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Preparation and evaluation of nano-hydroxyapatite/poly(styrene-divinylbenzene) porous microsphere for aspirin carrier

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Science China Chemistry 2012年第6期55卷 1134-1139页

作者： LI Sen WANG Kuan CHANG Kue-Chieh Alan ZONG ming WANG Jing cao YongGang BAI YuHua WEI Taiming ZHANG ZhiRen School of Pharmacy Daqing Campus Harbin Medical University Daqing 163319 China School of Life Science and Biotechnology Dalian University of Technology Dalian 116024 China Departments of Pharmacy and Cardiology The 2nd Affiliated Hospital of Harbin Medical University Key Laboratories of Ministry of Education for Myocardial lschemia Mechanism and Treatment Harbin Medical University Harbin 150086 China

A novel vehicle for the delivery of aspirin (ASA) was prepared from porous nano-hydroxyapatite/poly(styrene-divinylbenzene) [nano-HAP/P(St-DVB)] composite microspheres by grafting nano-HAP [Ca10(PO4)6(OH)2] onto porous P(St-DVB) microspheres. Four types of porous composite microspheres were prepared, each with different nano-HAP contents. The ASA-loaded composite microspheres prepared with 10% and 15% nano-HAP (mass ratio) exhibited excellent buoyancy with relatively short instantaneous floating time (within 10 min) and a long sustained floating time (12 h) in simulated gastric juice. They also offered good sustained release of ASA (up to 8 h). Furthermore, these composite microspheres displayed good buffering capacity that prevented the buildup of acidity caused by hydrolysis of ASA, keeping the pH of gastric juice within the normal range (pH 0.9 to 1.5). The results showed that porous nano-HAP/P(St-DVB) composite microspheres prepared with 10% and 15% nano-HAP could be used as a novel drug carrier for ASA, providing a sustained release dose without leading to stomach irritation, a side effect that is often associated with ASA medication.

关键词：纳米羟基磷灰石多孔微球阿司匹林药物载体二乙烯苯苯乙烯制备 ST-DVB

Chronic Active Hepatitis B with COVID-19 in Pregnancy: A Case Report

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Journal of Clinical and Translational Hepatology 2021年第1期9卷 133-135页

作者： Qiu-Yu Li Zhuo-Yu An Chao Li ming Zu lei Chen Jia-Nan Zhang Yang-Yu Zhao Ning Shen Qing-Gang Ge Department of Respiratory and Critical Care Medicine Peking University Third HospitalBeijingChina Peking University Institute of Hematology Peking University People’s HospitalBeijingChina Department of Critical Care Medicine Peking University Third HospitalBeijingChina Department of Gastroenterology Peking University Third HospitalBeijingChina Department of Respiratory and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Obstetrics and Gynecology Peking University Third HospitalBeijingChina

Currently,infection with coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),during pregnancy is a problem worthy of attention,especially in patients with underlying *** this case report,we present a case of chronic active hepatitis B with COVID-19 in pregnancy.A 31-year-old woman at 29 weeks of gestation who had a history of chronic hepatitis B virus infection discontinued antiviral treatment,was admitted to the hospital with chronic active hepatitis B,and tested positive for SARS-CoV-2 *** this case,we applied liver protective and antiviral agents,and low-dose dexamethasone therapy to successfully treat the critically ill pregnant woman suffering from chronic active hepatitis B combined with COVID-19.

关键词： COVID-19 SARS-CoV-2 Pregnancy Active hepatitis B

Effectiveness and safety of secukinumab in Chinese patients with plaque psoriasis in a clinical practice setting:a pilot study

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Chinese Medical Journal 2020年第24期133卷 3017-3019页

作者： Si-Man Zhu Wen-Hui Wang Jin-Zhu Guo Xin Guan Yue-Hua Men Hua Zhang Yi-ming Zhao Chun-lei Zhang Department of Dermatology Peking University Third HospitalBeijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China

To the Editor:Psoriasis is a chronic,recurrent,systemic,immune-mediated inflammatory disease that mainly affects the skin,nails,and *** psoriasis is the most common type of psoriasis,accounting for more than 80%to 90%of all ***,a human IgG monoclonal antibody that antagonizes interleukin 17A(IL-17A),was approved by the US Food and Drug Administration in 2015 to treat moderate-to-severe plaque psoriasis.A Chinese multicenter,double-blind,placebo-controlled phase III randomized clinical trial(RCT)demonstrated excellent efficacy and safety.[1]Secukinumab has been available on the Chinese market since May 2019,with a recommended dose of 300 *** is well-known that RCTs,due to their rigorous,normalized design schemes,cannot fully reflect what happens in clinical practice *** concept of the"efficacy-effectiveness gap"was also introduced,[2]which supports the importance of real-world ***,we retrospectively summarized all the inpatients with plaque psoriasis who were treated with secukinumab at Peking University Third Hospital from June to December *** information(sex,age,weight,body mass index,etc.)and clinical features(disease duration,family history,comorbidities,laboratory tests,previous treatments,concomitant treatments,etc.)were collected from clinical *** psoriasis area severity index(PASI),body surface area(BSA),dermatology life quality index(DLQI),psoriasis scalp severity index(PSSI),nail psoriasis severity index(NAPSI),and palmoplantar psoriasis area and severity index(ppPASI)were also recorded.

关键词： psoriasis clinical summarized

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中国能源经济效率动态分析及预测

中国人口·资源与环境 2011年第4期21卷 81-87页

作者：曹明中国矿业大学管理学院江苏徐州221116

能源经济效率的影响因素作用复杂,系统各要素之间存在复杂的动态关系。本文利用中国1978-2007年的实际数据,应用向量自回归模型(VectorAuto-regression,VAR)、脉冲响应分析、协整理论等计量理论与方法对中国能源经济效率的变动进行动态... 详细信息

能源经济效率的影响因素作用复杂,系统各要素之间存在复杂的动态关系。本文利用中国1978-2007年的实际数据,应用向量自回归模型(VectorAuto-regression,VAR)、脉冲响应分析、协整理论等计量理论与方法对中国能源经济效率的变动进行动态实证分析,并预测中国能源经济效率的发展趋势。结果表明,中国的能源经济效率、第三产业比重和能源价格指数之间存在协整关系,从长期来看,1%的第三产业结构或者能源价格变化可以分别给能源经济效率带来0.3477%和0.4785%的同方向变化;除了产业结构对能源价格短期响应之外,变量之间都是正向的冲击响应,滞后6-10期响应达到最大值,之后逐渐趋于稳定;依据VAR模型动态预测结果,未来10年中国能源经济效率发展趋势不容乐观,由于系统较长的滞后响应期,近几年能源经济效率、能源价格和产业结构的变动会在未来较长时间内对能源经济效率的提升产生不利影响,应当及时调整能源经济策略。

关键词： VAR模型脉冲响应分析协整能源经济效率

和差式相位测向法在吊放声纳改进中的运用研究

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测控技术 2023年第3期42卷 106-111页

作者：张明曹文航空工业洛阳电光设备研究所河南洛阳471000

国内某型吊放声纳在模拟信号处理过程中存在操作复杂和测向精度不高等问题,早期和差式相位测向法需要复杂的显示系统,对人员的操作要求较高,并且误差较大。通过分析影响吊放声纳测向的因素,在模拟处理转变为数字信号处理技术后,基于和... 详细信息

国内某型吊放声纳在模拟信号处理过程中存在操作复杂和测向精度不高等问题,早期和差式相位测向法需要复杂的显示系统,对人员的操作要求较高,并且误差较大。通过分析影响吊放声纳测向的因素,在模拟处理转变为数字信号处理技术后,基于和差式相位测向原理,同时引入恒虚假检测以及目标参数估计等后处理算法流程,可直接精确地计算出目标方位,降低了对操作技能的要求,最终确定数字化改造的方向,为早期模拟吊放声纳装备性能改进提供了依据和参考。

关键词：和差式测向吊放声纳数字信号处理

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Relationship between Waist Circumference and Elevation of Carotid Intima-media Thickness in Newly-diagnosed Diabetic Patients

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Biomedical and Environmental Sciences 2014年第5期27卷 335-342页

作者： ZHANG lei SHEN Yun ZHOU Jian PAN Jie Min YU Hao Yong CHEN Hai Bing LI Qing LI ming BAO Yu Qian JIA Wei Ping Department of Endocrinology and Metabolism Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus

Objective Waist circumference, as a brief indicator of visceral obesity, is associated with multi-metabolic disorders and cardiovascular diseases. The present study was aimed to find out the relationship between waist circumference and carotid intima media thickness （C-IMT）, as well as the best waist circumference cutoff for identifying C-IMT elevation in Chinese male patients with newly-diagnosed diabetes. Methods Five hundred and seventy-eight patients from Department of Endocrinology and Metabolism in Shanghai Sixth People＇s Hospital affiliated to Shanghai Jiao Tong University were enrolled. Both physical examination （for measurement of waist circumference） and carotid ultrasonography （for measurement of C-IMT） were performed. Results After grouping according to the quartiles of C-IMT, the waist circumference increased across all its quartiles. The waist circumference in 3rd and 4th quartiles （90.7_＋9.8 cm and 90.8＋9.6 cm） was significant higher than in 1st and 2nd quartiles （P〈0.05）. When subjects were divided into 4 groups according to waist circumference, the C-IMT of subjects with waist circumference 90-95 cm was significant higher than that of subjects with waist circumference 85-90 cm and less than 85 cm respectively （P〈0.05）. Both spearman and partial correlation analysis showed that C-IMT was positively correlated with waist circumference （P〈0.01）. C-IMT was found significantly elevated with the increase of waist circumference. Multiple stepwise regression analysis showed that waist circumference was one of the independent risk factors of C-IMT. After an average of 2.23_＋0.85 years follow up, there was a significant elevation of C-IMT in the group with baseline waist circumference over 90 cm P〈0.05）, while no significant difference was detected in the group with baseline waist circumference less than 90 cm （P=0.27）. Logistic regression showed that baseline waist circumference over 90 cm was associated with a relative risk to C-IMT elevation of 1.132 （95%

关键词： Waist circumference Carotid intima media thickness Metabolic syndrome

Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-β-susceptible hepatocellular carcinoma cells

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World Journal of Gastroenterology 2012年第17期18卷 2035-2042页

作者： lei Jiang Yiu-Kay Lai Jin-Fang Zhang Chu-Yan Chan Gang Lu Marie CM Lin ming-Liang He Ji-Cheng Li Hsiang-Fu Kung Laboratory of Internal Medicine The First AffiliatedHospital of Wenzhou Medical College Wenzhou 325000 Zhejiang Province China Department of Life Science National Tsing HuaUniversity Hsinchu 30013 Taiwan Stanley Ho Centre for Emerging Infectious Diseases The Chinese University of Hong Kong Shatin 999077 HongKong China Brain Tumor Centre and Division ofNeurosurgery Department of Surgery The Chinese University ofHong Kong Shatin 999077 Hong Kong China Institute of Cell Biology Zhejiang UniversityHangzhou 310058 Zhejiang Province China

AIM:To investigate the role of transforming growth factor(TGF)-β-inducible early gene 1(TIEG1) in TGF-β-induced growth inhibition in hepatocellular carcinoma(HCC) ***:Human hepatocyte and HCC cell lines with varied susceptibilities to TGF-β1 were tested by methylthiazoletetrazolium(MTT) *** expression changes of Smad2,Smad3,Smad4,Smad7,TIEG1 and TIEG2 gene following treatment with TGF-β1 in a TGF-β-sensitive hepatocyte cell line(MIHA),a TGF-β-sensitive hepatoma cell line(Hep3B) and two TGF-β-insensitive hepatoma cell lines(HepG2 and Bel7404) were *** targeting TIEG1 was transfected into Hep3B cells and the sensitivity of cells to TGF-β1 was *** of TIEG1 was induced by lentiviral-mediated transduction in TGF-β1-resistant hepatoma cell lines(Bel7404 and HepG2).MTT assay and 4',6-Diamidino-2-phenylindole staining were used to identify cell viability and apoptosis,*** expression level of stathmin was measured by reverse transcriptase polymerase chain reaction and Western-blotting analysis,and stathmin promoter activity by TIEG1 was monitored by a luciferase reporter gene ***:TIEG1 was significantly upregulated by TGF-β1 in the TGF-β1-sensitive HCC cell line,Hep3B,but not in the resistant cell *** suppression of TIEG1 by siRNAs decreased the sensitivity of Hep3B cells to TGF-β1,whereas the overexpression of TIEG1 mediated growth inhibition and apoptosis in TGF-β1-resistant HCC cell lines,which resembled those of TGF-β1-sensitive HCC cells treated with TGF-β*** data further suggested that stathmin was a direct target of TIEG1,as stathmin was signif icantly downregulated by TIEG1 overexpression,and stathmin promoter activity was inhibited by TIEG1 in a dose-dependent ***:Our data suggest that transactivation of TIEG1 conferred growth inhibition of TGF-β-susceptible human HCC cells.

关键词：逆转录聚合酶链反应转化生长因子细胞生长敏感性肝癌 Western印迹荧光素酶报告基因肝细胞株

基于抗肝纤维化生物活性及近红外谱效相关的鳖甲质量评价研究

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中草药 2023年第10期54卷 3150-3157页

作者：曹梦珍黄倩牛明赵旭肖小河成都中医药大学药学院四川成都610032 中国人民解放军总医院第五医学中心肝病医学部研究所北京100039

目的从鳖甲临床抗肝纤维化功效出发并结合近红外光谱,探索建立关联抗肝纤维化活性的鳖甲质量生物活性评价方法。方法建立转化生长因子-β1(transforming growth factor-β1,TGF-β1)诱导的LX-2肝纤维化细胞模型,采用qRTPCR检测鳖甲对I... 详细信息

目的从鳖甲临床抗肝纤维化功效出发并结合近红外光谱,探索建立关联抗肝纤维化活性的鳖甲质量生物活性评价方法。方法建立转化生长因子-β1(transforming growth factor-β1,TGF-β1)诱导的LX-2肝纤维化细胞模型,采用qRTPCR检测鳖甲对I型胶原(type I collagen,COL1)m RNA表达的影响,计算鳖甲对COL1 m RNA相对表达量的抑制率;采用Western blotting检测鳖甲对COL1蛋白表达的影响,以评价鳖甲在细胞模型上的抗肝纤维化生物活性。采集并处理不同批次鳖甲药材的近红外光谱数据,通过谱-效相关分析探究鳖甲药材近红外光谱数据与其抗肝纤维化活性的相关性,筛选活性波段,建立鳖甲的效应近红外谱,以效应近红外谱下面积评价鳖甲药材的质量。结果体外实验表明,与模型组比较,鳖甲水提物(water extract of Trionycis Carapax,WECT)处理组细胞中COL1 mRNA与蛋白表达水平显著下调(P0.6、P<0.05且波数大于8 cm^(-1)的活性波段3个,分别为5226~5235 cm^(-1)、5943~6071cm^(-1)与6379~6396 cm^(-1),以3个活性波段下面积为指标,建立鳖甲药材的效应近红外谱,计算各特征波段下面积和,并分析其与生物活性的相关性,两者相关系数R为0.81353。结论WECT可抑制LX-2细胞外基质的产生来治疗肝纤维化;效应波谱下面积和(5226~5235 cm^(-1)、5943~6071 cm^(-1)与6379~6396 cm^(-1))作为鳖甲药材的质量评价系数,用于评价鳖甲药材的质量,可区分不同批次鳖甲药材的抗肝纤维化活性。

关键词：鳖甲肝纤维化质量评价生物评价近红外光谱谱效相关分析

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受控外国公司规则与收入纳入规则的比较分析

国际税收 2022年第11期 24-29页

作者：曹琦欢郭鸣张宁陈颖国家税务总局国际税务司国家税务总局湖北省税务局国家税务总局深圳市税务局第四税务分局

经济合作与发展组织(OECD)发布的支柱二方案引入了全球最低税制度,其主体补税规则是收入纳入规则(IIR)。收入纳入规则与传统的受控外国公司(CFC)规则具有一定的相似性,对于已经制定CFC规则的辖区来说,引入IIR将面临如何协调IIR与CFC规... 详细信息

经济合作与发展组织(OECD)发布的支柱二方案引入了全球最低税制度,其主体补税规则是收入纳入规则(IIR)。收入纳入规则与传统的受控外国公司(CFC)规则具有一定的相似性,对于已经制定CFC规则的辖区来说,引入IIR将面临如何协调IIR与CFC规则的关系问题。本文从政策目标、计算规则、适用范围等方面分析二者的异同,以案例形式展现二者的适用场景与规则交互,并在此基础上提出了三点初步结论。

关键词：受控外国公司收入纳入规则全球最低税