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RepBoTNet-CESA:An Alzheimer’s Disease Computer Aided Diagnosis Method Using Structural Reparameterization BoTNet and Cubic Embedding Self Attention

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Computers, Materials & Continua 2024年第5期79卷 2879-2905页

作者： Xiabin Zhang Zhongyi hu lei xiao hui huang College of Computer Science and Artificial Intelligence Wenzhou UniversityWenzhou325035China Key Laboratory of Intelligence Image Processing and Analysis Wenzhou UniversityWenzhou325035China

Various deep learning models have been proposed for the accurate assisted diagnosis of early-stage Alzheimer’s disease(AD).Most studies predominantly employ Convolutional Neural Networks(CNNs),which focus solely on local features,thus encountering difficulties in handling global *** contrast to natural images,Structural Magnetic Resonance Imaging(sMRI)images exhibit a higher number of channel ***,during the Position Embedding stage ofMulti Head Self Attention(MHSA),the coded information related to the channel dimension is *** tackle these issues,we propose theRepBoTNet-CESA network,an advanced AD-aided diagnostic model that is capable of learning local and global features *** combines the advantages of CNN networks in capturing local information and Transformer networks in integrating global information,reducing computational costs while achieving excellent classification ***,it uses the Cubic Embedding Self Attention(CESA)proposed in this paper to incorporate the channel code information,enhancing the classification performance within the Transformer ***,the RepBoTNet-CESA performs well in various AD-aided diagnosis tasks,with an accuracy of 96.58%,precision of 97.26%,and recall of 96.23%in the AD/NC task;an accuracy of 92.75%,precision of 92.84%,and recall of 93.18%in the EMCI/NC task;and an accuracy of 80.97%,precision of 83.86%,and recall of 80.91%in the AD/EMCI/LMCI/NC *** demonstrates that RepBoTNet-CESA delivers outstanding outcomes in various AD-aided diagnostic ***,our study has shown that MHSA exhibits superior performance compared to conventional attention mechanisms in enhancing ResNet ***,the Deeper RepBoTNet-CESA network fails to make further progress in AD-aided diagnostic tasks.

关键词： Alzheimer CNN structural reparameterization multi head self attention computer aided diagnosis

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Pharmacological Effects of Botanical Drugs on Myocardial Metabolism in Chronic Heart Failure

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Chinese Journal of Integrative Medicine 2024年第5期30卷 458-467页

作者： hu Yu-xuan QIU Sheng-lei SHANG Ju-ju WANG Zi LAI xiao-lei Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing 100010China

Although there have been significant advances in the treatment of heart failure in recent years,chronic heart failure remains a leading cause of cardiovascular disease-related *** studies have found that targeted cardiac metabolic remodeling has good potential for the treatment of heart ***,most of the drugs that increase cardiac energy are still in the theoretical or testing *** research has found that botanical drugs not only increase myocardial energy metabolism through multiple targets but also have the potential to restore the balance of myocardial substrate *** this review,we summarized the mechanisms by which botanical drugs(the active ingredients/formulas/Chinese patent medicines)improve substrate utilization and promote myocardial energy metabolism by activating AMP-activated protein kinase(AMPK),peroxisome proliferator-activated receptors(PPARs)and other related *** the same time,some potential protective effects of botanical drugs on myocardium,such as alleviating oxidative stress and dysbiosis signaling,caused by metabolic disorders,were briefly discussed.

关键词： botanical drugs chronic heart failure myocardial metabolism pharmacological effects review

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Investigation of mechanical and electrical characteristics of selfsensing pneumatic torsional actuators

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Science China(Technological Sciences) 2024年第1期67卷 130-142页

作者： xiao Wei hu DeAn hu GuoLiang xiao Yihua Key Laboratory of Conveyance and Equipment Ministry of EducationEast China Jiaotong UniversityNanchang 330013China Key Laboratory of Advanced Design and Simulation Techniques for Special Equipment Ministry of EducationHunan UniversityChangsha 410082China

Soft pneumatic actuators are one of the most promising actuation for soft robots,and great achievements have been *** it remains challenging to endow sensing capabilities to pneumatic actuators,especially for the sensing ability originating directly from the actuator ***,a self-sensing pneumatic torsional actuator(SPTA)is designed based on the electromagnetic induction effect and magnetically responsive *** SPTA can generate feedback voltage and current with the deformation,in which the sensing function comes from its inherent *** investigate the mechanical and electrical characteristics,an experimental platform and a finite element model are established,*** find that the torsion angle and output torque increase in nonlinear with the actuating *** maximum torsion angle is 66.35°,which is 84.34%of that for the actuator fabricated by pure *** maximum output torque(24.9 N mm)improves by 23.19%compared with the actuator made by pure *** regards the electrical characteristics,the maximum feedback voltage and current are 2.90μV and 29.50 nA when the SPTA is actuated by a pressure of−40 *** also demonstrate that the relationship between the torsion angle and the magnetic flux change is approximately ***,the number of turns of wires,magnetic powders contents,and magnetic direction on the feedback voltage and current are *** show that the feedback voltage and current can be enhanced by increasing the number of turns and magnetic powders *** envision that the SPTA would be promising for soft robots to realize their accuracy control and intelligentization.

关键词： pneumatic torsional actuators self-sensing feedback voltage finite element modeling soft robots

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Relationship between AQP4 expression and structural damage to the blood-brain barrier at early stages of traumatic brain injury in rats

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Chinese Medical Journal 2013年第22期126卷 4316-4321页

作者： LU Hong lei xiao-yan hu hui HE Zhan-ping Department of Radiology Department of Nursing Affiliated Haikou Hospital Xiangya School of Medicine Central South University Haikou Hainan 570208 China

Background Although some studies have reported that aquaporin-4 （AQP4） plays an important role in the brain edema after traumatic brain injury （TBI）, little is known about the AQP4 expression in the early stage of TBI, or about the correlation between the structural damage to the blood-brain barrier （BBB） and angioedema. The aim of this project was to investigate the relationship between AQP4 expression and damage to the BBB at early stages of TBI. Methods One hundred and twenty healthy adult Wistar rats were randomly divided into two groups： sham operation group （SO） and TBI group. The TBI group was divided into five sub-groups according to the different time intervals： 1, 3, 6, 12, and 24 hours. The brains of the animals were taken out at different time points after TBI to measure brain water content. The cerebral edema and BBB changes in structure were examined with an optical microscopy （OM） and transmission electron microscopy （TEM）, and the IgG content and AQP4 protein expression in traumatic brain tissue were determined by means of immunohistochemistry and Western blotting. The data were analyzed with SPSS 13.0 statistical software. Results In the SO group, tissue was negative for IgG, and there were no abnormalities in brain water content or AQP4 expression. In the TBI group, brain water content significantly increased at 6 hours and peaked at 24 hours following injury. IgG expression significantly increased from 1 to 6 hours following injury, and remained at a high level at 24 hours. Pathological observation revealed BBB damage at 1 hour following injury. Angioedema appeared at 1 hour, was gradually aggravated, and became obvious at 6 hours. Intracellular edema occurred at 3 hours, with the presence of large glial cell bodies and mitochondrial swelling. These phenomena were aggravated with time and became obvious at 12 hours. In addition, microglial proliferation was visible at 24 hours. AQP4 protein expression were reduced at 1 hour, lowest at 6 hours, and

关键词： brain injury, edema, blood-brain barrier, aquaporins animal experiment

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Coupled conditional nonlinear optimal perturbations and their application to ENSO ensemble forecasts

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Science China Earth Sciences 2024年第3期67卷 826-842页

作者： Wansuo DUAN lei hu Rong FENG LASG Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

Limitations are existed in current ensemble forecasting initial perturbation methods for describing the interactions among various spheres of the Earth system. In this study, a new method is proposed, namely, the coupled conditional nonlinear optimal perturbation(C-CNOP) method, which incorporates multisphere interactions much appropriately. The El Nino-Southern Oscillation(ENSO) is a typical ocean-atmosphere “coupling”(or “interaction”) phenomenon. The C-CNOP method is applied to ensemble forecasting of ENSO. It is demonstrated that the C-CNOP method can generate coupled initial perturbations(CPs) that appropriately consider initial ocean-atmosphere coupling uncertainty for ENSO ensemble forecasts. Results reveal that the CPs effectively improve the ability of ENSO ensemble-mean forecasts in both temporal variability of Nio3.4 sea surface temperature anomalies(SSTAs) and spatial variability of ENSO mature-phase SSTAs. Notably, despite the weakest ocean-atmosphere coupling strength in the tropical Pacific occurring during the boreal spring and summer, CPs still capture the uncertainties of this weak coupling when ENSO predictions are initialized at these seasons. This performance of CPs significantly suppresses the rapid increase of ENSO prediction errors due to the high ocean-atmosphere coupling instability during these seasons, and thus effectively extends the lead time of skillful ENSO forecasting. Hence, the C-CNOP method is a suitable initial perturbation approach for ENSO ensemble forecast that can describe initial ocean-atmosphere coupling uncertainty. It is expected that the CCNOP method plays a significant role in predictions of other high-impact climate phenomena, and even future Earth system predictions.

关键词： Ensemble forecast Multisphere interaction Initial perturbations ENSO

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Effect of Central Multiphase Microstructure of Thick Plates on Work Hardening and Crack Propagation

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 325-338页

作者： lei hu Liqin Zhang Feng hu Kuan Zheng Guohong Zhang Collaborative Innovation Center for Advanced Steels Wuhan University of Science and TechnologyWuhan430081China Department of Applied Physics Wuhan University of Science and TechnologyWuhan430081China Analysis and Testing Center Wuhan University of Science and TechnologyWuhan430081China

The effect of multiphase microstructure in the center segregation zones(CSZ)of high-strength steel thick plates on work hardening characteristics and crack initiation/propagation were *** was correlated with deformation damage behavior by using Taylor factor(TF)gradients,kernel average misorientation(KAM),and geometric necessary dislocation(GND)*** results show that the segregation leads to a mixed structure of ferrite(soft phase)and martensite/bainite(hard phase)in the center of the thick *** to the 1/4 thickness(1/4 T)region,grain refinement occurred in the CSZ,with KAM values increasing from 0.24 to 0.49 and a decrease in the proportion of high-angle grain boundaries(>15°)from 77.4 to 51.8%.In the process of deformation,due to the influence of grain refinement and adjacent martensite/bainite,ferrite grains were divided into structural units with different TF *** higher KAM value and GND density at the interface between soft/hard phases resulted in severe work *** addition,the presence of micron-sized inclusions in the CSZ caused local strain concentration and non-continuous deformation of the matrix,which induced crack *** fracture surface showed a mixed mode of brittle cleavage fracture and ductile fracture.

关键词： Thick plate Center segregation zone Multiphase microstructure Taylor factor Crack propagation

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A review on surface coating strategies for anti-hygroscopic of high energy oxidizer ammonium dinitramide

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Defence Technology（防务技术） 2024年第3期33卷 237-269页

作者： Hongyu Yang Fuyao Chen Yiwen hu Qiangqiang Lu lei xiao Yinglei Wang Fengqi Zhao Wei Jiang Gazi Hao National Special Superfine Powder Engineering Research Center of China School of Chemistry and Chemical EngineeringNanjing University of Science and TechnologyNanjing 210094China Xi’an Modern Chemistry Research Institute Xi’an 710065China

Ammonium dinitramide(ADN),which has the advantages of high energy density,no halogen and low characteristic signal,is not only considered as a new high-energy oxidizer that is expected to replace the traditional oxidizer ammonium perchlorate(AP)in solid propellants,but also a good performance explosive in ***,due to the strong hygroscopicity of ADN,its application in solid propellants and explosives is greatly *** the hygroscopicity of ADN is the key to realize the wide application of *** this paper,we systematically review the research progress of anti-hygroscopic strategies of ADN *** surface coating methods are focusing on solvent volatilization,solvent-non-solvent,melt crystallization and atomic layer deposition *** characteristics of the different methods are compared and analyzed,and the basis for the classification and selection of the coating materials are introduced in *** addition,the feasibility of material for surface coating of ADN is evaluated by several compatibility analysis *** is highly expected that the liquid phase method(solvent volatilization method,solvent-non-solvent method)would be the promising method for future ADN coating because of its effective,safety and facile ***,polymer materials,are the preferred coating materials due to their high viscosity,easy adhesion,good anti-hygroscopic effect,and heat resistance,which make ADN weak hygroscopicity,less sensitive,easier to preserve and good compatibility.

关键词： Ammonium dinitramide(ADN) Energetic materials Anti-hygroscopic Surface coating Compatibility analysis

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CRD-CGAN:category-consistent and relativistic constraints for diverse text-to-image generation

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Frontiers of Computer Science 2024年第1期18卷 61-75页

作者： Tao hu Chengjiang LONG Chunxia xiao College of Intelligent Systems Science and Engineering Hubei Minzu UniversityEnshi 445000China School of Computer Science Wuhan UniversityWuhan 430072China Key Laboratory of Performing Art Equipment&System Technology Ministry of Culture and TourismBeijing 100007China Meta Reality Labs BurlingameCA94010USA

Generating photo-realistic images from a text description is a challenging problem in computer *** works have shown promising performance to generate synthetic images conditional on text by Generative Adversarial Networks(GANs).In this paper,we focus on the category-consistent and relativistic diverse constraints to optimize the diversity of synthetic *** on those constraints,a category-consistent and relativistic diverse conditional GAN(CRD-CGAN)is proposed to synthesize K photo-realistic images *** use the attention loss and diversity loss to improve the sensitivity of the GAN to word attention and ***,we employ the relativistic conditional loss to estimate the probability of relatively real or fake for synthetic images,which can improve the performance of basic conditional ***,we introduce a category-consistent loss to alleviate the over-category issues between K synthetic *** evaluate our approach using the Caltech-UCSD Birds-200-2011,Oxford 102 flower and MS COCO 2014 datasets,and the extensive experiments demonstrate superiority of the proposed method in comparison with state-of-the-art methods in terms of photorealistic and diversity of the generated synthetic images.

关键词： text-to-image diverse conditional GAN relativi-stic category-consistent

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2D–3D dual carbon layer confined ultrasmall VN nanoparticles for improving lithium-ion storage in hybrid capacitors

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Rare Metals 2024年第1期43卷 65-75页

作者： Zhao-Wei hu hui-Fang Li Peng Wang Wan-Li Wang lei Yang xiao-Jun Wang Zhi-Ming Liu College of Electromechanical Engineering Shandong Engineering Laboratory for Preparation and Application of High-Performance Carbon-MaterialsQingdao University of Science&TechnologyQingdao 266061China Research Center for Intelligent and Wearable Technology College of Textiles and ClothingQingdao UniversityQingdao 266071China

Lithium-ion capacitors(LICs) of achieving high power and energy density have garnered significant attention. However, the kinetics unbalance between anode and cathode can impede the application of LICs. Vanadium nitride(VN) with a high theoretical specific capacity(~ 1200 m Ah·g^(-1)) is a better pseudocapacitive anode to match the response of cathode in LICs. However, the insertion/extraction of Li-ions in VN's operation results in significant volume expansion. Herein, the VN/N-r GO-5composite that three-dimentional(3D) dicyandiamidederived-carbon(DDC) tightly wrapped VN quantum dots(VN QDTs) on two-dimentional(2D) reduced graphene oxid(r GO) was prepared by a facile strategy. The VN QDTs can reduce ion diffusion length and improve charge transfer kinetics. The 2D r GO as a template provides support for nanoparticle dispersion and improves electrical conductivity. The 3D DDC tightly encapsulated with VN QDTs mitigates agglomeration of VN particles as well as volume expansion. Correspondingly, the LICs with VN/Nr GO-5 composite as anode and activated carbon(AC) as cathode were fabricated, which exhibits a high energy density and power density. Such strategy provides a perspective for improving the electrochemical properties of LIC anode materials by suppressing volume expansion and enhancing conductivity.

关键词： Vanadium nitride(VN)quantum dots Reduced graphene oxide(rGO)nanosheets Dicyandiamide-derived-carbon 2D–3D dual carbon layer Lithium-ion capacitors

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Alcohol consumption in relation to the incidence of atrial fibrillation in an elderly Chinese population

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Journal of Geriatric Cardiology 2022年第1期19卷 52-60页

作者： xiao-Fei YE Wei ZHANG Yi CHEN Chao-Ying MIAO Qi-Fang huANG Chang-Sheng SHENG Shuai SHAO Dian WANG Shao-Kun XU lei lei Di ZHANG Yi-Lin CHEN lei-xiao hu Jia-hui XIA Yi-Bang CHENG Ying WANG Qian-hui GUO Yan LI Nicole Lowres Ben Freedman Ji-Guang WANG School of Public Health Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Cardiovascular Medicine The Shanghai Institute of HypertensionRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Heart Research Institute Sydney Medical SchoolCharles Perkins Centerand Cardiology DepartmentConcord HospitalUniversity of SydneySydneyAustralia

BACKGROUND Alcohol consumption is a known modifiable risk factor for atrial *** association,however,might differ according to *** investigated gender-specific associations between alcohol consumption and incident atrial fibrillation in an elderly Chinese *** Our study participants were elderly residents(≥65 years)recruited from five community health centers in the urban area of Shanghai(n=6,618).Alcohol intake was classified as never drinkers and current light-to-moderate(<40 g/day)and heavy drinkers(≥40 g/day).Atrial fibrillation was detected by a 30-s single-lead electrocardiography(ECG,AliveCor®Heart Monitor)and further evaluated with a regular 12-lead *** During a median of 2.1 years(interquartile range:2.0−2.2)follow-up,the incidence rate of atrial fibrillation was 1.10%in all study *** was slightly but non-significantly higher in men(n=2849)than women(n=3769,1.30%vs.0.96%,P=0.19)and in current drinkers(n=793)than never drinkers(n=5825,1.64%vs.1.03%,P=0.12).In both unadjusted and adjusted analyses,there was interaction between sex and current alcohol intake in relation to the incidence of atrial fibrillation(P<0.0001).After adjustment for confounding factors,current drinkers had a significantly higher incidence rate of atrial fibrillation than never drinkers in women(12.96%[7/54]vs.0.78%[29/3715],adjusted odds ratio[OR]=10.25,95%confidence interval[CI]:3.54−29.67,P<0.0001),but not in men(0.81%[6/739]vs.1.47%[31/2110],OR=0.62,95%CI:0.25−1.51,P=0.29).CONCLUSIONS Our study showed a significant association between alcohol intake and the incidence of atrial fibrillation in elderly Chinese women,but not men.

关键词： fibrillation intake Alcohol

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