistry and whole-exome sequencing(WES)*** primary endpoint was the objective response rate(ORR).Secondary outcomes included safety,overall survival(OS),progression-free survival(PFS),disease control rate(DCR)and duration of response(DoR).As of July 1,2022,the median follow-up time was 23.5 months,and the ORR was 80%.Twenty-three patients achieved partial response,and one achieved complete ***(21/30)with DNA damage response(DDR)-related gene mutations showed a higher ORR,while patients(14/30)with tumor area positivity≥1(PD-L1 staining)showed a trend of high ORR,but without significant *** median OS,PFS,and DoR were 22.5,10.2,and 11.0 months,*** DCR was 93.3%.Further,56.7%of patients experienced manageable grade≥3 adverse events(AEs),commonly neutropenia(40.0%)and leukocytopenia(23.3%).In conclusion,toripalimab plus lenvatinib and GEMOX are promising first-line regimens for the treatment of advanced ICC.A phase-III,multicenter,double-blinded,randomized study to validate our findings was approved by the National Medical Products Administration(NMPA,No.2021LP01825).

关键词： regimen intrahepatic treatment

Turner syndrome with positive SRY gene and non-classical congenital adrenal hyperplasia: A case report

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World Journal of Clinical Cases 2021年第10期9卷 2259-2267页

作者： Mei-Nan He Shan-Chao Zhao Ji-Min Li Lu-Lu Tong Xin-Zhao Fan Yao-ming Xue Xiao-Hong Lin Ying cao Department of Endocrinology and Metabolism Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Urology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Guangzhou KingMed Center for Clinical Laboratory Co. Ltd.Guangzhou 510005Guangdong ProvinceChina

BACKGROUND Co-morbidity of SRY gene turner syndrome(TS)with positive SRY gene and nonclassical congenital adrenal hyperplasia(NCAH)is extremely rare and has never been reported to *** SUMMARY In this article,we present a 14-year-old girl who was referred to our hospital with short stature(weight of 43 kg and height of 143 cm,<-2 SD)with no secondary sexual characteristics(labia minora dysplasia).Laboratory tests indicated hypergonadotropic hypogonadism with significantly increased androstenedione and 17-hydroxyprogesterone(17-OHP)*** was accompanied by the thickening of the extremity of the left adrenal medial *** patient’s karyotype was 45,X/46,X,+mar,and cytogenetic analysis using multiplex ligation-dependent probe amplification and high-throughput sequencing indicated that the SRY gene was positive with compound heterozygous mutations in CYP21A2 as the causative gene for congenital adrenal *** sites of the suspected candidate mutations were amplified and verified using Sanger *** patient was finally diagnosed as having SRY positive TS with *** patient and her family initially refused medical *** her most recent follow-up visit(age=15 years old),the patient presented facial hair,height increase to 148 cm,and weight of 52 kg,while androstenedione and 17-OHP levels remained *** patient was finally willing to take small doses of hydrocortisone(10 mg/d).CONCLUSIONIn conclusion, upon evaluation of the patient mentioned in the report, we feel that17-OHP measurement and cytogenetic analysis are necessary for TS patients evenin the absence of significant virilization signs. This will play a significant role inguiding diagnosis and treatment.

关键词： Turner syndrome SRY gene Congenital adrenal hyperplasia Tumor Diagnosis Endocrinology and metabolism Case report

Prognostic analysis of patients with gastrointestinal stromal tumors： a single unit experience with surgical treatment of primary disease

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Chinese Medical Journal 2010年第2期123卷 131-136页

作者： cao Hui ZHANG Yun WANG ming SHEN Dan-ping SHENG Zhi-yong NI Xing-zhi WU Zhi-yong LIU Qiang SHEN Yan-ying SONG Yan-yan Department of General Surgery Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Department of Pathology Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Department of Pharmacology and Biostatistics Institute of Medical Science Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Background Gastrointestinal stromal tumor （GIST）, the most common type of mesenchymal tumors of the gastrointestinal tract, is a recently recognized tumor. The biological behavior of GIST is highly variable. Surgical resection remains the major treatment for GIST. In this study we retrospectively analyzed our surgical experience with 181 GIST patients to determine the effects of the treatment and the pathological features and prognosis factors of these GIST patients. Methods The clinicopathological features and follow-up data of the 181 patients with GIST who had received surgical resection between January 1999 and December 2007 at Ren Ji Hospital were retrospectively reviewed. Immunohistochemical stains including CDl17 （KIT）, CD34, and other markers were used. Tumor size, mitotic index and other pathological parameters were recorded. According to the consensus of NIH risk-group stratification system based on maximum tumor size and mitotic index （per 50 high power field）, tumors were classified into very-low-risk group （15 tumors, 8.3%）, low-risk group （48, 26.5%）, intermediate-risk group （52, 28.7%） and high-risk group （66, 36.5%）. Prognostic factors were analyzed by Cox analysis including age, sex, tumor size, tumor site, mitotic index, NIH categories and surgical procedures. Results One hundred and seven （59.1%） of the 181 tumors were located in the stomach, 51 （28.2%） in the small intestine, 9 （5.0%） in the colon and rectum, and 14 （7.7%） in other sites including the omentum and mesentery. The median age of the patients was 58 （range, 24-84） years, and 102 patients （56.4%） were male. Tumor size ranged from 0.5 to 30 cm, while the mean size was 7.02 cm. Metastasis was found in 7 patients. One hundred and seventy-six （97.2%） of the 181 patients underwent radical resection, and among them 26 patients received extensive resection with the adjacent organ adherent to the tumors. The positive rate for the KIT protein （CDl17） in immunostaining was 94.5% （171/181）, while

关键词： gastrointestinal stromal tumors: prognosis surgical resection targeted therapy

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非临界压缩光场探测的实验方案研究

物理学报 2022年第1期71卷 11-17页

作者：刘鹏李娟项晓曹明涛董瑞芳刘涛张首刚中国科学院国家授时中心中国科学院时间频率基准重点实验室西安710600 中国科学院大学天文与空间科学学院北京100049

压缩态光场作为一种重要的量子光源,在量子计算、量子通信、精密测量等领域有广泛的应用前景.在非临界压缩光场产生的理论预测中,阈值以上泵浦的简并光学参量振荡器(DOPO)产生横向空间分布为一阶厄米高斯模式的非临界压缩光场,具有对泵... 详细信息

压缩态光场作为一种重要的量子光源,在量子计算、量子通信、精密测量等领域有广泛的应用前景.在非临界压缩光场产生的理论预测中,阈值以上泵浦的简并光学参量振荡器(DOPO)产生横向空间分布为一阶厄米高斯模式的非临界压缩光场,具有对泵浦光功率波动鲁棒性的量子特性,因此在实验中具有重要的应用价值.然而该非临界压缩光场的横向幅角随机旋转,导致无法利用本底探针光对其压缩特性进行稳定的平衡零拍实验探测.本文提出利用DOPO同时产生的与压缩光场空间正交的明亮光场作为本底探针光的实验探测方案.理论分析表明,该方案虽然引入了真空噪声,但可以很好地抵消压缩光场空间模式随机旋转引入的探测输出动态波动,得到3 d B的稳定探测结果,且对本底探针光的相位波动具有鲁棒性.因此该探测方案对于非临界压缩光场的实验研究具有重要的实用价值.

关键词：非临界压缩光场自发旋转对称破缺

激光功率对AZ31B镁合金与DP780镀锌钢激光热传导搭接焊接头微观组织与力学性能的影响

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Journal of Central South University 2022年第10期29卷 3463-3475页

作者：高居明王丹庄栋栋赵信毅雷玉成 School of Materials Science&Engineering Jiangsu UniversityZhenjiang 212013China

采用离焦激光束对AZ31B镁合金和DP780镀锌钢进行了激光热传导搭接焊(LHCLW)。研究了激光功率对接头组织和力学性能的影响,通过检测接头的拉伸剪切强度和显微硬度、观察分析微观组织等方法来评价接头的优劣,并且分析了镁/钢界面各种物相... 详细信息

采用离焦激光束对AZ31B镁合金和DP780镀锌钢进行了激光热传导搭接焊(LHCLW)。研究了激光功率对接头组织和力学性能的影响,通过检测接头的拉伸剪切强度和显微硬度、观察分析微观组织等方法来评价接头的优劣,并且分析了镁/钢界面各种物相的形成机理。结果表明,镀锌层通过改善熔融镁合金在钢界面上的扩散能力并与Mg发生反应,促进镁合金与钢的冶金结合,从而提高接头的强度。观察发现在接头界面处形成了连续致密的层状共晶组织(α-Mg+MgZn),焊缝边缘处和热影响区(HAZ)形成了MgZn_(2)和MgZn相,而无镀层钢与镁合金之间没有发生冶金反应。当功率为2.5 kW时,接头的拉伸剪切强度能够达到最大值,约为42.9 N/mm。然而,在2.6 kW时由于共晶反应层中产生了微裂纹而导致接头强度略有降低。

关键词： AZ31B镁合金 DP780镀锌钢激光热传导搭接焊激光功率微观组织力学性能