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Journal of Energy Chemistry 2024年第2期89卷 1-9,I0002页

作者： Bao Zhang Yi Zhao minghuang Li Qi Wang lei Cheng lei ming Xing Ou Xiaowei Wang National Engineering Laboratory for High-Efficiency Recovery of Refractory Nonferrous Metals School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083HunanChina Zhejiang Power New Energy Co. LTDZhuji 311800ZhejiangChina

Advancing high-voltage stability of layered sodium-ion oxides represents a pivotal avenue for their progress in energy storage *** this,a comprehensive understanding of the mechanisms underpinning their structural deterioration at elevated voltages remains insufficiently *** this study,we unveil a layer delamination phenomenon of Na_(0.67)Ni_(0.3)Mn_(0.7)O_(2)(NNM)within the 2.0-4.3 V voltage,attributed to considerable volumetric fluctuations along the c-axis and lattice oxygen reactions induced by the simultaneous Ni^(3+)/Ni^(4+)and anion redox *** introducing Mg doping to diminished Ni-O antibonding,the anion oxidation-reduction reactions are effectively mitigated,and the structural integrity of the P2 phase remains firmly intact,safeguarding active sites and precluding the formation of novel *** Na_(0.67)Mg_(0.05)Ni_(0.25)Mn_(0.7)O_(2)(NMNM-5)exhibits a specific capacity of100.7 mA h g^(-1),signifying an 83%improvement compared to the NNM material within the voltage of2.0-4.3 *** investigation underscores the intricate interplay between high-voltage stability and structural degradation mechanisms in layered sodium-ion oxides.

关键词： Soidum ion batteries Layer cathode materials P-type High-voltage performance Degradation analysis

Reflective ultrathin light-sheet microscopy with isotropic 3D resolutions

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Photonics Research 2024年第2期12卷 271-281页

作者： YUE WANG DASHAN DONG WENKAI YANG RENXI HE ming lei KEBIN SHI State Key Laboratory for Mesoscopic Physics Department of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Membrane Biology School of Life Sciencesand Biomedical Pioneering Innovation Center(BIOPIC)Peking UniversityBeijing 100871China School of Physics Xi’an Jiaotong UniversityXi’an 710049China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China

Light-sheet fluorescence microscopy(LSFM)has played an important role in bio-imaging due to its advantages of high photon efficiency,fast speed,and long-term imaging *** perpendicular layout between LSFM excitation and detection often limits the 3D resolutions as well as their ***,we report on a reflective type light-sheet microscope with a mini-prism used as an optical path *** conventional high NA objectives can be used both in excitation and detection with this *** resolutions in 3D down to300 nm could be achieved without *** proposed method also enables easy transform of a conventional fluorescence microscope to high performance light-sheet microscopy.

关键词： resolution excitation light

C_(Ar)-Br bond cleavage via cooperative EnT/NHC catalysis: mild access to indolines

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Science China Chemistry 2024年第3期67卷 922-927页

作者： Yi-Xiong Dong Cao-Bo Li ming-lei Jin Zhong-Hua Gao Song Ye Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The cooperative visible-light mediated and NHC-catalyzed dearomative arylation-acylation of N-(2-bromobenzoyl)indoles with aldehydes was developed, affording the corresponding highly functionalized polycyclic indolines in moderate to good yields with exclusive diastereoselectivities. Mechanism investigations support the activation of CAr-Br bond via visible-light mediated energy transfer(EnT) and the following single-electron-transfer(SET) with Breslow intermediate under NHC catalysis to give key aryl radical and ketyl radical. This protocol demonstrates the cleavage of CAr-Br bond under mild cooperative EnT/NHC catalysis.

关键词： energy transfer N-heterocyclic carbenes photocatalysis aryl radicals indolines

More than just aligning the teeth:Clear aligners with multifunctional prowess

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Nano Research 2024年第8期17卷 7665-7674页

作者： Yang Chen lei-ming Cao Nian-Nian Zhong Zi-Zhan Li Lin-Lin Bu Fang-Yi Huo Hong He State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool and Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Oral and Maxillofacial-Head Neck Oncology School and Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Zhuankou Clinical Branches School and Hospital of StomatologyWuhan UniversityWuhan 430000China Department of Orthodontics School and Hospital of StomatologyWuhan UniversityWuhan 430079China

With the increasing demand for beauty and health,clear aligners(CAs)have been widely applied among patients with ***,patients treated with CAs also face some potential complications,such as demineralization,dental caries,and periodontal *** addition,some patients have additional needs to improve their quality of life,such as bleaching *** order to prevent or solve these problems,the modification of CAs is a promising method because their extensive long-term contact with tooth surfaces makes them ideal devices for implementing adjuvant medical *** this review,we discuss various advanced CAs with medical functions based on the clinical needs of *** far as we know,the additional functions of CAs mainly include antibacterial,remineralization,whitening,and accelerating tooth *** functions are achieved by two major pathways,the combination of CAs with drugs/biomaterials and increasing the capacity or affinity of *** addition,we discuss the current limitations of in vitro experiments which are designed to explore the effectiveness and properties of novel CAs,and the challenges of bringing a multifunctional appliance from proposal to clinical *** the end of this review,we provide insights into the broader prospects for the improvement of CAs.

关键词： advanced clear aligners medical device modification drug delivery system personalized medicine

Epidemiology and prognostic nomogram for locally advanced gastric signet ring cell carcinoma:A population-based study

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2610-2630页

作者： Ze-Hao Yu lei-ming Zhang Zhi-Qi Dai Meng-Na Zhang Si-ming Zheng Health Science Center The First Affiliated Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina Health Science Center Ningbo UniversityNingbo 315211Zhejiang ProvinceChina College of Medicine The First Affiliated Hospital of Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina

BACKGROUND Gastric signet ring cell carcinoma(GSRC)represents a specific subtype of gastric cancer renowned for its contentious epidemiological features,treatment principles,and prognostic *** To investigate the epidemiology of GSRC and establish an improved model for predicting the prognosis of patients with locally advanced GSRC(LAGSRC)after *** The annual rates of GSRC incidence and mortality,covering the years 1975 to 2019,were extracted from the Surveillance,Epidemiology,and End Results(SEER)database to explore the temporal trends in both disease incidence and mortality rates using Joinpoint *** clinical data of 3793 postoperative LAGSRC patients were collected from the SEER database for the analysis of survival *** Cox regression model was used to explore the independent prognostic factors for overall survival(OS).The risk factors extracted were used to establish a prognostic *** The overall incidence of GSRC increased dramatically between 1975 and 1998,followed by a significant downward trend in incidence after *** recent years,there has been a similarly optimistic trend in GSRC mortality *** trend in GSRC showed discrepancies based on age and *** operating characteristic curves,calibration curves,and decision curve analysis for 1-year,3-year,and 5-year OS demonstrated the high discriminative ability and clinical utility of this *** area under the curve indicated that the performance of the new model outperformed that of the pathological staging *** The model we established can aid clinicians in the early prognostication of LAGSRC patients,resulting in improved clinical outcomes by modifying management strategies and patient health care.

关键词： Signet ring cell carcinoma Locally advanced gastric cancer Adjuvant chemotherapy Nomogram Epidemiology Overall survival

Novel lactylation-related signature to predict prognosis for pancreatic adenocarcinoma

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World Journal of Gastroenterology 2024年第19期30卷 2575-2602页

作者： Tian Peng Fang Sun Jia-Chun Yang Mei-Hong Cai Man-Xiu Huai Jia-Xing Pan Fei-Yu Zhang lei-ming Xu Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai 200092China

BACKGROUND Lactate,previously considered a metabolic byproduct,is pivotal in cancer progression and maintaining the immunosuppressive tumor *** investigations confirmed that lactate is a primary regulator,introducing recently described post-translational modifications of histone and non-histone proteins,termed lysine *** adenocarcinomas are characterized by increased glycolysis and lactate ***,our understanding of lactylation-related genes in pancreatic adenocarcinomas remains *** To construct a novel lactylation-related gene signature to predict the survival of patients with pancreatic *** RNA-seq and clinical data of pancreatic adenocarcinoma(PDAC)were obtained from the GTEx(Genotype-Tissue Expression)and TCGA(The Cancer Genome Atlas)databases via Xena Explorer,and GSE62452 datasets from *** on lactylation-related genes were obtained from publicly available *** expressed genes(DEGs)were acquired by using R package“DESeq2”in *** COX regression analysis,LASSO Cox and multivariate Cox regressions were produced to construct the lactylation-related prognostic *** analyses,including functional enrichment,ESTIMATE,and CIBERSORT,were performed to analyze immune status and treatment responses in patients with pancreatic *** and normal human cell lines were subjected to western blot analysis under lactic acid intervention;two PDAC cell lines with the most pronounced lactylation were ***,RT-PCR was employed to assess the expression of LRGs genes;SLC16A1,which showed the highest expression,was selected for further ***16A1-mediated lactylation was analyzed by immunofluorescence,lactate production analysis,colony formation,transwell,and wound healing assays to investigate its role in promoting the proliferation and migration of PDAC *** vivo validation was performed using an established tumor *** In this stud

关键词： Pancreatic adenocarcinoma Lactylation Prognosis Immunotherapy Tumor microenvironment

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乡土小说更新的双重逻辑与路径

河北学刊 2024年第2期44卷 131-140页

作者：雷鸣西北大学文学院

乡村和乡村生活始终存在,中国乡土小说不可能消亡,但须不断地转型与更新。更新的历史逻辑在于,百年乡土小说形成的几种传统叙事范式未能切近乡村与农民,表现为叙述视角的“他者化”、叙述方式的“工具化”、叙述模式的同质化,农民形象... 详细信息

乡村和乡村生活始终存在,中国乡土小说不可能消亡,但须不断地转型与更新。更新的历史逻辑在于,百年乡土小说形成的几种传统叙事范式未能切近乡村与农民,表现为叙述视角的“他者化”、叙述方式的“工具化”、叙述模式的同质化,农民形象匮缺主体性等。更新的现实逻辑在于,“乡土中国”已经裂变为市场时代的“后乡土中国”,农民、村庄、城乡关系等均发生了深刻变迁。新的时代感觉结构,自然孕育着新的乡土话语表达,未来乡土小说可在乡土文明价值认知、理解乡村新变趋势、城乡关系、叙事伦理、农民形象等五个维度进行更新,从而在主题凝练、人物塑造、叙事模式、美学面向、结构策略等方面发展和衍生更多新的范式。

关键词：乡土小说更新后乡土中国城乡关系叙事伦理农民形象

乡村振兴视域下文学新人形象建构的经验与问题

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中州学刊 2024年第3期 140-146页

作者：雷鸣西北大学文学院陕西西安710127

实施乡村振兴是新时代中国的一项伟大工程,也是一场新的山乡巨变。文学书写乡村振兴之类题材时,建构了大量文学新人形象。在塑造这些新人形象时,作家们或在历史纵深视野中讲述新人故事,或在“地方性知识”视角下记录新人成长,或在多重... 详细信息

实施乡村振兴是新时代中国的一项伟大工程,也是一场新的山乡巨变。文学书写乡村振兴之类题材时,建构了大量文学新人形象。在塑造这些新人形象时,作家们或在历史纵深视野中讲述新人故事,或在“地方性知识”视角下记录新人成长,或在多重生活面相中观照新人的生命状态,或在乡村振兴的复杂性中形塑新人多元的性格。这些都是值得总结的经验,但创作中亦存在着不少问题,如设置新人参与乡村振兴的动力与逻辑存在着随机性与偶然性,叙述新人引领乡村发展、振兴路径的雷同化与传奇化,推动乡村建设情节之普泛的程式化,直白式的议论语言过多。由此而言,作家需要执守乡村沉浸式写作伦理,具备历史视野与地方意识,抛弃商业惯性与思想惰性,方能创造更具社会价值与艺术价值的乡村振兴新人形象。

关键词：乡村振兴文学新人建构经验问题

求解分布式两阶段混合流水车间调度的反馈人工蜂群算法

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控制理论与应用 2024年第6期41卷 1137-1146页

作者：王移民雷德明武汉理工大学自动化学院湖北武汉430070

针对考虑工厂适用性和附加资源的分布式两阶段混合流水车间调度问题(DTHFSP),本文提出了一种反馈人工蜂群算法(FABC),以最小化最大完成时间和总延迟时间,该算法利用一种新型反馈机制动态调整搜索策略集.为此,本文共设计了5种特点各异的... 详细信息

针对考虑工厂适用性和附加资源的分布式两阶段混合流水车间调度问题(DTHFSP),本文提出了一种反馈人工蜂群算法(FABC),以最小化最大完成时间和总延迟时间,该算法利用一种新型反馈机制动态调整搜索策略集.为此,本文共设计了5种特点各异的搜索策略,将其用于初始策略集和备选策略集,同时,建立并调整雇佣蜂群和跟随蜂群的共享策略集,雇佣蜂阶段和跟随蜂阶段在种群划分的基础上采用随机选择和自适应选择方式确定搜索策略,在侦查蜂阶段完成后,对搜索策略集进行动态调整.文章进行了大量的计算实验,计算结果表明,FABC策略合理有效,且它对所求解的DTHFSP具有较强的搜索优势.

关键词：工厂适用性附加资源分布式两阶段混合流水车间调度反馈人工蜂群算法

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu ming-lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response